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ZNF774 Gene

protein-coding   GIFtS: 45
GCID: GC15P090895

Zinc Finger Protein 774

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 7741 2

External Ids:    HGNC: 331081   Entrez Gene: 3421322   Ensembl: ENSG000001963917   UniProtKB: Q6NX453   

Export aliases for ZNF774 gene to outside databases

Previous GC identifers: GC15P088697 GC15P067007


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF774 Gene:
ZNF774 (zinc finger protein 774) is a protein-coding gene. Diseases associated with ZNF774 include rheumatoid arthritis, and arthritis. An important paralog of this gene is ZNF436.

UniProtKB/Swiss-Prot: ZN774_HUMAN, Q6NX45
Function: May be involved in transcriptional regulation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF774 gene promoter:
         GCNF   FOXD1   CUTL1   AP-4   Tal-1beta   GCNF-1   FOXO4   FOXO1a   GCNF-2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF774 promoter sequence
   Search Chromatin IP Primers for ZNF774

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF774


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.1   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q26.1

ZNF774 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF774 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P090895:  view genomic region     (about GC identifiers)

Start:
90,895,477 bp from pter      End:
90,909,324 bp from pter
Size:
13,848 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN774_HUMAN, Q6NX45 (See protein sequence)
Recommended Name: Zinc finger protein 774  
Size: 483 amino acids; 55068 Da
Secondary accessions: A8K020

Explore the universe of human proteins at neXtProt for ZNF774: NX_Q6NX45

Explore proteomics data for ZNF774 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF774 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001004309.2  
    ENSEMBL proteins: 
     ENSP00000346348   ENSP00000453202   ENSP00000368383   ENSP00000454184  
    Reactome Protein details: Q6NX45

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q6NX45

    ProtoNet protein and cluster: Q6NX45

    UniProtKB/Swiss-Prot: ZN774_HUMAN, Q6NX45
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 12 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF774 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN774_HUMAN, Q6NX45
    Function: May be involved in transcriptional regulation (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    ZNF774 for ontologies           About GeneDecksing


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN774_HUMAN, Q6NX45: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytoskeleton1
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZNF774 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF774 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF774
        Generic Transcription Pathway



    ZNF774 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF774
    Interactions:

        Search GeneGlobe Interaction Network for ZNF774

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    ZNF774 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ZNF774 (ZN774)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF774 gene: 
    NM_001004309.2  

    Unigene Cluster for ZNF774:

    Zinc finger protein 774
    Hs.55307  [show with all ESTs]
    Unigene Representative Sequence: CR749343
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354377(uc002bpk.4) ENST00000560038 ENST00000558115 ENST00000379090
    ENST00000558586
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    Additional mRNA sequence: 

    AK289385.1 BC067279.1 CR749343.1 

    2 DOTS entries:

    DT.99956060  DT.95137735 

    23 AceView cDNA sequences:

    AI378000 BX112925 AK127462 BU619217 BQ890466 BE780366 BE670355 NM_001004309 
    BX118630 BU076434 BC067279 CR749343 BU076713 BX642937 BF447921 W31797 
    BE670329 AI243408 AA781528 BF803805 AW996686 W04695 F01146 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF774    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
    SP1:                                    
    SP2:              -                     


    ECgene alternative splicing isoforms for ZNF774

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF774 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAACCCTTCC
    ZNF774 Expression
    About this image

    ZNF774 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF774 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.55307
        Custom PCR Arrays for ZNF774
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF774

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF774 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF7741 zinc finger protein 774 89.42(n)
    90.04(a)
      488748  XM_545866.2  XP_545866.2 
    chicken
    (Gallus gallus)
    Aves --
    --
    (see all 10)
    Uncharacterized protein
    (see all 10)
    46(a)
    44(a)
    (see all 10)
    many ↔ many
    many ↔ many
    (see all 10)
    JH375242.1(146619-147632)
    JH376246.1(5829-12142)
    lizard
    (Anolis carolinensis)
    Reptilia ZNF7746
    zinc finger protein 774
    41(a)
    1 ↔ 1
    2(189436253-189451580)


    ENSEMBL Gene Tree for ZNF774 (if available)
    TreeFam Gene Tree for ZNF774 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF774 gene
    ZNF4362  ZNF1802  ZNF3222  ZNF712  ZNF5722  ZFP22  ZKSCAN72  ZNF6782  
    ZNF102  ZFP372  ZSCAN22  ZNF3292  ZNF8522  ZNF5442  ZFP32  ZNF6062  
    ZNF5022  ZNF8352  
    Selected SIMAP similar genes for ZNF774 using alignment to 4 protein entries:     ZN774_HUMAN (see all proteins) (see all similar genes):
    DKFZp781N2243    ZNF818P    HZF36    kr-znf3    ZNF544    ZSCAN16
    ZKSCAN7    ZNF180    ZNF211    ZNF213    ZNF417    ZNF587
    ZNF78L1    ZNF852    DKFZp547L155    ZNF16    ZNF569    ZNF84

    ZNF774 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF774 (see all 287)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs25899721,2
    C,F--90894691(-) TAAAAG/TAACAT 1 -- us2k13Minor allele frequency- T:0.23WA NA EA 358
    rs1838254561,2
    C--90894716(+) ACTGAA/GTCAAC 1 -- us2k10--------
    rs26011511,2
    C,F,A,H--90894883(-) AGGCGG/AGCGAG 1 -- us2k119Minor allele frequency- A:0.22NS EA NA CSA WA 2342
    rs1418232511,2
    --90894915(+) GAAAGG/TGGATG 1 -- us2k10--------
    rs1462813961,2
    --90894963(+) GTCTGA/TTTTCT 1 -- us2k10--------
    rs785978361,2
    F--90895263(+) CCAAAA/CAGGCG 1 -- us2k10--------
    rs64966691,2
    C,F,A,H--90895265(+) AAACAG/AGCGGT 1 -- us2k1 tfbs326Minor allele frequency- A:0.27NS EA NA WA CSA 2774
    rs1876718401,2
    --90895327(+) AACTGG/TACATC 1 -- us2k10--------
    rs25899711,2
    C,F,O,A,H--90895359(-) CCGAGC/GAAGAC 1 -- us2k1 tfbs327Minor allele frequency- G:0.22NA NS EA WA 2898
    rs766219501,2
    F--90895402(+) GACAGC/TTCTAT 1 -- us2k11Minor allele frequency- T:0.01EA 120

    HapMap Linkage Disequilibrium report for ZNF774 (90895477 - 90909324 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ZNF774:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833087CNV Loss17160897
    nsv457246CNV Gain19166990
    nsv904493CNV Gain21882294
    esv2751541CNV Gain17911159

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for ZNF774:    
    About MalaCards
    rheumatoid arthritis    arthritis


    ZNF774 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF774

    Export disorders for ZNF774 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF774 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF774)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. (PubMed id 22446963)1, 4 Okada Y....Yamamoto K. (Nat. Genet. 2012)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    5. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (Nature 2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 342132 HGNC: 33108 AceView: MGC75360 Ensembl:ENSG00000196391 euGenes: HUgn342132
    ECgene: ZNF774 H-InvDB: ZNF774

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF774 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF774 gene:
    Search GeneIP for patents involving ZNF774

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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