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ZNF776 Gene

protein-coding   GIFtS: 43
GCID: GC19P058258

Zinc Finger Protein 776

  Search for ZNF776
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 7761 2

External Ids:    HGNC: 267651   Entrez Gene: 2843092   Ensembl: ENSG000001524437   UniProtKB: Q68DI13   

Export aliases for ZNF776 gene to outside databases

Previous GC identifers: GC19P062950 GC19P054570


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF776 Gene:
ZNF776 (zinc finger protein 776) is a protein-coding gene. An important paralog of this gene is ZNF549.

UniProtKB/Swiss-Prot: ZN776_HUMAN, Q68DI1
Function: May be involved in transcriptional regulation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF776 gene promoter:
         AREB6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF776 promoter sequence
   Search Chromatin IP Primers for ZNF776

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF776


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

ZNF776 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF776 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P058258:  view genomic region     (about GC identifiers)

Start:
58,258,164 bp from pter      End:
58,269,527 bp from pter
Size:
11,364 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN776_HUMAN, Q68DI1 (See protein sequence)
Recommended Name: Zinc finger protein 776  
Size: 518 amino acids; 59613 Da
Sequence caution: Sequence=BAC04588.1; Type=Erroneous translation; Note=Wrong choice of frame;
Sequence=BAC87119.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q6ZS36 Q8N968

Explore the universe of human proteins at neXtProt for ZNF776: NX_Q68DI1

Explore proteomics data for ZNF776 at MOPED


See ZNF776 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_775903.3  
ENSEMBL proteins: 
 ENSP00000321812   ENSP00000405772   ENSP00000416901  
Reactome Protein details: Q68DI1

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ZNF: Zinc fingers, C2H2-type

4 InterPro protein domains:
 IPR001909 Krueppel-associated_box
 IPR015880 Znf_C2H2-like
 IPR013087 Znf_C2H2/integrase_DNA-bd
 IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q68DI1

ProtoNet protein and cluster: Q68DI1

2 Blocks protein domains:
IPB001909 KRAB box
IPB007086 C2H2-type zinc finger signature


UniProtKB/Swiss-Prot: ZN776_HUMAN, Q68DI1
Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
Similarity: Contains 11 C2H2-type zinc fingers
Similarity: Contains 1 KRAB domain


ZNF776 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ZN776_HUMAN, Q68DI1
Function: May be involved in transcriptional regulation (By similarity)

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003676nucleic acid binding ----
GO:0003677DNA binding IEA--
GO:0046872metal ion binding IEA--
     
ZNF776 for ontologies           About GeneDecksing


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hsa-mir-92a-3p (MIRT049664), hsa-mir-125a-5p (MIRT021305), hsa-mir-361-5p (MIRT020083), hsa-mir-340-5p (MIRT019538)

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4 qRT-PCR Assays for microRNAs that regulate ZNF776:
hsa-miR-199a-5p hsa-miR-199b-5p hsa-miR-4302 hsa-miR-1825
SwitchGear 3'UTR luciferase reporter plasmidZNF776 3' UTR sequence
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ZN776_HUMAN, Q68DI1: Nucleus (Probable)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus4
cytosol2

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular ----
GO:0005634nucleus IEA--

ZNF776 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ZNF776 About    
See pathways by source

SuperPathContained pathways About
1Gene Expression
Generic Transcription Pathway0.40
Gene Expression0.40

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for ZNF776
    Generic Transcription Pathway



ZNF776 for pathways           About GeneDecksing

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Interactions:

    Search GeneGlobe Interaction Network for ZNF776

Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated IEA--

ZNF776 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for ZNF776 (ZN776)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for ZNF776 gene: 
NM_173632.3  

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000317178(uc002qpx.3 uc002qqa.3) ENST00000473585 ENST00000431353
ENST00000451849 ENST00000489376
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hsa-miR-199a-5p hsa-miR-199b-5p hsa-miR-4302 hsa-miR-1825
SwitchGear 3'UTR luciferase reporter plasmidZNF776 3' UTR sequence
Inhib. RNA
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Selected AceView cDNA sequences (see all 27):

AA235235 AA765772 BX426164 BE897285 BP873288 BE294508 BX426025 BC005868 
BX538151 NM_173632 AA830791 W00358 BQ672779 CD557545 AI446541 BX484094 
CA336646 F03106 BQ058356 BF109985 F05269 BG290055 AK127764 NM_138347 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF776 (see all 6)    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1:                                                        -     -                     
SP2:                                                                                    
SP3:                                                                                    
SP4:                                                  -     -     -                     
SP5:              -                                                                     


ECgene alternative splicing isoforms for ZNF776

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZNF776 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTATGGAAAT
ZNF776 Expression
About this image

ZNF776 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ZNF776 Protein Expression
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of mammals.

Orthologs for ZNF776 gene from Selected species (see all 2)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia --
Uncharacterized protein
49(a)
1 → many
1(100275593-100284657)


ENSEMBL Gene Tree for ZNF776 (if available)
TreeFam Gene Tree for ZNF776 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ZNF776 gene
ZNF5492  ZNF5872  ZNF2112  ENSG000002695332  ZNF7922  ZNF4172  ZNF7492  ZNF5512  
ENSG000002687502  ENSG000002681332  ENSG000002681072  ZNF5472  ZNF4162  ZNF172  ZNF5482  ZNF5842  
ENSG000002690262  ZNF3042  ZNF587B2  ZNF7732  ZNF1322  ZIK12  ZNF5862  ZNF1342  
ZNF6712  ENSG000002681632  ZNF4182  ZNF2562  ZNF1542  ZNF5522  ZNF7722  ZNF5302  
ZNF4192  
Selected SIMAP similar genes for ZNF776 using alignment to 4 protein entries:     ZN776_HUMAN (see all proteins) (see all similar genes):
ZNF577    ZNF814    ZNF418    ZNF78L1    ZNF586    ZNF208
ZNF846    ZNF552    ZNF738    ZNF417    ZNF705A    ZNF548
ZNF274    ZNF397    ZNF587B    LOC101928664    ZNF226    HZF36

ZNF776 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZNF776 (see all 313)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1939210071,2
Cuntested158265072(+) AGTCAA/C/GACTTT 2 N H mis10--------
rs1890875241,2
--58256168(+) TTAGAC/TGGCTA 1 -- us2k10--------
rs1492719111,2
--58256211(+) TGATCA/GGATTA 1 -- us2k10--------
rs1818381311,2
--58256349(+) GCCAGA/TAGGTA 1 -- us2k10--------
rs1434305191,2
C--58256415(+) ATCAAC/GGTAGC 1 -- us2k10--------
rs1873125641,2
--58256452(+) GGCCTA/GAACCC 1 -- us2k10--------
rs752391061,2
C,F--58256526(+) GGACTA/GCAACA 1 -- us2k11Minor allele frequency- G:0.02WA 118
rs1378916331,2
C--58256614(+) ACTGAA/GTTCTT 1 -- us2k10--------
rs1456992421,2
C--58256640(+) GTCAC-/AAAAAA 1 -- us2k10--------
rs342435481,2
C--58256665(+) TTGGG-/AAAAAA 1 -- us2k13Minor allele frequency- A:0.17NA CSA 6

HapMap Linkage Disequilibrium report for ZNF776 (58258164 - 58269527 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for ZNF776:    About this table    
Variant IDTypeSubtypePubMed ID
nsv912529CNV Loss21882294
nsv912528CNV Gain21882294

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ZNF776 for disorders           About GeneDecksing

Genetic Association Database (GAD): ZNF776
Human Genome Epidemiology (HuGE) Navigator: ZNF776 (3 documents)

Export disorders for ZNF776 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ZNF776 gene integrated from 10 sources:
(articles sorted by number of sources associating them with ZNF776)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  3. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
  4. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
  5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 284309 HGNC: 26765 AceView: ZNF551andFLJ38288 Ensembl:ENSG00000152443 euGenes: HUgn284309
ECgene: ZNF776 H-InvDB: ZNF776

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ZNF776 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ZNF776 gene:
Search GeneIP for patents involving ZNF776

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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