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ZNF79 Gene

protein-coding   GIFtS: 56
GCID: GC09P130186

Zinc Finger Protein 79

(Previous name: zinc finger protein 79 (pT7))
  See ZNF79-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 791 2
ZNFpT72 3
Zinc Finger Protein 79 (PT7)1
pT72

External Ids:    HGNC: 131531   Entrez Gene: 76332   Ensembl: ENSG000001961527   OMIM: 1945525   UniProtKB: Q159373   

Export aliases for ZNF79 gene to outside databases

Previous GC identifers: GC09P121301 GC09P121833 GC09P123640 GC09P125562 GC09P127266 GC09P129227 GC09P099802


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF79 Gene:
ZNF79 (zinc finger protein 79) is a protein-coding gene. Diseases associated with ZNF79 include prostate carcinoma in situ. An important paralog of this gene is ZNF570.

UniProtKB/Swiss-Prot: ZNF79_HUMAN, Q15937
Function: May be involved in transcriptional regulation

Gene Wiki entry for ZNF79 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF79 gene promoter:
         Elk-1   AP-1   p53   NCX/Ncx   HTF   GATA-1   GATA-2   PPAR-gamma1   c-Myb   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF79 promoter sequence
   Search Chromatin IP Primers for ZNF79

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF79


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34   Ensembl cytogenetic band:  9q33.3   HGNC cytogenetic band: 9q34

ZNF79 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF79 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P130186:  view genomic region     (about GC identifiers)

Start:
130,186,653 bp from pter      End:
130,207,651 bp from pter
Size:
20,999 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZNF79_HUMAN, Q15937 (See protein sequence)
Recommended Name: Zinc finger protein 79  
Size: 498 amino acids; 55350 Da
Secondary accessions: Q5VVW1 Q96NV1

Explore the universe of human proteins at neXtProt for ZNF79: NX_Q15937

Explore proteomics data for ZNF79 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys443
  • Modification sites at PhosphoSitePlus

  • See ZNF79 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001273625.1  NP_001273626.1  NP_001273627.1  NP_009066.2  

    ENSEMBL proteins: 
     ENSP00000362446   ENSP00000438418  
    Reactome Protein details: Q15937

    ZNF79 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q15937

    ProtoNet protein and cluster: Q15937

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZNF79_HUMAN, Q15937
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 11 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF79           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZNF79_HUMAN, Q15937
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF79:
    zinc finger protein 79

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF79           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF79
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZNF79_HUMAN, Q15937: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    chloroplast1
    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF79           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF79 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF79           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF79
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF79
    Interactions:

        Search GeneGlobe Interaction Network for ZNF79

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0008150biological_process ND--

    Find genes that share ontologies with ZNF79           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF79



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF79 gene (4 alternative transcripts): 
    NM_001286696.1  NM_001286697.1  NM_001286698.1  NM_007135.2  

    Unigene Cluster for ZNF79:

    Zinc finger protein 79
    Hs.522399  [show with all ESTs]
    Unigene Representative Sequence: NM_007135
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000342483(uc004bqw.4 uc011maf.2 uc011mag.2) ENST00000543471

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      QuantiFast Probe-based Assays in human, mouse, rat ZNF79

    Additional mRNA sequence: 

    AK054606.1 AK302284.1 AK316233.1 BC062309.1 X65232.1 

    5 DOTS entries:

    DT.309987  DT.121170790  DT.121170694  DT.121170788  DT.121170819 

    Selected AceView cDNA sequences (see all 40):

    CB410249 BE378801 BM556774 AI301044 AI439129 AL041655 AA635153 AA680081 
    NM_007135 AK054606 AI246642 BE293194 AW805424 BX283871 AI700703 AA322087 
    BP351823 BF870852 BE219834 AW080350 BC062309 AL041656 BE799466 AA284829 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF79    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b
    SP1:                    -     -     -                                       
    SP2:                    -                                                   
    SP3:                          -     -                 -     -               
    SP4:                                                                        


    ECgene alternative splicing isoforms for ZNF79

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF79 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTAAAAAA
    ZNF79 Expression
    About this image

    ZNF79 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF79 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.522399
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZNF79 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF791 zinc finger protein 79 85.04(n)
    85.11(a)
      100685774  XM_005625342.1  XP_005625399.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG18323   -- 54(a)
    (best of 5)
      40F1   --


    ENSEMBL Gene Tree for ZNF79 (if available)
    TreeFam Gene Tree for ZNF79 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF79 gene
    ZNF5702  ZFP302  ZNF5292  ZNF286B2  ZNF7902  ZNF3832  ZNF1812  ZNF2872  
    ZNF5822  ZNF4712  ZFP822  ZNF286A2  ZNF2502  ZNF8792  ZNF354C2  ZNF742  
    ZNF5832  ZNF3912  ZNF5542  ZNF4542  ZFP902  ENSG000001876072  ZFP142  ZNF3312  
    ZNF354A2  ZNF4612  ZNF354B2  ZNF342  ZNF5272  ZNF5652  
    Selected SIMAP similar genes for ZNF79 using alignment to 2 protein entries:     ZNF79_HUMAN (see all proteins) (see all similar genes):
    ZNF78L1    ZNF818P    ZFP41    DKFZp313M0722    ZNF24    ZNF323
    ZNF826P    kr-znf3    DKFZp686M04222    ZFS-4    ZNF154    ZNF211
    ZNF416    ZNF345    DKFZp666C237    HZF30    HZF36    ZNF132

    Find genes that share paralogs with ZNF79           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ZNF79
    PGOHUM00000240537


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF79 (see all 525)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1916388351,2
    --130184941(+) AAGATA/TTCTCT 1 -- us2k10--------
    rs1837903071,2
    --130185042(+) CAACAC/TTGGGA 1 -- us2k10--------
    rs45874361,2
    C,F,H--130185217(+) TCCCGG/CTATCC 1 -- us2k19Minor allele frequency- C:0.27EA NS NA WA 636
    rs1441149681,2
    --130185301(+) ATCCCC/TGGAAC 1 -- us2k10--------
    rs39243081,2
    C,F,A,H--130185385(+) CTTAAC/AGATTC 1 -- us2k116Minor allele frequency- A:0.49NS EA NA WA CSA 1682
    rs1427963601,2
    --130185430(+) TGAGGA/GTCCTT 1 -- us2k10--------
    rs789172951,2
    F--130185458(+) GCGGAG/AGAGAG 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs787627071,2
    F--130185547(+) AAGGAT/CGCAGG 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs801297031,2
    C,F--130185688(+) CAAACT/CACAGC 1 -- us2k11Minor allele frequency- C:0.01NA 120
    rs74709711,2
    C,F,A,H--130185708(+) TAGAGA/TAGGGC 1 -- us2k112Minor allele frequency- N:0.00NS EA NA WA 700

    HapMap Linkage Disequilibrium report for ZNF79 (130186653 - 130207651 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZNF79:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1000498CNV Deletion20482838
    dgv1376e199CNV Deletion23128226
    esv2665517CNV Deletion23128226

    Human Gene Mutation Database (HGMD): ZNF79
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF79
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF79

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 194552    OMIM disorders: --

    1 disease for ZNF79:    
    About MalaCards
    prostate carcinoma in situ

    1 disease from the University of Copenhagen DISEASES database for ZNF79:
    Prostate carcinoma in situ

    Find genes that share disorders with ZNF79           About GenesLikeMe

    Genetic Association Database (GAD): ZNF79
    Human Genome Epidemiology (HuGE) Navigator: ZNF79 (2 documents)

    Export disorders for ZNF79 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF79 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with ZNF79)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal localization of four human zinc finger cDNAs. (PubMed id 8478004)1, 2, 3 Huebner K....Lania L. (Hum. Genet. 1993)
    2. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (Am. J. Hypertens. 2010)
    3. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7633 HGNC: 13153 AceView: ZNF79 Ensembl:ENSG00000196152 euGenes: HUgn7633
    ECgene: ZNF79 H-InvDB: ZNF79

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF79 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF79 gene:
    Search GeneIP for patents involving ZNF79

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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