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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF782 Gene

protein-coding   GIFtS: 45
GCID: GC09M099578

Zinc Finger Protein 782

  Search for ZNF782
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 7821 2

External Ids:    HGNC: 331101   Entrez Gene: 1584312   Ensembl: ENSG000001965977   UniProtKB: Q6ZMW23   

Export aliases for ZNF782 gene to outside databases

Previous GC identifers: GC09M098619 GC09M069190


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF782 Gene: 
ZNF782 (zinc finger protein 782) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF334.

UniProtKB/Swiss-Prot: ZN782_HUMAN, Q6ZMW2
Function: May be involved in transcriptional regulation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF782 gene promoter:
         HFH-3   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   Evi-1   FOXI1   Nkx6-1   POU2F1a   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF782 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF782

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF782


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.33   Ensembl cytogenetic band:  9q22.33   HGNC cytogenetic band: 9q22.33

ZNF782 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF782 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M099578:  view genomic region     (about GC identifiers)

Start:
99,578,754 bp from pter      End:
99,637,905 bp from pter
Size:
59,152 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN782_HUMAN, Q6ZMW2 (See protein sequence)
Recommended Name: Zinc finger protein 782  
Size: 699 amino acids; 80904 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: B2RNR0

Explore the universe of human proteins at neXtProt for ZNF782: NX_Q6ZMW2

Explore proteomics data for ZNF782 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6ZMW2

  • ZNF782 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF782 Protein Expression
    REFSEQ proteins: NP_001001662.1  
    ENSEMBL proteins: 
     ENSP00000419397   ENSP00000418686   ENSP00000417577   ENSP00000419978   ENSP00000440624  
    Reactome Protein details: Q6ZMW2
    Human Recombinant Protein Products for ZNF782: 
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    Cloud-Clone Corp. Proteins for ZNF782 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF782 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q6ZMW2

    ProtoNet protein and cluster: Q6ZMW2

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN782_HUMAN, Q6ZMW2
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 15 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF782 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN782_HUMAN, Q6ZMW2
    Function: May be involved in transcriptional regulation (By similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF782 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF782 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF782 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF782


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF782 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF782
        Generic Transcription Pathway
    Gene Expression



    ZNF782 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF782

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF782 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF782 (ZN782)

    Search CenterWatch for drugs/clinical trials and news about ZNF782 / ZN782

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF782 gene: 
    NM_001001662.1  

    Unigene Cluster for ZNF782:

    Zinc finger protein 782
    Hs.732126  [show with all ESTs]
    Unigene Representative Sequence: AK131468
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000481138(uc004awp.1 uc011lup.1) ENST00000289032 ENST00000466833
    ENST00000478850 ENST00000430274 ENST00000498811 ENST00000485322 ENST00000535338

    miRNA
    Products:
         
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF782:
    hsa-miR-188-3p hsa-miR-539
    SwitchGear 3'UTR luciferase reporter plasmidZNF782 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZNF782
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF782
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF782
    Sirion Biotech Customized lentivirus for stable overexpression of ZNF782 
                         Customized lentivirus expression plasmids for stable overexpression of ZNF782 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF782
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF782

    Additional mRNA sequence: 

    AK131468.1 AK302460.1 BC137073.1 

    4 DOTS entries:

    DT.102822336  DT.106579  DT.97778258  DT.97815737 

    24/35 AceView cDNA sequences (see all 35):

    CB121164 AA490476 AI208312 Z21188 BX089738 NM_001001662 W76661 AA856776 
    CR619806 AA019430 BX103276 BQ227337 AK131468 W73073 BF435209 Z32829 
    N35244 BX953109 CD103090 AL540705 AV725290 AA490699 CA390459 Z44630 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF782 expression in normal human tissues (normalized intensities)      ZNF782 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF782 Expression
    About this image


    ZNF782 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...

    See ZNF782 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF782

    SOURCE GeneReport for Unigene cluster: Hs.732126
        SABiosciences Custom PCR Arrays for ZNF782
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF782
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF782

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZNF782 gene from 2/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF7821 zinc finger protein 782 85.73(n)
    79.17(a)
      100687500  XM_003432604.1  XP_003432652.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG312246
    --
    9(a)
    1 → many
    3R(14475843-14484963)


    ENSEMBL Gene Tree for ZNF782 (if available)
    TreeFam Gene Tree for ZNF782 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF782 gene
    ZNF3342  ZNF1752  ZNF6742  ZNF4872  ZNF5102  LOC1002875152  ZNF6142  RBAK2  
    ZNF262  ZNF6132  ZNF812  ZNF6492  KRBOX42  ZNF33B2  ENSG000002673602  ZNF122  
    ENSG000002296312  ZNF5672  ZNF1822  ZNF37A2  ZNF2482  ZNF3002  ZNF3822  
    18/542 SIMAP similar genes for ZNF782 using alignment to 5 protein entries:     ZN782_HUMAN (see all proteins) (see all similar genes):
    FIK    HZF16    POM121C    ZNF300P1    ZNF78L1    kr-znf3
    HZF36    ZFS-4    DKFZp686M04222    ZNF436    DKFZp434J0650    ZNF833P
    ZNF664    ZNF    ZNF253    ZNF558    ZNF56    ZNF826P

    ZNF782 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF782
    PGOHUM00000236720


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/749 SNPs in ZNF782 are shown (see all 749)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1462306191,2
    C--99578780(+) TTTTT-/GTTCTT 1 -- ds50010--------
    rs1162272841,2
    C,F--99578987(+) AAATTA/GTCATA 1 -- ds50011Minor allele frequency- G:0.07WA 118
    rs1155527941,2
    F--99579011(+) TTTGGG/CTGTGT 1 -- ds50011Minor allele frequency- C:0.03WA 118
    rs1918139141,2
    --99579033(+) TGTGTC/GTGTGT 1 -- ds50010--------
    rs109791521,2
    C,F,H--99579100(+) CTGATG/AAGGAA 1 -- ds500115Minor allele frequency- A:0.09NS EA NA 2124
    rs1496384291,2
    C--99579305(+) CCTCAA/CTGCAA 1 -- ut310--------
    rs1833712751,2
    --99579344(+) AACTCC/GATGCC 1 -- ut310--------
    rs1866768251,2
    C--99579370(+) GACCCA/GGGTTC 1 -- ut310--------
    rs1899068141,2
    --99579518(+) CTAGAA/GGGTAA 1 -- ut310--------
    rs556947371,2
    C--99579536(+) ACCCCG/CTTTAG 1 -- ut311Minor allele frequency- C:0.50WA 2

    HapMap Linkage Disequilibrium report for ZNF782 (99578754 - 99637905 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ZNF782:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2668332CNV Deletion23128226
    nsv831661CNV Loss17160897
    nsv520001CNV Loss19592680
    nsv6624CNV Loss18451855
    nsv831660CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF782 for disorders           About MalaCards

    ZNF782 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF782
    Human Genome Epidemiology (HuGE) Navigator: ZNF782 (1 document)

    Export disorders for ZNF782 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF782 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF782)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association scan for stature in Chinese: evidence for ethnic specific loci. (PubMed id 19030899)1, 4 Lei S.F....Deng H.W. (2008)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    4. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 158431 HGNC: 33110 AceView: FLJ16636 Ensembl:ENSG00000196597 euGenes: HUgn158431
    ECgene: ZNF782 H-InvDB: ZNF782

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF782 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF782 gene:
    Search GeneIP for patents involving ZNF782

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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