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Aliases for ZNF768 Gene

Aliases for ZNF768 Gene

  • Zinc Finger Protein 768 2 3

External Ids for ZNF768 Gene

Previous GeneCards Identifiers for ZNF768 Gene

  • GC16M030443
  • GC16M030444
  • GC16M030535
  • GC16M028098

Summaries for ZNF768 Gene

GeneCards Summary for ZNF768 Gene

ZNF768 (Zinc Finger Protein 768) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is PLAGL1.

UniProtKB/Swiss-Prot for ZNF768 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF768 Gene

Genomics for ZNF768 Gene

Regulatory Elements for ZNF768 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF768 Gene

Chromosome:
16
Start:
30,524,001 bp from pter
End:
30,526,821 bp from pter
Size:
2,821 bases
Orientation:
Minus strand

Genomic View for ZNF768 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF768 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF768 Gene

Proteins for ZNF768 Gene

  • Protein details for ZNF768 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H5H4-ZN768_HUMAN
    Recommended name:
    Zinc finger protein 768
    Protein Accession:
    Q9H5H4
    Secondary Accessions:
    • Q569L7
    • Q96CX4

    Protein attributes for ZNF768 Gene

    Size:
    540 amino acids
    Molecular mass:
    60229 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH13760.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH92403.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15652.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF768 Gene

Proteomics data for ZNF768 Gene at MOPED

Post-translational modifications for ZNF768 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF768 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF768 Gene

Domains & Families for ZNF768 Gene

Gene Families for ZNF768 Gene

Protein Domains for ZNF768 Gene

Suggested Antigen Peptide Sequences for ZNF768 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H5H4

UniProtKB/Swiss-Prot:

ZN768_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 10 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 10 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF768: view

Function for ZNF768 Gene

Molecular function for ZNF768 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF768 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF768: view

Phenotypes for ZNF768 Gene

GenomeRNAi human phenotypes for ZNF768:
genes like me logo Genes that share phenotypes with ZNF768: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF768

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF768 Gene

Localization for ZNF768 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF768 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF768 Gene COMPARTMENTS Subcellular localization image for ZNF768 gene
Compartment Confidence
cytoskeleton 2
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for ZNF768 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005665 DNA-directed RNA polymerase II, core complex IEA --
genes like me logo Genes that share ontologies with ZNF768: view

Pathways & Interactions for ZNF768 Gene

SuperPathways for ZNF768 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF768 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with ZNF768: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF768 Gene

Drugs & Compounds for ZNF768 Gene

No Compound Related Data Available

Transcripts for ZNF768 Gene

mRNA/cDNA for ZNF768 Gene

Unigene Clusters for ZNF768 Gene

Zinc finger protein 768:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF768

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF768 Gene

No ASD Table

Relevant External Links for ZNF768 Gene

GeneLoc Exon Structure for
ZNF768
ECgene alternative splicing isoforms for
ZNF768

Expression for ZNF768 Gene

mRNA expression in normal human tissues for ZNF768 Gene

Protein differential expression in normal tissues from HIPED for ZNF768 Gene

This gene is overexpressed in Lung (38.6) and Liver (28.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF768 Gene



SOURCE GeneReport for Unigene cluster for ZNF768 Gene Hs.85658

genes like me logo Genes that share expression patterns with ZNF768: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF768 Gene

Orthologs for ZNF768 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF768 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF768 36
  • 100 (a)
OneToOne
LOC100615883 35
  • 98.89 (n)
  • 98.33 (a)
mouse
(Mus musculus)
Mammalia Zfp768 36
  • 86 (a)
OneToOne
Zfp768 16
Zfp768 35
  • 87.96 (n)
  • 91.25 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNF768 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF768 36
  • 94 (a)
OneToOne
ZNF768 35
  • 91.73 (n)
  • 94.26 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 93 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
ZNF768 35
  • 91.05 (n)
  • 93.52 (a)
rat
(Rattus norvegicus)
Mammalia LOC102553763 35
  • 88.56 (n)
  • 92.58 (a)
zebrafish
(Danio rerio)
Actinopterygii ZNF768 36
  • 14 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG2116 36
  • 15 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MET32 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10667 36
  • 10 (a)
OneToOne
Species with no ortholog for ZNF768:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF768 Gene

ENSEMBL:
Gene Tree for ZNF768 (if available)
TreeFam:
Gene Tree for ZNF768 (if available)

Paralogs for ZNF768 Gene

Paralogs for ZNF768 Gene

(508) SIMAP similar genes for ZNF768 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF768: view

Variants for ZNF768 Gene

Sequence variations from dbSNP and Humsavar for ZNF768 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1051417 -- 30,524,063(-) TCCCT(C/T)TTCTT utr-variant-3-prime
rs1051418 -- 30,524,060(-) CTCTT(C/T)TTCCT utr-variant-3-prime
rs3751847 -- 30,525,351(-) ATCTG(C/T)GGCAT synonymous-codon, reference
rs3751848 - 30,524,678(-) GGTGC(G/T)CCGTG reference, missense
rs3794703 -- 30,526,938(-) TCCTC(A/G)CCCAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF768 Gene

Variant ID Type Subtype PubMed ID
nsv905726 CNV Loss 21882294
nsv1784 CNV Insertion 18451855

Variation tolerance for ZNF768 Gene

Residual Variation Intolerance Score: 16.47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.09; 84.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF768 Gene

HapMap Linkage Disequilibrium report
ZNF768

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF768 Gene

Disorders for ZNF768 Gene

Relevant External Links for ZNF768

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF768
genes like me logo Genes that share disorders with ZNF768: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF768 Gene

Publications for ZNF768 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 67
  4. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 67
  5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. (PMID: 22681889) Baltz A.G. … Landthaler M. (Mol. Cell 2012) 67

Products for ZNF768 Gene

Sources for ZNF768 Gene

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