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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF765 Gene

protein-coding   GIFtS: 38
GCID: GC19P053898

zinc finger protein 765
  Search for ZNF765
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ZNF765    

Aliases
for ZNF765 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Zinc Finger Protein 7651 2

External Ids:    HGNC: 250921   Entrez Gene: 916612   Ensembl: ENSG000001964177   UniProtKB: Q7L2R63   

Export aliases for ZNF765 gene to outside databases

Previous GC identifers: GC19P058591 GC19P050219


Summaries
for ZNF765 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: ZN765_HUMAN, Q7L2R6
Function: May be involved in transcriptional regulation (By similarity)




Genomic Views
for ZNF765 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF765 gene promoter:
         AREB6   IRF-1   Ik-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ZNF765

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF765


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.41

ZNF765 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF765 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P053898:  view genomic region     (about GC identifiers)

Start:
 53,893,046 bp from pter      End:
 53,930,574 bp from pter
Size:
 37,529 bases      Orientation:
 plus strand

Proteins
for ZNF765 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ZN765_HUMAN, Q7L2R6 (See protein sequence)
Recommended Name: Zinc finger protein 765  
Size: 523 amino acids; 61633 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: A8MYG0 B4DF18 B7ZAI5 B9EIL1 Q9BV49
Alternative splicing: 2 isoforms:  Q7L2R6-1   Q7L2R6-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for ZNF765: NX_Q7L2R6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q7L2R6

    • ZNF765 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001035275.1  
    ENSEMBL proteins: 
     ENSP00000424395   ENSP00000340432   ENSP00000379689   ENSP00000425657   ENSP00000421579  

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    Uscn Proteins for ZNF765

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--


    ZNF765 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for ZNF765 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ZNF765 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q7L2R6

    ProtoNet protein and cluster: Q7L2R6

    1 Blocks protein family: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN765_HUMAN, Q7L2R6
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 11 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Function
    for ZNF765 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ZN765_HUMAN, Q7L2R6
    Function: May be involved in transcriptional regulation (By similarity)

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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding IEA--


    ZNF765 for ontologies           About GeneDecksing



    Pathways & Interactions
    for ZNF765 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF765

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--


    ZNF765 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ZNF765 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ZNF765
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    Transcripts
    for ZNF765 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section
    REFSEQ mRNAs for ZNF765 gene (2 alternative transcripts): 
    NM_001040185.1  NM_138372.1  

    Unigene Cluster for ZNF765:

    Zinc finger protein 765
    Hs.685640  [show with all ESTs]
    Unigene Representative Sequence: BX647981
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000504146 ENST00000504235(uc002qbn.3) ENST00000340310 ENST00000396408(uc010ydx.2 uc002qbm.3)
    ENST00000507045 ENST00000505866

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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF765
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    Additional cDNA sequence: 

    AK293890.1 AK295840.1 AK316300.1 BC001610.1 BC140724.1 BX647981.1 

    16 DOTS entries:

    DT.70104669  DT.92417373  DT.75120794  DT.100797477  DT.99978722  DT.100637745  DT.92418937  DT.95132340 
    DT.100015972  DT.100033392  DT.102839359  DT.102843486  DT.121462066  DT.121462218  DT.445532  DT.92418217 

    15 AceView cDNA sequences:

    NM_138372 BU854779 BC001610 BM834105 BC017357 BU179607 BU860089 BX647981 
    BG166444 CF128052 BX473962 BG391944 AI208772 AA299149 CD656338 

    GeneLoc Exon Structure


    Expression
    for ZNF765 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF765 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCGTCTACAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See ZNF765 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF765

    SOURCE GeneReport for Unigene cluster: Hs.685640
        SABiosciences Custom PCR Arrays for ZNF765
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    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ZNF765

    Orthologs
    for ZNF765 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    		   --

    ENSEMBL Gene Tree for ZNF765 (if available)
    TreeFam Gene Tree for ZNF765 (if available) 

    Paralogs
    for ZNF765 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF765 gene
    ZNF5342  ZNF321P2  ZNF4682  ZNF5782  ZNF8802  ZNF7662  ZNF3202  ZNF5252  
    ZNF8602  ZNF4152  ZNF6002  ZNF282  ZNF5282  ZNF6112  ZNF6772  ZNF832  
    ZNF8162  ZNF6102  ZNF7012  ZNF4802  ZNF8132  
    18/491 SIMAP similar genes for ZNF765 using alignment to 3 protein entries:     ZN765_HUMAN (see all proteins) (see all similar genes):
    ZNF813    ZNF845    kr-znf3    ZNF761    ZNF78L1    MGC12518
    ZNF808    ZNF321P    ZNF578    ZNF738    DKFZp686M04222    ZNF232
    ZNF28    ZNF611    ZNF701    ZFS-5    ZKSCAN1    ZNF397

    ZNF765 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for ZNF765
    PGOHUM00000234391 PGOHUM00000234411 PGOHUM00000250623


    Genomic Variants
    for ZNF765 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/439 NCBI SNPs in ZNF765 are shown (see all 439)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs72529421,2
    		C,F,A,H,--53896437(+) TTGAAC/TCCAAG 1 -- us2k11Minor allele frequency- T:0.50NA 6
    rs1928670761,2
    		--53896626(+) AGTGTA/TTGACT 1 -- us2k10--------
    rs126106021,2
    		C,F,A,H,--53896633(+) GACTCC/TGTCAC 1 -- us2k120Minor allele frequency- T:0.31NS EA NA WA 2314
    rs730591251,2
    		C,--53896634(+) ACTCCA/GTCACC 1 -- us2k10--------
    rs1144053031,2
    		F,--53896684(+) AAATGT/AGTTGA 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs72523441,2
    		C,F,H,--53896692(+) tgattC/Atccta 1 -- us2k15Minor allele frequency- A:0.02NS EA WA 538
    rs1397362141,2
    		--53896968(+) CCCTCC/TCTCTG 1 -- us2k10--------
    rs104206371,2
    		C,F,--53897065(+) GTCCTT/CTTCCC 1 -- us2k16Minor allele frequency- C:0.18NA WA EA 364
    rs1844871831,2
    		--53897122(+) GTATAC/GAACTG 1 -- us2k10--------
    rs26176431,2
    		C,H,--53897162(-) GCAAAC/GAGCTA 1 -- us2k112Minor allele frequency- G:0.00NA WA CSA EA 259

    HapMap Linkage Disequilibrium report for ZNF765 (53893046 - 53930574 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for ZNF765
         3 CNVs: 32267 9812 3198

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    Disorders / Diseases
    for ZNF765 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ZNF765 for disorders           About MalaCards

    ZNF765 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: ZNF765 (1 document)

    Export disorders for ZNF765 gene to outside databases

    Publications
    for ZNF765 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF765 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF765)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    2. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

    External Searches for ZNF765 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ZNF765 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 91661 HGNC: 25092 AceView: LOC91661 Ensembl:ENSG00000196417 euGenes: HUgn91661
    ECgene: ZNF765 H-InvDB: ZNF765

    Other Databases showing ZNF765 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ZNF765 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF765 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ZNF765 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ZNF765 gene:
    Search GeneIP for patents involving ZNF765

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ZNF765 gene

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    About This Section

     
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