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ZNF785 Gene

protein-coding   GIFtS: 46
GCID: GC16M030590

Zinc Finger Protein 785

Pneumococci & Pneumococcal Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 7851 2

External Ids:    HGNC: 264961   Entrez Gene: 1465402   Ensembl: ENSG000001971627   UniProtKB: A8K8V03   

Export aliases for ZNF785 gene to outside databases

Previous GC identifers: GC16M030498 GC16M030008 GC16M028154


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF785 Gene:
ZNF785 (zinc finger protein 785) is a protein-coding gene. Diseases associated with ZNF785 include hiv-1. An important paralog of this gene is ZNF747.

UniProtKB/Swiss-Prot: ZN785_HUMAN, A8K8V0
Function: May be involved in transcriptional regulation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_187260.1  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF785 gene promoter:
         STAT1   STAT1beta   NF-kappaB   STAT1alpha   CREB   deltaCREB   STAT3   ZIC2/Zic2   NF-kappaB1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF785 promoter sequence
   Search Chromatin IP Primers for ZNF785

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF785


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

ZNF785 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF785 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M030590:  view genomic region     (about GC identifiers)

Start:
30,585,061 bp from pter      End:
30,597,092 bp from pter
Size:
12,032 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN785_HUMAN, A8K8V0 (See protein sequence)
Recommended Name: Zinc finger protein 785  
Size: 405 amino acids; 46168 Da
Secondary accessions: O75701 Q8IW91 Q8WV14 Q96MN0
Alternative splicing: 2 isoforms:  A8K8V0-1   A8K8V0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF785: NX_A8K8V0

Explore proteomics data for ZNF785 at MOPED


See ZNF785 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_689671.2  
ENSEMBL proteins: 
 ENSP00000456097   ENSP00000420340   ENSP00000378642   ENSP00000458511  
Reactome Protein details: A8K8V0

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ZNF: Zinc fingers, C2H2-type

4 InterPro protein domains:
 IPR001909 Krueppel-associated_box
 IPR015880 Znf_C2H2-like
 IPR013087 Znf_C2H2/integrase_DNA-bd
 IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry A8K8V0

ProtoNet protein and cluster: A8K8V0

UniProtKB/Swiss-Prot: ZN785_HUMAN, A8K8V0
Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
Similarity: Contains 7 C2H2-type zinc fingers
Similarity: Contains 1 KRAB domain


ZNF785 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ZN785_HUMAN, A8K8V0
Function: May be involved in transcriptional regulation (By similarity)

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003676nucleic acid binding ----
GO:0003677DNA binding IEA--
GO:0046872metal ion binding IEA--
     
ZNF785 for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for ZNF785:
 Decreased Tat-dependent transc  Increased G1 DNA content 

Animal Models:
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miRNA
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miRTarBase miRNAs that target ZNF785:
hsa-mir-92a-3p (MIRT049045), hsa-mir-375 (MIRT020008)

Block miRNA regulation of human, mouse, rat ZNF785 using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate ZNF785:
hsa-miR-10b* hsa-miR-532-5p hsa-miR-151-3p
SwitchGear 3'UTR luciferase reporter plasmidZNF785 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat ZNF785

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ZN785_HUMAN, A8K8V0: Nucleus (Probable)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus4
cytosol2

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular ----
GO:0005634nucleus IEA--

ZNF785 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ZNF785 About    
See pathways by source

SuperPathContained pathways About
1Gene Expression
Generic Transcription Pathway0.40
Gene Expression0.40

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for ZNF785
    Generic Transcription Pathway



ZNF785 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF785
Interactions:

    Search GeneGlobe Interaction Network for ZNF785

Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated IEA--

ZNF785 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ZNF785 (ZN785)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for ZNF785 gene: 
NM_152458.6  

Unigene Cluster for ZNF785:

Zinc finger protein 785
Hs.513509  [show with all ESTs]
Unigene Representative Sequence: NM_152458
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000562128 ENST00000470110(uc002dyv.2) ENST00000395216(uc002dyw.2 uc010vez.2)
ENST00000567773

miRNA
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3 qRT-PCR Assays for microRNAs that regulate ZNF785:
hsa-miR-10b* hsa-miR-532-5p hsa-miR-151-3p
SwitchGear 3'UTR luciferase reporter plasmidZNF785 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for ZNF785
Predesigned siRNA for gene silencing in human, mouse, rat ZNF785
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GenScript: all cDNA clones in your preferred vector: ZNF785 (NM_152458)
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Primer
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Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF785
  QuantiTect SYBR Green Assays in human, mouse, rat ZNF785
  QuantiFast Probe-based Assays in human, mouse, rat ZNF785

Additional mRNA sequence: 

AK309511.1 BC040642.2 

6 DOTS entries:

DT.456418  DT.111480  DT.95353439  DT.95365947  DT.86839031  DT.97775105 

Selected AceView cDNA sequences (see all 36):

AI283029 AI004601 W01951 AA427747 AI918488 CB989423 AI375066 AF086220 
AI680525 AW969032 AI160875 BE265745 AW043743 BQ212320 AI144506 AK056692 
AW273256 AA960897 AI934019 AA631784 AA427746 AI114543 BC040642 CB054315 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF785    About this scheme

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c
SP1:                          -           -     -                     
SP2:              -     -     -           -     -                     
SP3:                          -                                       
SP4:                          -     -                                 
SP5:                                      -     -                     


ECgene alternative splicing isoforms for ZNF785

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZNF785 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
ZNF785 Expression
About this image

ZNF785 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ZNF785 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.513509
    Custom PCR Arrays for ZNF785
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF785

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of mammals.

Orthologs for ZNF785 gene from Selected species (see all 3)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia ZNF7851 zinc finger protein 785 82.29(n)
77.19(a)
  607501  XM_844192.3  XP_849285.2 


ENSEMBL Gene Tree for ZNF785 (if available)
TreeFam Gene Tree for ZNF785 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ZNF785 gene
ZNF7472  ZNF7642  ZNF6882  ENSG000002614592  ENSG000002608692  ZNF6892  
Selected SIMAP similar genes for ZNF785 using alignment to 3 protein entries:     ZN785_HUMAN (see all proteins) (see all similar genes):
ZNF688    ZNF695    ZNF707    ZFS-6    ZNF175    ZNF213
ZNF790    ZNF83    ZNF    ZNF271    ZNF320    ZNF519
ZNF616    kr-znf3    ZNF793    ZNF324    ZNF814    DKFZp434G1930

ZNF785 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZNF785 (see all 166)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1867583691,2
--30591609(+) GTTCAA/GGCCAT 1 -- ds50010--------
rs1384254271,2
C--30591862(+) TAGTAC/GAGACG 1 -- ds50010--------
rs1391904541,2
--30591922(+) CTGCCC/TGCCTC 1 -- ds50010--------
rs80463311,2
C--30591965(+) gccaaC/Tgtgcc 1 -- ds50010--------
rs742499491,2
C,F--30592110(+) GAGCCG/ACCGCG 1 -- ut311Minor allele frequency- A:0.00NA 2
rs2004787441,2
--30592220(+) TCTTT-/AAAAAA 1 -- ut310--------
rs1915003771,2
--30592547(+) AGGCCA/GAGGCG 1 -- ut310--------
rs1838102091,2
--30592562(+) GATCAC/TGAAGT 1 -- ut310--------
rs1884485841,2
--30592576(+) GAGATC/TGAGAC 1 -- ut310--------
rs1486518541,2
--30592729(+) TGAGCA/GTAGCT 1 -- ut310--------

HapMap Linkage Disequilibrium report for ZNF785 (30585061 - 30597092 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for ZNF785:    About this table    
Variant IDTypeSubtypePubMed ID
nsv905727CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing ZNF785
DNA2.0 Custom Variant and Variant Library Synthesis for ZNF785

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease for ZNF785:    
About MalaCards
hiv-1


ZNF785 for disorders           About GeneDecksing


Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
Genetic Association Database (GAD): ZNF785
Human Genome Epidemiology (HuGE) Navigator: ZNF785 (1 document)

Export disorders for ZNF785 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ZNF785 gene integrated from 10 sources:
(articles sorted by number of sources associating them with ZNF785)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  3. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 3 Loftus B.J.... Adams M.D. (Genomics 1999)
  4. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
  5. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PubMed id 21083371)4 Chinn L.W....O'Brien S.J. (J. Infect. Dis. 2010)
  6. Identification of host proteins required for HIV infection through a functional genomic screen. (PubMed id 18187620)1 Brass A.L....Elledge S.J. (Science 2008)
  7. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 146540 HGNC: 26496 AceView: FLJ32130 Ensembl:ENSG00000197162 euGenes: HUgn146540
ECgene: ZNF785 H-InvDB: ZNF785

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ZNF785 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ZNF785 gene:
Search GeneIP for patents involving ZNF785

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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