ZNF768 Gene
protein-coding GIFtS: 44
GCID: GC16M030535
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|
zinc finger protein 768
| |
Aliases
for ZNF768 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 7681 2 | | FLJ234361 |
Export aliases for ZNF768 gene to outside databasesPrevious GC identifers: GC16M030443 GC16M030444 GC16M028098 |
Summaries
for ZNF768 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN768_HUMAN, Q9H5H4Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF768 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF768 gene promoter:
NF-1 AML1a p53 Olf-1 Nkx2-5 c-Ets-1 CREB deltaCREB
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF768
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF768 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11.2ZNF768 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M030535: view genomic region
(about GC identifiers)
Start:
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30,535,322 bp from pter |
End:
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30,538,142 bp from pter |
Size:
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2,821 bases |
Orientation:
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minus strand |
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Proteins
for ZNF768 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN768_HUMAN, Q9H5H4 (See
protein sequence)Recommended Name: Zinc finger protein 768 Size: 540 amino acids; 60229 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAH13760.1; Type=Erroneous initiation; Sequence=AAH92403.2; Type=Erroneous initiation;Sequence=BAB15652.1; Type=Erroneous initiation;
Secondary accessions: Q569L7 Q96CX4Explore the universe of human proteins at neXtProt for ZNF768: NX_Q9H5H4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H5H4
ZNF768 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_078947.3
ENSEMBL proteins: ENSP00000369777 ENSP00000456527
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005665 | DNA-directed RNA polymerase II, core complex |
IEA | -- |
ZNF768 for ontologies About GeneDecksing
ZNF768 Antibody Products:
Assay Products for ZNF768: |
Protein
Domains /
Families
for ZNF768 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF768 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H5H4ProtoNet protein and cluster: Q9H5H4 UniProtKB/Swiss-Prot: ZN768_HUMAN, Q9H5H4Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 10 C2H2-type zinc fingers |
Function
for ZNF768 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN768_HUMAN, Q9H5H4Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF768 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF768 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for ZNF768 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF768 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF768 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZNF768 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF768 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF768
STRING Interaction
Network Preview (showing 5 interactants - click image to see 18)
5/25 Interacting proteins for ZNF768 (Q9H5H42, 3 ENSP000003697774) via UniProtKB, MINT, STRING, and/or I2D (see all 25)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0006366 | transcription from RNA polymerase II promoter |
IEA | -- |
ZNF768 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF768 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF768
Search CenterWatch for drugs/clinical trials and news about ZNF768 / ZN768
|
Transcripts
for ZNF768 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF768 gene: NM_024671.3 Unigene Cluster for ZNF768: Zinc finger protein 768 Hs.85658 [show with all ESTs]Unigene Representative Sequence: NM_0246712 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000380412(uc002dyk.4 uc010vew.2 uc010vex.2) ENST00000562803
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF768 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF768 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF768 (NM_024671) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF768 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF768 |
Additional cDNA sequence: AK027089.1 AK295274.1 AK315449.1 BC013760.1 BC092403.1 5 DOTS entries: DT.208394 DT.100776957 DT.91912141 DT.95292985 DT.100772561 24/108 AceView cDNA sequences (see all 108): BQ049238 BQ643450 AW072931 NM_024671 BC013760 BG820398 BF001175 AI352633 CB153639 BU195383 AI005358 AI690711 AW662201 BM805112 BU507691 BQ004665 BQ060707 AI972482 CR615704 BE873067 AI287775 BE207197 BF447099 AK027089
GeneLoc Exon Structure
|
Expression
for ZNF768 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF768 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCTGGAGAC
About this image
See ZNF768 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF768
SOURCE GeneReport for Unigene cluster: Hs.85658
SABiosciences Custom PCR Arrays for ZNF768
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF768
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF768 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF768 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF768 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF768 |
Orthologs
for ZNF768 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF768 gene from 3/11 species (see all 11) About this table
ENSEMBL Gene Tree for ZNF768 (if available)
TreeFam Gene Tree for ZNF768 (if available) |
Paralogs
for ZNF768 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF768 gene
- ZNF5812 ZNF7872 ZNF3582 ZNF5752 ZNF5242 ZNF5802 ZNF702
18/502 SIMAP similar genes for ZNF768 using alignment to 2 protein entries: ZN768_HUMAN (see all proteins)
(see all similar genes):ZNF818P ZNF78L1 ZNF132 ZNF22 ZFS-4 ZNF154
ZNF204 ZNF211 ZNF418 ZNF551 ZSCAN16 DKFZp547L155
ZFP2 ZFP41 ZKSCAN7 ZNF135 ZNF16 ZNF167
ZNF768 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF768 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF768 (30535322 - 30538142 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF768: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF768 |
|
Disorders
/ Diseases
for ZNF768 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF768 for disorders About GeneDecksing
1  disease for ZNF768: About MalaCardsretinitis
Export disorders for ZNF768 gene to outside databases
|
Publications
for ZNF768 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF768 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with ZNF768) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
- Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (2008)
|
External Searches for ZNF768 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF768 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF768 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF768 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF768 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF768 gene:
Search GeneIP for patents involving ZNF768
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF768 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF768 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF768 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF768 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF768 | | OriGene 3'-UTR Clone for ZNF768 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF768 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF768 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF768 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF768 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF768 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF768 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF768 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF768 |
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| | | | Search Tocris compounds for ZNF768 |
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 | | | ZNF768 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF768 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF768 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF768 |
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