Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF778 Gene

Aliases for ZNF778 Gene

  • Zinc Finger Protein 778 2 3 5

External Ids for ZNF778 Gene

Previous GeneCards Identifiers for ZNF778 Gene

  • GC16P087812
  • GC16P089284
  • GC16P074983

Summaries for ZNF778 Gene

Entrez Gene Summary for ZNF778 Gene

  • The protein encoded by this gene is a member of the krueppel C2H2-type zinc-finger protein family, and it contains one KRAB domain and eighteen C2H2-type zinc fingers. This gene is a candidate gene for autism and variable cognitive impairment in the 16q24.3 microdeletion syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for ZNF778 Gene

ZNF778 (Zinc Finger Protein 778) is a Protein Coding gene. Diseases associated with ZNF778 include 16Q24.3 Microdeletion Syndrome and Kbg Syndrome. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF562.

UniProtKB/Swiss-Prot for ZNF778 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF778 Gene

Genomics for ZNF778 Gene

Regulatory Elements for ZNF778 Gene

Enhancers for ZNF778 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF778 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF778 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF778 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF778 Gene

89,202,038 bp from pter
89,237,071 bp from pter
35,034 bases
Plus strand

Genomic View for ZNF778 Gene

Genes around ZNF778 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF778 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF778 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF778 Gene

Proteins for ZNF778 Gene

  • Protein details for ZNF778 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 778
    Protein Accession:
    Secondary Accessions:
    • Q08AG0

    Protein attributes for ZNF778 Gene

    729 amino acids
    Molecular mass:
    81964 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB71183.1; Type=Frameshift; Positions=393; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF778 Gene


neXtProt entry for ZNF778 Gene

Proteomics data for ZNF778 Gene at MOPED

Post-translational modifications for ZNF778 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF778 Gene

No data available for DME Specific Peptides for ZNF778 Gene

Domains & Families for ZNF778 Gene

Gene Families for ZNF778 Gene

Protein Domains for ZNF778 Gene

Suggested Antigen Peptide Sequences for ZNF778 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 18 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 18 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF778: view

Function for ZNF778 Gene

Molecular function for ZNF778 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes for ZNF778 Gene

genes like me logo Genes that share phenotypes with ZNF778: view

Animal Model Products

CRISPR Products

miRNA for ZNF778 Gene

miRTarBase miRNAs that target ZNF778

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF778 Gene

Localization for ZNF778 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF778 Gene

Subcellular locations from

Jensen Localization Image for ZNF778 Gene COMPARTMENTS Subcellular localization image for ZNF778 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF778 Gene

Pathways & Interactions for ZNF778 Gene

SuperPathways for ZNF778 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF778: view

Pathways by source for ZNF778 Gene

2 Reactome pathways for ZNF778 Gene

Interacting Proteins for ZNF778 Gene

Gene Ontology (GO) - Biological Process for ZNF778 Gene


No data available for SIGNOR curated interactions for ZNF778 Gene

Drugs & Compounds for ZNF778 Gene

No Compound Related Data Available

Transcripts for ZNF778 Gene

Unigene Clusters for ZNF778 Gene

Zinc finger protein 778:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF778 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: -
SP3: -

Relevant External Links for ZNF778 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF778 Gene

mRNA expression in normal human tissues for ZNF778 Gene

Protein differential expression in normal tissues from HIPED for ZNF778 Gene

This gene is overexpressed in Pancreas (48.7) and Platelet (18.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF778 Gene

SOURCE GeneReport for Unigene cluster for ZNF778 Gene Hs.647385

genes like me logo Genes that share expression patterns with ZNF778: view

Protein tissue co-expression partners for ZNF778 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF778 Gene

Orthologs for ZNF778 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF778 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Zfp26 35
  • 65.03 (n)
  • 53.02 (a)
Zfp26 16
Zfp560 36
  • 40 (a)
(Pan troglodytes)
Mammalia ZNF778 35
  • 98.54 (n)
  • 97.62 (a)
ZNF778 36
  • 94 (a)
(Rattus norvegicus)
Mammalia Zfp26 35
  • 64.79 (n)
  • 52.46 (a)
(Bos Taurus)
Mammalia -- 36
  • 36 (a)
Species with no ortholog for ZNF778:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF778 Gene

Gene Tree for ZNF778 (if available)
Gene Tree for ZNF778 (if available)

Paralogs for ZNF778 Gene

Paralogs for ZNF778 Gene

(545) SIMAP similar genes for ZNF778 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF778: view

Variants for ZNF778 Gene

Sequence variations from dbSNP and Humsavar for ZNF778 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs55974122 - 89,228,419(+) CATAC(A/G)ATAGG nc-transcript-variant, reference, missense
rs8062253 -- 89,214,609(+) taata(A/C)tacta intron-variant
rs8063641 -- 89,216,611(+) TGAGA(C/G)TCCCT intron-variant, upstream-variant-2KB
rs8063653 -- 89,216,637(+) CAAAG(C/T)ttgtg intron-variant, upstream-variant-2KB
rs8063987 -- 89,210,708(+) tgcct(G/T)tgggg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF778 Gene

Variant ID Type Subtype PubMed ID
dgv2998n71 CNV Loss 21882294
nsv907357 CNV Loss 21882294
dgv3002n71 CNV Loss 21882294
dgv3004n71 CNV Loss 21882294
nsv907394 CNV Loss 21882294
nsv509638 CNV Insertion 20534489
dgv3006n71 CNV Loss 21882294
esv2665882 CNV Deletion 23128226
nsv469681 CNV Complex 16826518
nsv457622 CNV Loss 19166990
nsv827843 CNV Gain 20364138
nsv428331 CNV Gain+Loss 18775914
nsv827844 CNV Gain 20364138
esv268384 CNV Insertion 20981092
esv1006131 CNV Deletion 20482838

Variation tolerance for ZNF778 Gene

Residual Variation Intolerance Score: 97.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.37; 63.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF778 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF778 Gene

Disorders for ZNF778 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF778 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
16q24.3 microdeletion syndrome
  • chromosome 16q24.3 microdeletion syndrome
kbg syndrome
  • short stature, characteristic facies, macrodontia, mental retardation, and skeletal anomalies
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF778

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ZNF778: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF778 Gene

Publications for ZNF778 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Identification of ANKRD11 and ZNF778 as candidate genes for autism and variable cognitive impairment in the novel 16q24.3 microdeletion syndrome. (PMID: 19920853) Willemsen M.H. … Kleefstra T. (Eur. J. Hum. Genet. 2010) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for ZNF778 Gene

Sources for ZNF778 Gene