ZNF778 Gene
protein-coding GIFtS: 48
GCID: GC16P089284
|
|
zinc finger protein 778
| |
Aliases
for ZNF778 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Zinc Finger Protein 7781 2 | | FLJ318751 |
| External Ids: | HGNC: 264791 | Entrez Gene: 1973202 | Ensembl: ENSG000001701007 | UniProtKB: Q96MU63 | | ORGUL members: | |
|---|
| NONCODE:n410541 | |
Export aliases for ZNF778 gene to outside databasesPrevious GC identifers: GC16P087812 GC16P074983
|---|
Summaries
for ZNF778 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZNF778:
The protein encoded by this gene is a member of the krueppel C2H2-type zinc-finger protein family, and it contains oneKRAB domain and eighteen C2H2-type zinc fingers. This gene is a candidate gene for autism and variable cognitiveimpairment in the 16q24.3 microdeletion syndrome. Alternatively spliced transcript variants have been found for thisgene. (provided by RefSeq, Jan 2011)
UniProtKB/Swiss-Prot: ZN778_HUMAN, Q96MU6Function: May be involved in transcriptional regulation (By similarity)
|
Genomic Views
for ZNF778 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010542.15
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ZNF778
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF778
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF778 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q24.3 Ensembl cytogenetic band: 16q24.3 HGNC cytogenetic band: 16q24.3ZNF778 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P089284: view genomic region
(about GC identifiers)
Start:
|
89,284,111 bp from pter |
End:
|
89,295,363 bp from pter |
Size:
|
11,253 bases |
Orientation:
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plus strand |
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Proteins
for ZNF778 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN778_HUMAN, Q96MU6 (See
protein sequence)Recommended Name: Zinc finger protein 778 Size: 729 amino acids; 81964 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAB71183.1; Type=Frameshift; Positions=393;
Secondary accessions: Q08AG0Alternative splicing: 2 isoforms: Q96MU6-1 Q96MU6-2 Explore the universe of human proteins at neXtProt for ZNF778: NX_Q96MU6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96MU6
ZNF778 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001188336.1 NP_872337.2
ENSEMBL proteins: ENSP00000457800 ENSP00000405289 ENSP00000456655 ENSP00000305203 Reactome Protein details: Q96MU6
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF778 for ontologies About GeneDecksing
ZNF778 Antibody Products:
Assay Products for ZNF778: |
Protein
Domains /
Families
for ZNF778 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF778 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96MU6ProtoNet protein and cluster: Q96MU6 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZN778_HUMAN, Q96MU6Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 18 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF778 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN778_HUMAN, Q96MU6Function: May be involved in transcriptional regulation (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF778 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF778
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Synthesis Service for ZNF778 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF778 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF778 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF778 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZNF778:
|
Pathways & Interactions
for ZNF778 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF778
ZNF778 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF778
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF778 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF778 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF778
Search CenterWatch for drugs/clinical trials and news about ZNF778 / ZN778
|
Transcripts
for ZNF778 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF778 gene (2 alternative transcripts): NM_001201407.1 NM_182531.3 Unigene Cluster for ZNF778: Zinc finger protein 778 Hs.647385 [show with all ESTs]Unigene Representative Sequence: NM_0012014076 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000565877 ENST00000564906 ENST00000433976(uc021tms.1 uc010vpg.2 uc002fmv.3 uc002fmw.2)
ENST00000567651 ENST00000306502 ENST00000565414
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF778 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF778
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ZNF778 (NM_182531) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF778 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF778 |
Additional cDNA sequence: AK056437.1 BC015872.1 BC125192.1 BC143524.1 NR_037705.1 2 DOTS entries: DT.40209848 DT.75123045 15 AceView cDNA sequences: BU608778 BM697683 NM_182531 BG563705 BC015872 BF035326 BU735850 AK056437 W95098 W95097 BI669263 BM147023 BF095126 BQ219517 BF964392
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF778 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 |
|---|
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| SP1: | | | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF778
|
Expression
for ZNF778 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF778 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAAAACTCA
About this image
See ZNF778 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF778
SOURCE GeneReport for Unigene cluster: Hs.647385
SABiosciences Custom PCR Arrays for ZNF778
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF778
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF778 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF778 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF778 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF778 |
Orthologs
for ZNF778 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF778 gene from 1/4 species (see all 4) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
rainbow trout
(Oncorhynchus mykiss) |
Actinopterygii |
BX867429.12 |
-- |
75.42(n) |
|
BX867429.1 |
ENSEMBL Gene Tree for ZNF778 (if available)
TreeFam Gene Tree for ZNF778 (if available) |
Paralogs
for ZNF778 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF778 gene
- ZNF8122 ZNF4262 ZNF2662 ZNF5602 ZNF8462 ZNF1212 ZNF5612 ZNF5592
- ZNF5622
18/541 SIMAP similar genes for ZNF778 using alignment to 4 protein entries: ZN778_HUMAN (see all proteins)
(see all similar genes):MGC12518 ZNF738 ZFP90 ZNF78L1 ZNF506 ZNF669
KRBOX4 ZNF84 ZNF559 ZNF596 ZNF577 ZNF302
ZNF846 ZNF624 ZNF721 ZFS-4 ZNF625 ZNF331
ZNF778 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF778 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF778 (89284111 - 89295363 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF778: --
Human Gene Mutation Database (HGMD): ZNF778
| SABiosciences Cancer Mutation PCR Assays |
| 2 SABiosciences qBiomarker Copy Number PCR Arrays containing ZNF778: |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF778 |
|
Disorders
/ Diseases
for ZNF778 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF778 for disorders About GeneDecksing
2  diseases for ZNF778: About MalaCardslearning disability kbg syndrome
1 disease from the University of Copenhagen DISEASES database for ZNF778:KBG syndrome Export disorders for ZNF778 gene to outside databases
|
Publications
for ZNF778 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF778 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF778) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Identification of ANKRD11 and ZNF778 as candidate gen es for autism and variable cognitive impairment in the novel 16q24.3 microdelet ion syndrome. (PubMed id 19920853)1 Willemsen M.H....Kleefstra T. (2010)
- A germline-specific class of small RNAs binds mammali an Piwi proteins. (PubMed id 16751776)1 Girard A....Carmell M.A. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
|
External Searches for ZNF778 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF778 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF778 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF778 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF778 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF778 gene:
Search GeneIP for patents involving ZNF778
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF778 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF778 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF778 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF778 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF778 | | OriGene 3'-UTR Clone for ZNF778 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF778 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF778 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF778 | | OriGene Custom Protein Services for ZNF778 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF778 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF778 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF778 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF778 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF778 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF778 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for ZNF778 |
| |  |  |  |  | | | | |
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 | | | ZNF778 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF778 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF778 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF778 |
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