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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF783 Gene

protein-coding   GIFtS: 33
GCID: GC07P148959

Zinc Finger Family Member 783

  Search for ZNF783
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Family Member 7831 2
Protein ZNF7832

External Ids:    HGNC: 272221   Entrez Gene: 1002896782   Ensembl: ENSG000002049467   UniProtKB: Q6ZMS73   

Export aliases for ZNF783 gene to outside databases

Previous GC identifer: GC07P148590


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF783 Gene: 
ZNF783 (zinc finger family member 783) is a protein-coding gene. GO annotations related to this gene include DNA binding. An important paralog of this gene is ZNF282.

UniProtKB/Swiss-Prot: ZN783_HUMAN, Q6ZMS7
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF783 gene promoter:
         Tal-1   MyoD   Nkx2-5   GATA-1   E47   AREB6   CP2   Hand1   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): ZNF783 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF783

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF783


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.1   Ensembl cytogenetic band:  7q36.1   HGNC cytogenetic band: 7q36.1

ZNF783 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF783 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P148959:  view genomic region     (about GC identifiers)

Start:
148,959,262 bp from pter      End:
148,994,393 bp from pter
Size:
35,132 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 148,297,268-148,320,088     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN783_HUMAN, Q6ZMS7 (See protein sequence)
Recommended Name: Protein ZNF783  
Size: 281 amino acids; 31422 Da
Subcellular location: Nucleus (Probable)
Caution: Despite its name, it does not contain a canonical C2H2-type zinc-finger

Explore the universe of human proteins at neXtProt for ZNF783: NX_Q6ZMS7

Explore proteomics data for ZNF783 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6ZMS7

  • ZNF783 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF783 Protein Expression
    REFSEQ proteins: NP_001182149.1  
    ENSEMBL proteins: 
     ENSP00000410890   ENSP00000367291   ENSP00000418666   ENSP00000419521   ENSP00000391817  

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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF783 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    2 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR022137 DUF3669_Znf

    Graphical View of Domain Structure for InterPro Entry Q6ZMS7

    ProtoNet protein and cluster: Q6ZMS7

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN783_HUMAN, Q6ZMS7
    Similarity: Contains 1 KRAB domain


    ZNF783 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN783_HUMAN, Q6ZMS7
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding ----
         
    ZNF783 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF783

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF783 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ZNF783 (ZN783)

    Search CenterWatch for drugs/clinical trials and news about ZNF783 / ZN783

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for ZNF783 gene: 
    NM_001195220.1  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000434415(uc011kuo.2) ENST00000378052(uc003wfr.4) ENST00000476295
    ENST00000481519 ENST00000489518 ENST00000418158
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    SwitchGear 3'UTR luciferase reporter plasmidZNF783 3' UTR sequence
    Inhib. RNA
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF783 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF783 Expression
    About this image


    See ZNF783 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF783
        SABiosciences Custom PCR Arrays for ZNF783
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF783

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF783 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    --
    Uncharacterized protein
    24(a)
    19(a)
    possible ortholog
    possible ortholog
    2(482598-491135)
    2(498988-504322)
    lizard
    (Anolis carolinensis)
    Reptilia ZNF7836
    zinc finger family member 783
    31(a)
    1 ↔ 1
    AAWZ02037767(3896-11046)
            Species with no ortholog for ZNF783

    ENSEMBL Gene Tree for ZNF783 (if available)
    TreeFam Gene Tree for ZNF783 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF783 gene
    ZNF2822  ZNF7772  ZNF2122  ZNF7462  ZNF3982  
    18/82 SIMAP similar genes for ZNF783 using alignment to 4 protein entries:     ZN783_HUMAN (see all proteins) (see all similar genes):
    ZNF767    LOC155060    ZNF66    ZNF569    ZNF789    MGC12518
    ZNF273    ZNF300P1    ZNF3    ZNF331    ZFP41    ZNF573
    ZNF718    ZNF93    ZNF81    ZNF212    ZFS-4    ZNF254

    ZNF783 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/588 SNPs in ZNF783 are shown (see all 588)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0694664
    ----see VAR_0694662 R C mis40--------
    rs1430551631,2
    C--148957330(+) GATAAA/GCAGTG 1 -- us2k10--------
    rs97850101,2
    C,A--148957462(+) tgtgcC/Ttagca 1 -- us2k14Minor allele frequency- T:0.05NA CSA WA 124
    rs1822419951,2
    --148957463(+) GTGCCC/TAGCAT 1 -- us2k10--------
    rs1880586531,2
    --148957492(+) ACCCTC/GAGTGA 1 -- us2k10--------
    rs722851231,2
    C--148957647(+) TGACC-/CTTT  
            
    CTTTC
    1 -- us2k10--------
    rs1994987211,2
    --148957658(+) TTCTT-/TCTTTTT 1 -- us2k10--------
    rs570627791,2
    C--148957659(+) TCTTT-/C/CTTT
            
    TTCTT
    1 -- us2k11NA 2
    rs1930955421,2
    --148957894(+) CATCCA/GCCTCA 1 -- us2k10--------
    rs102280071,2
    C,F,H--148958052(+) CTGATA/GAGATC 1 -- us2k113Minor allele frequency- G:0.05NS NA WA 1594

    HapMap Linkage Disequilibrium report for ZNF783 (148959262 - 148994393 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZNF783:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv889402CNV Loss21882294
    nsv6001CNV Loss18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF783 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF783)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)1, 2 Gauci S....Mohammed S. (2009)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (1997)
    4. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (1996)
    5. Exome sequencing identifies PDE4D mutations in acrodys ostosis. (PubMed id 22464252)2 Lee H....Cohn D.H. (2012)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
    8. Toward a complete human genome sequence. (PubMed id 9847074)1 Wilson R. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 100289678 HGNC: 27222 Ensembl:ENSG00000204946 euGenes: HUgn100289678 ECgene: ZNF783
    H-InvDB: ZNF783

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF783 gene:
    Search GeneIP for patents involving ZNF783

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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