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Aliases for ZNF763 Gene

Aliases for ZNF763 Gene

  • Zinc Finger Protein 763 2 3 5
  • Zinc Finger Protein 440 Like 3
  • DNA-Binding Protein 3
  • ZNF440L 3
  • ZNF 3

External Ids for ZNF763 Gene

Previous GeneCards Identifiers for ZNF763 Gene

  • GC19P011938
  • GC19P012099
  • GC19P012100
  • GC19P011650
  • GC19P012050

Summaries for ZNF763 Gene

GeneCards Summary for ZNF763 Gene

ZNF763 (Zinc Finger Protein 763) is a Protein Coding gene. Diseases associated with ZNF763 include Split Hand-Foot Malformation 1. GO annotations related to this gene include nucleic acid binding and transcription cofactor activity. An important paralog of this gene is ENSG00000267179.

UniProtKB/Swiss-Prot for ZNF763 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF763 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF763 Gene

Genomics for ZNF763 Gene

Regulatory Elements for ZNF763 Gene

Enhancers for ZNF763 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H011531 1.5 FANTOM5 Ensembl ENCODE 56.7 -432.6 -432599 1.6 PKNOX1 ATF1 ZNF493 ZFP64 FOS ZNF202 ZC3H11A REST ZNF623 ZNF518A ZNF627 ZNF136 ILF3 ZNF442 ZNF844 ZNF625 ZNF44 KRI1 ZNF20 ZNF763
GH19H012781 1.9 FANTOM5 ENCODE dbSUPER 37 +824.3 824261 16 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D ZNF610 ZNF136 CCDC130 ZNF791 ZNF44 ZNF442 ZNF564 TRMT1 ZNF844 TRIR ZNF700
GH19H011924 1.1 ENCODE 44.9 -39.6 -39620 3.4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 ZNF136 ZNF763 ZNF44 ZNF20 ZNF627 ZNF564 TRIR ZNF799 WDR83OS ZNF625
GH19H012918 1.1 ENCODE 44.2 +954.8 954834 2.2 HDGF PKNOX1 ARNT SIN3A ZNF2 YY1 ZNF143 ZNF207 DEK SP3 ZNF136 CCDC130 ZNF791 ZNF442 ZNF564 ZNF844 TRMT1 ZNF763 ZNF44 ZNF20
GH19H012936 1.7 FANTOM5 ENCODE dbSUPER 27 +974.1 974095 5.8 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207 ZNF136 TRMT1 CCDC130 ZNF625 RPS6P25 ZNF791 ZNF442 ZNF844 ZNF44 ZNF788
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF763 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF763 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000107234 263 1001 PKNOX1 FOXA2 SIN3A ARID4B RAD21 ZNF143 ZNF207 ATF7 RUNX3 IKZF2

Genomic Locations for ZNF763 Gene

Genomic Locations for ZNF763 Gene
15,363 bases
Plus strand

Genomic View for ZNF763 Gene

Genes around ZNF763 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF763 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF763 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF763 Gene

Proteins for ZNF763 Gene

  • Protein details for ZNF763 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 763
    Protein Accession:
    Secondary Accessions:
    • B3KRU3
    • B4DRE7

    Protein attributes for ZNF763 Gene

    394 amino acids
    Molecular mass:
    46099 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF763 Gene


neXtProt entry for ZNF763 Gene

Post-translational modifications for ZNF763 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF763 Gene

No data available for DME Specific Peptides for ZNF763 Gene

Domains & Families for ZNF763 Gene

Gene Families for ZNF763 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF763 Gene


Suggested Antigen Peptide Sequences for ZNF763 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF763: view

Function for ZNF763 Gene

Molecular function for ZNF763 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF763 Gene

Gene Ontology (GO) - Molecular Function for ZNF763 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF763: view
genes like me logo Genes that share phenotypes with ZNF763: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF763 Gene

Localization for ZNF763 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF763 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF763 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF763 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with ZNF763: view

Pathways & Interactions for ZNF763 Gene

SuperPathways for ZNF763 Gene

No Data Available

Interacting Proteins for ZNF763 Gene

Gene Ontology (GO) - Biological Process for ZNF763 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF763: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF763 Gene

Drugs & Compounds for ZNF763 Gene

No Compound Related Data Available

Transcripts for ZNF763 Gene

mRNA/cDNA for ZNF763 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF763 Gene

Zinc finger protein 763:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF763 Gene

No ASD Table

Relevant External Links for ZNF763 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF763 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF763 Gene

Protein differential expression in normal tissues from HIPED for ZNF763 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF763 Gene

Protein tissue co-expression partners for ZNF763 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF763 Gene:


SOURCE GeneReport for Unigene cluster for ZNF763 Gene:

genes like me logo Genes that share expression patterns with ZNF763: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF763 Gene

Orthologs for ZNF763 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF763 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 98 (a)
(Bos Taurus)
Mammalia -- 34
  • 39 (a)
Species where no ortholog for ZNF763 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF763 Gene

Gene Tree for ZNF763 (if available)
Gene Tree for ZNF763 (if available)

Paralogs for ZNF763 Gene

(517) SIMAP similar genes for ZNF763 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with ZNF763: view

Variants for ZNF763 Gene

Sequence variations from dbSNP and Humsavar for ZNF763 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000031080 -- 11,974,612(+) TTGGG(C/G/T)GGGGG intron-variant
rs1000307814 -- 11,963,343(+) TCCCA(C/G)TTTGG intron-variant, upstream-variant-2KB
rs1000711128 -- 11,963,142(+) GAAGT(-/GCA)GCAGT intron-variant, upstream-variant-2KB
rs1000948702 -- 11,972,766(+) ACATT(C/T)TTCTT intron-variant
rs1001060725 -- 11,967,010(+) GACAA(A/G)TCGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF763 Gene

Variant ID Type Subtype PubMed ID
esv2718189 CNV deletion 23290073
esv3643688 CNV loss 21293372
nsv525966 CNV gain 19592680
nsv578619 CNV loss 21841781
nsv960791 CNV duplication 23825009

Variation tolerance for ZNF763 Gene

Residual Variation Intolerance Score: 95.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.87; 48.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF763 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF763 Gene

Disorders for ZNF763 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF763 Gene - From: DISEASES

Disorder Aliases PubMed IDs
split hand-foot malformation 1
  • shfd1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF763

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ZNF763: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF763 Gene

Publications for ZNF763 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M … Moll S (Journal of proteomics 2013) 3 60
  4. A synthetic interaction screen identifies factors selectively required for proliferation and TERT transcription in p53-deficient human cancer cells. (PMID: 23284306) Xie L … Green MR (PLoS genetics 2012) 3 60
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 60

Products for ZNF763 Gene

Sources for ZNF763 Gene

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