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ZNF768 Gene

protein-coding   GIFtS: 46
GCID: GC16M030535

Zinc Finger Protein 768

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 7681 2

External Ids:    HGNC: 262731   Entrez Gene: 797242   Ensembl: ENSG000001699577   UniProtKB: Q9H5H43   

Export aliases for ZNF768 gene to outside databases

Previous GC identifers: GC16M030443 GC16M030444 GC16M028098


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF768 Gene:
ZNF768 (zinc finger protein 768) is a protein-coding gene. An important paralog of this gene is PLAGL1.

UniProtKB/Swiss-Prot: ZN768_HUMAN, Q9H5H4
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_187260.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF768 gene promoter:
         NF-1   AML1a   p53   Olf-1   Nkx2-5   c-Ets-1   CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF768 promoter sequence
   Search Chromatin IP Primers for ZNF768

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF768


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

ZNF768 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF768 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M030535:  view genomic region     (about GC identifiers)

Start:
30,535,322 bp from pter      End:
30,538,142 bp from pter
Size:
2,821 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN768_HUMAN, Q9H5H4 (See protein sequence)
Recommended Name: Zinc finger protein 768  
Size: 540 amino acids; 60229 Da
Sequence caution: Sequence=AAH13760.1; Type=Erroneous initiation; Sequence=AAH92403.2; Type=Erroneous initiation;
Sequence=BAB15652.1; Type=Erroneous initiation;
Secondary accessions: Q569L7 Q96CX4

Explore the universe of human proteins at neXtProt for ZNF768: NX_Q9H5H4

Explore proteomics data for ZNF768 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF768 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_078947.3  
    ENSEMBL proteins: 
     ENSP00000369777   ENSP00000456527  

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    antibodies-online antibodies for ZNF768 (19 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR000684 RNA_pol_II_repeat_euk
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9H5H4

    ProtoNet protein and cluster: Q9H5H4

    UniProtKB/Swiss-Prot: ZN768_HUMAN, Q9H5H4
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 10 C2H2-type zinc fingers


    Find genes that share domains with ZNF768           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN768_HUMAN, Q9H5H4
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0044822poly(A) RNA binding IDA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF768           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF768

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    hsa-miR-4293 hsa-miR-888
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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN768_HUMAN, Q9H5H4: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytoskeleton1
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005665DNA-directed RNA polymerase II, core complex IEA--

    Find genes that share ontologies with ZNF768           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF768
    Interactions:

        Search GeneGlobe Interaction Network for ZNF768

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for ZNF768 (Q9H5H42, 3 ENSP000003697774) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HMP19Q9Y3282, 3MINT-8258467 I2D: score=2 
    TNNT1P138052, 3MINT-8275160 I2D: score=2 
    NDUFA12Q9UI092, 3, ENSP000003307374MINT-8263577 I2D: score=2 STRING: ENSP00000330737
    UVRAGQ9P2Y53, ENSP000003484554I2D: score=1 STRING: ENSP00000348455
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006366transcription from RNA polymerase II promoter IEA--

    Find genes that share ontologies with ZNF768           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF768 (ZN768)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF768 gene: 
    NM_024671.3  

    Unigene Cluster for ZNF768:

    Zinc finger protein 768
    Hs.85658  [show with all ESTs]
    Unigene Representative Sequence: NM_024671
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380412(uc002dyk.4 uc010vew.2 uc010vex.2) ENST00000562803

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate ZNF768:
    hsa-miR-4293 hsa-miR-888
    SwitchGear 3'UTR luciferase reporter plasmidZNF768 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF768
      QuantiFast Probe-based Assays in human, mouse, rat ZNF768

    Additional mRNA sequence: 

    AK027089.1 AK295274.1 AK315449.1 BC013760.1 BC092403.1 

    5 DOTS entries:

    DT.208394  DT.100776957  DT.91912141  DT.95292985  DT.100772561 

    Selected AceView cDNA sequences (see all 108):

    BG820398 AW072931 BF001175 AW662201 BQ060707 CF131957 BC013760 AI352633 
    BQ643450 AI690711 AK027089 BU195383 BQ215492 CR615704 BQ004665 BQ049238 
    BU558332 BQ635980 CB153639 AI287775 BE207197 BU507691 BM805112 AI972482 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF768 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTGGAGAC
    ZNF768 Expression
    About this image

    ZNF768 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF768 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.85658
        Custom PCR Arrays for ZNF768
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZNF768 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp7681 , 5 zinc finger protein 7681, 5 87.96(n)1
    91.25(a)1
      7 (69.47 cM)5
    2338901  NM_146202.11  NP_666314.11 
     1273427975 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX754742.12   -- 79.66(n)    BX754742.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ZNF7686
    zinc finger protein 768
    14(a)
    1 ↔ 1
    24(24778862-24785589) ENSDARG00000087483
    fruit fly
    (Drosophila melanogaster)
    Insecta CG21166
    --
    15(a)
    1 ↔ 1
    X(8023773-8025816)


    ENSEMBL Gene Tree for ZNF768 (if available)
    TreeFam Gene Tree for ZNF768 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF768 gene
    PLAGL12  PLAGL22  PLAG12  
    Selected SIMAP similar genes for ZNF768 using alignment to 2 protein entries:     ZN768_HUMAN (see all proteins) (see all similar genes):
    ZNF818P    ZNF78L1    ZNF132    ZNF22    ZFS-4    ZNF436
    ZNF154    ZNF204    ZNF211    ZNF418    ZSCAN16    DKFZp547L155
    ZFP2    ZFP41    ZNF135    ZNF16    ZNF167    ZNF180

    Find genes that share paralogs with ZNF768           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF768 (see all 117)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1467441201,2
    --30535007(+) CGGGCA/GCCTGT 1 -- int10--------
    rs1876494121,2
    --30535069(+) GCAGAA/GGTTGC 1 -- int10--------
    rs1403640251,2
    C--30535129(+) ACTCCA/GTCTCA 1 -- int10--------
    rs1897061921,2
    --30535270(+) TACTGG/TTGTCT 1 -- int10--------
    rs746506111,2
    F--30535305(+) GCACAC/TATTTT 1 -- int11Minor allele frequency- T:0.01WA 118
    rs1822925911,2
    --30535617(+) CTCTCC/TCCATT 1 -- ut310--------
    rs37518481,2,,4
    C,F,H--30535999(-) GGTGCG/TCCGTG 2 A S mis1 ese39Minor allele frequency- T:0.01EA NS NA 2258
    rs2003196521,2
    --30536012(+) TAGGGC/GCGCTC 2 R syn10--------
    rs1386671051,2
    C--30536061(+) AGCGAT/CTGAAG 2 /N /S mis11Minor allele frequency- C:0.00NA 4244
    rs1454510151,2
    C,F--30536513(+) TTGTAG/AGGCCG 2 /P syn11Minor allele frequency- A:0.01NA 4546

    HapMap Linkage Disequilibrium report for ZNF768 (30535322 - 30538142 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZNF768:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1784CNV Insertion18451855
    nsv905726CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF768 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with ZNF768)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    2. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    3. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    4. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    5. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    7. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (Cell 2010)
    10. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79724 HGNC: 26273 AceView: FLJ23436 Ensembl:ENSG00000169957 euGenes: HUgn79724
    ECgene: ZNF768 H-InvDB: ZNF768

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF768 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF768 gene:
    Search GeneIP for patents involving ZNF768

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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