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ZNF789 Gene

protein-coding   GIFtS: 43
GCID: GC07P099078

Zinc Finger Protein 789

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 7891 2

External Ids:    HGNC: 278011   Entrez Gene: 2859892   Ensembl: ENSG000001985567   UniProtKB: Q5FWF63   

Export aliases for ZNF789 gene to outside databases

Previous GC identifers: GC07P098908 GC07P099072 GC07P093707 GC07P099074


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF789 Gene:
ZNF789 (zinc finger protein 789) is a protein-coding gene. Diseases associated with ZNF789 include fanconi's anemia.

UniProtKB/Swiss-Prot: ZN789_HUMAN, Q5FWF6
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF789 gene promoter:
         Pax-6   HNF-3beta   GATA-1   C/EBPalpha   RORalpha1   N-Myc   FAC1   CP2   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF789 promoter sequence
   Search Chromatin IP Primers for ZNF789

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF789


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

ZNF789 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF789 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P099078:  view genomic region     (about GC identifiers)

Start:
99,070,464 bp from pter      End:
99,101,273 bp from pter
Size:
30,810 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 98,430,287-98,444,989     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN789_HUMAN, Q5FWF6 (See protein sequence)
Recommended Name: Zinc finger protein 789  
Size: 425 amino acids; 49984 Da
Sequence caution: Sequence=EAL23876.1; Type=Erroneous gene model prediction;
Secondary accessions: A4D282 A6NH61 Q6ZMZ9
Alternative splicing: 3 isoforms:  Q5FWF6-1   Q5FWF6-2   Q5FWF6-3   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for ZNF789: NX_Q5FWF6

Explore proteomics data for ZNF789 at MOPED


See ZNF789 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001013276.1  NP_998768.2  

ENSEMBL proteins: 
 ENSP00000331927   ENSP00000417227   ENSP00000405206   ENSP00000419500   ENSP00000401255  
 ENSP00000369047  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ZNF: Zinc fingers, C2H2-type

4 InterPro protein domains:
 IPR001909 Krueppel-associated_box
 IPR015880 Znf_C2H2-like
 IPR013087 Znf_C2H2/integrase_DNA-bd
 IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q5FWF6

ProtoNet protein and cluster: Q5FWF6

1 Blocks protein domain: IPB001909 KRAB box

UniProtKB/Swiss-Prot: ZN789_HUMAN, Q5FWF6
Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
Similarity: Contains 8 C2H2-type zinc fingers
Similarity: Contains 1 KRAB domain


ZNF789 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ZN789_HUMAN, Q5FWF6
Function: May be involved in transcriptional regulation

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003676nucleic acid binding ----
GO:0003677DNA binding IEA--
GO:0003700sequence-specific DNA binding transcription factor activity IBA--
GO:0046872metal ion binding IEA--
     
ZNF789 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for ZNF789:
 Increased gamma-H2AX phosphory 

Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ZN789_HUMAN, Q5FWF6: Nucleus (Probable)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus4
cytosol2

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular ----
GO:0005634nucleus IDA--
GO:0005730NOT nucleolus IDA--

ZNF789 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF789
Interactions:

    Search GeneGlobe Interaction Network for ZNF789

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for ZNF789 (Q5FWF63 ENSP000003319274) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
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Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated IBA--

ZNF789 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ZNF789 (ZN789)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for ZNF789 gene (2 alternative transcripts): 
NM_001013258.1  NM_213603.2  

Unigene Cluster for ZNF789:

Zinc finger protein 789
Hs.440384  [show with all ESTs]
Unigene Representative Sequence: BC031249
12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000331410(uc003uqq.1 uc010lfw.1 uc003uqr.1) ENST00000483089(uc003uqp.3)
ENST00000481472 ENST00000448667 ENST00000488485 ENST00000493485 ENST00000447047
ENST00000379724 ENST00000465438 ENST00000468705 ENST00000481108 ENST00000494186

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Additional mRNA sequence: 

AK093141.1 AK131429.1 AK309467.1 BC031249.1 BC089424.1 BX648360.1 

18 DOTS entries:

DT.91666644  DT.95369456  DT.121119262  DT.95081173  DT.100751050  DT.97790204  DT.97807721  DT.97840084 
DT.92419038  DT.100697478  DT.92037312  DT.97763494  DT.40200501  DT.95158132  DT.95214485  DT.97777350 
DT.108964  DT.91650408 

Selected AceView cDNA sequences (see all 89):

BX106455 AW139865 BU681899 BQ889954 CB157176 AI383178 CB140921 CA429032 
AK093141 BQ775440 BC050286 AA804804 BM717468 BU741860 CA427224 BC031249 
AX747949 BE502854 BX954520 BM840293 BM841754 BF761998 BM845593 BM838714 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF789    About this scheme

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1:                                      -     -     -     -                     
SP2:                                            -                                 
SP3:                          -           -     -     -     -                     
SP4:                                                                              
SP5:                                                                              


ECgene alternative splicing isoforms for ZNF789

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZNF789 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
ZNF789 Expression
About this image

ZNF789 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ZNF789 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.440384
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of mammals.

Orthologs for ZNF789 gene from Selected species (see all 3)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia ZNF7891 zinc finger protein 789 81.75(n)
75.83(a)
  102153308  XM_005621091.1  XP_005621148.1 


ENSEMBL Gene Tree for ZNF789 (if available)
TreeFam Gene Tree for ZNF789 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ZNF789 gene
Selected SIMAP similar genes for ZNF789 using alignment to 5 protein entries:     ZN789_HUMAN (see all proteins) (see all similar genes):
ZNF547    ZNF548    ZNF573    ZNF846    ZNF514    MGC12518
ZFP90    ZNF33B    ZNF320    FIK    ZNF506    ZNF669
ZNF738    ZNF177    ZNF655    ZNF527    ZNF257    ZNF616

ZNF789 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZNF789 (see all 343)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1923220001,2
--99068612(+) GAGTAA/GCTGGG 2 -- us2k10--------
rs803561671,2
C,F--99068626(+) ACATAC/TTCCTG 2 -- us2k11Minor allele frequency- T:0.50WA 2
rs1897452601,2
--99068648(+) GGCTAA/GTTTTT 2 -- us2k10--------
rs1507462441,2
--99068756(+) GAATTG/TCAGGC 2 -- us2k10--------
rs1395193141,2
--99068922(+) AATGAA/GATCCT 2 -- us2k10--------
rs1436705901,2
--99069003(+) AAACAC/GAGCAT 2 -- us2k10--------
rs1817792611,2
--99069120(+) TAGAGA/GATGGG 2 -- us2k10--------
rs1862082701,2
--99069182(+) GCACGC/TGTATC 2 -- us2k10--------
rs1891674681,2
C--99069204(+) GTTTTC/GTTTAG 2 -- us2k10--------
rs1818261201,2
--99069219(+) AATAAA/GAAACA 2 -- us2k10--------

HapMap Linkage Disequilibrium report for ZNF789 (99070464 - 99101273 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for ZNF789:    About this table    
Variant IDTypeSubtypePubMed ID
nsv831069CNV Loss17160897

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease for ZNF789:    About MalaCards
fanconi's anemia


ZNF789 for disorders           About GeneDecksing


Export disorders for ZNF789 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ZNF789 gene integrated from 10 sources:
(articles sorted by number of sources associating them with ZNF789)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  2. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  4. TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. (PubMed id 19850743)1 Vanderwerf S.M....Bagby G.C. (Blood 2009)
  5. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H.... Kim N.S. (Mamm. Genome 2005)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  7. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (Nature 2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 285989 HGNC: 27801 AceView: LOC285989 Ensembl:ENSG00000198556 euGenes: HUgn285989
ECgene: ZNF789 H-InvDB: ZNF789

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ZNF789 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ZNF789 gene:
Search GeneIP for patents involving ZNF789

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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