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Aliases for ZNF780A Gene

Aliases for ZNF780A Gene

  • Zinc Finger Protein 780A 2 3 5
  • ZNF780 3

External Ids for ZNF780A Gene

Previous GeneCards Identifiers for ZNF780A Gene

  • GC19M045268
  • GC19M040575
  • GC19M037011

Summaries for ZNF780A Gene

GeneCards Summary for ZNF780A Gene

ZNF780A (Zinc Finger Protein 780A) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF780B.

UniProtKB/Swiss-Prot for ZNF780A Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF780A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF780A Gene

Genomics for ZNF780A Gene

Regulatory Elements for ZNF780A Gene

Enhancers for ZNF780A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H039397 2 FANTOM5 ENCODE dbSUPER 63.6 +684.7 684662 20 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 HNRNPL ZNF780B FBL SUPT5H AKT2 RN7SL566P ZNF780A EID2B PLEKHG2 ZFP36
GH19H040747 1.8 FANTOM5 ENCODE dbSUPER 47.8 -661.0 -661026 9 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 ZNF416 ZNF143 SP3 NFYC HNRNPUL1 SNRPA ENSG00000269843 CCDC97 COQ8B ZNF780A AKT2 ZNF780B ITPKC FBL
GH19H040089 1.4 ENCODE dbSUPER 46.7 +1.2 1208 2 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ENSG00000269843 SNRPA ZNF780A FBL PLEKHG2 ITPKC SUPT5H CYP2G1P PAF1 RN7SL566P
GH19H040596 1.8 FANTOM5 ENCODE dbSUPER 35.3 -510.0 -509960 10 MLX FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 SP3 NFYC ZC3H11A HNRNPUL1 SNRPA ZNF780B ENSG00000269843 CCDC97 CYP2G1P AKT2 FBL ZNF780A NUMBL
GH19H039125 1.7 Ensembl ENCODE dbSUPER 35.1 +964.4 964383 4 HDGF PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B HNRNPL FBL ENSG00000269172 ZNF780B ZNF780A ENSG00000269688 PAK4 EID2B RN7SL566P ENSG00000266963
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF780A on UCSC Golden Path with GeneCards custom track

Promoters for ZNF780A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109476 1036 1801 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for ZNF780A Gene

Chromosome:
19
Start:
40,069,152 bp from pter
End:
40,091,736 bp from pter
Size:
22,585 bases
Orientation:
Minus strand

Genomic View for ZNF780A Gene

Genes around ZNF780A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF780A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF780A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF780A Gene

Proteins for ZNF780A Gene

  • Protein details for ZNF780A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75290-Z780A_HUMAN
    Recommended name:
    Zinc finger protein 780A
    Protein Accession:
    O75290
    Secondary Accessions:
    • E9PB48
    • Q6ZN87

    Protein attributes for ZNF780A Gene

    Size:
    641 amino acids
    Molecular mass:
    74531 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC34327.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF780A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF780A Gene

Post-translational modifications for ZNF780A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF780A Gene

Domains & Families for ZNF780A Gene

Gene Families for ZNF780A Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF780A Gene

Suggested Antigen Peptide Sequences for ZNF780A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75290

UniProtKB/Swiss-Prot:

Z780A_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF780A: view

Function for ZNF780A Gene

Molecular function for ZNF780A Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF780A Gene

Gene Ontology (GO) - Molecular Function for ZNF780A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF780A: view

Phenotypes for ZNF780A Gene

GenomeRNAi human phenotypes for ZNF780A:
genes like me logo Genes that share phenotypes with ZNF780A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF780A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF780A Gene

Localization for ZNF780A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF780A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF780A gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF780A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF780A: view

Pathways & Interactions for ZNF780A Gene

SuperPathways for ZNF780A Gene

No Data Available

Interacting Proteins for ZNF780A Gene

Gene Ontology (GO) - Biological Process for ZNF780A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF780A: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF780A Gene

Drugs & Compounds for ZNF780A Gene

No Compound Related Data Available

Transcripts for ZNF780A Gene

Unigene Clusters for ZNF780A Gene

Zinc finger protein 780A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF780A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF780A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1: -
SP2: -
SP3: -
SP4: - - -

Relevant External Links for ZNF780A Gene

GeneLoc Exon Structure for
ZNF780A
ECgene alternative splicing isoforms for
ZNF780A

Expression for ZNF780A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF780A Gene

Protein differential expression in normal tissues from HIPED for ZNF780A Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF780A Gene



Protein tissue co-expression partners for ZNF780A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF780A Gene:

ZNF780A

SOURCE GeneReport for Unigene cluster for ZNF780A Gene:

Hs.115140
genes like me logo Genes that share expression patterns with ZNF780A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF780A Gene

Orthologs for ZNF780A Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF780A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF780A 34
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp607 33 34
  • 69.43 (n)
C030039L03Rik 34
  • 55 (a)
OneToMany
Zfp59 34
  • 51 (a)
OneToMany
Zfp60 34
  • 49 (a)
OneToMany
Zfp850 34
  • 49 (a)
OneToMany
Zfp607b 16
cow
(Bos Taurus)
Mammalia ZNF383 34
  • 49 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 47 (a)
OneToMany
Species where no ortholog for ZNF780A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF780A Gene

ENSEMBL:
Gene Tree for ZNF780A (if available)
TreeFam:
Gene Tree for ZNF780A (if available)

Paralogs for ZNF780A Gene

Paralogs for ZNF780A Gene

(525) SIMAP similar genes for ZNF780A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF780A: view

Variants for ZNF780A Gene

Sequence variations from dbSNP and Humsavar for ZNF780A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000292012 -- 40,091,716(+) CCAGA(A/G)TTGTG upstream-variant-2KB
rs1000360503 -- 40,085,610(+) GGCAC(A/G)GTGGC intron-variant
rs1000384518 -- 40,069,700(+) TAAAT(A/G)GTTAT utr-variant-3-prime
rs1000549972 -- 40,088,752(+) CCTAC(A/G)CGTCT intron-variant
rs1000603683 -- 40,093,403(+) TGGAA(A/G)AATTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF780A Gene

Variant ID Type Subtype PubMed ID
esv3644341 CNV loss 21293372
nsv2488 CNV deletion 18451855
nsv963048 CNV duplication 23825009

Variation tolerance for ZNF780A Gene

Residual Variation Intolerance Score: 67.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.23; 52.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF780A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF780A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF780A Gene

Disorders for ZNF780A Gene

Relevant External Links for ZNF780A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF780A

No disorders were found for ZNF780A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF780A Gene

Publications for ZNF780A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A … Hentze MW (Cell 2012) 3 60
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60

Products for ZNF780A Gene

Sources for ZNF780A Gene

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