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Aliases for ZNF774 Gene

Aliases for ZNF774 Gene

  • Zinc Finger Protein 774 2 3 5

External Ids for ZNF774 Gene

Previous GeneCards Identifiers for ZNF774 Gene

  • GC15P088697
  • GC15P090895
  • GC15P067007
  • GC15P090297

Summaries for ZNF774 Gene

GeneCards Summary for ZNF774 Gene

ZNF774 (Zinc Finger Protein 774) is a Protein Coding gene. Among its related pathways are Gene Expression. An important paralog of this gene is ZNF180.

UniProtKB/Swiss-Prot for ZNF774 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF774 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF774 Gene

Genomics for ZNF774 Gene

Regulatory Elements for ZNF774 Gene

Enhancers for ZNF774 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H090398 2 FANTOM5 Ensembl ENCODE dbSUPER 24.1 +51.6 51556 11.2 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 ZNF766 FOS JUNB MIER3 IQGAP1 ZNF774 CRTC3 LOC100631255 UNC45A RPL36AP43 ENSG00000259212 GABARAPL3 VPS33B ARPIN
GH15H090392 1.1 Ensembl ENCODE dbSUPER 25.7 +41.4 41409 3.1 ZNF664 ZNF707 MAFF ZNF316 POLR2A MAFG EMSY IQGAP1 ZNF774 ENSG00000259212 GABARAPL3 VPS33B NGRN ENSG00000259177
GH15H090647 2 FANTOM5 Ensembl ENCODE dbSUPER 10.1 +297.1 297108 4.7 HDGF PKNOX1 ARNT YY1 ZNF766 ZNF143 ZNF207 FOS SP3 REST ENSG00000259314 UNC45A ENSG00000259212 RPL36AP43 BLM CRTC3 ENSG00000200677 GABARAPL3 ZNF774 FES
GH15H090157 2 FANTOM5 Ensembl ENCODE dbSUPER 9.7 -188.7 -188704 12.2 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YBX1 ZNF2 CIB1 RCCD1 SEMA4B RPL36AP43 GDPGP1 NGRN ENSG00000259314 UNC45A GABARAPL3 ZNF774
GH15H090418 1.4 Ensembl ENCODE dbSUPER 13.1 +67.9 67905 3.7 INSM2 KLF17 FEZF1 BATF ZEB1 RFX5 ZNF366 ZSCAN5C RCOR1 ATF7 IQGAP1 ZNF774 GC15P090443 ENSG00000259177
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF774 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF774 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000081049 155 1201 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZBTB7B ETS1 SLC30A9 GLIS2 ELK1

Genomic Locations for ZNF774 Gene

Genomic Locations for ZNF774 Gene
chr15:90,352,245-90,369,146
(GRCh38/hg38)
Size:
16,902 bases
Orientation:
Plus strand
chr15:90,895,477-90,909,324
(GRCh37/hg19)

Genomic View for ZNF774 Gene

Genes around ZNF774 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF774 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF774 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF774 Gene

Proteins for ZNF774 Gene

  • Protein details for ZNF774 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NX45-ZN774_HUMAN
    Recommended name:
    Zinc finger protein 774
    Protein Accession:
    Q6NX45
    Secondary Accessions:
    • A8K020

    Protein attributes for ZNF774 Gene

    Size:
    483 amino acids
    Molecular mass:
    55068 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF774 Gene

Post-translational modifications for ZNF774 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF774 Gene

No data available for DME Specific Peptides for ZNF774 Gene

Domains & Families for ZNF774 Gene

Gene Families for ZNF774 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF774 Gene

Suggested Antigen Peptide Sequences for ZNF774 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6NX45

UniProtKB/Swiss-Prot:

ZN774_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF774: view

Function for ZNF774 Gene

Molecular function for ZNF774 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF774 Gene

Gene Ontology (GO) - Molecular Function for ZNF774 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF774: view

Phenotypes for ZNF774 Gene

genes like me logo Genes that share phenotypes with ZNF774: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF774 Gene

Localization for ZNF774 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF774 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF774 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF774 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF774: view

Pathways & Interactions for ZNF774 Gene

SuperPathways for ZNF774 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF774: view

Pathways by source for ZNF774 Gene

2 Reactome pathways for ZNF774 Gene

Gene Ontology (GO) - Biological Process for ZNF774 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF774: view

No data available for SIGNOR curated interactions for ZNF774 Gene

Drugs & Compounds for ZNF774 Gene

No Compound Related Data Available

Transcripts for ZNF774 Gene

Unigene Clusters for ZNF774 Gene

Zinc finger protein 774:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF774 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for ZNF774 Gene

GeneLoc Exon Structure for
ZNF774
ECgene alternative splicing isoforms for
ZNF774

Expression for ZNF774 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF774 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF774 Gene:

ZNF774

SOURCE GeneReport for Unigene cluster for ZNF774 Gene:

Hs.55307

Evidence on tissue expression from TISSUES for ZNF774 Gene

  • Adrenal gland(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF774: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF774 Gene

Orthologs for ZNF774 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF774 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF774 33 34
  • 99.24 (n)
dog
(Canis familiaris)
Mammalia ZNF774 33
  • 89.42 (n)
cow
(Bos Taurus)
Mammalia ZNF774 34
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF774 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 38 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 34
  • 46 (a)
ManyToMany
-- 34
  • 44 (a)
ManyToMany
-- 34
  • 43 (a)
ManyToMany
-- 34
  • 43 (a)
ManyToMany
-- 34
  • 43 (a)
ManyToMany
-- 34
  • 42 (a)
ManyToMany
-- 34
  • 41 (a)
ManyToMany
ZNF302 34
  • 40 (a)
ManyToMany
-- 34
  • 37 (a)
ManyToMany
-- 34
  • 34 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia ZNF774 34
  • 41 (a)
OneToOne
Species where no ortholog for ZNF774 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF774 Gene

ENSEMBL:
Gene Tree for ZNF774 (if available)
TreeFam:
Gene Tree for ZNF774 (if available)

Paralogs for ZNF774 Gene

(497) SIMAP similar genes for ZNF774 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF774: view

Variants for ZNF774 Gene

Sequence variations from dbSNP and Humsavar for ZNF774 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000068961 -- 90,349,950(+) TTCTA(C/T)GCCTC upstream-variant-2KB
rs1000395556 -- 90,349,697(+) GCCGG(A/G)CGTGG upstream-variant-2KB
rs1000487147 -- 90,354,013(+) AGAGT(G/T)GTGTT intron-variant, upstream-variant-2KB
rs1000509981 -- 90,354,267(+) GCTTG(A/C)TGAGG intron-variant, upstream-variant-2KB
rs1001466338 -- 90,352,453(+) GCGCG(C/G)TGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF774 Gene

Variant ID Type Subtype PubMed ID
nsv833087 CNV loss 17160897
nsv570395 CNV loss 21841781
nsv570394 CNV gain 21841781
nsv457246 CNV gain 19166990
nsv1113731 CNV deletion 24896259
esv3637223 CNV loss 21293372
esv3552836 CNV deletion 23714750
esv2761843 CNV gain 21179565
esv2751541 CNV gain 17911159
dgv4705n54 CNV gain 21841781
dgv2659n100 CNV gain 25217958
dgv2658n100 CNV gain 25217958

Variation tolerance for ZNF774 Gene

Residual Variation Intolerance Score: 83.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.48; 71.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF774 Gene

Human Gene Mutation Database (HGMD)
ZNF774
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF774

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF774 Gene

Disorders for ZNF774 Gene

Relevant External Links for ZNF774

Genetic Association Database (GAD)
ZNF774
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF774

No disorders were found for ZNF774 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF774 Gene

Publications for ZNF774 Gene

  1. Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. (PMID: 22446963) Okada Y … Yamamoto K (Nature genetics 2012) 3 45 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  4. CBFβ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. (PMID: 23333304) Kim DY … Gross JD (Molecular cell 2013) 3 60
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H … Vidal M (Nature methods 2011) 3 60

Products for ZNF774 Gene

Sources for ZNF774 Gene

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