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ZNF787 Gene

protein-coding   GIFtS: 45
GCID: GC19M056598

Zinc Finger Protein 787

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 7871 2
TTF-I-Interacting Peptide 202 3
TIP202
Transcription Termination Factor I Interacting Peptide 202
TTF-I Interacting Peptide 202

External Ids:    HGNC: 269981   Entrez Gene: 1262082   Ensembl: ENSG000001424097   UniProtKB: Q6DD873   

Export aliases for ZNF787 gene to outside databases

Previous GC identifers: GC19M061291 GC19M052909


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF787 Gene:
ZNF787 (zinc finger protein 787) is a protein-coding gene. An important paralog of this gene is YY2.

UniProtKB/Swiss-Prot: ZN787_HUMAN, Q6DD87
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF787 gene promoter:
         E2F-3a   E2F-4   Sox5   E2F-5   E2F-2   PPAR-gamma1   E2F-1   E2F   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF787 promoter sequence
   Search Chromatin IP Primers for ZNF787

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF787


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.42

ZNF787 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF787 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M056598:  view genomic region     (about GC identifiers)

Start:
56,598,732 bp from pter      End:
56,632,649 bp from pter
Size:
33,918 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN787_HUMAN, Q6DD87 (See protein sequence)
Recommended Name: Zinc finger protein 787  
Size: 383 amino acids; 40543 Da
Sequence caution: Sequence=AAB58413.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: O00455

Explore the universe of human proteins at neXtProt for ZNF787: NX_Q6DD87

Explore proteomics data for ZNF787 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF787 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001002836.2  
    ENSEMBL proteins: 
     ENSP00000270459   ENSP00000471514   ENSP00000465647  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q6DD87

    ProtoNet protein and cluster: Q6DD87

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZN787_HUMAN, Q6DD87
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 7 C2H2-type zinc fingers


    Find genes that share domains with ZNF787           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN787_HUMAN, Q6DD87
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF787           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF787
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    2 qRT-PCR Assays for microRNAs that regulate ZNF787:
    hsa-miR-3184 hsa-miR-423-5p
    SwitchGear 3'UTR luciferase reporter plasmidZNF787 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN787_HUMAN, Q6DD87: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF787           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF787
    Interactions:

        Search GeneGlobe Interaction Network for ZNF787

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZNF787 (Q6DD873 ENSP000002704594) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTENP604843, ENSP000003610214I2D: score=1 STRING: ENSP00000361021
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF787           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF787 (ZN787)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF787 gene: 
    NM_001002836.2  

    Unigene Cluster for ZNF787:

    Zinc finger protein 787
    Hs.397153  [show with all ESTs]
    Unigene Representative Sequence: BC077728
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000270459(uc010eth.1 uc002qml.1) ENST00000586787 ENST00000587279

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate ZNF787:
    hsa-miR-3184 hsa-miR-423-5p
    SwitchGear 3'UTR luciferase reporter plasmidZNF787 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat ZNF787
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF787
      QuantiFast Probe-based Assays in human, mouse, rat ZNF787

    Additional mRNA sequence: 

    AF000560.1 BC058034.1 BC077728.1 

    5 DOTS entries:

    DT.442078  DT.100760993  DT.121352101  DT.99938673  DT.99994741 

    Selected AceView cDNA sequences (see all 116):

    AI377107 BF941806 BU751817 AI923715 AI887074 AI928550 BM661910 AI373204 
    AI352619 BU732211 BM696130 AA557164 BC037737 AI022401 BM666920 R70344 
    AA029811 BV194082 BC012495 AI563947 AI091160 BV195141 AI272013 BU538478 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF787 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGGGCGCGG
    ZNF787 Expression
    About this image

    ZNF787 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF787 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.397153
        Custom PCR Arrays for ZNF787
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF787

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZNF787 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp7871 , 5 zinc finger protein 7871, 5 85.74(n)1
    92.65(a)1
      7 (3.55 cM)5
    671091  NM_001013012.11  NP_001013030.11 
     61314895 
    zebrafish
    (Danio rerio)
    Actinopterygii ZNF7876
    zinc finger protein 787
    34(a)
    1 → many
    17(50980703-50986718) ENSDARG00000097191
    fruit fly
    (Drosophila melanogaster)
    Insecta pho6
    phol6
    pleiohomeotic like
    7(a)
    6(a)
    many ↔ many
    many ↔ many
    4(1193094-1202271)
    3L(9446148-9449381)


    ENSEMBL Gene Tree for ZNF787 (if available)
    TreeFam Gene Tree for ZNF787 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF787 gene
    YY22  ZFP422  ZNF8532  YY12  
    Selected SIMAP similar genes for ZNF787 using alignment to 3 protein entries:     ZN787_HUMAN (see all proteins) (see all similar genes):
    ZNF78L1    ZNF818P    kr-znf3    ZNF286A    ZNF286B    DKFZp666C237
    GLI4    ZNF514    ZKSCAN1    ZNF22    ZNF232    DKFZp686O111
    ZNF667    ZNF707    ZSCAN32    ZFS-5    ZNF419    ZNF626

    Find genes that share paralogs with ZNF787           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF787 (see all 1085)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs785577931,2
    C,F--56598342(+) ACGTGC/GGCCCT 1 -- ds50011Minor allele frequency- G:0.12WA 118
    rs1445939271,2
    --56598380(+) GGAGGC/GAGGAG 1 -- ds50010--------
    rs1911880441,2
    --56598386(+) AGGAGC/GAGGGT 1 -- ds50010--------
    rs616880151,2
    C,F--56598437(+) AGGAAG/ACCAGC 1 -- ds50016Minor allele frequency- A:0.35NA WA EA 364
    rs11097131,2
    C--56598442(+) GCCAGC/TCGCCC 1 -- ds50016Minor allele frequency- T:0.42NA MN CSA EA 430
    rs11097141,2
    C--56598448(+) CGCCCC/TTGTGA 1 -- ds50015Minor allele frequency- T:0.25NA MN CSA EA 428
    rs129846291,2
    C,A--56598517(+) CAGTCC/TGCCCT 1 -- ds50018Minor allele frequency- T:0.40NA WA EA 368
    rs5262751,2
    C,A--56598538(-) GGAGCC/TGCTTG 1 -- ds500110Minor allele frequency- T:0.11MN NA WA CSA EA 437
    rs610360241,2
    C,F--56598553(+) CCCTGT/GGAGTG 1 -- ds50012Minor allele frequency- G:0.12CSA WA 120
    rs6039441,2
    C,A--56598557(+) GTGAGT/CGCCCG 1 -- ds50017Minor allele frequency- C:0.25MN NA CSA WA EA 547

    HapMap Linkage Disequilibrium report for ZNF787 (56598732 - 56632649 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZNF787 (see all 22):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1322949CNV Deletion17803354
    esv2719013CNV Deletion23290073
    esv2719010CNV Deletion23290073
    esv2719015CNV Deletion23290073
    esv991692CNV Deletion20482838
    esv2719018CNV Deletion23290073
    esv2657534CNV Deletion23128226
    dgv585e201CNV Deletion23290073
    esv2719019CNV Deletion23290073
    esv2719016CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF787
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF787 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with ZNF787)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6. (PubMed id 23151878)1 Evsyukova I....Garcia-Blanco M.A. (RNA 2013)
    2. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    4. Proteomic investigation of the interactome of FMNL1 in hematopoietic cells unveils a role in calcium-dependent membrane plasticity. (PubMed id 23182705)1 Han Y....Krackhardt A.M. (J Proteomics 2013)
    5. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    6. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    7. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    8. Analysis of phosphatase and tensin homolog tumor suppressor interacting proteins by in vitro and in silico proteomics. (PubMed id 15717329)1 Crockett D.K....Lim M.S. (Proteomics 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 126208 HGNC: 26998 AceView: LOC126208 Ensembl:ENSG00000142409 euGenes: HUgn126208
    ECgene: ZNF787 H-InvDB: ZNF787

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF787 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF787 gene:
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    GeneCards and IP:
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