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ZNF784 Gene

protein-coding   GIFtS: 46
GCID: GC19M056132

Zinc Finger Protein 784

  Search for ZNF784
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 7841 2

External Ids:    HGNC: 331111   Entrez Gene: 1478082   Ensembl: ENSG000001799227   UniProtKB: Q8NCA93   

Export aliases for ZNF784 gene to outside databases

Previous GC identifers: GC19M060824 GC19M052442


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF784 Gene:
ZNF784 (zinc finger protein 784) is a protein-coding gene. An important paralog of this gene is ZNF628.

UniProtKB/Swiss-Prot: ZN784_HUMAN, Q8NCA9
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF784 gene promoter:
         HFH-3   Lmo2   NF-kappaB   HNF-3beta   Tal-1beta   FOXI1   PPAR-gamma1   PPAR-gamma2   NF-kappaB1   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF784 promoter sequence
   Search Chromatin IP Primers for ZNF784

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF784


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.42

ZNF784 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF784 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M056132:  view genomic region     (about GC identifiers)

Start:
56,132,107 bp from pter      End:
56,135,967 bp from pter
Size:
3,861 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN784_HUMAN, Q8NCA9 (See protein sequence)
Recommended Name: Zinc finger protein 784  
Size: 323 amino acids; 34237 Da

Explore the universe of human proteins at neXtProt for ZNF784: NX_Q8NCA9

Explore proteomics data for ZNF784 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF784 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_976308.1  
    ENSEMBL proteins: 
     ENSP00000320096   ENSP00000467725  

    ZNF784 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8NCA9

    ProtoNet protein and cluster: Q8NCA9

    UniProtKB/Swiss-Prot: ZN784_HUMAN, Q8NCA9
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 6 C2H2-type zinc fingers


    ZNF784 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN784_HUMAN, Q8NCA9
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    ZNF784 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF784:
     Cell cycle / mitosis defect 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF784
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    miRNA
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    miRTarBase miRNAs that target ZNF784:
    hsa-mir-615-3p (MIRT040464)

    Block miRNA regulation of human, mouse, rat ZNF784 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZNF784 (see all 24):
    hsa-miR-148b hsa-let-7d hsa-miR-202 hsa-miR-301a hsa-let-7c hsa-let-7g hsa-miR-633 hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidZNF784 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN784_HUMAN, Q8NCA9: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZNF784 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF784
    Interactions:

        Search GeneGlobe Interaction Network for ZNF784

    Selected Interacting proteins for ZNF784 (Q8NCA92, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253836 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253836 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253836 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253836 I2D: score=2 
    ENSG00000228875P678702, 3MINT-8253836 I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    ZNF784 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF784 (ZN784)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF784 gene: 
    NM_203374.1  

    Unigene Cluster for ZNF784:

    Zinc finger protein 784
    Hs.53996  [show with all ESTs]
    Unigene Representative Sequence: BC065822
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000325351(uc010etb.1 uc002qll.1) ENST00000591479
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZNF784 (see all 24):
    hsa-miR-148b hsa-let-7d hsa-miR-202 hsa-miR-301a hsa-let-7c hsa-let-7g hsa-miR-633 hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidZNF784 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZNF784
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF784
      QuantiFast Probe-based Assays in human, mouse, rat ZNF784

    Additional mRNA sequence: 

    AF086055.1 AK074859.1 AK309967.1 BC065822.1 

    3 DOTS entries:

    DT.100774191  DT.100694138  DT.121465365 

    Selected AceView cDNA sequences (see all 49):

    BM021379 CR604701 BC065822 AA282235 BM772555 CR618267 BQ084072 NM_203374 
    CD106357 AF086055 CK904252 N54663 BM719455 BX372363 AI919487 CB306270 
    AK074859 BQ448574 BQ898577 CA448526 BQ277623 BX379254 AI268861 BG471427 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF784    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b
    SP1:              -               
    SP2:                              


    ECgene alternative splicing isoforms for ZNF784

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF784 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGGCTGGC
    ZNF784 Expression
    About this image

    ZNF784 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF784 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.53996
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF784 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp7841 , 5 zinc finger protein 7841, 5 80.89(n)1
    85.32(a)1
      7 (2.91 cM)5
    6548011  NM_001039532.21  NP_001034621.11 
     50344395 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkeyp-2e4.36
    si:dkeyp-2e4.56
    (see all 6)
    si:dkeyp-2e4.5
    (see all 6)
    26(a)
    26(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    13(45460293-45463416) ENSDARG00000095283
    13(45451172-45454492) ENSDARG00000095497


    ENSEMBL Gene Tree for ZNF784 (if available)
    TreeFam Gene Tree for ZNF784 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF784 gene
    ZNF6282  
    Selected SIMAP similar genes for ZNF784 using alignment to 2 protein entries:     ZN784_HUMAN (see all proteins) (see all similar genes):
    ZNF    ZNF808    ZNF72    ZNF844    DKFZp666M039    ZFP41
    ZNF26    ZNF135    ZNF323    ZNF551    ZNF211    ZNF420
    ZNF792    ZNF816    ZSCAN20    ZSCAN30    DKFZp686B16128    ZFP2

    ZNF784 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF784 (see all 131)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1138321501,2
    C,F--56131666(+) AGGGAC/TTGGAC 1 -- int12Minor allele frequency- T:0.05CSA WA 120
    rs730583111,2
    C,F--56131709(+) CCCAGG/ATATCC 1 -- int12Minor allele frequency- A:0.11NA 122
    rs104204471,2
    C--56131737(+) CAATGA/TCATCA 1 -- int10--------
    rs1464554621,2
    --56131749(+) AAGCAC/TGGAGG 1 -- int10--------
    rs1408768061,2
    C--56131810(+) GAGTTA/CTCTCA 1 -- int10--------
    rs5201251,2
    C,F,H--56131883(-) TCAACG/ATGCTT 1 -- int117Minor allele frequency- A:0.03NS EA NA WA CSA 789
    rs1438168951,2
    C--56131945(+) TAACAC/TGTAAC 1 -- int10--------
    rs22928101,2
    C,F,H--56131965(+) GCCTAC/TTCACC 1 -- int114Minor allele frequency- T:0.19EA NS NA CSA WA 2284
    rs1458008431,2
    --56132033(+) CTGGTA/GGCAAA 1 -- int10--------
    rs1863743131,2
    --56132051(+) TGAGGA/CCCCTC 1 -- int10--------

    HapMap Linkage Disequilibrium report for ZNF784 (56132107 - 56135967 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for ZNF784:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912499CNV Loss21882294
    nsv828643CNV Loss20364138
    nsv912502CNV Loss21882294
    dgv4025n71CNV Loss21882294
    nsv912473CNV Loss21882294
    nsv912500CNV Loss21882294
    nsv912501CNV Loss21882294
    nsv912486CNV Loss21882294
    dgv4026n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    ZNF784 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF784

    Export disorders for ZNF784 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF784 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF784)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    4. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 147808 HGNC: 33111 AceView: LOC147808 Ensembl:ENSG00000179922 euGenes: HUgn147808
    ECgene: ZNF784 H-InvDB: ZNF784

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF784 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF784 gene:
    Search GeneIP for patents involving ZNF784

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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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