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Aliases for ZNF764 Gene

Aliases for ZNF764 Gene

  • Zinc Finger Protein 764 2 3 5

External Ids for ZNF764 Gene

Previous GeneCards Identifiers for ZNF764 Gene

  • GC16M030473
  • GC16M028128

Summaries for ZNF764 Gene

GeneCards Summary for ZNF764 Gene

ZNF764 (Zinc Finger Protein 764) is a Protein Coding gene. Diseases associated with ZNF764 include Thyroid Hormone Resistance. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ENSG00000261459.

UniProtKB/Swiss-Prot for ZNF764 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF764 Gene

Genomics for ZNF764 Gene

Regulatory Elements for ZNF764 Gene

Enhancers for ZNF764 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F030555 1.5 Ensembl ENCODE 113.8 +0.4 427 4.2 CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 NFYC ENSG00000260267 ZNF764 SMG1P2 NPIPB13 ENSG00000260304 ZNF785 BCL7C MIR762HG ENSG00000261474 PRR14
GH16F030566 1.5 FANTOM5 ENCODE 76.1 -11.4 -11377 6.0 PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF302 ENSG00000260267 NPIPB13 ZNF747 SMG1P2 ZNF764 ENSG00000260304 BCL7C ENSG00000261474 ZNF785 ENSG00000235560
GH16F030052 1.2 ENCODE 95 +504.3 504294 3.1 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 ZNF747 ZNF764 SMG1P2 NPIPB13 BCL7C ZNF785 PRR14 ZNF629 ZNF689 ENSG00000235560
GH16F031025 1.2 Ensembl ENCODE 64.9 -467.6 -467603 1.0 ZNF493 ZFP64 ARID4B DMAP1 ZNF48 SLC30A9 GLIS2 ZNF302 ZNF143 ZNF548 ENSG00000260267 ZNF747 ZNF720 NPIPB13 ZNF764 ENSG00000260304 BCL7C ZNF785 ENSG00000261474 KAT8
GH16F031252 1.6 FANTOM5 Ensembl ENCODE 44.8 -695.4 -695403 2.6 ATF1 PKNOX1 ARNT ZNF493 FOS ZNF202 JUNB NCOA1 REST ZNF623 ENSG00000260267 ZNF720 ZNF747 ZNF764 ENSG00000260304 NPIPB13 PYDC1 BCL7C ZNF785 ENSG00000261474
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF764 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF764 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001504701 398 1801 PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for ZNF764 Gene

Chromosome:
16
Start:
30,553,764 bp from pter
End:
30,558,498 bp from pter
Size:
4,735 bases
Orientation:
Minus strand

Genomic View for ZNF764 Gene

Genes around ZNF764 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF764 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF764 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF764 Gene

Proteins for ZNF764 Gene

  • Protein details for ZNF764 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96H86-ZN764_HUMAN
    Recommended name:
    Zinc finger protein 764
    Protein Accession:
    Q96H86
    Secondary Accessions:
    • A8MZF4
    • B3KSN2
    • H9KV99
    • Q9BWS1

    Protein attributes for ZNF764 Gene

    Size:
    408 amino acids
    Molecular mass:
    44943 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF764 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF764 Gene

Post-translational modifications for ZNF764 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF764 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF764 Gene

Domains & Families for ZNF764 Gene

Gene Families for ZNF764 Gene

Protein Domains for ZNF764 Gene

Suggested Antigen Peptide Sequences for ZNF764 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96H86

UniProtKB/Swiss-Prot:

ZN764_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 7 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 7 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF764: view

Function for ZNF764 Gene

Molecular function for ZNF764 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF764 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF764: view

Phenotypes for ZNF764 Gene

genes like me logo Genes that share phenotypes with ZNF764: view

Animal Model Products

miRNA for ZNF764 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF764 Gene

Localization for ZNF764 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF764 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF764 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF764 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF764: view

Pathways & Interactions for ZNF764 Gene

SuperPathways for ZNF764 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF764: view

Pathways by source for ZNF764 Gene

2 Reactome pathways for ZNF764 Gene

Gene Ontology (GO) - Biological Process for ZNF764 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF764: view

No data available for SIGNOR curated interactions for ZNF764 Gene

Transcripts for ZNF764 Gene

mRNA/cDNA for ZNF764 Gene

Unigene Clusters for ZNF764 Gene

Zinc finger protein 764:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF764 Gene

No ASD Table

Relevant External Links for ZNF764 Gene

GeneLoc Exon Structure for
ZNF764
ECgene alternative splicing isoforms for
ZNF764

Expression for ZNF764 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF764 Gene

Protein differential expression in normal tissues from HIPED for ZNF764 Gene

This gene is overexpressed in Adipocyte (68.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF764 Gene



Protein tissue co-expression partners for ZNF764 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF764 Gene:

ZNF764

SOURCE GeneReport for Unigene cluster for ZNF764 Gene:

Hs.132227
genes like me logo Genes that share expression patterns with ZNF764: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF764 Gene

Orthologs for ZNF764 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF764 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF764 34 35
  • 99.18 (n)
cow
(Bos Taurus)
Mammalia ZNF764 34
  • 82.72 (n)
rat
(Rattus norvegicus)
Mammalia LOC102553962 34
  • 70.15 (n)
mouse
(Mus musculus)
Mammalia Zfp764 34 16
  • 68.87 (n)
Zfp747 35
  • 38 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 63 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 34 (a)
ManyToMany
Species where no ortholog for ZNF764 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF764 Gene

ENSEMBL:
Gene Tree for ZNF764 (if available)
TreeFam:
Gene Tree for ZNF764 (if available)

Paralogs for ZNF764 Gene

(313) SIMAP similar genes for ZNF764 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF764: view

Variants for ZNF764 Gene

Sequence variations from dbSNP and Humsavar for ZNF764 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs112260046 -- 30,558,837(+) TGGCG(C/T)AGTGG upstream-variant-2KB
rs112425159 -- 30,558,017(+) CTCCC(G/T)CATCA reference, synonymous-codon
rs112468997 -- 30,559,953(+) TGGGC(A/C/G)TAAGA upstream-variant-2KB
rs113928511 -- 30,555,261(+) CGTGG(A/C)CAGGG reference, missense
rs114054790 -- 30,556,788(+) TTAGC(C/T)CCAGG intron-variant

Variation tolerance for ZNF764 Gene

Residual Variation Intolerance Score: 84.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.73; 57.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF764 Gene

Human Gene Mutation Database (HGMD)
ZNF764
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF764

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF764 Gene

Disorders for ZNF764 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF764 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
thyroid hormone resistance
  • thyroid hormone resistance syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF764

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF764
genes like me logo Genes that share disorders with ZNF764: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF764 Gene

Publications for ZNF764 Gene

  1. ZNF764 haploinsufficiency may explain partial glucocorticoid, androgen, and thyroid hormone resistance associated with 16p11.2 microdeletion. (PMID: 22577170) Kino T. … Stratakis C.A. (J. Clin. Endocrinol. Metab. 2012) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. (PMID: 24104479) Vizeacoumar F.J. … Moffat J. (Mol. Syst. Biol. 2013) 3 64
  5. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PMID: 20562864) Nozawa R.S. … Obuse C. (Nat. Cell Biol. 2010) 3 64

Products for ZNF764 Gene

Sources for ZNF764 Gene

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