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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF775 Gene

protein-coding GIFtS: 45
GCID: GC07P150067

zinc finger protein 775

Search for ZNF775
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger Protein 775¹ ²
MGC33584¹

External Ids:	HGNC: 28501¹	Entrez Gene: 285971²	Ensembl: ENSG00000196456⁷	UniProtKB: Q96BV0³

Export aliases for ZNF775 gene to outside databases

Previous GC identifers: GC07P149707 GC07P143892

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN775_HUMAN, Q96BV0

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF775 gene promoter:
NF-1 Sp1 C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZNF775 promoter sequence

Search SABiosciences Chromatin IP Primers for ZNF775

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF775

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.1 Ensembl cytogenetic band: 7q36.1 HGNC cytogenetic band: 7q36.1

ZNF775 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF775 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P150067: view genomic region (about GC identifiers)

Start:	150,065,879 bp from pter	End:	150,109,558 bp from pter
Size:	43,680 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 149,414,255-149,433,562

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN775_HUMAN, Q96BV0 (See protein sequence)

Recommended Name: Zinc finger protein 775

Size: 537 amino acids; 59752 Da

Subcellular location: Nucleus (Probable)

Secondary accessions: Q8IY24

Explore the universe of human proteins at neXtProt for ZNF775: NX_Q96BV0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96BV0

ZNF775 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_775951.2

ENSEMBL proteins:

ENSP00000419336 ENSP00000330838 ENSP00000417483

Reactome Protein details: Q96BV0
Human Recombinant Protein Products for ZNF775:

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IEA	--

ZNF775 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF775 for domains About GeneDecksing

3 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q96BV0

ProtoNet protein and cluster: Q96BV0

UniProtKB/Swiss-Prot: ZN775_HUMAN, Q96BV0

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 11 C2H2-type zinc fingers

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ZN775_HUMAN, Q96BV0

Function: May be involved in transcriptional regulation

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZNF775 for ontologies About GeneDecksing

Phenotypes:
4 GenomeRNAi human phenotypes for ZNF775:

Downregulation of NF-kappaB pa

Increased G1 DNA content

Synthetic lethal with Ras

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ZNF775

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF775

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Generic Transcription Pathway

Generic Transcription Pathway

1.00

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Reactome Pathways for ZNF775

	Generic Transcription Pathway
	Gene Expression

ZNF775 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF775

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

5/6 Interacting proteins for ZNF775 (Q96BV0^{2, 3} ENSP00000330838⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAPK6	Q16659²^,³	MINT-8262264 I2D: score=2
OSGEP	Q9NPF4²^,³	MINT-8265362 I2D: score=2
PPP2CB	P62714²^,³	MINT-8267206 I2D: score=2
RPS6KA5	O75582²^,³	MINT-8269725 I2D: score=2
ZAK	Q9NYL2²^,³	MINT-8277433 I2D: score=2

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZNF775 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF775
Search CenterWatch for drugs/clinical trials and news about ZNF775 / ZN775

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZNF775 gene:

NM_173680.3

Unigene Cluster for ZNF775:

Zinc finger protein 775

Hs.655734 [show with all ESTs]

Unigene Representative Sequence: NM_173680

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000478789 ENST00000483664 ENST00000329630(uc003whf.1) ENST00000490973

ENST00000486297 ENST00000476489(uc003whg.3 uc011kus.2 uc011kut.2)

ENST00000464630 ENST00000480389 ENST00000498682 ENST00000481877 ENST00000491664

ENST00000474836

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		hsa-miR-3649
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Additional cDNA sequence:

BC015152.2 BC038111.2

4 DOTS entries:

DT.100022258 DT.95183725 DT.114928 DT.92418406

24/491 AceView cDNA sequences (see all 491):

AI086022 AA026355 AA731638 BU787509 BU162054 BM792622 AW453033 BE855485

AA570329 BX376275 BM833309 BM856394 AI680299 CB047663 AI369489 CD673613

BM822939 AI383834 BQ787965 AA565815 AI383384 AI768126 AW961073 AI598195

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF775 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGCGGCCTC

About this image

ZNF775 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Limb Bud

Limb

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ZNF775 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF775

SOURCE GeneReport for Unigene cluster: Hs.655734

SABiosciences Custom PCR Arrays for ZNF775

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ZNF775 gene from 2/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
tropical clawed frog (Xenopus tropicalis)	Amphibia	142015480²	--	72.56(n)		142015480
zebrafish (Danio rerio)	Actinopterygii	BQ605424.1²	--	77.92(n)		BQ605424.1

ENSEMBL Gene Tree for ZNF775 (if available)
TreeFam Gene Tree for ZNF775 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs146526002^1,2		--	150074408(+)	`TGGAA-/GGTGAC`	1	--	us2k¹		0	--	--	--	--
rs201172908^1,2	C	--	150074410(+)	`GGAAGG/TGACCC`	1	--	us2k¹		0	--	--	--	--
rs139255790^1,2		--	150074431(+)	`GGGTCC/TTAATT`	1	--	us2k¹		0	--	--	--	--
rs147542344^1,2		--	150074467(+)	`GTCAAA/GATGTC`	1	--	us2k¹		0	--	--	--	--
rs2108850^1,2	C,F,A,H	--	150074560(-)	`aatgaC/Tctgct`	1	--	us2k¹ tfbs³		9		NS EA WA NA CSA	661
rs188883090^1,2		--	150074650(+)	`TTTTCA/GTGCAT`	1	--	us2k¹		0	--	--	--	--
rs181677060^1,2		--	150074863(+)	`GGTGGC/GAGGAT`	1	--	us2k¹		0	--	--	--	--
rs6971465^1,2	C,F,A,H	--	150074994(+)	`GACTCC/TAAAGT`	1	--	us2k¹		21		NS EA NA WA CSA	2239
rs138133130^1,2		--	150075138(+)	`ACCCTA/GTTTTA`	1	--	us2k¹		0	--	--	--	--
rs79198823^1,2	F	--	150075156(+)	`ATAAGT/CCAAAG`	1	--	us2k¹		2		NA EA	240

HapMap Linkage Disequilibrium report for ZNF775 (150065879 - 150109558 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF775: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF775

DNA2.0 Custom Variant and Variant Library Synthesis for ZNF775

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF775 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF775)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)¹ Vinayagam A....Wanker E.E. (2011)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)¹ Olsen J.V....Mann M. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 285971	HGNC: 28501	AceView: MGC33584andLOC155036	Ensembl:ENSG00000196456	euGenes: HUgn285971
ECgene: ZNF775	H-InvDB: ZNF775

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF775	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF775 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF775 gene:
Search GeneIP for patents involving ZNF775

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZNF775 gene at Home site.

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ZNF775 Gene

zinc finger protein 775

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ZNF775 Gene

zinc finger protein 775

Aliasesfor ZNF775 gene

Summariesfor ZNF775 gene

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for ZNF775 gene

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