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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF789 Gene

protein-coding GIFtS: 45
GCID: GC07P099072

zinc finger protein 789

Explore 2 diseases affiliated with
ZNF789 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger Protein 789¹ ²

External Ids:	HGNC: 27801¹	Entrez Gene: 285989²	Ensembl: ENSG00000198556⁷	UniProtKB: Q5FWF6³

Export aliases for ZNF789 gene to outside databases

Previous GC identifers: GC07P098908 GC07P093707

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN789_HUMAN, Q5FWF6

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF789 gene promoter:
Pax-6 HNF-3beta GATA-1 C/EBPalpha RORalpha1 N-Myc FAC1 CP2 FOXO1a FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF789 promoter sequence

Search SABiosciences Chromatin IP Primers for ZNF789

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF789

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q22.1

ZNF789 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF789 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P099072: view genomic region (about GC identifiers)

Start:	99,070,464 bp from pter	End:	99,101,273 bp from pter
Size:	30,810 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 98,430,287-98,444,989

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN789_HUMAN, Q5FWF6 (See protein sequence)

Recommended Name: Zinc finger protein 789

Size: 425 amino acids; 49984 Da

Subcellular location: Nucleus (Probable)

Sequence caution: Sequence=EAL23876.1; Type=Erroneous gene model prediction;

Secondary accessions: A4D282 Q6ZMZ9

Alternative splicing: 2 isoforms: Q5FWF6-1 Q5FWF6-2 (No experimental confirmation available. Ref.1 (BAD18576) sequence differs from that shown due to frameshifts in positions 85 and 271)

Explore the universe of human proteins at neXtProt for ZNF789: NX_Q5FWF6

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5FWF6

ZNF789 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001013276.1 NP_998768.2

ENSEMBL proteins:

ENSP00000331927 ENSP00000417227 ENSP00000405206 ENSP00000419500 ENSP00000401255

ENSP00000369047

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	Uscn Proteins for ZNF789

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IEA	--

ZNF789 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF789 for domains About GeneDecksing

4 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR001909 Krueppel-associated_box

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q5FWF6

ProtoNet protein and cluster: Q5FWF6

1 Blocks protein family: IPB001909 KRAB box

UniProtKB/Swiss-Prot: ZN789_HUMAN, Q5FWF6

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 8 C2H2-type zinc fingers

Similarity: Contains 1 KRAB domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ZN789_HUMAN, Q5FWF6

Function: May be involved in transcriptional regulation

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZNF789 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for ZNF789:

Increased gamma-H2AX phosphory

Animal Models:

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF789

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF789

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for ZNF789 (Q5FWF6³ ENSP00000331927⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZNF789 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF789
Search CenterWatch for drugs/clinical trials and news about ZNF789 / ZN789

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZNF789 gene (2 alternative transcripts):

NM_001013258.1 NM_213603.2

Unigene Cluster for ZNF789:

Zinc finger protein 789

Hs.440384 [show with all ESTs]

Unigene Representative Sequence: BC031249

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000331410(uc003uqq.1 uc010lfw.1 uc003uqr.1) ENST00000483089(uc003uqp.3)

ENST00000481472 ENST00000448667 ENST00000488485 ENST00000493485 ENST00000447047

ENST00000379724 ENST00000465438 ENST00000468705 ENST00000481108 ENST00000494186

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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence:

AK093141.1 AK131429.1 AK309467.1 BC031249.1 BC089424.1 BX648360.1

19 DOTS entries:

DT.91666644 DT.95369456 DT.97790204 DT.121119262 DT.95081173 DT.97807721 DT.100751050 DT.97840084

DT.92419038 DT.100697478 DT.108964 DT.92037312 DT.97763494 DT.40200501 DT.92416491 DT.95158132

DT.95214485 DT.97777350 DT.91650408

24/89 AceView cDNA sequences (see all 89):

AA804804 BM717468 AK093141 BU741860 CA427224 AW139865 BU681899 BQ889954

CB140921 BC031249 AI383178 CB157176 CA429032 BE502854 BQ775440 BC050286

BX106455 AX747949 CK004745 BM842096 AI355709 AW575071 AW515437 BM845593

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF789 About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	·	3c	^	4	^	5a	·	5b	^	6a	·	6b
SP1:													-		-		-		-
SP2:															-
SP3:									-				-		-		-		-
SP4:
SP5:

ECgene alternative splicing isoforms for ZNF789

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF789 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
See ZNF789 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF789

SOURCE GeneReport for Unigene cluster: Hs.440384
SABiosciences Custom PCR Arrays for ZNF789

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for ZNF789 (if available)
TreeFam Gene Tree for ZNF789 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF789 gene

ZNF2²

18/458 SIMAP similar genes for ZNF789 using alignment to 6 protein entries: ZN789_HUMAN (see all proteins) (see all similar genes):

ZNF573 ZNF846 ZNF514 AVGR5 ZNF66 MGC12518

MRPS17 ZNF56 ZNF738 ZNF205 ZNF506 ZNF655

ZNF559 ZNF33B ZFP57 ZFP90 ZNF527 KRBOX1

ZNF789 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs192322000^1,2		--	99068612(+)	`GAGTAA/GCTGGG`	2	--	us2k¹		0	--	--	--	--
rs80356167^1,2	C	--	99068626(+)	`ACATAC/TTCCTG`	2	--	us2k¹		1		WA	2
rs189745260^1,2		--	99068648(+)	`GGCTAA/GTTTTT`	2	--	us2k¹		0	--	--	--	--
rs150746244^1,2		--	99068756(+)	`GAATTG/TCAGGC`	2	--	us2k¹		0	--	--	--	--
rs139519314^1,2		--	99068922(+)	`AATGAA/GATCCT`	2	--	us2k¹		0	--	--	--	--
rs143670590^1,2		--	99069003(+)	`AAACAC/GAGCAT`	2	--	us2k¹		0	--	--	--	--
rs181779261^1,2		--	99069120(+)	`TAGAGA/GATGGG`	2	--	us2k¹		0	--	--	--	--
rs186208270^1,2		--	99069182(+)	`GCACGC/TGTATC`	2	--	us2k¹		0	--	--	--	--
rs189167468^1,2		--	99069204(+)	`GTTTTC/GTTTAG`	2	--	us2k¹		0	--	--	--	--
rs181826120^1,2		--	99069219(+)	`AATAAA/GAAACA`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZNF789 (99070464 - 99101273 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZNF789
1 CNV: 4548

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZNF789 for disorders About GeneDecksing

2 diseases for ZNF789: About MalaCards

fanconi's anemia anemia

Export disorders for ZNF789 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF789 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF789)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)^{1, 2} Scherer S.W.... Tsui L.-C. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. (PubMed id 19850743)¹ Vanderwerf S.M....Bagby G.C. (2009)
Transcriptome analysis of human gastric cancer. (PubMed id 16341674)¹ Oh J.H....Kim N.S. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 285989	HGNC: 27801	AceView: LOC285989	Ensembl:ENSG00000198556	euGenes: HUgn285989
ECgene: ZNF789	H-InvDB: ZNF789

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF789	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF789 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF789 gene:
Search GeneIP for patents involving ZNF789

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZNF789 gene at Home site.

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ZNF789 Gene

zinc finger protein 789

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ZNF789 Gene

zinc finger protein 789

Aliasesfor ZNF789 gene

Summariesfor ZNF789 gene

Genomic Viewsfor ZNF789 gene

Proteinsfor ZNF789 gene

Protein Domains /Familiesfor ZNF789 gene

Functionfor ZNF789 gene

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Genome Databases showing ZNF789 gene

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for ZNF789 gene

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for ZNF789 gene

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for ZNF789 gene

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for ZNF789 gene

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