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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF776 Gene

protein-coding   GIFtS: 46
GCID: GC19P058258

Zinc Finger Protein 776

  Search for ZNF776
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 7761 2

External Ids:    HGNC: 267651   Entrez Gene: 2843092   Ensembl: ENSG000001524437   UniProtKB: Q68DI13   

Export aliases for ZNF776 gene to outside databases

Previous GC identifers: GC19P062950 GC19P054570


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF776 Gene: 
ZNF776 (zinc finger protein 776) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF549.

UniProtKB/Swiss-Prot: ZN776_HUMAN, Q68DI1
Function: May be involved in transcriptional regulation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF776 gene promoter:
         AREB6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF776 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF776

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF776


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

ZNF776 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF776 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P058258:  view genomic region     (about GC identifiers)

Start:
58,258,164 bp from pter      End:
58,269,527 bp from pter
Size:
11,364 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN776_HUMAN, Q68DI1 (See protein sequence)
Recommended Name: Zinc finger protein 776  
Size: 518 amino acids; 59613 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAC04588.1; Type=Erroneous translation; Note=Wrong choice of frame;
Sequence=BAC87119.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q6ZS36 Q8N968

Explore the universe of human proteins at neXtProt for ZNF776: NX_Q68DI1

Explore proteomics data for ZNF776 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q68DI1

  • ZNF776 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF776 Protein Expression
    REFSEQ proteins: NP_775903.3  
    ENSEMBL proteins: 
     ENSP00000321812   ENSP00000405772   ENSP00000416901  
    Reactome Protein details: Q68DI1
    Human Recombinant Protein Products for ZNF776: 
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    Cloud-Clone Corp. Proteins for ZNF776 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF776 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q68DI1

    ProtoNet protein and cluster: Q68DI1

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN776_HUMAN, Q68DI1
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 11 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF776 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN776_HUMAN, Q68DI1
    Function: May be involved in transcriptional regulation (By similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF776 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF776 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF776
        Generic Transcription Pathway
    Gene Expression



    ZNF776 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF776

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF776 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF776 (ZN776)

    Search CenterWatch for drugs/clinical trials and news about ZNF776 / ZN776

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF776 gene: 
    NM_173632.3  

    Unigene Clusters for ZNF776:

    Zinc finger protein 776
    Hs.720254  [show with all ESTs], Hs.737521
    Unigene Representative Sequences: NM_173632, AK095607
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000317178(uc002qpx.3 uc002qqa.3) ENST00000473585 ENST00000431353
    ENST00000451849 ENST00000489376
    miRNA
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF776:
    hsa-miR-199a-5p hsa-miR-199b-5p hsa-miR-4302 hsa-miR-1825
    SwitchGear 3'UTR luciferase reporter plasmidZNF776 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZNF776
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF776
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    Sirion Biotech Customized lentivirus for stable overexpression of ZNF776 
                         Customized lentivirus expression plasmids for stable overexpression of ZNF776 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF776
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF776

    Additional mRNA sequence: AK095607.1 

    10 DOTS entries:

    DT.91991731  DT.95368142  DT.95368143  DT.121503725  DT.110732  DT.40310079  DT.100643825  DT.100838168 
    DT.121503809  DT.97781230 

    24/27 AceView cDNA sequences (see all 27):

    BE294508 BG290055 BQ672779 AA765772 BP873288 AA235235 BX538151 BQ058356 
    BX484094 NM_173632 AK127764 AI446541 AA830791 BX426025 W00358 AI799034 
    BE897285 CD557545 F03106 BC005868 BF109985 CA336646 F05269 BX426164 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF776 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
    SP1:                                                        -     -                     
    SP2:                                                                                    
    SP3:                                                                                    
    SP4:                                                  -     -     -                     
    SP5:              -                                                                     


    ECgene alternative splicing isoforms for ZNF776

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF776 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTATGGAAAT
    ZNF776 Expression
    About this image


    See ZNF776 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF776

    SOURCE GeneReport for Unigene clusters: Hs.720254 Hs.737521
        SABiosciences Custom PCR Arrays for ZNF776
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF776

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF776 gene from 1/2 species (see all 2)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    cow
    (Bos taurus)
    Mammalia ZIK11 zinc finger protein 551-like 66.4(n)
    51.73(a)
      789983  XM_003587370.1  XP_003587418.1 


    ENSEMBL Gene Tree for ZNF776 (if available)
    TreeFam Gene Tree for ZNF776 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF776 gene
    ZNF5492  ZNF5872  ZNF2112  ENSG000002695332  ZNF7922  ZNF4172  ZNF7492  ZNF5512  
    ENSG000002687502  ENSG000002681332  ENSG000002681072  ZNF5472  ZNF4162  ZNF172  ZNF5482  ZNF5842  
    ENSG000002690262  ZNF3042  ZNF587B2  ZNF7732  ZNF1322  ZIK12  ZNF5862  ZNF1342  
    ZNF6712  ZNF4182  ZNF2562  ZNF1542  ZNF5522  ZNF7722  ZNF5302  ZNF8142  
    ZNF4192  
    18/518 SIMAP similar genes for ZNF776 using alignment to 4 protein entries:     ZN776_HUMAN (see all proteins) (see all similar genes):
    ZNF577    ZNF814    ZNF78L1    ZNF586    ZNF208    ZNF418
    ZNF846    ZNF552    ZNF738    ZNF705A    ZNF548    ZNF274
    ZNF397    ZNF417    ZNF226    HZF36    ZNF79    ZNF324B

    ZNF776 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/313 SNPs in ZNF776 are shown (see all 313)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1939210071,2
    Cuntested158265072(+) AGTCAA/C/GACTTT 2 N H mis10--------
    rs1890875241,2
    --58256168(+) TTAGAC/TGGCTA 1 -- us2k10--------
    rs1492719111,2
    --58256211(+) TGATCA/GGATTA 1 -- us2k10--------
    rs1818381311,2
    --58256349(+) GCCAGA/TAGGTA 1 -- us2k10--------
    rs1434305191,2
    C--58256415(+) ATCAAC/GGTAGC 1 -- us2k10--------
    rs1873125641,2
    --58256452(+) GGCCTA/GAACCC 1 -- us2k10--------
    rs752391061,2
    C,F--58256526(+) GGACTA/GCAACA 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1378916331,2
    C--58256614(+) ACTGAA/GTTCTT 1 -- us2k10--------
    rs1456992421,2
    C--58256640(+) GTCAC-/AAAAAA 1 -- us2k10--------
    rs342435481,2
    C--58256665(+) TTGGG-/AAAAAA 1 -- us2k13Minor allele frequency- A:0.17NA CSA 6

    HapMap Linkage Disequilibrium report for ZNF776 (58258164 - 58269527 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZNF776:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv912529CNV Loss21882294
    nsv912528CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF776 for disorders           About MalaCards

    ZNF776 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF776
    Human Genome Epidemiology (HuGE) Navigator: ZNF776 (3 documents)

    Export disorders for ZNF776 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF776 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF776)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    4. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 284309 HGNC: 26765 AceView: ZNF551andFLJ38288 Ensembl:ENSG00000152443 euGenes: HUgn284309
    ECgene: ZNF776 H-InvDB: ZNF776

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF776 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF776 gene:
    Search GeneIP for patents involving ZNF776

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
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