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Aliases for ZNF770 Gene

Aliases for ZNF770 Gene

  • Zinc Finger Protein 770 2 3 5
  • PRO1914 3

External Ids for ZNF770 Gene

Previous GeneCards Identifiers for ZNF770 Gene

  • GC15M033058
  • GC15M035270
  • GC15M012115

Summaries for ZNF770 Gene

GeneCards Summary for ZNF770 Gene

ZNF770 (Zinc Finger Protein 770) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding.

UniProtKB/Swiss-Prot for ZNF770 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF770 Gene

Genomics for ZNF770 Gene

Regulatory Elements for ZNF770 Gene

Enhancers for ZNF770 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G034984 1.1 ENCODE 8.7 +1.2 1210 5.0 HNRNPUL1 PKNOX1 FOXA2 CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 AQR HNRNPLP2 ZNF770 ENSG00000279364
GH15G034993 0.9 ENCODE 10.6 -6.4 -6369 2.2 ATF1 TBL1XR1 ZNF766 CBX5 SCRT2 RELB ETV6 IKZF2 KLF13 CREM ZNF770 ENSG00000259181 ENSG00000280396
GH15G035018 1 Ensembl ENCODE 8.8 -31.7 -31723 3.2 CTCF SIN3A NFXL1 RAD21 YY1 EGR2 ZNF263 SP3 ZNF740 HLF ZNF770 AQR ENSG00000259587 ENSG00000259181 LOC105370763 ENSG00000259665
GH15G034968 1.1 ENCODE 7.7 +18.8 18829 1.9 HDGF PKNOX1 CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1 YY1 AQR HNRNPLP2 ENSG00000259336 ZNF770 GC15P034944
GH15G034854 0.6 ENCODE 4.9 +132.9 132853 1.6 CEBPB SUPT20H EP300 ZSCAN21 JUND ZNF692 ZBTB48 STAT3 FOS TCF7L2 ACTC1 GJD2 LOC101928174 ENSG00000259181 ZNF770 LOC100132824 RPL36AP8
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF770 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF770 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000074859 196 2201 HNRNPUL1 PKNOX1 FOXA2 CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A FEZF1 ZNF2

Genomic Location for ZNF770 Gene

Chromosome:
15
Start:
34,978,341 bp from pter
End:
34,988,296 bp from pter
Size:
9,956 bases
Orientation:
Minus strand

Genomic View for ZNF770 Gene

Genes around ZNF770 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF770 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF770 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF770 Gene

Proteins for ZNF770 Gene

  • Protein details for ZNF770 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IQ21-ZN770_HUMAN
    Recommended name:
    Zinc finger protein 770
    Protein Accession:
    Q6IQ21
    Secondary Accessions:
    • Q6ZMZ6
    • Q9NWV2

    Protein attributes for ZNF770 Gene

    Size:
    691 amino acids
    Molecular mass:
    80007 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD18579.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF770 Gene

Post-translational modifications for ZNF770 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF770 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF770 Gene

Domains & Families for ZNF770 Gene

Gene Families for ZNF770 Gene

Suggested Antigen Peptide Sequences for ZNF770 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6IQ21

UniProtKB/Swiss-Prot:

ZN770_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF770: view

Function for ZNF770 Gene

Molecular function for ZNF770 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF770 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF770: view
genes like me logo Genes that share phenotypes with ZNF770: view

Animal Model Products

CRISPR Products

miRNA for ZNF770 Gene

miRTarBase miRNAs that target ZNF770

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF770 Gene

Localization for ZNF770 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF770 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF770 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF770 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
genes like me logo Genes that share ontologies with ZNF770: view

Pathways & Interactions for ZNF770 Gene

SuperPathways for ZNF770 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF770: view

Pathways by source for ZNF770 Gene

2 Reactome pathways for ZNF770 Gene

Gene Ontology (GO) - Biological Process for ZNF770 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with ZNF770: view

No data available for SIGNOR curated interactions for ZNF770 Gene

Transcripts for ZNF770 Gene

mRNA/cDNA for ZNF770 Gene

Unigene Clusters for ZNF770 Gene

Zinc finger protein 770:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF770 Gene

No ASD Table

Relevant External Links for ZNF770 Gene

GeneLoc Exon Structure for
ZNF770
ECgene alternative splicing isoforms for
ZNF770

Expression for ZNF770 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF770 Gene

Protein differential expression in normal tissues from HIPED for ZNF770 Gene

This gene is overexpressed in Amniocyte (50.8) and Lung (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF770 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF770 Gene:

ZNF770

SOURCE GeneReport for Unigene cluster for ZNF770 Gene:

Hs.744990
genes like me logo Genes that share expression patterns with ZNF770: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF770 Gene

Orthologs for ZNF770 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF770 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF770 34 35
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia ZNF770 34 35
  • 88.77 (n)
cow
(Bos Taurus)
Mammalia ZNF770 34 35
  • 87.68 (n)
rat
(Rattus norvegicus)
Mammalia Zfp770 34
  • 83.14 (n)
mouse
(Mus musculus)
Mammalia Zfp770 34 16 35
  • 82.58 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF770 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF770 34 35
  • 65.81 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia znf770 34
  • 54.03 (n)
Str.12795 34
zebrafish
(Danio rerio)
Actinopterygii BX004873.1 35
  • 29 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta crol 35
  • 14 (a)
OneToMany
Species where no ortholog for ZNF770 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF770 Gene

ENSEMBL:
Gene Tree for ZNF770 (if available)
TreeFam:
Gene Tree for ZNF770 (if available)

Paralogs for ZNF770 Gene

Pseudogenes.org Pseudogenes for ZNF770 Gene

genes like me logo Genes that share paralogs with ZNF770: view

No data available for Paralogs for ZNF770 Gene

Variants for ZNF770 Gene

Sequence variations from dbSNP and Humsavar for ZNF770 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000546953 -- 34,989,947(+) AACCT(C/T)CCCCA intron-variant, upstream-variant-2KB
rs1000783648 -- 34,982,785(+) AACAT(C/T)GAAAA reference, missense
rs1001134146 -- 34,982,235(+) TTTCT(A/C)TTGCC reference, missense
rs1001618515 -- 34,987,278(+) ACTTA(A/C)TGGGA intron-variant, upstream-variant-2KB
rs1001833659 -- 34,987,048(+) TTTGG(A/T)ATAAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF770 Gene

Variant ID Type Subtype PubMed ID
esv2761865 CNV gain 21179565
esv3569431 CNV gain 25503493
nsv522411 CNV gain 19592680
nsv827295 CNV gain 20364138

Variation tolerance for ZNF770 Gene

Residual Variation Intolerance Score: 9.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.45; 28.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF770 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF770

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF770 Gene

Disorders for ZNF770 Gene

Relevant External Links for ZNF770

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF770

No disorders were found for ZNF770 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF770 Gene

Publications for ZNF770 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. A genome-wide association study (GWAS) for bronchopulmonary dysplasia. (PMID: 23897914) Wang H. … O'Brodovich H.M. (Pediatrics 2013) 3 64

Products for ZNF770 Gene

Sources for ZNF770 Gene

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