Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF77 Gene

Aliases for ZNF77 Gene

  • Zinc Finger Protein 77 2 3 5
  • ZNFpT1 3 4
  • Zinc Finger Protein 77 (PT1) 2
  • PT1 3

External Ids for ZNF77 Gene

Previous GeneCards Identifiers for ZNF77 Gene

  • GC19U990110
  • GC19M002873
  • GC19M002884
  • GC19M002847
  • GC19M002701
  • GC19M002897
  • GC19M002917

Summaries for ZNF77 Gene

GeneCards Summary for ZNF77 Gene

ZNF77 (Zinc Finger Protein 77) is a Protein Coding gene. Diseases associated with ZNF77 include Tuberculous Epididymitis and Bladder Diverticulum. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF699.

UniProtKB/Swiss-Prot for ZNF77 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF77 Gene

Genomics for ZNF77 Gene

Regulatory Elements for ZNF77 Gene

Enhancers for ZNF77 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F002160 1.6 FANTOM5 ENCODE 31.7 +777.5 777539 13.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 ZNF77 GADD45B DOT1L LOC100288123 SF3A2 ZNF554 ENSG00000267139 CIRBP ENSG00000267317 ADAT3
GH19F002773 1.4 FANTOM5 Ensembl ENCODE 28.3 +169.9 169906 2.9 ATF1 ARID4B RARA YY1 ZNF548 CREM THAP11 ZNF202 ZHX2 CEBPB CACTIN SF3A2 ZNF77 CACTIN-AS1 LOC100288123 APBA3 THOP1 GADD45B ENSG00000267139 ZNF555
GH19F003034 1.8 FANTOM5 Ensembl ENCODE 20.2 -90.6 -90551 3.6 HDGF PKNOX1 ARNT MLX WRNIP1 SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF77 CACTIN ZNF554 SF3A2 CACTIN-AS1 APBA3 DOHH THOP1 SGTA NCLN
GH19F003150 1.7 FANTOM5 Ensembl ENCODE 20.9 -208.1 -208110 6.0 HDGF PKNOX1 ARNT CREB3L1 SIN3A YBX1 ZNF766 FOS DEK ZNF263 CACTIN ZNF77 GNA15 FZR1 NCLN GNA11 AES C19orf35 S1PR4 GC19P003153
GH19F002474 1.5 FANTOM5 ENCODE 23.2 +467.8 467845 5.6 MLX YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 ZFP41 SSRP1 ZNF77 SF3A2 GADD45B ZNF555 LOC100288123 ENSG00000261526 ZNF554 DOT1L TIMM13 LOC101928631
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF77 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF77 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001417397 279 2000 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF143 FOS KLF13

Genomic Location for ZNF77 Gene

Chromosome:
19
Start:
2,933,218 bp from pter
End:
2,945,279 bp from pter
Size:
12,062 bases
Orientation:
Minus strand

Genomic View for ZNF77 Gene

Genes around ZNF77 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF77 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF77 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF77 Gene

Proteins for ZNF77 Gene

  • Protein details for ZNF77 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15935-ZNF77_HUMAN
    Recommended name:
    Zinc finger protein 77
    Protein Accession:
    Q15935
    Secondary Accessions:
    • Q86XJ3
    • Q9NPP0

    Protein attributes for ZNF77 Gene

    Size:
    545 amino acids
    Molecular mass:
    61964 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA46337.1; Type=Frameshift; Positions=98, 317; Evidence={ECO:0000305};

neXtProt entry for ZNF77 Gene

Post-translational modifications for ZNF77 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF77 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF77 Gene

Domains & Families for ZNF77 Gene

Gene Families for ZNF77 Gene

Protein Domains for ZNF77 Gene

Suggested Antigen Peptide Sequences for ZNF77 Gene

Graphical View of Domain Structure for InterPro Entry

Q15935

UniProtKB/Swiss-Prot:

ZNF77_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF77: view

Function for ZNF77 Gene

Molecular function for ZNF77 Gene

GENATLAS Biochemistry:
zinc finger protein 77
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF77 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF77: view
genes like me logo Genes that share phenotypes with ZNF77: view

Animal Model Products

miRNA for ZNF77 Gene

miRTarBase miRNAs that target ZNF77

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF77 Gene

Localization for ZNF77 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF77 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF77 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ZNF77 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF77: view

Pathways & Interactions for ZNF77 Gene

SuperPathways for ZNF77 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF77: view

Pathways by source for ZNF77 Gene

2 Reactome pathways for ZNF77 Gene

Gene Ontology (GO) - Biological Process for ZNF77 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZNF77: view

No data available for SIGNOR curated interactions for ZNF77 Gene

Transcripts for ZNF77 Gene

mRNA/cDNA for ZNF77 Gene

Unigene Clusters for ZNF77 Gene

Zinc finger protein 77:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF77 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4
SP1: -
SP2:

Relevant External Links for ZNF77 Gene

GeneLoc Exon Structure for
ZNF77
ECgene alternative splicing isoforms for
ZNF77

Expression for ZNF77 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF77 Gene

Protein differential expression in normal tissues from HIPED for ZNF77 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF77 Gene



Protein tissue co-expression partners for ZNF77 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF77 Gene:

ZNF77

SOURCE GeneReport for Unigene cluster for ZNF77 Gene:

Hs.38004
genes like me logo Genes that share expression patterns with ZNF77: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF77 Gene

Orthologs for ZNF77 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF77 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF77 34 35
  • 98.65 (n)
dog
(Canis familiaris)
Mammalia ZNF77 34 35
  • 73.52 (n)
cow
(Bos Taurus)
Mammalia ZNF77 35
  • 45 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 45 (a)
ManyToMany
-- 35
  • 42 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
-- 35
  • 39 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm4723 35
  • 45 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 42 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 38 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii CR388132.2 35
  • 36 (a)
ManyToMany
CT573234.2 35
  • 36 (a)
ManyToMany
Species where no ortholog for ZNF77 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF77 Gene

ENSEMBL:
Gene Tree for ZNF77 (if available)
TreeFam:
Gene Tree for ZNF77 (if available)

Paralogs for ZNF77 Gene

(459) SIMAP similar genes for ZNF77 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF77: view

Variants for ZNF77 Gene

Sequence variations from dbSNP and Humsavar for ZNF77 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10410034 -- 2,939,270(+) ATGAC(A/G)CCACC intron-variant, utr-variant-5-prime
rs10418565 -- 2,942,345(+) gatta(C/G)aggtg intron-variant
rs10423550 -- 2,934,521(+) TTCAC(A/G)TATGT reference, synonymous-codon
rs10423911 -- 2,946,872(+) AGGAG(A/G)ATCAC upstream-variant-2KB
rs10424873 -- 2,942,337(+) agtgc(G/T)aggat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF77 Gene

Variant ID Type Subtype PubMed ID
nsv1065985 CNV loss 25217958
esv3893157 CNV loss 25118596
esv3426491 CNV duplication 20981092
esv2717921 CNV deletion 23290073
esv2717920 CNV deletion 23290073
dgv1690n106 CNV deletion 24896259

Variation tolerance for ZNF77 Gene

Residual Variation Intolerance Score: 90.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.81; 58.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF77 Gene

Human Gene Mutation Database (HGMD)
ZNF77
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF77

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF77 Gene

Disorders for ZNF77 Gene

MalaCards: The human disease database

(6) MalaCards diseases for ZNF77 Gene - From: DISEASES

Disorder Aliases PubMed IDs
tuberculous epididymitis
  • tuberculosis of epididymis
bladder diverticulum
  • diverticulum - bladder
bone squamous cell carcinoma
non-invasive bladder papillary urothelial neoplasm
  • bladder papillary neoplasm of low malignant potential
acute interstitial pneumonia
  • idiopathic pulmonary fibrosis
- elite association - COSMIC cancer census association via MalaCards
Search ZNF77 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ZNF77

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF77
genes like me logo Genes that share disorders with ZNF77: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF77 Gene

Publications for ZNF77 Gene

  1. Chromosomal localization of four human zinc finger cDNAs. (PMID: 8478004) Huebner K. … Lania L. (Hum. Genet. 1993) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 64
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64

Products for ZNF77 Gene

Sources for ZNF77 Gene

Content
Loading form....