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Aliases for ZNF780A Gene

Aliases for ZNF780A Gene

  • Zinc Finger Protein 780A 2 3 5
  • ZNF780 3

External Ids for ZNF780A Gene

Previous GeneCards Identifiers for ZNF780A Gene

  • GC19M045268
  • GC19M040575
  • GC19M037011

Summaries for ZNF780A Gene

GeneCards Summary for ZNF780A Gene

ZNF780A (Zinc Finger Protein 780A) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF780B.

UniProtKB/Swiss-Prot for ZNF780A Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF780A Gene

Genomics for ZNF780A Gene

Regulatory Elements for ZNF780A Gene

Enhancers for ZNF780A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F040142 0.7 Ensembl ENCODE 34.1 -52.6 -52565 3.8 BCOR PKNOX1 MXI1 USF1 TBL1XR1 ZNF133 CHD4 ZMYM3 ZNF664 ZNF366 ZNF780A FCGBP GC19M040148 VN1R96P
GH19F040146 0.9 Ensembl ENCODE 33.4 -56.0 -56026 1.9 ZNF280D JUN ZIC2 ZEB1 ZNF121 ZFHX2 JUND POLR2A IKZF1 FOS ZNF780A GC19M040148 VN1R96P
GH19F040055 0.4 ENCODE 33 +35.5 35492 1.7 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF302 ZNF416 ZNF780A ENSG00000205041 RPS16 SERTAD3 SNRPA LGALS14 ENSG00000269188 LOC105372399 ENSG00000269792 ENSG00000269172
GH19F040085 0.7 ENCODE 31.6 +6.6 6558 0.2 ARID4B ZSCAN9 RARA EGR2 THAP11 SP5 CEBPB MIER2 ATF4 CEBPA ZNF780A TTC9B CNTD2 ENSG00000269296 PIR50002
GH19F040089 0.9 ENCODE 29.8 +1.2 1208 2.4 HDGF PKNOX1 ARNT MLX CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ENSG00000269843 SNRPA FBL ZNF780A ITPKC RPS16 RN7SL566P ENSG00000268366 SERTAD3 LGALS14
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF780A on UCSC Golden Path with GeneCards custom track

Promoters for ZNF780A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000216576 1236 2600 HDGF PKNOX1 ARNT MLX CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for ZNF780A Gene

Chromosome:
19
Start:
40,069,152 bp from pter
End:
40,091,736 bp from pter
Size:
22,585 bases
Orientation:
Minus strand

Genomic View for ZNF780A Gene

Genes around ZNF780A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF780A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF780A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF780A Gene

Proteins for ZNF780A Gene

  • Protein details for ZNF780A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75290-Z780A_HUMAN
    Recommended name:
    Zinc finger protein 780A
    Protein Accession:
    O75290
    Secondary Accessions:
    • E9PB48
    • Q6ZN87

    Protein attributes for ZNF780A Gene

    Size:
    641 amino acids
    Molecular mass:
    74531 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC34327.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF780A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF780A Gene

Post-translational modifications for ZNF780A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF780A Gene

Domains & Families for ZNF780A Gene

Gene Families for ZNF780A Gene

Suggested Antigen Peptide Sequences for ZNF780A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75290

UniProtKB/Swiss-Prot:

Z780A_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 17 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 17 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF780A: view

Function for ZNF780A Gene

Molecular function for ZNF780A Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF780A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF780A: view

Phenotypes for ZNF780A Gene

GenomeRNAi human phenotypes for ZNF780A:
genes like me logo Genes that share phenotypes with ZNF780A: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF780A Gene

Localization for ZNF780A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF780A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF780A Gene COMPARTMENTS Subcellular localization image for ZNF780A gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ZNF780A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF780A: view

Pathways & Interactions for ZNF780A Gene

SuperPathways for ZNF780A Gene

No Data Available

Interacting Proteins for ZNF780A Gene

Gene Ontology (GO) - Biological Process for ZNF780A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF780A: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF780A Gene

Transcripts for ZNF780A Gene

Unigene Clusters for ZNF780A Gene

Zinc finger protein 780A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF780A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1: -
SP2: -
SP3: -
SP4: - - -

Relevant External Links for ZNF780A Gene

GeneLoc Exon Structure for
ZNF780A
ECgene alternative splicing isoforms for
ZNF780A

Expression for ZNF780A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF780A Gene

Protein differential expression in normal tissues from HIPED for ZNF780A Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF780A Gene



Protein tissue co-expression partners for ZNF780A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF780A Gene:

ZNF780A

SOURCE GeneReport for Unigene cluster for ZNF780A Gene:

Hs.115140
genes like me logo Genes that share expression patterns with ZNF780A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF780A Gene

Orthologs for ZNF780A Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF780A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF780A 35
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp607 34 35
  • 69.43 (n)
C030039L03Rik 35
  • 55 (a)
OneToMany
Zfp59 35
  • 51 (a)
OneToMany
Zfp60 35
  • 49 (a)
OneToMany
Zfp850 35
  • 49 (a)
OneToMany
Zfp607b 16
cow
(Bos Taurus)
Mammalia ZNF383 35
  • 49 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 47 (a)
OneToMany
Species where no ortholog for ZNF780A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF780A Gene

ENSEMBL:
Gene Tree for ZNF780A (if available)
TreeFam:
Gene Tree for ZNF780A (if available)

Paralogs for ZNF780A Gene

(525) SIMAP similar genes for ZNF780A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF780A: view

Variants for ZNF780A Gene

Sequence variations from dbSNP and Humsavar for ZNF780A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10421829 -- 40,090,289(+) CAGAC(A/T)AAGTT intron-variant, utr-variant-5-prime
rs10537216 -- 40,089,618(+) ACAGT(-/ACAC)ACACA intron-variant
rs106082 -- 40,089,121(+) tatct(A/C)caatt intron-variant
rs111328091 -- 40,076,907(+) CCACC(C/G)AGCCC intron-variant
rs111440583 -- 40,080,625(+) ACACC(A/G)AGTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF780A Gene

Variant ID Type Subtype PubMed ID
esv3644341 CNV loss 21293372
nsv2488 CNV deletion 18451855
nsv963048 CNV duplication 23825009

Variation tolerance for ZNF780A Gene

Residual Variation Intolerance Score: 67.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.23; 52.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF780A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF780A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF780A Gene

Disorders for ZNF780A Gene

Relevant External Links for ZNF780A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF780A

No disorders were found for ZNF780A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF780A Gene

Publications for ZNF780A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3 64
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for ZNF780A Gene

Sources for ZNF780A Gene

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