ZNF777 Gene
protein-coding GIFtS: 48
GCID: GC07M149128
|
|
zinc finger protein 777
| |
Aliases
for ZNF777 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 7771 2 | | KIAA12851 3 |
Export aliases for ZNF777 gene to outside databasesPrevious GC identifers: GC07M148759 GC07M143204 |
Summaries
for ZNF777 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN777_HUMAN, Q9ULD5Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF777 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF777 gene promoter:
GR USF1 GR-beta USF2 USF-1:USF-2 HFH-1 USF-1 ZIC2/Zic2 GR-alpha ATF
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF777
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF777 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q36.1 Ensembl cytogenetic band: 7q36.1 HGNC cytogenetic band: 7q36.1ZNF777 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M149128: view genomic region
(about GC identifiers)
Start:
|
149,128,454 bp from pter |
End:
|
149,158,214 bp from pter |
Size:
|
29,761 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 148,466,512-148,496,088 |
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Proteins
for ZNF777 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN777_HUMAN, Q9ULD5 (See
protein sequence)Recommended Name: Zinc finger protein 777 Size: 760 amino acids; 85176 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAH23985.2; Type=Erroneous initiation; Sequence=BAA86599.1; Type=Erroneous initiation;Sequence=BAC11033.1; Type=Erroneous initiation;
Secondary accessions: Q8N2R2 Q8N659Alternative splicing: 3 isoforms: Q9ULD5-1 Q9ULD5-2 Q9ULD5-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZNF777: NX_Q9ULD5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9ULD5
ZNF777 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_056509.2
ENSEMBL proteins: ENSP00000247930 Reactome Protein details: Q9ULD5
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF777 for ontologies About GeneDecksing
ZNF777 Antibody Products:
Assay Products for ZNF777: |
Protein
Domains /
Families
for ZNF777 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF777 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9ULD5ProtoNet protein and cluster: Q9ULD5 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZN777_HUMAN, Q9ULD5Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 6 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF777 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN777_HUMAN, Q9ULD5Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF777 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF777
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for ZNF777 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF777 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF777 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF777 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for ZNF777:
|
Pathways & Interactions
for ZNF777 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF777
ZNF777 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF777
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
3 Interacting proteins for ZNF777 (Q9ULD53 ENSP000002479304) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0008150 | biological_process |
ND | -- |
ZNF777 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF777 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF777
Search CenterWatch for drugs/clinical trials and news about ZNF777 / ZN777
|
Transcripts
for ZNF777 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF777 gene: NM_015694.2 Unigene Cluster for ZNF777: Zinc finger protein 777 Hs.38512 [show with all ESTs]Unigene Representative Sequence: NM_0156941 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000247930(uc003wfv.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF777 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF777
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF777 (NM_015694) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF777 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF777 |
Additional cDNA sequence: AB033111.1 AK074515.1 AK075032.1 BC023985.2 BC105968.1 7 DOTS entries: DT.111020 DT.100813859 DT.100689279 DT.75102052 DT.91805795 DT.95134411 DT.100813858 24/128 AceView cDNA sequences (see all 128): BQ187409 BF439015 AI160902 AI126361 AK074515 BQ268869 BE675022 AI828085 AI494302 NM_015694 AI992236 BI907620 BM792176 BC023985 AK075032 AI199305 AI608638 BE796328 AI264568 BG152534 BX331347 AA913866 BM932073 BM930335
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF777 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b |
|---|
|
| SP1: | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF777
|
Expression
for ZNF777 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF777 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGGCAGTGA
About this image
See ZNF777 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF777
SOURCE GeneReport for Unigene cluster: Hs.38512
SABiosciences Custom PCR Arrays for ZNF777
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF777
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF777 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF777 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF777 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF777 |
Orthologs
for ZNF777 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF777 gene from 2/9 species (see all 9) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ZNF7776 |
Uncharacterized protein |
34(a) |
1 ↔ 1 |
2(403451-408502) |
lizard
(Anolis carolinensis) |
Reptilia |
ZNF7776 |
-- |
60(a) |
1 ↔ 1 |
GL343620.1(86796-95045) |
ENSEMBL Gene Tree for ZNF777 (if available)
TreeFam Gene Tree for ZNF777 (if available) |
Paralogs
for ZNF777 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF777 gene
- ZNF2822 ZNF7462 ZNF2122 ZNF3982 ZNF7832
18/107 SIMAP similar genes for ZNF777 using alignment to 2 protein entries: ZN777_HUMAN (see all proteins)
(see all similar genes):ZNF767 LOC155060 ZNF66 MGC12518 ZNF273 ZNF300P1
ZNF761 ZNF506 ZNF93 kr-znf3 ZNF28 ZNF573
ZNF720 ZFS-4 ZNF33A ZNF738 ZNF248 ZFS-5
ZNF777 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for ZNF777
PGOHUM00000250919 PGOHUM00000250977
|
Genomic Variants
for ZNF777 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF777 (149128454 - 149158214 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZNF777
1 CNV: 70073 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF777 |
|
Disorders
/ Diseases
for ZNF777 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZNF777 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF777 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF777) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (1999)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZNF777 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF777 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF777 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ZNF777 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF777 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF777 gene:
Search GeneIP for patents involving ZNF777
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF777 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF777 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF777 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF777 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF777 | | OriGene 3'-UTR Clone for ZNF777 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF777 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF777 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF777 | | OriGene Custom Protein Services for ZNF777 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF777 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF777 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF777 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF777 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF777 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF777 |
| |
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| |  |  |  |  | | | | |
 |
 |
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 | | | ZNF777 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF777 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF777 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF777 |
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