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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF773 Gene

protein-coding   GIFtS: 46
GCID: GC19P058011

Zinc Finger Protein 773

(Previous name: zinc finger protein 419B)
(Previous symbol: ZNF419B)
  Search for ZNF773
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 7731 2
Zinc Finger Protein 419B1 2 3
ZNF419B1 2 3

External Ids:    HGNC: 304871   Entrez Gene: 3749282   Ensembl: ENSG000001524397   UniProtKB: Q6PK813   

Export aliases for ZNF773 gene to outside databases

Previous GC identifers: GC19P062706 GC19P054323


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF773 Gene: 
ZNF773 (zinc finger protein 773) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF549.

UniProtKB/Swiss-Prot: ZN773_HUMAN, Q6PK81
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF773 gene promoter:
         c-Fos   AP-1   HTF   SREBP-1c   AP-4   XBP-1   SREBP-1b   SREBP-1a   Nkx6-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF773 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF773

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF773


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

ZNF773 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF773 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P058011:  view genomic region     (about GC identifiers)

Start:
58,011,283 bp from pter      End:
58,029,772 bp from pter
Size:
18,490 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN773_HUMAN, Q6PK81 (See protein sequence)
Recommended Name: Zinc finger protein 773  
Size: 442 amino acids; 50502 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: Q96DL8
Alternative splicing: 2 isoforms:  Q6PK81-1   Q6PK81-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF773: NX_Q6PK81

Explore proteomics data for ZNF773 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6PK81

  • ZNF773 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF773 Protein Expression
    REFSEQ proteins: NP_940944.1  
    ENSEMBL proteins: 
     ENSP00000470189   ENSP00000469416   ENSP00000468846   ENSP00000282292   ENSP00000469199  
    Reactome Protein details: Q6PK81
    Human Recombinant Protein Products for ZNF773: 
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    Novus Biologicals ZNF773 Lysates
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for ZNF773 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF773 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q6PK81

    ProtoNet protein and cluster: Q6PK81

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN773_HUMAN, Q6PK81
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 9 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF773 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN773_HUMAN, Q6PK81
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF773 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF773:
     Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF773 
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF773


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF773 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF773
        Generic Transcription Pathway
    Gene Expression



    ZNF773 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF773

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for ZNF773 (Q6PK813 ENSP000002822924) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JUNBP172753I2D: score=1 
    CBX5ENSP000002098754STRING: ENSP00000209875
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF773 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF773 (ZN773)

    Search CenterWatch for drugs/clinical trials and news about ZNF773 / ZN773

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF773 gene: 
    NM_198542.1  

    Unigene Cluster for ZNF773:

    Zinc finger protein 773
    Hs.579576  [show with all ESTs]
    Unigene Representative Sequence: AK160372
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000593916 ENST00000598770 ENST00000599847 ENST00000282292(uc002qox.3 uc002qoy.3 uc021vcl.1)
    ENST00000597061 ENST00000601958
    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZNF773
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF773
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF773
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF773

    Additional mRNA sequence: 

    AK057209.1 AK160372.1 BC005167.2 

    8 DOTS entries:

    DT.101982763  DT.102821719  DT.91676953  DT.121495870  DT.91653758  DT.100672047  DT.100773971  DT.91869102 

    24/29 AceView cDNA sequences (see all 29):

    BX417519 NM_198542 BU623103 CR606221 BC005167 CK002901 BX382674 BF971223 
    BX382673 BF743864 BX329120 BX389839 BX490453 AK057209 BI038296 BX487145 
    AA905153 BX365407 AK160372 AI798448 BX365406 BI038003 BI752081 BX490368 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF773    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5
    SP1:                                                
    SP2:                                                
    SP3:                                -     -         


    ECgene alternative splicing isoforms for ZNF773

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF773 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACCTAGGAG
    ZNF773 Expression
    About this image


    See ZNF773 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.579576
        SABiosciences Custom PCR Arrays for ZNF773
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF773

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZNF773 gene from 1/2 species (see all 2)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp7735 zinc finger protein 773   --   7 (4.14 cM) 7130678 


    ENSEMBL Gene Tree for ZNF773 (if available)
    TreeFam Gene Tree for ZNF773 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF773 gene
    ZNF5492  ENSG000002695332  ZNF4172  ENSG000002681332  ENSG000002681072  ZNF4162  ZNF172  ZNF5482  
    ZNF587B2  ZIK12  ZNF1342  ZNF6712  ZNF7722  ZNF5302  ZNF4192  ZNF5872  
    ZNF2112  ZNF7922  ZNF7492  ZNF5512  ENSG000002687502  ZNF7762  ZNF5472  ZNF5842  
    ENSG000002690262  ZNF3042  ZNF1322  ZNF5862  ZNF4182  ZNF2562  ZNF5522  ZNF1542  
    ZNF8142  
    18/500 SIMAP similar genes for ZNF773 using alignment to 3 protein entries:     ZN773_HUMAN (see all proteins) (see all similar genes):
    FLJ00301    ZNF577    ZNF548    ZNF22    ZNF418    ZNF419
    DKFZp666C237    HZF30    HZF36    ZNF17    ZNF169    ZNF146
    ZNF776    DKFZp686M04222    ZNF323    ZNF501    ZNF697    zf30

    ZNF773 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ZNF773
    PGOHUM00000263017 PGOHUM00000249737


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/379 SNPs in ZNF773 are shown (see all 379)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs581553711,2
    C,F--54321593(+) TGTTTC/TTAAAA 1 -- us2k16Minor allele frequency- T:0.20NA WA CSA 15
    rs1426253391,2
    C--54321597(+) TTAAA-/ACACA 
     CACACAT
    ACACA
    1 -- cds10--------
    rs108538971,2
    C,F,A,H--58009358(+) aaaatC/Tcctga 1 -- us2k112Minor allele frequency- T:0.44NS EA NA WA CSA 775
    rs730709551,2
    C--58009378(+) AAGAAA/GCCAGA 1 -- us2k10--------
    rs1900024631,2
    --58009474(+) ATTGAC/GCCTGC 1 -- us2k10--------
    rs1811990071,2
    --58009485(+) GGTCTA/GAGGGG 1 -- us2k10--------
    rs1426156511,2
    C--58009500(+) GTTCTC/GACTGA 1 -- us2k10--------
    rs104096351,2
    C,F,H--58009510(+) aaagaA/Gtacag 1 -- us2k112Minor allele frequency- G:0.32WA NA CSA EA 378
    rs104090921,2
    C,F,H--58009514(+) agtacG/Aggaaa 1 -- us2k113Minor allele frequency- A:0.32NA WA CSA EA 382
    rs1861950511,2
    --58009560(+) CTGTGC/TTGGTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF773 (58011283 - 58029772 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ZNF773:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2719074CNV Deletion23290073
    esv2719072CNV Deletion23290073
    esv2719071CNV Deletion23290073
    nsv522762CNV Loss19592680
    nsv525323CNV Loss19592680
    nsv912525CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF773 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF773)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    4. Human POGZ modulates dissociation of HP1alpha from mi totic chromosome arms through Aurora B activation. (PubMed id 20562864)1 Nozawa R.S....Obuse C. (2010)
    5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 374928 HGNC: 30487 AceView: MGC4728 Ensembl:ENSG00000152439 euGenes: HUgn374928
    ECgene: ZNF773 H-InvDB: ZNF773

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF773 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF773 gene:
    Search GeneIP for patents involving ZNF773

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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