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ZNF772 Gene

protein-coding   GIFtS: 44
GCID: GC19M057982

Zinc Finger Protein 772

  Search for ZNF772
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 7721 2

External Ids:    HGNC: 331061   Entrez Gene: 4007202   Ensembl: ENSG000001971287   UniProtKB: Q68DY93   

Export aliases for ZNF772 gene to outside databases

Previous GC identifers: GC19M062674 GC19M054293


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF772 Gene:
ZNF772 (zinc finger protein 772) is a protein-coding gene. An important paralog of this gene is ZNF549.

UniProtKB/Swiss-Prot: ZN772_HUMAN, Q68DY9
Function: May be involved in transcriptional regulation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF772 gene promoter:
         COUP-TF1   HTF   COUP   AP-4   HNF-4alpha2   XBP-1   HNF-4alpha1   Nkx6-1   COUP-TF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF772 promoter sequence
   Search Chromatin IP Primers for ZNF772

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF772


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

ZNF772 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF772 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M057982:  view genomic region     (about GC identifiers)

Start:
57,978,031 bp from pter      End:
57,988,938 bp from pter
Size:
10,908 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN772_HUMAN, Q68DY9 (See protein sequence)
Recommended Name: Zinc finger protein 772  
Size: 489 amino acids; 55367 Da
Secondary accessions: A6NJK9 B4DH56 B4DYS0
Alternative splicing: 3 isoforms:  Q68DY9-1   Q68DY9-2   Q68DY9-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF772: NX_Q68DY9

Explore proteomics data for ZNF772 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF772 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001019767.1  NP_001137540.1  

    ENSEMBL proteins: 
     ENSP00000471079   ENSP00000471647   ENSP00000341165   ENSP00000395967   ENSP00000348992  
     ENSP00000415214   ENSP00000400754  
    Reactome Protein details: Q68DY9

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q68DY9

    ProtoNet protein and cluster: Q68DY9

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZN772_HUMAN, Q68DY9
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 10 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF772           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN772_HUMAN, Q68DY9
    Function: May be involved in transcriptional regulation (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF772           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF772
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    miRNA
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    miRTarBase miRNAs that target ZNF772:
    hsa-mir-222-3p (MIRT046590)

    Block miRNA regulation of human, mouse, rat ZNF772 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate ZNF772:
    hsa-miR-3910 hsa-miR-223 hsa-miR-135b hsa-miR-4279 hsa-miR-1827 hsa-miR-135a
    SwitchGear 3'UTR luciferase reporter plasmidZNF772 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF772


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN772_HUMAN, Q68DY9: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF772           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF772 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF772           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF772
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF772
    Interactions:

        Search GeneGlobe Interaction Network for ZNF772

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF772           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF772 (ZN772)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF772 gene (2 alternative transcripts): 
    NM_001024596.2  NM_001144068.1  

    Unigene Cluster for ZNF772:

    Zinc finger protein 772
    Hs.388810  [show with all ESTs]
    Unigene Representative Sequence: NM_001024596
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000600175 ENST00000601768 ENST00000343280(uc002qot.3 uc010ygy.2 uc010ygz.2 uc010yha.2)
    ENST00000427512(uc002qou.3) ENST00000356584 ENST00000425074 ENST00000450712

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZNF772 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate ZNF772:
    hsa-miR-3910 hsa-miR-223 hsa-miR-135b hsa-miR-4279 hsa-miR-1827 hsa-miR-135a
    SwitchGear 3'UTR luciferase reporter plasmidZNF772 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat ZNF772
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    GenScript: all cDNA clones in your preferred vector (see all 2): ZNF772 (NM_001144068)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF772
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF772
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF772
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF772
      QuantiFast Probe-based Assays in human, mouse, rat ZNF772

    Additional mRNA sequence: 

    AK293825.1 AK294941.1 AK301562.1 AK302574.1 BC150292.1 BX647068.1 CR749225.1 

    6 DOTS entries:

    DT.97822396  DT.430458  DT.121495875  DT.95142568  DT.91645036  DT.99963543 

    Selected AceView cDNA sequences (see all 74):

    NM_020633 CD630261 AF255342 BU931511 AA505364 CD630267 AI985650 AA936324 
    CD630263 AF302903 AI801007 BM664629 BX110882 CR594998 BM989211 BM677325 
    AW073285 AK094452 BX442402 BG167434 AA334110 BM979074 CD642604 BP872194 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF772    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
    SP1:                                          
    SP2:                          -               


    ECgene alternative splicing isoforms for ZNF772

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF772 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCACTTGAA
    ZNF772 Expression
    About this image

    ZNF772 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF772 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.388810
        Custom PCR Arrays for ZNF772
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF772

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF772 gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF7721 zinc finger protein 772 87.16(n)
    80.53(a)
      484262  XM_541377.4  XP_541377.4 


    ENSEMBL Gene Tree for ZNF772 (if available)
    TreeFam Gene Tree for ZNF772 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF772 gene
    ZNF5492  ENSG000002695332  ZNF4172  ENSG000002681332  ENSG000002681072  ZNF4162  ZNF172  ZNF5482  
    ZNF587B2  ZNF7732  ZIK12  ZNF1342  ZNF6712  ENSG000002681632  ZNF5302  ZNF4192  
    ZNF5872  ZNF2112  ZNF7922  ZNF7492  ZNF5512  ENSG000002687502  ZNF7762  ZNF5472  
    ZNF5842  ENSG000002690262  ZNF3042  ZNF1322  ZNF5862  ZNF4182  ZNF2562  ZNF5522  
    ZNF1542  
    Selected SIMAP similar genes for ZNF772 using alignment to 5 protein entries:     ZN772_HUMAN (see all proteins) (see all similar genes):
    ZNF78L1    ZNF818P    ZSCAN23    kr-znf3    ZKSCAN8    DKFZp666C237
    HZF30    ZNF501    ZSCAN30    ZNF808    HZF36    ZNF
    DKFZp686D2168    DKFZp686H10254    ZNF696    ZSCAN16    ZSCAN21    ZSCAN22

    Find genes that share paralogs with ZNF772           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for ZNF772
    PGOHUM00000234287 PGOHUM00000259924 PGOHUM00000243453


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF772 (see all 286)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1939208341,2
    Cuntested157988667(-) GGCGG-/GGCCTGAG 2 GP cds10--------
    rs1883294751,2
    --57980532(+) ACCACC/GTGAAA 2 -- int10--------
    rs72544551,2
    C,F,A,H--57980609(+) tgagtA/Taaaaa 2 -- int111Minor allele frequency- T:0.42NS EA WA NA CSA 779
    rs560331161,2
    C,F--57980693(+) TTAAAA/GTGTAT 2 -- int15Minor allele frequency- G:0.19NA WA EA 362
    rs1932848611,2
    --57980716(+) TCATCA/GAGAAA 2 -- int10--------
    rs1848358091,2
    --57980861(+) TTAAAC/TCATGT 2 -- int10--------
    rs48014881,2
    C,F,A,H--57981001(+) CATACC/TAAAAT 2 -- ut3126Minor allele frequency- T:0.34NS EA NA WA CSA 2488
    rs800322061,2
    C--57981009(+) AATATG/ATGAAG 2 -- ut312Minor allele frequency- A:0.03CSA WA 119
    rs48014891,2
    C,F,A--57981093(+) ttgctA/Ggaacc 2 -- ut31 ese316Minor allele frequency- G:0.32EA NA WA CSA 591
    rs1484967261,2
    --57981162(+) CTAATC/TAACAC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF772 (57978031 - 57988938 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ZNF772:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912524CNV Loss21882294
    nsv912525CNV Loss21882294
    nsv9773CNV Gain18304495
    esv24439CNV Gain19812545
    nsv828655CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF772
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF772 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF772)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    2. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    3. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 400720 HGNC: 33106 AceView: VN1R1 Ensembl:ENSG00000197128 euGenes: HUgn400720
    ECgene: ZNF772 H-InvDB: ZNF772

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF772 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF772 gene:
    Search GeneIP for patents involving ZNF772

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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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