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Aliases for ZNF778 Gene

Aliases for ZNF778 Gene

  • Zinc Finger Protein 778 2 3 5

External Ids for ZNF778 Gene

Previous GeneCards Identifiers for ZNF778 Gene

  • GC16P087812
  • GC16P089284
  • GC16P074983

Summaries for ZNF778 Gene

Entrez Gene Summary for ZNF778 Gene

  • The protein encoded by this gene is a member of the krueppel C2H2-type zinc-finger protein family, and it contains one KRAB domain and eighteen C2H2-type zinc fingers. This gene is a candidate gene for autism and variable cognitive impairment in the 16q24.3 microdeletion syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for ZNF778 Gene

ZNF778 (Zinc Finger Protein 778) is a Protein Coding gene. Diseases associated with ZNF778 include 16Q24.3 Microdeletion Syndrome and Kbg Syndrome. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF560.

UniProtKB/Swiss-Prot for ZNF778 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF778 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF778 Gene

Genomics for ZNF778 Gene

Regulatory Elements for ZNF778 Gene

Enhancers for ZNF778 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H089993 1.6 Ensembl ENCODE dbSUPER 37.6 +793.2 793210 3 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A ZNF2 ZBTB7B SLC30A9 ENSG00000259877 AFG3L1P ANKRD11 MC1R TCF25 ACSF3 ZNF778 LINC00304 LOC101927863 SNORD68
GH16H089480 2.1 FANTOM5 Ensembl ENCODE dbSUPER 26.2 +284.7 284716 12 HDGF PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B SPG7 ZNF778 ZC3H18 AFG3L1P MC1R ANKRD11 ENSG00000259877 RPL13 TCF25 RNU6-430P
GH16H088662 1.1 ENCODE 26.2 -538.8 -538832 2 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZBTB7B YY1 ZNF143 FOS ZNF778 ZC3H18 SNAI3-AS1 ANKRD11 ENSG00000259877 CTU2 KLHDC4 BANP LINC00304 DPEP1
GH16H089699 1.2 ENCODE 20.4 +499.2 499161 2 HDGF PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ANKRD11 ZNF778 CDK10 TCF25 CHMP1A ACSF3 GALNS SNORD68 ENSG00000268218 LOC101927863
GH16H088329 2 FANTOM5 Ensembl ENCODE dbSUPER 12.2 -869.2 -869182 6 HDGF PKNOX1 ARNT SIN3A YBX1 ZBTB7B ZNF766 ZNF207 FOS MCM3 ACSF3 ZC3H18 ENSG00000259877 BANP ENSG00000268218 ENSG00000260121 GALNS PIEZO1 ZCCHC14 ZNF778
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF778 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF778 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000089652 -138 601 TBP MXI1 RB1 SAP130 ARID4B SIN3A ZIC2 POLR2A ZSCAN29 EZH2

Genomic Location for ZNF778 Gene

Chromosome:
16
Start:
89,202,038 bp from pter
End:
89,237,071 bp from pter
Size:
35,034 bases
Orientation:
Plus strand

Genomic View for ZNF778 Gene

Genes around ZNF778 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF778 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF778 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF778 Gene

Proteins for ZNF778 Gene

  • Protein details for ZNF778 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MU6-ZN778_HUMAN
    Recommended name:
    Zinc finger protein 778
    Protein Accession:
    Q96MU6
    Secondary Accessions:
    • Q08AG0

    Protein attributes for ZNF778 Gene

    Size:
    729 amino acids
    Molecular mass:
    81964 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71183.1; Type=Frameshift; Positions=393; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF778 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF778 Gene

Post-translational modifications for ZNF778 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF778 Gene

Domains & Families for ZNF778 Gene

Gene Families for ZNF778 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF778 Gene

Suggested Antigen Peptide Sequences for ZNF778 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96MU6

UniProtKB/Swiss-Prot:

ZN778_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF778: view

Function for ZNF778 Gene

Molecular function for ZNF778 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF778 Gene

Gene Ontology (GO) - Molecular Function for ZNF778 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF778: view

Phenotypes for ZNF778 Gene

genes like me logo Genes that share phenotypes with ZNF778: view

Animal Model Products

CRISPR Products

miRNA for ZNF778 Gene

miRTarBase miRNAs that target ZNF778

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF778
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF778 Gene

Localization for ZNF778 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF778 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF778 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF778 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF778: view

Pathways & Interactions for ZNF778 Gene

SuperPathways for ZNF778 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF778: view

Pathways by source for ZNF778 Gene

2 Reactome pathways for ZNF778 Gene

Gene Ontology (GO) - Biological Process for ZNF778 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF778: view

No data available for SIGNOR curated interactions for ZNF778 Gene

Drugs & Compounds for ZNF778 Gene

No Compound Related Data Available

Transcripts for ZNF778 Gene

Unigene Clusters for ZNF778 Gene

Zinc finger protein 778:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF778
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF778 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: -
SP2:
SP3: -

Relevant External Links for ZNF778 Gene

GeneLoc Exon Structure for
ZNF778
ECgene alternative splicing isoforms for
ZNF778

Expression for ZNF778 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF778 Gene

Protein differential expression in normal tissues from HIPED for ZNF778 Gene

This gene is overexpressed in Pancreas (48.7) and Platelet (18.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF778 Gene



Protein tissue co-expression partners for ZNF778 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF778 Gene:

ZNF778

SOURCE GeneReport for Unigene cluster for ZNF778 Gene:

Hs.647385
genes like me logo Genes that share expression patterns with ZNF778: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF778 Gene

Orthologs for ZNF778 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF778 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF778 33 34
  • 98.54 (n)
mouse
(Mus musculus)
Mammalia Zfp26 33 16
  • 65.03 (n)
Zfp560 34
  • 40 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Zfp26 33
  • 64.79 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 36 (a)
OneToMany
Species where no ortholog for ZNF778 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF778 Gene

ENSEMBL:
Gene Tree for ZNF778 (if available)
TreeFam:
Gene Tree for ZNF778 (if available)

Paralogs for ZNF778 Gene

(545) SIMAP similar genes for ZNF778 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF778: view

Variants for ZNF778 Gene

Sequence variations from dbSNP and Humsavar for ZNF778 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs150830617 Benign 89,224,749(+) GATCT(A/G)TTGGC intron-variant, nc-transcript-variant, reference, missense, utr-variant-5-prime
rs1000037757 -- 89,211,977(+) TCACC(A/G)TGTTA intron-variant
rs1000041781 -- 89,201,760(+) CCTGA(C/G)TCCAG upstream-variant-2KB
rs1000054584 -- 89,208,727(+) GCGAG(A/G)CTTGG intron-variant
rs1000162116 -- 89,223,595(+) CTAAC(A/T)CTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF778 Gene

Variant ID Type Subtype PubMed ID
dgv3066n100 CNV gain 25217958
esv1006131 CNV deletion 20482838
esv2665882 CNV deletion 23128226
esv2763149 CNV gain 21179565
esv3304105 CNV mobile element insertion 20981092
esv3441548 CNV insertion 20981092
esv3639571 CNV loss 21293372
esv3892939 CNV loss 25118596
nsv1063024 CNV gain 25217958
nsv428331 CNV gain+loss 18775914
nsv457622 CNV loss 19166990
nsv469681 CNV loss 16826518
nsv482951 CNV loss 15286789
nsv509638 CNV insertion 20534489
nsv573674 CNV gain 21841781
nsv573734 CNV loss 21841781
nsv827843 CNV gain 20364138
nsv827844 CNV gain 20364138

Variation tolerance for ZNF778 Gene

Residual Variation Intolerance Score: 97.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.37; 63.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF778 Gene

Human Gene Mutation Database (HGMD)
ZNF778
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF778

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF778 Gene

Disorders for ZNF778 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF778 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
16q24.3 microdeletion syndrome
  • chromosome 16q24.3 microdeletion syndrome
kbg syndrome
  • short stature, characteristic facies, macrodontia, mental retardation, and skeletal anomalies
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF778

Genetic Association Database (GAD)
ZNF778
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF778
genes like me logo Genes that share disorders with ZNF778: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF778 Gene

Publications for ZNF778 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  5. Identification of ANKRD11 and ZNF778 as candidate genes for autism and variable cognitive impairment in the novel 16q24.3 microdeletion syndrome. (PMID: 19920853) Willemsen MH … Kleefstra T (European journal of human genetics : EJHG 2010) 3 60

Products for ZNF778 Gene

Sources for ZNF778 Gene

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