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ZNF763 Gene

protein-coding   GIFtS: 43
GCID: GC19P012050

Zinc Finger Protein 763

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 7631 2
ZNF2
ZNF440L2
DNA-Binding Protein2
Zinc Finger Protein 440 Like2

External Ids:    HGNC: 276141   Entrez Gene: 2843902   Ensembl: ENSG000001970547   UniProtKB: Q0D2J53   

Export aliases for ZNF763 gene to outside databases

Previous GC identifers: GC19P011938 GC19P012099 GC19P012100 GC19P011650


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF763 Gene:
ZNF763 (zinc finger protein 763) is a protein-coding gene. Diseases associated with ZNF763 include enamel erosion. An important paralog of this gene is ZNF669.

UniProtKB/Swiss-Prot: ZN763_HUMAN, Q0D2J5
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ZNF763
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF763 promoter sequence
   Search Chromatin IP Primers for ZNF763

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF763


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

ZNF763 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF763 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P012050:  view genomic region     (about GC identifiers)

Start:
12,035,890 bp from pter      End:
12,091,214 bp from pter
Size:
55,325 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN763_HUMAN, Q0D2J5 (See protein sequence)
Recommended Name: Zinc finger protein 763  
Size: 394 amino acids; 46099 Da
Secondary accessions: B3KRU3
Alternative splicing: 2 isoforms:  Q0D2J5-1   Q0D2J5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF763: NX_Q0D2J5

Explore proteomics data for ZNF763 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF763 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001012771.1  
    ENSEMBL proteins: 
     ENSP00000465057   ENSP00000465145   ENSP00000369774   ENSP00000402017   ENSP00000468692  
     ENSP00000438117   ENSP00000446166  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q0D2J5

    ProtoNet protein and cluster: Q0D2J5

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN763_HUMAN, Q0D2J5
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 8 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF763 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN763_HUMAN, Q0D2J5
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    ZNF763 for ontologies           About GeneDecksing


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    hsa-let-7d-5p (MIRT032116), hsa-mir-181a-5p (MIRT005544), hsa-mir-196a-5p (MIRT026043), hsa-mir-151a-3p (MIRT005722)

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    3 qRT-PCR Assays for microRNAs that regulate ZNF763:
    hsa-miR-188-3p hsa-miR-1260b hsa-miR-1260
    SwitchGear 3'UTR luciferase reporter plasmidZNF763 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN763_HUMAN, Q0D2J5: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF763 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF763
    Interactions:

        Search GeneGlobe Interaction Network for ZNF763

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    ZNF763 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF763 (ZN763)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF763 gene: 
    NM_001012753.1  

    Unigene Cluster for ZNF763:

    Zinc finger protein 763
    Hs.646386  [show with all ESTs]
    Unigene Representative Sequence: NM_001012753
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000592625 ENST00000586494 ENST00000343949(uc010xmf.2 uc002msv.3 uc002msw.3 uc010xmg.2)
    ENST00000358987 ENST00000481745 ENST00000538752 ENST00000545530
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate ZNF763:
    hsa-miR-188-3p hsa-miR-1260b hsa-miR-1260
    SwitchGear 3'UTR luciferase reporter plasmidZNF763 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat ZNF763

    Additional mRNA sequence: 

    AK092240.1 AK299182.1 AK299224.1 BC105711.1 BC105712.1 BC105713.1 

    8 DOTS entries:

    DT.40203564  DT.97808567  DT.92414483  DT.121462822  DT.121463007  DT.121462744  DT.404909  DT.442793 

    3 AceView cDNA sequences:

    AX747424 AK092240 AA382704 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF763 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTAGGACTCA
    ZNF763 Expression
    About this image

    ZNF763 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF763 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.646386
        Custom PCR Arrays for ZNF763
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF763

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF763 gene from Selected species (see all 2)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    cow
    (Bos taurus)
    Mammalia --
    Uncharacterized protein
    39(a)
    many ↔ many
    7(14307682-14311244)


    ENSEMBL Gene Tree for ZNF763 (if available)
    TreeFam Gene Tree for ZNF763 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF763 gene
    ZNF6692  ZNF5642  ZNF4902  ZNF4412  ZNF625-ZNF202  ZNF8782  ENSG000002671792  ZNF142  
    ENSG000002697552  ENSG000001968262  ZNF7002  ZNF692  ZNF4402  ZNF4432  ZNF670-ZNF6952  ZNF442  
    ZNF4392  ZNF8232  ENSG000001884742  ZNF4912  ZNF5552  ENSG000002688702  ZNF7092  ZNF6252  
    ZNF7992  ZNF202  ZNF7882  ZNF1012  ZNF7912  ZNF4422  ZNF4332  ZNF572  
    ZNF6272  ZNF5632  ENSG000002573552  ZNF1362  ZNF5562  ENSG000002687442  ZNF8442  ZNF772  
    Selected SIMAP similar genes for ZNF763 using alignment to 8 protein entries:     ZN763_HUMAN (see all proteins) (see all similar genes):
    ZNF440    ZNF69    ZNF439    ZNF274    ZNF625-ZNF20    ZNF700
    ZNF224    DCTN5    ZNF55    ZNF84    ZNF43    ZNF625
    ZNF761    ZNF790    ZNF235    ZNF844    ZNF470    ZNF195

    ZNF763 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF763 (see all 463)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1398178881,2
    C--12073889(+) TTGGT-/GAGAGA
    GAGAGAGA
    GAGAG
    1 -- us2k10--------
    rs586134381,2
    C--12073904(+) GAGAG-/AGAGAGAG
    AGAGAGAG
    /GT
    TGTGT
    1 -- us2k10--------
    rs3907671,2
    C--12073905(+) GAGAgT/Agtgtg 1 -- us2k12Minor allele frequency- A:0.00NA 4
    rs1449913761,2
    C--12074056(+) CACACC/TACCTC 1 -- us2k10--------
    rs1889684281,2
    --12074137(+) ACTTCC/TGTCTT 1 -- us2k10--------
    rs781876401,2
    F--12074149(+) AAGTGC/TTCCTC 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1932118141,2
    --12074162(+) ACTTTA/GGCCTC 1 -- us2k10--------
    rs1490924591,2
    --12074183(+) GGGATA/TACAGG 1 -- us2k10--------
    rs1843534811,2
    --12074206(+) TATCCA/GGCCTC 1 -- us2k10--------
    rs38529041,2
    C,F,A,H--12074271(+) TCCCTC/GACAGT 1 -- us2k110Minor allele frequency- G:0.16NS EA NA WA CSA 658

    HapMap Linkage Disequilibrium report for ZNF763 (12035890 - 12091214 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ZNF763:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718189CNV Deletion23290073
    nsv911069CNV Loss21882294
    nsv525966CNV Gain19592680
    nsv911068CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for ZNF763:    
    About MalaCards
    enamel erosion


    ZNF763 for disorders           About GeneDecksing


    Export disorders for ZNF763 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF763 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF763)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    3. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PubMed id 1505991)1 Lichter P.... Ward D.C. (Genomics 1992)
    7. Characterization and mapping of human genes encoding zinc finger proteins. (PubMed id 1946370)1 Bray P.L.... Dawid I.B. (Proc. Natl. Acad. Sci. U.S.A. 1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 284390 HGNC: 27614 AceView: LOC284390.1 Ensembl:ENSG00000197054 euGenes: HUgn284390
    ECgene: ZNF763 H-InvDB: ZNF763

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF763 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF763 gene:
    Search GeneIP for patents involving ZNF763

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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