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ZNF773 Gene

protein-coding   GIFtS: 47
GCID: GC19P058011

Zinc Finger Protein 773

(Previous name: zinc finger protein 419B)
(Previous symbol: ZNF419B)
  Search for ZNF773
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 7731 2
Zinc Finger Protein 419B1 2 3
ZNF419B1 2 3

External Ids:    HGNC: 304871   Entrez Gene: 3749282   Ensembl: ENSG000001524397   UniProtKB: Q6PK813   

Export aliases for ZNF773 gene to outside databases

Previous GC identifers: GC19P062706 GC19P054323


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF773 Gene:
ZNF773 (zinc finger protein 773) is a protein-coding gene. An important paralog of this gene is ZNF549.

UniProtKB/Swiss-Prot: ZN773_HUMAN, Q6PK81
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF773 gene promoter:
         c-Fos   AP-1   HTF   SREBP-1c   AP-4   XBP-1   SREBP-1b   SREBP-1a   Nkx6-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF773 promoter sequence
   Search Chromatin IP Primers for ZNF773

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF773


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

ZNF773 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF773 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P058011:  view genomic region     (about GC identifiers)

Start:
58,011,283 bp from pter      End:
58,029,772 bp from pter
Size:
18,490 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN773_HUMAN, Q6PK81 (See protein sequence)
Recommended Name: Zinc finger protein 773  
Size: 442 amino acids; 50502 Da
Secondary accessions: Q96DL8
Alternative splicing: 2 isoforms:  Q6PK81-1   Q6PK81-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF773: NX_Q6PK81

Explore proteomics data for ZNF773 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys203, Lys217, Lys320, Lys343
  • Modification sites at PhosphoSitePlus

  • See ZNF773 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_940944.1  
    ENSEMBL proteins: 
     ENSP00000470189   ENSP00000469416   ENSP00000468846   ENSP00000282292   ENSP00000469199  
    Reactome Protein details: Q6PK81

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q6PK81

    ProtoNet protein and cluster: Q6PK81

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN773_HUMAN, Q6PK81
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 9 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF773           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN773_HUMAN, Q6PK81
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF773           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF773:
     Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF773
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN773_HUMAN, Q6PK81: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF773           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF773 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF773           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF773
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF773
    Interactions:

        Search GeneGlobe Interaction Network for ZNF773

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for ZNF773 (Q6PK813 ENSP000002822924) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JUNBP172753I2D: score=1 
    CBX5ENSP000002098754STRING: ENSP00000209875
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF773           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF773 (ZN773)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF773 gene: 
    NM_198542.1  

    Unigene Cluster for ZNF773:

    Zinc finger protein 773
    Hs.579576  [show with all ESTs]
    Unigene Representative Sequence: AK160372
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000593916 ENST00000598770 ENST00000599847 ENST00000282292(uc002qox.3 uc002qoy.3 uc021vcl.1)
    ENST00000597061 ENST00000601958
    miRNA
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat ZNF773

    Additional mRNA sequence: 

    AK057209.1 AK160372.1 BC005167.2 

    8 DOTS entries:

    DT.101982763  DT.102821719  DT.91676953  DT.121495870  DT.91653758  DT.100672047  DT.100773971  DT.91869102 

    Selected AceView cDNA sequences (see all 29):

    BX417519 BC005167 CR606221 BU623103 NM_198542 BX389839 BX365407 AA905153 
    BI752081 BX382673 BX365406 AK057209 BX382674 CK002901 BF743864 AI798448 
    BX329120 BF971223 BI038296 AK160372 BX487145 BX490453 BI038003 BX490368 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF773    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5
    SP1:                                                
    SP2:                                                
    SP3:                                -     -         


    ECgene alternative splicing isoforms for ZNF773

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF773 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACCTAGGAG
    ZNF773 Expression
    About this image

    ZNF773 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF773 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.579576
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZNF773 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp7735
    Zfp7721
    zinc finger protein 7735
    zinc finger protein 7721
    65.07(n)1
    52.13(a)1
      7 (4.14 cM)5
    2328551  NM_145577.21  NP_663552.21 
     71306785 


    ENSEMBL Gene Tree for ZNF773 (if available)
    TreeFam Gene Tree for ZNF773 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF773 gene
    ZNF5492  ENSG000002695332  ZNF4172  ENSG000002681332  ENSG000002681072  ZNF4162  ZNF172  ZNF5482  
    ZNF587B2  ZIK12  ZNF1342  ZNF6712  ENSG000002681632  ZNF7722  ZNF5302  ZNF4192  
    ZNF5872  ZNF2112  ZNF7922  ZNF7492  ZNF5512  ENSG000002687502  ZNF7762  ZNF5472  
    ZNF5842  ENSG000002690262  ZNF3042  ZNF1322  ZNF5862  ZNF4182  ZNF2562  ZNF5522  
    ZNF1542  
    Selected SIMAP similar genes for ZNF773 using alignment to 3 protein entries:     ZN773_HUMAN (see all proteins) (see all similar genes):
    FLJ00301    ZNF577    ZNF548    ZNF22    ZNF418    DKFZp666C237
    HZF30    HZF36    ZNF419    ZNF17    ZNF169    ZNF146
    ZNF776    DKFZp686M04222    ZNF323    ZNF501    ZNF662    ZNF697

    Find genes that share paralogs with ZNF773           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for ZNF773
    PGOHUM00000263017 PGOHUM00000249737


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF773 (see all 379)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs581553711,2
    C,F--54321593(+) TGTTTC/TTAAAA 1 -- us2k16Minor allele frequency- T:0.20NA WA CSA 15
    rs1426253391,2
    C--54321597(+) TTAAA-/ACACA 
     CACACAT
    ACACA
    1 -- cds10--------
    rs108538971,2
    C,F,A,H--58009358(+) aaaatC/Tcctga 1 -- us2k112Minor allele frequency- T:0.44NS EA NA WA CSA 775
    rs730709551,2
    C--58009378(+) AAGAAA/GCCAGA 1 -- us2k10--------
    rs1900024631,2
    --58009474(+) ATTGAC/GCCTGC 1 -- us2k10--------
    rs1811990071,2
    --58009485(+) GGTCTA/GAGGGG 1 -- us2k10--------
    rs1426156511,2
    C--58009500(+) GTTCTC/GACTGA 1 -- us2k10--------
    rs104096351,2
    C,F,H--58009510(+) aaagaA/Gtacag 1 -- us2k112Minor allele frequency- G:0.32WA NA CSA EA 378
    rs104090921,2
    C,F,H--58009514(+) agtacG/Aggaaa 1 -- us2k113Minor allele frequency- A:0.32NA WA CSA EA 382
    rs1861950511,2
    --58009560(+) CTGTGC/TTGGTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF773 (58011283 - 58029772 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ZNF773:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2719074CNV Deletion23290073
    esv2719072CNV Deletion23290073
    esv2719071CNV Deletion23290073
    nsv522762CNV Loss19592680
    nsv525323CNV Loss19592680
    nsv912525CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF773 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF773)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    4. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PubMed id 20562864)1 Nozawa R.S.... Obuse C. (Nat. Cell Biol. 2010)
    5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 374928 HGNC: 30487 AceView: MGC4728 Ensembl:ENSG00000152439 euGenes: HUgn374928
    ECgene: ZNF773 H-InvDB: ZNF773

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF773 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF773 gene:
    Search GeneIP for patents involving ZNF773

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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