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Aliases for ZNF789 Gene

Aliases for ZNF789 Gene

  • Zinc Finger Protein 789 2 3 5

External Ids for ZNF789 Gene

Previous GeneCards Identifiers for ZNF789 Gene

  • GC07P098908
  • GC07P099072
  • GC07P093707
  • GC07P099074
  • GC07P099078

Summaries for ZNF789 Gene

GeneCards Summary for ZNF789 Gene

ZNF789 (Zinc Finger Protein 789) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF2.

UniProtKB/Swiss-Prot for ZNF789 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF789 Gene

Genomics for ZNF789 Gene

Regulatory Elements for ZNF789 Gene

Enhancers for ZNF789 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F099579 1.4 FANTOM5 Ensembl ENCODE 24 +107.5 107473 1.4 ZNF2 RAD21 ZBTB40 ZNF354C ZNF366 ZNF202 ZNF263 ZNF680 REST ZNF518A ZSCAN25 TRRAP LOC100131859 ZNF655 ENSG00000242798 STAG3L5P AP4M1 LOC101927550 LOC100419643 PPP1R35
GH07F100356 1.2 Ensembl ENCODE 23.5 +885.1 885110 2.7 ZFP64 RAD21 ZNF354C FOS EGR2 ZNF202 ZNF680 ZNF654 ZBTB11 ZEB2 ZSCAN25 GIGYF1 PILRA LOC100131859 ZNF655 STAG3L5P AP4M1 ENSG00000242798 PPP1R35 PCOLCE-AS1
GH07F100438 1.7 FANTOM5 Ensembl ENCODE 12.9 +970.0 969994 8.0 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B DMAP1 YY1 SLC30A9 FOS PILRA ZNF789 C7orf61 TSC22D4 NYAP1 ENSG00000242798 IRS3P SAP25 FBXO24 LRCH4
GH07F099140 1.4 FANTOM5 ENCODE 12.9 -330.0 -329967 4.7 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YBX1 ZNF548 SP3 KAT8 TRRAP ZNF655 ZSCAN25 LOC101927550 ZNF789 LOC100131859 ENSG00000242798 LOC100419643 ARPC1B COPS6
GH07F100449 1.4 Ensembl ENCODE 12.9 +977.5 977535 2.2 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZNF143 ZSCAN25 ZNF655 ENSG00000242798 GIGYF1 STAG3L5P MEPCE AP4M1 PPP1R35 ZNF789 TSC22D4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF789 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF789 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000631002 -29 2801 PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207

Genomic Location for ZNF789 Gene

Chromosome:
7
Start:
99,472,829 bp from pter
End:
99,503,650 bp from pter
Size:
30,822 bases
Orientation:
Plus strand

Genomic View for ZNF789 Gene

Genes around ZNF789 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF789 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF789 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF789 Gene

Proteins for ZNF789 Gene

  • Protein details for ZNF789 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5FWF6-ZN789_HUMAN
    Recommended name:
    Zinc finger protein 789
    Protein Accession:
    Q5FWF6
    Secondary Accessions:
    • A4D282
    • A6NH61
    • Q6ZMZ9

    Protein attributes for ZNF789 Gene

    Size:
    425 amino acids
    Molecular mass:
    49984 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=EAL23876.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF789 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF789 Gene

Post-translational modifications for ZNF789 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF789 Gene

Domains & Families for ZNF789 Gene

Gene Families for ZNF789 Gene

Protein Domains for ZNF789 Gene

Suggested Antigen Peptide Sequences for ZNF789 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5FWF6

UniProtKB/Swiss-Prot:

ZN789_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 8 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 8 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF789: view

Function for ZNF789 Gene

Molecular function for ZNF789 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF789 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF789: view
genes like me logo Genes that share phenotypes with ZNF789: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF789 Gene

Localization for ZNF789 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF789 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF789 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF789 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF789: view

Pathways & Interactions for ZNF789 Gene

SuperPathways for ZNF789 Gene

No Data Available

Interacting Proteins for ZNF789 Gene

Gene Ontology (GO) - Biological Process for ZNF789 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF789: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF789 Gene

Transcripts for ZNF789 Gene

Unigene Clusters for ZNF789 Gene

Zinc finger protein 789:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF789 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - - - -
SP2: -
SP3: - - - - -
SP4:
SP5:

Relevant External Links for ZNF789 Gene

GeneLoc Exon Structure for
ZNF789
ECgene alternative splicing isoforms for
ZNF789

Expression for ZNF789 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF789 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF789 Gene:

ZNF789

SOURCE GeneReport for Unigene cluster for ZNF789 Gene:

Hs.440384
genes like me logo Genes that share expression patterns with ZNF789: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF789 Gene

Orthologs for ZNF789 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF789 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF789 34 35
  • 99.53 (n)
dog
(Canis familiaris)
Mammalia ZNF789 34 35
  • 81.75 (n)
cow
(Bos Taurus)
Mammalia ZNF789 34 35
  • 80 (n)
Species where no ortholog for ZNF789 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF789 Gene

ENSEMBL:
Gene Tree for ZNF789 (if available)
TreeFam:
Gene Tree for ZNF789 (if available)

Paralogs for ZNF789 Gene

Paralogs for ZNF789 Gene

(429) SIMAP similar genes for ZNF789 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF789: view

Variants for ZNF789 Gene

Sequence variations from dbSNP and Humsavar for ZNF789 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10235235 -- 99,478,208(+) aggag(C/T)tacCA intron-variant, upstream-variant-2KB
rs10244158 -- 99,482,621(+) aggtc(A/G)aggtg intron-variant, downstream-variant-500B, utr-variant-5-prime
rs10273355 -- 99,482,388(+) acctg(C/T)gtttt intron-variant, downstream-variant-500B, utr-variant-5-prime
rs10274078 -- 99,476,942(+) AGGAA(C/G)TTCTC intron-variant
rs10274095 -- 99,476,976(+) ATGAA(C/T)GGGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF789 Gene

Variant ID Type Subtype PubMed ID
nsv831069 CNV loss 17160897
esv3614278 CNV loss 21293372
esv3576408 CNV gain 25503493

Variation tolerance for ZNF789 Gene

Residual Variation Intolerance Score: 55.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.38; 90.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF789 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF789

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF789 Gene

Disorders for ZNF789 Gene

Relevant External Links for ZNF789

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF789

No disorders were found for ZNF789 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF789 Gene

Publications for ZNF789 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for ZNF789 Gene

Sources for ZNF789 Gene

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