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Aliases for ZNF786 Gene

Aliases for ZNF786 Gene

  • Zinc Finger Protein 786 2 3 5

External Ids for ZNF786 Gene

Previous GeneCards Identifiers for ZNF786 Gene

  • GC07M148397
  • GC07M148088
  • GC07M148766
  • GC07M142845

Summaries for ZNF786 Gene

GeneCards Summary for ZNF786 Gene

ZNF786 (Zinc Finger Protein 786) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF425.

UniProtKB/Swiss-Prot for ZNF786 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF786 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF786 Gene

Genomics for ZNF786 Gene

Regulatory Elements for ZNF786 Gene

Enhancers for ZNF786 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H149143 1.6 Ensembl ENCODE dbSUPER 35.6 -55.7 -55742 6 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF766 CBX5 ZNF143 ZNF783 LOC155060 ZNF398 ZNF212 ZNF425 ZNF282 ZNF786 ENSG00000271664 ZNF777 ZNF767P
GH07H149690 1.4 Ensembl ENCODE 28.1 -600.2 -600228 1 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF2 ZNF416 SP3 ZNF592 ZNF783 ZNF777 ZNF398 ENSG00000271664 LOC155060 ZNF212 ZNF767P ZNF282 ZNF786 ZNF862
GH07H149064 1.4 Ensembl ENCODE 24 +25.2 25240 2 HDGF MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B ZNF398 ZNF212 ZNF425 ZNF786 ZNF783 ZNF746 ZNF282 ENSG00000271664 RNU6-650P PDIA4
GH07H148940 1.4 Ensembl ENCODE 21.2 +149.4 149382 2 PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 CBX5 ZNF783 ZNF398 ZNF777 ENSG00000271664 ZNF767P LOC155060 ZNF212 ZNF282 ZNF786 CUL1
GH07H148962 1.1 ENCODE 24.2 +127.2 127185 2 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 ZNF777 ZNF398 ZNF786 ENSG00000271664 ZNF783 ZNF212 LOC155060 ZNF282 ZNF767P EZH2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF786 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF786 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000219582 -118 2201 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for ZNF786 Gene

Chromosome:
7
Start:
149,069,641 bp from pter
End:
149,090,782 bp from pter
Size:
21,142 bases
Orientation:
Minus strand

Genomic View for ZNF786 Gene

Genes around ZNF786 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF786 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF786 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF786 Gene

Proteins for ZNF786 Gene

  • Protein details for ZNF786 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N393-ZN786_HUMAN
    Recommended name:
    Zinc finger protein 786
    Protein Accession:
    Q8N393
    Secondary Accessions:
    • A1A568
    • B4DMI1

    Protein attributes for ZNF786 Gene

    Size:
    782 amino acids
    Molecular mass:
    89815 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF786 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF786 Gene

Post-translational modifications for ZNF786 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF786 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF786 Gene

Domains & Families for ZNF786 Gene

Gene Families for ZNF786 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF786 Gene

Suggested Antigen Peptide Sequences for ZNF786 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N393

UniProtKB/Swiss-Prot:

ZN786_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF786: view

Function for ZNF786 Gene

Molecular function for ZNF786 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF786 Gene

Gene Ontology (GO) - Molecular Function for ZNF786 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF786: view
genes like me logo Genes that share phenotypes with ZNF786: view

Animal Model Products

CRISPR Products

miRNA for ZNF786 Gene

miRTarBase miRNAs that target ZNF786

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF786
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF786 Gene

Localization for ZNF786 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF786 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF786 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF786 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with ZNF786: view

Pathways & Interactions for ZNF786 Gene

SuperPathways for ZNF786 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF786: view

Pathways by source for ZNF786 Gene

2 Reactome pathways for ZNF786 Gene

Interacting Proteins for ZNF786 Gene

Gene Ontology (GO) - Biological Process for ZNF786 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF786: view

No data available for SIGNOR curated interactions for ZNF786 Gene

Drugs & Compounds for ZNF786 Gene

No Compound Related Data Available

Transcripts for ZNF786 Gene

mRNA/cDNA for ZNF786 Gene

Unigene Clusters for ZNF786 Gene

Zinc finger protein 786:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF786
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF786 Gene

No ASD Table

Relevant External Links for ZNF786 Gene

GeneLoc Exon Structure for
ZNF786
ECgene alternative splicing isoforms for
ZNF786

Expression for ZNF786 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF786 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF786 Gene



Protein tissue co-expression partners for ZNF786 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF786 Gene:

ZNF786

SOURCE GeneReport for Unigene cluster for ZNF786 Gene:

Hs.729572

Evidence on tissue expression from TISSUES for ZNF786 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF786: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF786 Gene

Orthologs for ZNF786 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF786 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF786 33 34
  • 98.98 (n)
dog
(Canis familiaris)
Mammalia ZNF425 33
  • 79.68 (n)
ZNF786 34
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp786 33
  • 74.47 (n)
mouse
(Mus musculus)
Mammalia Zfp786 33 16 34
  • 74.42 (n)
cow
(Bos Taurus)
Mammalia ZNF786 34
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 40 (a)
ManyToMany
Species where no ortholog for ZNF786 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF786 Gene

ENSEMBL:
Gene Tree for ZNF786 (if available)
TreeFam:
Gene Tree for ZNF786 (if available)

Paralogs for ZNF786 Gene

Paralogs for ZNF786 Gene

(481) SIMAP similar genes for ZNF786 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF786: view

Variants for ZNF786 Gene

Sequence variations from dbSNP and Humsavar for ZNF786 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000047007 -- 149,077,785(+) TGATG(A/G)ATAAT intron-variant
rs1000100585 -- 149,080,432(+) TAACA(A/G)TGTTG intron-variant
rs1000101943 -- 149,082,379(+) AGTAT(C/T)GTTTA intron-variant
rs1000151714 -- 149,071,725(+) TTCCC(C/T)TCCTG reference, synonymous-codon
rs1000331858 -- 149,076,666(+) GTGAG(C/T)CGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF786 Gene

Variant ID Type Subtype PubMed ID
esv2666491 CNV deletion 23128226
esv2668984 CNV deletion 23128226
nsv1018754 CNV gain 25217958
nsv1140856 CNV deletion 24896259

Variation tolerance for ZNF786 Gene

Residual Variation Intolerance Score: 5.72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.57; 30.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF786 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF786

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF786 Gene

Disorders for ZNF786 Gene

Relevant External Links for ZNF786

Genetic Association Database (GAD)
ZNF786
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF786

No disorders were found for ZNF786 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF786 Gene

Publications for ZNF786 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  3. A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PMID: 19875614) Paterson AD … Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group (Diabetes 2010) 45 60
  4. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 60
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60

Products for ZNF786 Gene

Sources for ZNF786 Gene

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