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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF79 Gene

protein-coding   GIFtS: 56
GCID: GC09P130186

Zinc Finger Protein 79

(Previous name: zinc finger protein 79 (pT7))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 791 2
ZNFpT72 3
Zinc Finger Protein 79 (PT7)1
pT72

External Ids:    HGNC: 131531   Entrez Gene: 76332   Ensembl: ENSG000001961527   OMIM: 1945525   UniProtKB: Q159373   

Export aliases for ZNF79 gene to outside databases

Previous GC identifers: GC09P121301 GC09P121833 GC09P123640 GC09P125562 GC09P127266 GC09P129227 GC09P099802


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF79 Gene: 
ZNF79 (zinc finger protein 79) is a protein-coding gene. Diseases associated with ZNF79 include prostate carcinoma in situ, and vaccinia, and among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and molecular_function. An important paralog of this gene is ZNF570.

UniProtKB/Swiss-Prot: ZNF79_HUMAN, Q15937
Function: May be involved in transcriptional regulation

Gene Wiki entry for ZNF79 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF79 gene promoter:
         Elk-1   AP-1   p53   NCX/Ncx   HTF   GATA-1   GATA-2   PPAR-gamma1   c-Myb   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF79 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF79

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF79


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34   Ensembl cytogenetic band:  9q33.3   HGNC cytogenetic band: 9q34

ZNF79 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF79 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P130186:  view genomic region     (about GC identifiers)

Start:
130,186,653 bp from pter      End:
130,207,651 bp from pter
Size:
20,999 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZNF79_HUMAN, Q15937 (See protein sequence)
Recommended Name: Zinc finger protein 79  
Size: 498 amino acids; 55350 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: Q5VVW1 Q96NV1

Explore the universe of human proteins at neXtProt for ZNF79: NX_Q15937

Explore proteomics data for ZNF79 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15937

  • ZNF79 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF79 Protein Expression
    REFSEQ proteins: NP_009066.2  
    ENSEMBL proteins: 
     ENSP00000362446   ENSP00000438418  
    Reactome Protein details: Q15937
    Human Recombinant Protein Products for ZNF79: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for ZNF79 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus NAS--

    ZNF79 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q15937

    ProtoNet protein and cluster: Q15937

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZNF79_HUMAN, Q15937
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 11 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF79 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZNF79_HUMAN, Q15937
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF79:
    zinc finger protein 79

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF79 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF79 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF79
        Generic Transcription Pathway
    Gene Expression



    ZNF79 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF79

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0008150biological_process ND--

    ZNF79 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF79

    Search CenterWatch for drugs/clinical trials and news about ZNF79

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF79 gene: 
    NM_007135.2  

    Unigene Cluster for ZNF79:

    Zinc finger protein 79
    Hs.522399  [show with all ESTs]
    Unigene Representative Sequence: NM_007135
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000342483(uc004bqw.4 uc011maf.2 uc011mag.2) ENST00000543471

    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK054606.1 AK302284.1 AK316233.1 BC062309.1 X65232.1 

    5 DOTS entries:

    DT.309987  DT.121170790  DT.121170694  DT.121170788  DT.121170819 

    24/40 AceView cDNA sequences (see all 40):

    AI439129 BM556774 AI301044 BE378801 CB410249 AW805424 BE799466 AI246642 
    BE293194 AA635153 AI700703 BE219834 BP351823 AA680081 BF870852 AL041655 
    AK054606 AL041656 AW080350 AA284829 BX283871 NM_007135 BC062309 AA322087 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF79    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b
    SP1:                    -     -     -                                       
    SP2:                    -                                                   
    SP3:                          -     -                 -     -               
    SP4:                                                                        


    ECgene alternative splicing isoforms for ZNF79

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF79 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTAAAAAA
    ZNF79 Expression
    About this image


    See ZNF79 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF79

    SOURCE GeneReport for Unigene cluster: Hs.522399
        SABiosciences Custom PCR Arrays for ZNF79
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF79 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF791 zinc finger protein 79 85.04(n)
    85.11(a)
      100685774  XM_003435311.1  XP_003435359.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005369151 zinc finger protein 135-like 61.94(n)
    57.09(a)
      100536915  XM_003198450.1  XP_003198498.1 


    ENSEMBL Gene Tree for ZNF79 (if available)
    TreeFam Gene Tree for ZNF79 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF79 gene
    ZNF5702  ZFP302  ZNF5292  ZNF7902  ZNF4832  ZNF3832  ZNF1812  ZNF2872  
    ZNF5822  ZNF4712  ZFP822  ZNF2502  ZNF8792  ZNF354C2  ZNF742  ZNF5832  
    ZNF4852  ZNF4542  ZFP902  ZFP142  ZNF3312  ZNF354A2  ZNF4612  ZNF3112  
    ZNF354B2  ZNF3452  ZNF5682  ZNF342  ZNF5652  
    18/549 SIMAP similar genes for ZNF79 using alignment to 2 protein entries:     ZNF79_HUMAN (see all proteins) (see all similar genes):
    ZNF78L1    ZNF818P    ZFP41    DKFZp313M0722    ZNF24    ZNF323
    ZNF826P    kr-znf3    DKFZp686M04222    ZFS-4    ZNF154    ZNF211
    ZNF416    ZNF345    DKFZp666C237    HZF30    HZF36    ZNF132

    ZNF79 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF79
    PGOHUM00000240537


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/525 SNPs in ZNF79 are shown (see all 525)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1916388351,2
    --130184941(+) AAGATA/TTCTCT 1 -- us2k10--------
    rs1837903071,2
    --130185042(+) CAACAC/TTGGGA 1 -- us2k10--------
    rs45874361,2
    C,F,H--130185217(+) TCCCGG/CTATCC 1 -- us2k19Minor allele frequency- C:0.27EA NS NA WA 636
    rs1441149681,2
    --130185301(+) ATCCCC/TGGAAC 1 -- us2k10--------
    rs39243081,2
    C,F,A,H--130185385(+) CTTAAC/AGATTC 1 -- us2k116Minor allele frequency- A:0.49NS EA NA WA CSA 1682
    rs1427963601,2
    --130185430(+) TGAGGA/GTCCTT 1 -- us2k10--------
    rs789172951,2
    F--130185458(+) GCGGAG/AGAGAG 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs787627071,2
    F--130185547(+) AAGGAT/CGCAGG 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs801297031,2
    C,F--130185688(+) CAAACT/CACAGC 1 -- us2k11Minor allele frequency- C:0.01NA 120
    rs74709711,2
    C,F,A,H--130185708(+) TAGAGA/TAGGGC 1 -- us2k112Minor allele frequency- N:0.00NS EA NA WA 700

    HapMap Linkage Disequilibrium report for ZNF79 (130186653 - 130207651 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZNF79:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1000498CNV Deletion20482838
    dgv1376e199CNV Deletion23128226
    esv2665517CNV Deletion23128226


    Human Gene Mutation Database (HGMD): ZNF79
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 194552    OMIM disorders: --

    5 diseases for ZNF79:    About MalaCards
    prostate carcinoma in situ    vaccinia    thyroid cancer    thyroiditis
    prostatitis

    1 disease from the University of Copenhagen DISEASES database for ZNF79:
    Prostate carcinoma in situ

    ZNF79 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF79
    Human Genome Epidemiology (HuGE) Navigator: ZNF79 (2 documents)

    Export disorders for ZNF79 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF79 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with ZNF79)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal localization of four human zinc finger cDNAs. (PubMed id 8478004)1, 2, 3 Huebner K....Lania L. (1993)
    2. Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (2010)
    3. Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. The zinc finger-associated SCAN box is a conserved oligomerization domain. (PubMed id 10567577)1 Williams A.J....Collins T. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7633 HGNC: 13153 AceView: ZNF79 Ensembl:ENSG00000196152 euGenes: HUgn7633
    ECgene: ZNF79 H-InvDB: ZNF79

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF79 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF79 gene:
    Search GeneIP for patents involving ZNF79

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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