Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF774 Gene

Aliases for ZNF774 Gene

  • Zinc Finger Protein 774 2 3 5

External Ids for ZNF774 Gene

Previous GeneCards Identifiers for ZNF774 Gene

  • GC15P088697
  • GC15P090895
  • GC15P067007
  • GC15P090297

Summaries for ZNF774 Gene

GeneCards Summary for ZNF774 Gene

ZNF774 (Zinc Finger Protein 774) is a Protein Coding gene. Among its related pathways are Gene Expression. An important paralog of this gene is ZNF70.

UniProtKB/Swiss-Prot for ZNF774 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF774 Gene

Genomics for ZNF774 Gene

Regulatory Elements for ZNF774 Gene

Promoters for ZNF774 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF774 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF774 Gene

Chromosome:
15
Start:
90,352,245 bp from pter
End:
90,369,146 bp from pter
Size:
16,902 bases
Orientation:
Plus strand

Genomic View for ZNF774 Gene

Genes around ZNF774 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF774 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF774 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF774 Gene

Proteins for ZNF774 Gene

  • Protein details for ZNF774 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NX45-ZN774_HUMAN
    Recommended name:
    Zinc finger protein 774
    Protein Accession:
    Q6NX45
    Secondary Accessions:
    • A8K020

    Protein attributes for ZNF774 Gene

    Size:
    483 amino acids
    Molecular mass:
    55068 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF774 Gene

Proteomics data for ZNF774 Gene at MOPED

Post-translational modifications for ZNF774 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF774 Gene

No data available for DME Specific Peptides for ZNF774 Gene

Domains & Families for ZNF774 Gene

Gene Families for ZNF774 Gene

Protein Domains for ZNF774 Gene

Suggested Antigen Peptide Sequences for ZNF774 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6NX45

UniProtKB/Swiss-Prot:

ZN774_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF774: view

Function for ZNF774 Gene

Molecular function for ZNF774 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes for ZNF774 Gene

genes like me logo Genes that share phenotypes with ZNF774: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF774 Gene

Localization for ZNF774 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF774 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF774 Gene COMPARTMENTS Subcellular localization image for ZNF774 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZNF774 Gene

Pathways & Interactions for ZNF774 Gene

SuperPathways for ZNF774 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF774: view

Pathways by source for ZNF774 Gene

2 Reactome pathways for ZNF774 Gene

Gene Ontology (GO) - Biological Process for ZNF774 Gene

None

No data available for SIGNOR curated interactions for ZNF774 Gene

Drugs & Compounds for ZNF774 Gene

No Compound Related Data Available

Transcripts for ZNF774 Gene

Unigene Clusters for ZNF774 Gene

Zinc finger protein 774:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF774 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for ZNF774 Gene

GeneLoc Exon Structure for
ZNF774
ECgene alternative splicing isoforms for
ZNF774

Expression for ZNF774 Gene

mRNA expression in normal human tissues for ZNF774 Gene

SOURCE GeneReport for Unigene cluster for ZNF774 Gene Hs.55307

genes like me logo Genes that share expression patterns with ZNF774: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF774 Gene

Orthologs for ZNF774 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF774 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ZNF774 35
  • 89.42 (n)
  • 90.04 (a)
chimpanzee
(Pan troglodytes)
Mammalia ZNF774 35
  • 99.24 (n)
  • 98.76 (a)
ZNF774 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF774 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF774 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 38 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 34 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
ZNF302 36
  • 40 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia ZNF774 36
  • 41 (a)
OneToOne
Species with no ortholog for ZNF774:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF774 Gene

ENSEMBL:
Gene Tree for ZNF774 (if available)
TreeFam:
Gene Tree for ZNF774 (if available)

Paralogs for ZNF774 Gene

(497) SIMAP similar genes for ZNF774 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF774: view

Variants for ZNF774 Gene

Sequence variations from dbSNP and Humsavar for ZNF774 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs16944267 - 90,358,940(+) GATCC(C/T)GAGGG reference, missense
rs2589957 - 90,360,079(+) GGACA(A/G)TTCTG reference, missense
rs11854320 - 90,360,270(+) GATAT(A/G)TAGGA reference, missense
rs1869179 -- 90,352,332(-) GAGGC(A/G/T)GTGCC utr-variant-5-prime
rs1869180 -- 90,352,235(-) CCCCC(A/G)TCCTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF774 Gene

Variant ID Type Subtype PubMed ID
nsv833087 CNV Loss 17160897
esv2751541 CNV Gain 17911159
nsv904493 CNV Gain 21882294
nsv457246 CNV Gain 19166990

Variation tolerance for ZNF774 Gene

Residual Variation Intolerance Score: 83.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.48; 71.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF774 Gene

HapMap Linkage Disequilibrium report
ZNF774
Human Gene Mutation Database (HGMD)
ZNF774

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF774 Gene

Disorders for ZNF774 Gene

Relevant External Links for ZNF774

Genetic Association Database (GAD)
ZNF774
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF774

No disorders were found for ZNF774 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF774 Gene

Publications for ZNF774 Gene

  1. Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. (PMID: 22446963) Okada Y. … Yamamoto K. (Nat. Genet. 2012) 3 48 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. CBFI^ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. (PMID: 23333304) Kim D.Y. … Gross J.D. (Mol. Cell 2013) 3
  4. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for ZNF774 Gene

Sources for ZNF774 Gene

Back to Top

Content