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ZNF788 Gene

protein-coding   GIFtS: 33
GCID: GC19P012204

Zinc Finger Family Member 788

  Search for ZNF788
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Family Member 7881 2

External Ids:    HGNC: 331121   Entrez Gene: 3885072   Ensembl: ENSG000002141897   UniProtKB: Q6ZQV53   
ORGUL members:         

Export aliases for ZNF788 gene to outside databases

Previous GC identifers: GC19P012075 GC19P012076 GC19P012077 GC19P012084 GC19P012087 GC19P012089 GC19P012095 GC19P012097 GC19P011778


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF788 Gene:
ZNF788 (zinc finger family member 788) is a protein-coding gene. An important paralog of this gene is ZNF669.

UniProtKB/Swiss-Prot: ZN788_HUMAN, Q6ZQV5
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF788 gene promoter:
         AML1a   FOXD1   HSF1 (long)   LCR-F1   E47   HSF1short   Hand1   Chx10   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ZNF788

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF788


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

ZNF788 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF788 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P012204:  view genomic region     (about GC identifiers)

Start:
12,203,078 bp from pter      End:
12,248,050 bp from pter
Size:
44,973 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for ZNF788

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN788_HUMAN, Q6ZQV5 (See protein sequence)
Recommended Name: Zinc finger protein 788  
Size: 615 amino acids; 71992 Da
Sequence caution: Sequence=BAC87366.1; Type=Erroneous initiation;
Secondary accessions: Q6ZRE4

Explore the universe of human proteins at neXtProt for ZNF788: NX_Q6ZQV5

Explore proteomics data for ZNF788 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF788 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


    ENSEMBL proteins: 
     ENSP00000391703   ENSP00000473243  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q6ZQV5

    ProtoNet protein and cluster: Q6ZQV5

    UniProtKB/Swiss-Prot: ZN788_HUMAN, Q6ZQV5
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 17 C2H2-type zinc fingers


    ZNF788 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN788_HUMAN, Q6ZQV5
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    ZNF788 for ontologies           About GeneDecksing


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN788_HUMAN, Q6ZQV5: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF788 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF788
    Interactions:

        Search GeneGlobe Interaction Network for ZNF788

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    ZNF788 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for ZNF788 (ZN788)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF788 gene: 
    NM_001004314.2  

    Unigene Cluster for ZNF788:

    Zinc finger family member 788
    Hs.127473  [show with all ESTs]
    Unigene Representative Sequence: NR_027049
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000596096 ENST00000430298(uc002mtd.3) ENST00000595703 ENST00000601686
    ENST00000397755(uc002mtc.1) ENST00000596883
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    Additional mRNA sequence: 

    AK124155.1 AK128282.1 AK128700.1 NR_027049.1 

    4 DOTS entries:

    DT.404097  DT.101958280  DT.121449775  DT.97821142 

    17 AceView cDNA sequences:

    AK093787 AX748306 BM781919 BU193672 AK124155 NM_001004314 AK128700 AI478464 
    AW243441 BF366276 AI190287 AA953412 AK128282 AA608898 CK000275 AI566055 
    BX110909 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF788 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTAACTGTG
    ZNF788 Expression
    About this image

    ZNF788 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF788 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.127473
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF788 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    2(a)
    1 → many
    AAWZ02038665(3150-4763)
    zebrafish
    (Danio rerio)
    Actinopterygii CT573234.26
    CR388132.26
    Uncharacterized protein
    2(a)
    2(a)
    many ↔ many
    many ↔ many
    Zv9_scaffold3530(1425476-1452687) ENSDARG00000093555
    4(28399744-28423465) ENSDARG00000092942
            Species with no ortholog for ZNF788

    ENSEMBL Gene Tree for ZNF788 (if available)
    TreeFam Gene Tree for ZNF788 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF788 gene
    ZNF6692  ZNF5642  ZNF4902  ZNF4412  ZNF625-ZNF202  ZNF8782  ENSG000002671792  ZNF142  
    ENSG000002697552  ENSG000001968262  ZNF7002  ZNF692  ZNF4402  ZNF4432  ZNF670-ZNF6952  ZNF442  
    ZNF4392  ZNF8232  ENSG000001884742  ZNF4912  ZNF5552  ENSG000002688702  ZNF7092  ZNF6252  
    ZNF7992  ZNF202  ZNF1012  ZNF7912  ZNF4422  ZNF4332  ZNF572  ZNF6272  
    ZNF5632  ENSG000002573552  ZNF1362  ZNF5562  ZNF7632  ENSG000002687442  ZNF8442  ZNF772  
    Selected SIMAP similar genes for ZNF788 using alignment to 2 protein entries:     ZN788_HUMAN (see all proteins) (see all similar genes):
    ZNF274    LOC101928664    ZNF625-ZNF20    ZNF738    ZNF525    ZNF844
    ZNF226    ZNF763    ZNF649    ZNF320    ZNF235    ZNF596
    ZNF625    ZNF155    ZNF562    ZFS-4    ZNF669    ZNF615

    ZNF788 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF788 (see all 370)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1471561221,2
    --12201137(+) CCTTCA/CAGGTA 1 -- us2k10--------
    rs767229891,2
    F--12201198(+) TGACAA/GTGAGA 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1404226761,2
    C--12201377(+) CAATCA/GGGCTT 1 -- us2k10--------
    rs558884031,2
    C,F--12201649(+) ACCGCC/TGCCAC 1 -- us2k12Minor allele frequency- T:0.05WA 120
    rs1921096601,2
    --12201784(+) GTTGGC/TCTGGT 1 -- us2k10--------
    rs1841976211,2
    --12201845(+) CAGAGC/GCCAAG 1 -- us2k10--------
    rs739233911,2
    C,F--12201855(+) GACCAG/ACCTGG 1 -- us2k12Minor allele frequency- A:0.04WA 120
    rs1180976881,2
    F--12201890(+) GCTCCC/TTTGGG 1 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1178301731,2
    F--12201895(+) CTTGGG/CTGTTT 1 -- us2k11Minor allele frequency- C:0.01NA 120
    rs1496573221,2
    --12202010(+) GGAGGC/TGTTCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF788 (12203078 - 12248050 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ZNF788:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911069CNV Loss21882294
    nsv833753CNV Loss17160897
    nsv525966CNV Gain19592680
    nsv911068CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF788 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF788)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Common genetic variation and performance on standardized cognitive tests. (PubMed id 20125193)1 Cirulli E.T....Goldstein D.B. (Eur. J. Hum. Genet. 2010)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 388507 HGNC: 33112 AceView: FLJ46419 Ensembl:ENSG00000214189 euGenes: HUgn388507
    ECgene: ZNF788 H-InvDB: ZNF788

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF788 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF788 gene:
    Search GeneIP for patents involving ZNF788

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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