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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF789 Gene

protein-coding   GIFtS: 44
GCID: GC07P099074

Zinc Finger Protein 789

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 7891 2

External Ids:    HGNC: 278011   Entrez Gene: 2859892   Ensembl: ENSG000001985567   UniProtKB: Q5FWF63   

Export aliases for ZNF789 gene to outside databases

Previous GC identifers: GC07P098908 GC07P099072 GC07P093707


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF789 Gene: 
ZNF789 (zinc finger protein 789) is a protein-coding gene. Diseases associated with ZNF789 include fanconi's anemia, and anemia. GO annotations related to this gene include DNA binding and zinc ion binding.

UniProtKB/Swiss-Prot: ZN789_HUMAN, Q5FWF6
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF789 gene promoter:
         Pax-6   HNF-3beta   GATA-1   C/EBPalpha   RORalpha1   N-Myc   FAC1   CP2   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF789 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF789

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF789


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

ZNF789 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF789 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P099074:  view genomic region     (about GC identifiers)

Start:
99,070,464 bp from pter      End:
99,101,273 bp from pter
Size:
30,810 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 98,430,287-98,444,989     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN789_HUMAN, Q5FWF6 (See protein sequence)
Recommended Name: Zinc finger protein 789  
Size: 425 amino acids; 49984 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=EAL23876.1; Type=Erroneous gene model prediction;
Secondary accessions: A4D282 A6NH61 Q6ZMZ9
Alternative splicing: 3 isoforms:  Q5FWF6-1   Q5FWF6-2   Q5FWF6-3   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for ZNF789: NX_Q5FWF6

Explore proteomics data for ZNF789 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5FWF6

  • ZNF789 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF789 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001013276.1  NP_998768.2  

    ENSEMBL proteins: 
     ENSP00000331927   ENSP00000417227   ENSP00000405206   ENSP00000419500   ENSP00000401255  
     ENSP00000369047  

    Human Recombinant Protein Products for ZNF789: 
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    Cloud-Clone Corp. Proteins for ZNF789 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF789 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q5FWF6

    ProtoNet protein and cluster: Q5FWF6

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN789_HUMAN, Q5FWF6
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 8 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF789 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN789_HUMAN, Q5FWF6
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF789 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF789:
     Increased gamma-H2AX phosphory 

    Animal Models:
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF789


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF789

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZNF789 (Q5FWF63 ENSP000003319274) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF789 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF789 (ZN789)

    Search CenterWatch for drugs/clinical trials and news about ZNF789 / ZN789

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF789 gene (2 alternative transcripts): 
    NM_001013258.1  NM_213603.2  

    Unigene Cluster for ZNF789:

    Zinc finger protein 789
    Hs.440384  [show with all ESTs]
    Unigene Representative Sequence: BC031249
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000331410(uc003uqq.1 uc010lfw.1 uc003uqr.1) ENST00000483089(uc003uqp.3)
    ENST00000481472 ENST00000448667 ENST00000488485 ENST00000493485 ENST00000447047
    ENST00000379724 ENST00000465438 ENST00000468705 ENST00000481108 ENST00000494186

    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK093141.1 AK131429.1 AK309467.1 BC031249.1 BC089424.1 BX648360.1 

    18 DOTS entries:

    DT.91666644  DT.95369456  DT.121119262  DT.95081173  DT.100751050  DT.97790204  DT.97807721  DT.97840084 
    DT.92419038  DT.100697478  DT.92037312  DT.97763494  DT.40200501  DT.95158132  DT.95214485  DT.97777350 
    DT.108964  DT.91650408 

    24/89 AceView cDNA sequences (see all 89):

    BQ775440 CA429032 CB157176 BE502854 AX747949 BX106455 AI383178 BC031249 
    AK093141 BU741860 CA427224 BQ889954 AA804804 BM717468 BU681899 CB140921 
    BC050286 AW139865 AA766782 BX504435 BE780761 CB988329 BG764587 BI835214 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF789    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b
    SP1:                                      -     -     -     -                     
    SP2:                                            -                                 
    SP3:                          -           -     -     -     -                     
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for ZNF789

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF789 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF789 Expression
    About this image


    See ZNF789 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF789

    SOURCE GeneReport for Unigene cluster: Hs.440384
        SABiosciences Custom PCR Arrays for ZNF789
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF789 gene from 2/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF7896
    zinc finger protein 789
    68(a)
    1 ↔ 1
    6(10053075-10067676)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    26(a)
    1 → many
    GL343417.1(237294-242292)


    ENSEMBL Gene Tree for ZNF789 (if available)
    TreeFam Gene Tree for ZNF789 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF789 gene
    18/426 SIMAP similar genes for ZNF789 using alignment to 5 protein entries:     ZN789_HUMAN (see all proteins) (see all similar genes):
    ZNF547    ZNF548    ZNF573    ZNF846    ZNF514    MGC12518
    ZFP90    ZNF33B    ZNF320    FIK    ZNF506    ZNF669
    ZNF738    ZNF655    ZNF527    ZNF257    ZNF616    ZNF34

    ZNF789 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/343 SNPs in ZNF789 are shown (see all 343)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1923220001,2
    --99068612(+) GAGTAA/GCTGGG 2 -- us2k10--------
    rs803561671,2
    C,F--99068626(+) ACATAC/TTCCTG 2 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1897452601,2
    --99068648(+) GGCTAA/GTTTTT 2 -- us2k10--------
    rs1507462441,2
    --99068756(+) GAATTG/TCAGGC 2 -- us2k10--------
    rs1395193141,2
    --99068922(+) AATGAA/GATCCT 2 -- us2k10--------
    rs1436705901,2
    --99069003(+) AAACAC/GAGCAT 2 -- us2k10--------
    rs1817792611,2
    --99069120(+) TAGAGA/GATGGG 2 -- us2k10--------
    rs1862082701,2
    --99069182(+) GCACGC/TGTATC 2 -- us2k10--------
    rs1891674681,2
    C--99069204(+) GTTTTC/GTTTAG 2 -- us2k10--------
    rs1818261201,2
    --99069219(+) AATAAA/GAAACA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF789 (99070464 - 99101273 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF789:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831069CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    3 diseases for ZNF789:    About MalaCards
    fanconi's anemia    anemia    gastric cancer


    ZNF789 for disorders           About GeneDecksing


    Export disorders for ZNF789 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF789 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF789)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. (PubMed id 19850743)1 Vanderwerf S.M....Bagby G.C. (2009)
    5. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 285989 HGNC: 27801 AceView: LOC285989 Ensembl:ENSG00000198556 euGenes: HUgn285989
    ECgene: ZNF789 H-InvDB: ZNF789

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF789 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF789 gene:
    Search GeneIP for patents involving ZNF789

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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