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Aliases for ZNF768 Gene

Aliases for ZNF768 Gene

  • Zinc Finger Protein 768 2 3 5

External Ids for ZNF768 Gene

Previous GeneCards Identifiers for ZNF768 Gene

  • GC16M030443
  • GC16M030444
  • GC16M030535
  • GC16M028098

Summaries for ZNF768 Gene

GeneCards Summary for ZNF768 Gene

ZNF768 (Zinc Finger Protein 768) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is ZNF358.

UniProtKB/Swiss-Prot for ZNF768 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF768 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF768 Gene

Genomics for ZNF768 Gene

Regulatory Elements for ZNF768 Gene

Enhancers for ZNF768 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H030566 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -43.1 -43054 6 ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 SP3 NFYC ZC3H11A SETD1A SRCAP ENSG00000260267 ZNF747 NPIPB13 INO80E ZNF764 C16orf58 SMG1P5 SMG1P2
GH16H031125 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -604.3 -604318 10.7 HDGF ARNT SIN3A ZNF766 ZNF207 ZNF548 SP3 MCM3 ZNF592 SREBF1 SRCAP SETD1A ENSG00000260267 SMG1P5 ZNF764 ENSG00000260304 KAT8 BCL7C TGFB1I1 ITGAX
GH16H030547 1.5 Ensembl ENCODE dbSUPER 11.1 -22.2 -22152 2.4 PKNOX1 ATF1 ARNT FEZF1 GLI4 ZNF2 TCF12 FOS ATF7 NCOA1 ZNF689 ZNF764 SETD1A ENSG00000239791 ZNF688 ZNF785 DCTPP1 ENSG00000222701 ITGAL SEPHS2
GH16H030555 1.4 ENCODE dbSUPER 11 -31.3 -31251 4.2 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC ZNF585B GLIS1 SETD1A SRCAP ZNF764 INO80E ENSG00000260267 SMG1P5 SMG1P2 RNF40 NPIPB13 ENSG00000260304
GH16H030994 1.5 FANTOM5 Ensembl ENCODE 10 -467.8 -467801 0.4 HDGF PTBP1 INSM2 ZNF76 KLF17 ZBTB40 BATF ZBTB7B ZSCAN5C FOS KAT8 SETD1A ENSG00000260267 BCL7C ENSG00000260304 SMG1P5 SRCAP ZNF747 ZNF768 ITGAX
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF768 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF768 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000085207 21 1601 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF207 ZNF143

Genomic Locations for ZNF768 Gene

Genomic Locations for ZNF768 Gene
chr16:30,524,001-30,526,821
(GRCh38/hg38)
Size:
2,821 bases
Orientation:
Minus strand
chr16:30,535,322-30,538,142
(GRCh37/hg19)

Genomic View for ZNF768 Gene

Genes around ZNF768 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF768 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF768 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF768 Gene

Proteins for ZNF768 Gene

  • Protein details for ZNF768 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H5H4-ZN768_HUMAN
    Recommended name:
    Zinc finger protein 768
    Protein Accession:
    Q9H5H4
    Secondary Accessions:
    • Q569L7
    • Q96CX4

    Protein attributes for ZNF768 Gene

    Size:
    540 amino acids
    Molecular mass:
    60229 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH13760.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH92403.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15652.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF768 Gene

Post-translational modifications for ZNF768 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF768 Gene

No data available for DME Specific Peptides for ZNF768 Gene

Domains & Families for ZNF768 Gene

Gene Families for ZNF768 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF768 Gene

Suggested Antigen Peptide Sequences for ZNF768 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H5H4

UniProtKB/Swiss-Prot:

ZN768_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF768: view

Function for ZNF768 Gene

Molecular function for ZNF768 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF768 Gene

Gene Ontology (GO) - Molecular Function for ZNF768 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IDA 22681889
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF768: view

Phenotypes for ZNF768 Gene

GenomeRNAi human phenotypes for ZNF768:
genes like me logo Genes that share phenotypes with ZNF768: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF768 Gene

Localization for ZNF768 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF768 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF768 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF768 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005665 DNA-directed RNA polymerase II, core complex IEA --
genes like me logo Genes that share ontologies with ZNF768: view

Pathways & Interactions for ZNF768 Gene

SuperPathways for ZNF768 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF768 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with ZNF768: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF768 Gene

Drugs & Compounds for ZNF768 Gene

No Compound Related Data Available

Transcripts for ZNF768 Gene

mRNA/cDNA for ZNF768 Gene

Unigene Clusters for ZNF768 Gene

Zinc finger protein 768:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF768 Gene

No ASD Table

Relevant External Links for ZNF768 Gene

GeneLoc Exon Structure for
ZNF768
ECgene alternative splicing isoforms for
ZNF768

Expression for ZNF768 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF768 Gene

Protein differential expression in normal tissues from HIPED for ZNF768 Gene

This gene is overexpressed in Lung (38.6) and Liver (28.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF768 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF768 Gene:

ZNF768

SOURCE GeneReport for Unigene cluster for ZNF768 Gene:

Hs.85658

Evidence on tissue expression from TISSUES for ZNF768 Gene

  • Nervous system(4.2)
  • Muscle(2.3)
genes like me logo Genes that share expression patterns with ZNF768: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF768 Gene

Orthologs for ZNF768 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF768 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF768 34
  • 100 (a)
OneToOne
LOC100615883 33
  • 98.89 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 94 (a)
OneToMany
-- 34
  • 93 (a)
OneToMany
ZNF768 33
  • 91.05 (n)
dog
(Canis familiaris)
Mammalia ZNF768 33 34
  • 91.73 (n)
rat
(Rattus norvegicus)
Mammalia LOC102553763 33
  • 88.56 (n)
mouse
(Mus musculus)
Mammalia Zfp768 33 16 34
  • 87.96 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF768 34
  • 80 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ZNF768 34
  • 14 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG2116 34
  • 15 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MET32 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10667 34
  • 10 (a)
OneToOne
Species where no ortholog for ZNF768 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF768 Gene

ENSEMBL:
Gene Tree for ZNF768 (if available)
TreeFam:
Gene Tree for ZNF768 (if available)

Paralogs for ZNF768 Gene

Paralogs for ZNF768 Gene

(508) SIMAP similar genes for ZNF768 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF768: view

Variants for ZNF768 Gene

Sequence variations from dbSNP and Humsavar for ZNF768 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000200368 -- 30,525,419(+) AAGGG(C/T)TCCTG reference, missense
rs1000220204 -- 30,527,561(+) CCTGT(A/C)GGCCA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000720862 -- 30,527,392(+) CCAGA(C/G)GCACA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000868120 -- 30,530,020(+) GAGAC(A/G)GGGTT intron-variant
rs1000978717 -- 30,530,482(+) TGAGG(A/G)TTAGG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF768 Gene

Variant ID Type Subtype PubMed ID
nsv1784 CNV insertion 18451855
nsv1136213 CNV deletion 24896259

Variation tolerance for ZNF768 Gene

Residual Variation Intolerance Score: 16.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.09; 84.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF768 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF768

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF768 Gene

Disorders for ZNF768 Gene

Relevant External Links for ZNF768

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF768

No disorders were found for ZNF768 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF768 Gene

Publications for ZNF768 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert JP … Gingras AC (Journal of proteomics 2015) 3 60
  4. Diagnostic potential of zinc finger protein-specific autoantibodies and associated linear B-cell epitopes in colorectal cancer. (PMID: 25875936) O'Reilly JA … Kijanka GS (PloS one 2015) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for ZNF768 Gene

Sources for ZNF768 Gene

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