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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF768 Gene

protein-coding   GIFtS: 46
GCID: GC16M030535

Zinc Finger Protein 768

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 7681 2

External Ids:    HGNC: 262731   Entrez Gene: 797242   Ensembl: ENSG000001699577   UniProtKB: Q9H5H43   

Export aliases for ZNF768 gene to outside databases

Previous GC identifers: GC16M030443 GC16M030444 GC16M028098


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF768 Gene: 
ZNF768 (zinc finger protein 768) is a protein-coding gene. Diseases associated with ZNF768 include retinitis. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is PLAGL1.

UniProtKB/Swiss-Prot: ZN768_HUMAN, Q9H5H4
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF768 gene promoter:
         NF-1   AML1a   p53   Olf-1   Nkx2-5   c-Ets-1   CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF768 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF768

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF768


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

ZNF768 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF768 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M030535:  view genomic region     (about GC identifiers)

Start:
30,535,322 bp from pter      End:
30,538,142 bp from pter
Size:
2,821 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN768_HUMAN, Q9H5H4 (See protein sequence)
Recommended Name: Zinc finger protein 768  
Size: 540 amino acids; 60229 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAH13760.1; Type=Erroneous initiation; Sequence=AAH92403.2; Type=Erroneous initiation;
Sequence=BAB15652.1; Type=Erroneous initiation;
Secondary accessions: Q569L7 Q96CX4

Explore the universe of human proteins at neXtProt for ZNF768: NX_Q9H5H4

Explore proteomics data for ZNF768 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H5H4

  • ZNF768 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF768 Protein Expression
    REFSEQ proteins: NP_078947.3  
    ENSEMBL proteins: 
     ENSP00000369777   ENSP00000456527  

    Human Recombinant Protein Products for ZNF768: 
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF768 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005665DNA-directed RNA polymerase II, core complex IEA--

    ZNF768 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR000684 RNA_pol_II_repeat_euk
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9H5H4

    ProtoNet protein and cluster: Q9H5H4

    UniProtKB/Swiss-Prot: ZN768_HUMAN, Q9H5H4
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 10 C2H2-type zinc fingers


    ZNF768 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN768_HUMAN, Q9H5H4
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF768 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF768 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF768 
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    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF768:
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    SwitchGear 3'UTR luciferase reporter plasmidZNF768 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF768


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF768

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/25 Interacting proteins for ZNF768 (Q9H5H42, 3 ENSP000003697774) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HMP19Q9Y3282, 3MINT-8258467 I2D: score=2 
    TNNT1P138052, 3MINT-8275160 I2D: score=2 
    NDUFA12Q9UI092, 3, ENSP000003307374MINT-8263577 I2D: score=2 STRING: ENSP00000330737
    UVRAGQ9P2Y53, ENSP000003484554I2D: score=1 STRING: ENSP00000348455
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006366transcription from RNA polymerase II promoter IEA--

    ZNF768 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF768 (ZN768)

    Search CenterWatch for drugs/clinical trials and news about ZNF768 / ZN768

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF768 gene: 
    NM_024671.3  

    Unigene Cluster for ZNF768:

    Zinc finger protein 768
    Hs.85658  [show with all ESTs]
    Unigene Representative Sequence: NM_024671
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380412(uc002dyk.4 uc010vew.2 uc010vex.2) ENST00000562803

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZNF768
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF768:
    hsa-miR-4293 hsa-miR-888
    SwitchGear 3'UTR luciferase reporter plasmidZNF768 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZNF768
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF768
    Clone
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    Sirion Biotech Customized lentivirus for stable overexpression of ZNF768 
                         Customized lentivirus expression plasmids for stable overexpression of ZNF768 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ZNF768
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF768
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF768

    Additional mRNA sequence: 

    AK027089.1 AK295274.1 AK315449.1 BC013760.1 BC092403.1 

    5 DOTS entries:

    DT.208394  DT.100776957  DT.91912141  DT.95292985  DT.100772561 

    24/108 AceView cDNA sequences (see all 108):

    AI690711 AK027089 AW662201 CB153639 BQ635980 BQ215492 AW072931 BF001175 
    BE207197 NM_024671 BG820398 AI005358 BQ004665 BU507691 CR615704 BU195383 
    AI352633 BM805112 CF131957 BQ049238 BF447099 BQ643450 BC013760 BQ060707 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF768 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTGGAGAC
    ZNF768 Expression
    About this image


    See ZNF768 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF768

    SOURCE GeneReport for Unigene cluster: Hs.85658
        SABiosciences Custom PCR Arrays for ZNF768
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF768

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZNF768 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp7681 , 5 zinc finger protein 7681, 5 87.9(n)1
    91.25(a)1
      7 (69.47 cM)5
    2338901  NM_146202.11  NP_666314.11 
     1273427975 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    26(a)
    possible ortholog
    GL344516.1(3581-57538)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX754742.12   -- 79.66(n)    BX754742.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkeyp-53d3.36
    si:dkeyp-53d3.3
    36(a)
    possible ortholog
    22(2605686-2617104)
    fruit fly
    (Drosophila melanogaster)
    Insecta Meics6
    Meiotic central spindle
    20(a)
    1 → many
    3L(13955758-13957802)


    ENSEMBL Gene Tree for ZNF768 (if available)
    TreeFam Gene Tree for ZNF768 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF768 gene
    PLAGL12  PLAGL22  PLAG12  
    18/508 SIMAP similar genes for ZNF768 using alignment to 2 protein entries:     ZN768_HUMAN (see all proteins) (see all similar genes):
    ZNF818P    ZNF78L1    ZNF132    ZNF22    ZFS-4    ZNF154
    ZNF204    ZNF211    ZNF418    ZSCAN16    DKFZp547L155    ZFP2
    ZFP41    ZNF135    ZNF16    ZNF167    ZNF180    ZNF271

    ZNF768 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/117 SNPs in ZNF768 are shown (see all 117)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1467441201,2
    --30535007(+) CGGGCA/GCCTGT 1 -- int10--------
    rs1876494121,2
    --30535069(+) GCAGAA/GGTTGC 1 -- int10--------
    rs1403640251,2
    C--30535129(+) ACTCCA/GTCTCA 1 -- int10--------
    rs1897061921,2
    --30535270(+) TACTGG/TTGTCT 1 -- int10--------
    rs746506111,2
    F--30535305(+) GCACAC/TATTTT 1 -- int11Minor allele frequency- T:0.01WA 118
    rs1822925911,2
    --30535617(+) CTCTCC/TCCATT 1 -- ut310--------
    rs37518481,2,4
    C,F,H--30535999(-) GGTGCG/TCCGTG 2 A S mis1 ese39Minor allele frequency- T:0.01EA NS NA 2258
    rs2003196521,2
    --30536012(+) TAGGGC/GCGCTC 2 R syn10--------
    rs1386671051,2
    C--30536061(+) AGCGAT/CTGAAG 2 /N /S mis11Minor allele frequency- C:0.00NA 4244
    rs1454510151,2
    C,F--30536513(+) TTGTAG/AGGCCG 2 /P syn11Minor allele frequency- A:0.01NA 4546

    HapMap Linkage Disequilibrium report for ZNF768 (30535322 - 30538142 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZNF768:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv1784CNV Insertion18451855
    nsv905726CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF768
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for ZNF768:    About MalaCards
    retinitis    


    ZNF768 for disorders           About GeneDecksing


    Export disorders for ZNF768 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF768 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with ZNF768)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    2. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    3. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    4. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    5. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
    10. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79724 HGNC: 26273 AceView: FLJ23436 Ensembl:ENSG00000169957 euGenes: HUgn79724
    ECgene: ZNF768 H-InvDB: ZNF768

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF768 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF768 gene:
    Search GeneIP for patents involving ZNF768

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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