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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF763 Gene

protein-coding GIFtS: 41
GCID: GC19P012050

zinc finger protein 763

Explore 1 disease affiliated with
ZNF763 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger Protein 763¹ ²
ZNF440L¹ ²
ZNF²
DNA-Binding Protein²
Zinc Finger Protein 440 Like²

External Ids:	HGNC: 27614¹	Entrez Gene: 284390²	Ensembl: ENSG00000197054⁷	UniProtKB: Q0D2J5³

Export aliases for ZNF763 gene to outside databases

Previous GC identifers: GC19P011938 GC19P012099 GC19P012100 GC19P011650

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN763_HUMAN, Q0D2J5

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011295.11

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for ZNF763
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF763 promoter sequence

Search SABiosciences Chromatin IP Primers for ZNF763

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF763

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2

ZNF763 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF763 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P012050: view genomic region (about GC identifiers)

Start:	12,035,890 bp from pter	End:	12,091,214 bp from pter
Size:	55,325 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN763_HUMAN, Q0D2J5 (See protein sequence)

Recommended Name: Zinc finger protein 763

Size: 394 amino acids; 46099 Da

Subcellular location: Nucleus (Probable)

Secondary accessions: B3KRU3

Alternative splicing: 2 isoforms: Q0D2J5-1 Q0D2J5-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF763: NX_Q0D2J5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q0D2J5

ZNF763 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001012771.1

ENSEMBL proteins:

ENSP00000465057 ENSP00000465145 ENSP00000369774 ENSP00000402017 ENSP00000468692

ENSP00000438117 ENSP00000446166

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IEA	--

ZNF763 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF763 for domains About GeneDecksing

4 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR001909 Krueppel-associated_box

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q0D2J5

ProtoNet protein and cluster: Q0D2J5

1 Blocks protein family: IPB001909 KRAB box

UniProtKB/Swiss-Prot: ZN763_HUMAN, Q0D2J5

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 8 C2H2-type zinc fingers

Similarity: Contains 1 KRAB domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZN763_HUMAN, Q0D2J5

Function: May be involved in transcriptional regulation

miRNA Products:		miRTarBase miRNAs that target ZNF763: hsa-mir-181a (MIRT005544), hsa-mir-151-3p (MIRT005722)

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Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZNF763 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF763

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZNF763 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF763
Search CenterWatch for drugs/clinical trials and news about ZNF763 / ZN763

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZNF763 gene:

NM_001012753.1

Unigene Cluster for ZNF763:

Zinc finger protein 763

Hs.646386 [show with all ESTs]

Unigene Representative Sequence: NM_001012753

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000592625 ENST00000586494 ENST00000343949(uc010xmf.2 uc002msv.3 uc002msw.3 uc010xmg.2)

ENST00000358987 ENST00000481745 ENST00000538752 ENST00000545530

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Additional cDNA sequence:

AK092240.1 AK299182.1 AK299224.1 BC105711.1 BC105712.1 BC105713.1

8 DOTS entries:

DT.40203564 DT.97808567 DT.92414483 DT.121462822 DT.121463007 DT.121462744 DT.404909 DT.442793

3 AceView cDNA sequences:

AX747424 AK092240 AA382704

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF763 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTAGGACTCA

About this image
See ZNF763 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF763

SOURCE GeneReport for Unigene cluster: Hs.646386

SABiosciences Custom PCR Arrays for ZNF763

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for ZNF763 (if available)
TreeFam Gene Tree for ZNF763 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF763 gene

ZNF669² ZNF490² ZNF564² ZNF441² ZNF878² ENSG00000267179² ZNF14² ENSG00000196826²

ZNF700² ZNF69² ZNF440² ZNF443² ZNF44² ZNF439² ZNF823² ZNF491²

ENSG00000188474² ZNF555² ZNF709² ZNF625² ZNF799² ZNF20² ZNF101² ZNF791²

ZNF442² ZNF433² ZNF57² ZNF563² ZNF627² ENSG00000257355² ZNF136² ZNF556²

ZNF670² ZNF124² ZNF699² ZNF844² ZNF77²

18/463 SIMAP similar genes for ZNF763 using alignment to 6 protein entries: ZN763_HUMAN (see all proteins) (see all similar genes):

ZNF440 ZNF69 ZNF439 ZNF224 ZNF700 ZNF55

ZNF761 ZNF84 ZNF790 ZNF625 ZNF844 ZNF235

ZNF195 ZNF826P MGC12518 ZNF596 ZNF624 ZNF726

ZNF763 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs139817888^1,2		--	12073889(+)	`TTGGT-/GAGAGA GAGAGAGAGAGAG`	1	--	us2k¹		0	--	--	--	--
rs390767^1,2	C	--	12073905(+)	`GAGAgT/Agtgtg`	1	--	us2k¹		2		NA	4
rs144991376^1,2		--	12074056(+)	`CACACC/TACCTC`	1	--	us2k¹		0	--	--	--	--
rs188968428^1,2		--	12074137(+)	`ACTTCC/TGTCTT`	1	--	us2k¹		0	--	--	--	--
rs78187640^1,2	F,	--	12074149(+)	`AAGTGC/TTCCTC`	1	--	us2k¹		1		WA	118
rs193211814^1,2		--	12074162(+)	`ACTTTA/GGCCTC`	1	--	us2k¹		0	--	--	--	--
rs149092459^1,2		--	12074183(+)	`GGGATA/TACAGG`	1	--	us2k¹		0	--	--	--	--
rs184353481^1,2		--	12074206(+)	`TATCCA/GGCCTC`	1	--	us2k¹		0	--	--	--	--
rs3852904^1,2	C,F,A,H,	--	12074271(+)	`TCCCTC/GACAGT`	1	--	us2k¹		10		NS EA NA WA CSA	658
rs117315415^1,2	F,	--	12074288(+)	`CTCATC/GCTTTG`	1	--	us2k¹		1		NA	120

HapMap Linkage Disequilibrium report for ZNF763 (12035890 - 12091214 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF763: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZNF763 for disorders About GeneDecksing

1 disease for ZNF763: About MalaCards

enamel erosion

Export disorders for ZNF763 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF763 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF763)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)² Grimwood J.... Lucas S.M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PubMed id 1505991)¹ Lichter P....Ward D.C. (1992)
Characterization and mapping of human genes encoding zinc finger proteins. (PubMed id 1946370)¹ Bray P.L.... Dawid I.B. (1991)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 284390	HGNC: 27614	AceView: LOC284390.1	Ensembl:ENSG00000197054	euGenes: HUgn284390
ECgene: ZNF763	H-InvDB: ZNF763

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF763	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF763 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF763 gene:
Search GeneIP for patents involving ZNF763

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZNF763 gene at Home site.

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ZNF763 Gene

zinc finger protein 763

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ZNF763 Gene

zinc finger protein 763

Aliasesfor ZNF763 gene

Summariesfor ZNF763 gene

Genomic Viewsfor ZNF763 gene

Proteinsfor ZNF763 gene

Protein Domains /Familiesfor ZNF763 gene

Functionfor ZNF763 gene

Pathways & Interactionsfor ZNF763 gene

Drugs & Compoundsfor ZNF763 gene

Transcriptsfor ZNF763 gene

Expression for ZNF763 gene

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Genomic Variantsfor ZNF763 gene

Disorders / Diseasesfor ZNF763 gene

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Genome Databases showing ZNF763 gene

Other Databases showing ZNF763 gene

Specialized Databases showing ZNF763 gene

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Productsfor ZNF763 gene

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for ZNF763 gene

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for ZNF763 gene

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for ZNF763 gene

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for ZNF763 gene

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for ZNF763 gene

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for ZNF763 gene

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for ZNF763 gene

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for ZNF763 gene

Transcripts
for ZNF763 gene

Expression
for ZNF763 gene

Orthologs
for ZNF763 gene

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for ZNF763 gene

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for ZNF763 gene

Disorders / Diseases
for ZNF763 gene

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for ZNF763 gene

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for ZNF763 gene

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for ZNF763 gene