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Aliases for ZNF778 Gene

Aliases for ZNF778 Gene

  • Zinc Finger Protein 778 2 3

External Ids for ZNF778 Gene

Previous GeneCards Identifiers for ZNF778 Gene

  • GC16P087812
  • GC16P089284
  • GC16P074983

Summaries for ZNF778 Gene

Entrez Gene Summary for ZNF778 Gene

  • The protein encoded by this gene is a member of the krueppel C2H2-type zinc-finger protein family, and it contains one KRAB domain and eighteen C2H2-type zinc fingers. This gene is a candidate gene for autism and variable cognitive impairment in the 16q24.3 microdeletion syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for ZNF778 Gene

ZNF778 (Zinc Finger Protein 778) is a Protein Coding gene. Diseases associated with ZNF778 include kbg syndrome and 16q24.3 microdeletion syndrome. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF426.

UniProtKB/Swiss-Prot for ZNF778 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF778 Gene

Genomics for ZNF778 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF778 Gene

Start:
89,217,703 bp from pter
End:
89,237,071 bp from pter
Size:
19,369 bases
Orientation:
Plus strand

Genomic View for ZNF778 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF778 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF778 Gene

No data available for Regulatory Elements for ZNF778 Gene

Proteins for ZNF778 Gene

  • Protein details for ZNF778 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MU6-ZN778_HUMAN
    Recommended name:
    Zinc finger protein 778
    Protein Accession:
    Q96MU6
    Secondary Accessions:
    • Q08AG0

    Protein attributes for ZNF778 Gene

    Size:
    729 amino acids
    Molecular mass:
    81964 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71183.1; Type=Frameshift; Positions=393; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF778 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF778 Gene

Proteomics data for ZNF778 Gene at MOPED

Post-translational modifications for ZNF778 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF778 Gene

No data available for DME Specific Peptides for ZNF778 Gene

Domains for ZNF778 Gene

Gene Families for ZNF778 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF778 Gene

Suggested Antigen Peptide Sequences for ZNF778 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96MU6

UniProtKB/Swiss-Prot:

ZN778_HUMAN :
  • Q96MU6
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 18 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF778: view

Function for ZNF778 Gene

Molecular function for ZNF778 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF778 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF778: view

Phenotypes for ZNF778 Gene

GenomeRNAi human phenotypes for ZNF778:
genes like me logo Genes that share phenotypes with ZNF778: view

Animal Model Products

CRISPR Products

miRNA for ZNF778 Gene

miRTarBase miRNAs that target ZNF778

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF778 Gene

Localization for ZNF778 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF778 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF778 Gene COMPARTMENTS Subcellular localization image for ZNF778 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF778 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF778: view

Pathways for ZNF778 Gene

SuperPathways for ZNF778 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF778: view

Pathways by source for ZNF778 Gene

2 Reactome pathways for ZNF778 Gene

Interacting Proteins for ZNF778 Gene

Gene Ontology (GO) - Biological Process for ZNF778 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF778: view

Transcripts for ZNF778 Gene

Unigene Clusters for ZNF778 Gene

Zinc finger protein 778:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF778

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZNF778
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF778 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: -
SP2:
SP3: -

Relevant External Links for ZNF778 Gene

GeneLoc Exon Structure for
ZNF778
ECgene alternative splicing isoforms for
ZNF778

Expression for ZNF778 Gene

mRNA expression in normal human tissues for ZNF778 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF778 Gene

SOURCE GeneReport for Unigene cluster for ZNF778 Gene Hs.647385

genes like me logo Genes that share expressions with ZNF778: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF778 Gene

Orthologs for ZNF778 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF778 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF778 35
  • 98.54 (n)
  • 97.62 (a)
ZNF778 36
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 36 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfp26 35
  • 65.03 (n)
  • 53.02 (a)
Zfp560 16
Zfp560 36
  • 40 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Zfp26 35
  • 64.79 (n)
  • 52.46 (a)
Species with no ortholog for ZNF778:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF778 Gene

ENSEMBL:
Gene Tree for ZNF778 (if available)
TreeFam:
Gene Tree for ZNF778 (if available)

Paralogs for ZNF778 Gene

Paralogs for ZNF778 Gene

Selected SIMAP similar genes for ZNF778 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF778: view

Variants for ZNF778 Gene

Sequence variations from dbSNP and Humsavar for ZNF778 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs3803722 -- 89,217,878(-) GGGTC(C/T)ACCGC utr-variant-5-prime, nc-transcript-variant
rs3803723 -- 89,217,675(-) AAGAG(C/G)GGCCG upstream-variant-2KB
rs4785608 -- 89,216,939(+) TGTCA(C/G)TAGCA upstream-variant-2KB
rs4785609 -- 89,218,141(+) CGGGG(C/G)GGGAG intron-variant
rs4785610 -- 89,219,040(+) tggca(C/G)aggtt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF778 Gene

Variant ID Type Subtype PubMed ID
dgv2998n71 CNV Loss 21882294
nsv907357 CNV Loss 21882294
dgv3002n71 CNV Loss 21882294
dgv3004n71 CNV Loss 21882294
nsv907394 CNV Loss 21882294
nsv509638 CNV Insertion 20534489
dgv3006n71 CNV Loss 21882294
esv2665882 CNV Deletion 23128226
nsv469681 CNV Complex 16826518
nsv457622 CNV Loss 19166990
nsv827843 CNV Gain 20364138
nsv428331 CNV Gain+Loss 18775914
nsv827844 CNV Gain 20364138
esv268384 CNV Insertion 20981092
esv1006131 CNV Deletion 20482838

Relevant External Links for ZNF778 Gene

HapMap Linkage Disequilibrium report
ZNF778
Human Gene Mutation Database (HGMD)
ZNF778

PCR Panel Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF778 Gene

Disorders for ZNF778 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for ZNF778 Gene including...

Search for ZNF778 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ZNF778 Gene

Relevant External Links for ZNF778

Genetic Association Database (GAD)
ZNF778
genes like me logo Genes that share disorders with ZNF778: view

No data available for UniProtKB/Swiss-Prot for ZNF778 Gene

Publications for ZNF778 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A. … Carmell M.A. (Nature 2006) 3
  5. Identification of ANKRD11 and ZNF778 as candidate genes for autism and variable cognitive impairment in the novel 16q24.3 microdeletion syndrome. (PMID: 19920853) Willemsen M.H. … Kleefstra T. (Eur. J. Hum. Genet. 2010) 3

Products for ZNF778 Gene

Sources for ZNF778 Gene

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