ZNF77 Gene
protein-coding GIFtS: 48
GCID: GC19M002933
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|
zinc finger protein 77(Previous name: zinc finger protein 77 (pT1) )
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Aliases
for ZNF77 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 771 2 | | PT11 | | ZNFpT12 3 | | Zinc Finger Protein 77 (PT1)1 |
Export aliases for ZNF77 gene to outside databasesPrevious GC identifers: GC19U990110 GC19M002873 GC19M002884 GC19M002847 GC19M002701 GC19M002897 |
Summaries
for ZNF77 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZNF77_HUMAN, Q15935Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF77 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF77 gene promoter:
p53 AP-1 HTF ATF-2 FOXD3 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF77
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF77 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3ZNF77 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M002933: view genomic region
(about GC identifiers)
Start:
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2,933,216 bp from pter |
End:
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2,944,969 bp from pter |
Size:
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11,754 bases |
Orientation:
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minus strand |
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Proteins
for ZNF77 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZNF77_HUMAN, Q15935 (See
protein sequence)Recommended Name: Zinc finger protein 77 Size: 545 amino acids; 61964 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=CAA46337.1; Type=Frameshift; Positions=98, 317;
Secondary accessions: Q86XJ3 Q9NPP0Explore the universe of human proteins at neXtProt for ZNF77: NX_Q15935
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15935
ZNF77 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_067040.1
ENSEMBL proteins: ENSP00000319053 Reactome Protein details: Q15935
Human Recombinant Protein Products for ZNF77:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
ZNF77 for ontologies About GeneDecksing
ZNF77 Antibody Products:
Assay Products for ZNF77: |
Protein
Domains /
Families
for ZNF77 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF77 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q15935ProtoNet protein and cluster: Q15935 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZNF77_HUMAN, Q15935Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 12 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF77 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ZNF77_HUMAN, Q15935Function: May be involved in transcriptional regulation Genatlas biochemistry entry for ZNF77:zinc finger protein 77
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF77 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF77
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF77
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Synthesis Service for ZNF77 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF77 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF77 |
|
Pathways & Interactions
for ZNF77 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF77
ZNF77 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF77
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for ZNF77 (ENSP000003190534) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0008150 | biological_process |
ND | -- |
ZNF77 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF77 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF77
Search CenterWatch for drugs/clinical trials and news about ZNF77
|
Transcripts
for ZNF77 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF77 gene: NM_021217.2 Unigene Cluster for ZNF77: Zinc finger protein 77 Hs.38004 [show with all ESTs]Unigene Representative Sequence: BC0433542 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000314531(uc002lws.4) ENST00000588050
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF77
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF77
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF77 (NM_015694) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF77 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF77 |
Additional cDNA sequence: AK290979.1 AL365370.1 BC043354.1 BC062561.1 X65230.1 2 DOTS entries: DT.412003 DT.101981291 24/30 AceView cDNA sequences (see all 30): BE218483 H61816 AA602630 X65230 AL365370 BQ421765 BC043354 AI015670 AW450750 BC062561 BQ894383 AI632748 AV725780 W74188 BU855158 AA477486 AV726497 NM_021217 W79226 AA026736 AA770163 BG990570 AA026624 AA477610
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF77 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 |
|---|
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| SP1: | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF77
|
Expression
for ZNF77 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF77 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTCAGCCTT
About this image
See ZNF77 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF77
SOURCE GeneReport for Unigene cluster: Hs.38004
SABiosciences Custom PCR Arrays for ZNF77
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF77
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF77 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF77 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF77 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF77 |
Orthologs
for ZNF77 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZNF77 gene from 2/9 species (see all 9) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG178296 |
-- |
13(a) |
1 → many |
X(519588-522052) |
worm
(Caenorhabditis elegans) |
Secernentea |
F39B2.16 |
-- |
15(a) |
1 → many |
I(14791027-14793977) |
ENSEMBL Gene Tree for ZNF77 (if available)
TreeFam Gene Tree for ZNF77 (if available) |
Paralogs
for ZNF77 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF77 gene
- ZNF6692 ZNF4902 ZNF5642 ZNF4412 ZNF8782 ENSG000002671792 ZNF142 ENSG000001968262
- ZNF7002 ZNF692 ZNF4402 ZNF4432 ZNF442 ZNF4392 ZNF8232 ZNF4912
- ENSG000001884742 ZNF5552 ZNF7092 ZNF6252 ZNF7992 ZNF202 ZNF1012 ZNF7912
- ZNF4422 ZNF4332 ZNF572 ZNF5632 ZNF6272 ENSG000002573552 ZNF1362 ZNF5562
- ZNF6702 ZNF7632 ZNF1242 ZNF6992 ZNF8442
18/462 SIMAP similar genes for ZNF77 using alignment to 2 protein entries: ZNF77_HUMAN (see all proteins)
(see all similar genes):MGC12518 HZF36 ZNF78L1 ZNF833P ZNF ZNF282
DKFZp666C237 HZF16 kr-znf3 Nbla00121 ZFS-4 ZSCAN23
zf30 DKFZp434J0650 DKFZp686N14223 DKFZp686O1631 ZNF397 ZNF3
ZNF77 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZNF77
PGOHUM00000250557
|
Genomic Variants
for ZNF77 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF77 (2933216 - 2944969 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF77: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF77 |
|
Disorders
/ Diseases
for ZNF77 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF77 for disorders About GeneDecksing
OMIM gene information: 194551
OMIM disorders: --
7  diseases for ZNF77: About MalaCardstuberculous epididymitis bladder diverticulum hemorrhagic thrombocythemia urinary bladder cancer
gastroenteritis epididymitis thrombocytosis
3 diseases from the University of Copenhagen DISEASES database for ZNF77:Tuberculous epididymitis Thrombocytosis Bladder diverticulum Export disorders for ZNF77 gene to outside databases
|
Publications
for ZNF77 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF77 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF77) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Chromosomal localization of four human zinc finger cDNAs. (PubMed id 8478004)1, 2, 3 Huebner K....Lania L. (1993)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZNF77 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF77 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF77 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF77 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF77 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF77 gene:
Search GeneIP for patents involving ZNF77
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF77 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF77 |
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