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Aliases for ZNF76 Gene

Aliases for ZNF76 Gene

  • Zinc Finger Protein 76 2 3 5
  • Zinc Finger Protein 76 (Expressed In Testis) 2 3
  • Zinc Finger Protein 523 3 4
  • D6S229E 3 4
  • ZNF523 3 4
  • Zfp523 3

External Ids for ZNF76 Gene

Previous HGNC Symbols for ZNF76 Gene

  • D6S229E

Previous GeneCards Identifiers for ZNF76 Gene

  • GC06P035229
  • GC06P035274
  • GC06P035335
  • GC06P034948
  • GC06P035227
  • GC06P035323
  • GC06P035779
  • GC06P036306
  • GC06P037292
  • GC06P035481
  • GC06P035534
  • GC06P037762
  • GC06P038386
  • GC06P038976

Summaries for ZNF76 Gene

GeneCards Summary for ZNF76 Gene

ZNF76 (Zinc Finger Protein 76) is a Protein Coding gene. Diseases associated with ZNF76 include Cataract 1, Multiple Types. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF143.

UniProtKB/Swiss-Prot for ZNF76 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF76 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF76 Gene

Genomics for ZNF76 Gene

Regulatory Elements for ZNF76 Gene

Enhancers for ZNF76 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G035237 1 ENCODE dbSUPER 24.2 -20.2 -20157 2.3 CTCF TEAD4 BMI1 CEBPG ZNF2 RAD21 TEAD3 POLR2A ZNF143 ZNF207 ZNF76 TCP11 UHRF1BP1 SCUBE3 DEF6 GC06M037880 PIR55616
GH06G035309 1.6 FANTOM5 Ensembl ENCODE dbSUPER 13.4 +52.3 52336 4.1 PKNOX1 NFIB FEZF1 ZBTB40 ZNF366 POLR2A ETV6 PRDM10 ZNF263 NR2F1 DEF6 ZNF76 TAF11 RPL10A FKBP5 PPARD
GH06G035296 1.7 FANTOM5 ENCODE dbSUPER 12.3 +42.5 42484 8.8 HDGF PKNOX1 CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 SLC30A9 ZNF766 DEF6 ZNF76 TAF11 PPARD ANKS1A
GH06G035194 0.9 dbSUPER 23 -62.4 -62390 5.0 ELF3 FOXA2 ZNF133 ARID4B ZBTB40 RAD21 YY1 CREM EGR2 SP5 ZNF76 TCP11 DEF6 UHRF1BP1 C6orf106 GC06P041035
GH06G035195 0.9 dbSUPER 23 -62.4 -62390 5.0 ELF3 FOXA2 ZNF133 ARID4B ZBTB40 RAD21 YY1 CREM EGR2 SP5 ZNF76 TCP11 DEF6 UHRF1BP1 C6orf106 GC06P041035
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF76 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF76 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000196060 591 1801 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3

Genomic Location for ZNF76 Gene

Chromosome:
6
Start:
35,258,909 bp from pter
End:
35,295,987 bp from pter
Size:
37,079 bases
Orientation:
Plus strand

Genomic View for ZNF76 Gene

Genes around ZNF76 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF76 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF76 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF76 Gene

Proteins for ZNF76 Gene

  • Protein details for ZNF76 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36508-ZNF76_HUMAN
    Recommended name:
    Zinc finger protein 76
    Protein Accession:
    P36508
    Secondary Accessions:
    • Q9BQB2

    Protein attributes for ZNF76 Gene

    Size:
    570 amino acids
    Molecular mass:
    61831 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF76 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF76 Gene

Post-translational modifications for ZNF76 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF76 Gene

Domains & Families for ZNF76 Gene

Gene Families for ZNF76 Gene

Protein Domains for ZNF76 Gene

Suggested Antigen Peptide Sequences for ZNF76 Gene

Graphical View of Domain Structure for InterPro Entry

P36508

UniProtKB/Swiss-Prot:

ZNF76_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF76: view

Function for ZNF76 Gene

Molecular function for ZNF76 Gene

GENATLAS Biochemistry:
zinc finger protein 76 (C2H2 type,Kruppel-like),transactivator protein,DNA protein related to Xenopus laevis STAF and ZNF143
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF76 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF76: view
genes like me logo Genes that share phenotypes with ZNF76: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF76 Gene

Localization for ZNF76 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF76 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF76 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF76 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF76: view

Pathways & Interactions for ZNF76 Gene

SuperPathways for ZNF76 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF76 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 9705341
GO:0006359 regulation of transcription from RNA polymerase III promoter TAS 9705341
genes like me logo Genes that share ontologies with ZNF76: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF76 Gene

Transcripts for ZNF76 Gene

Unigene Clusters for ZNF76 Gene

Zinc finger protein 76:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF76 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c · 13d ^ 14 ^ 15 ^
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: - - - - - -
SP5: - - -
SP6: -
SP7: - - -
SP8: -
SP9: - -
SP10:

ExUns: 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for ZNF76 Gene

GeneLoc Exon Structure for
ZNF76
ECgene alternative splicing isoforms for
ZNF76

Expression for ZNF76 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF76 Gene

Protein differential expression in normal tissues from HIPED for ZNF76 Gene

This gene is overexpressed in Plasma (61.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF76 Gene



Protein tissue co-expression partners for ZNF76 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF76 Gene:

ZNF76

SOURCE GeneReport for Unigene cluster for ZNF76 Gene:

Hs.388024

mRNA Expression by UniProt/SwissProt for ZNF76 Gene:

P36508-ZNF76_HUMAN
Tissue specificity: Testis.
genes like me logo Genes that share expression patterns with ZNF76: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF76 Gene

Orthologs for ZNF76 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF76 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF76 34 35
  • 99.24 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF76 35
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF76 34 35
  • 90.92 (n)
dog
(Canis familiaris)
Mammalia ZNF76 34 35
  • 90.76 (n)
rat
(Rattus norvegicus)
Mammalia Zfp523 34
  • 89.08 (n)
mouse
(Mus musculus)
Mammalia Zfp523 34 16 35
  • 88.91 (n)
chicken
(Gallus gallus)
Aves ZNF76 34 35
  • 68.25 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:153635 34
  • 66.14 (n)
ZNF76 35
  • 63 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 52 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8333 34
Species where no ortholog for ZNF76 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF76 Gene

ENSEMBL:
Gene Tree for ZNF76 (if available)
TreeFam:
Gene Tree for ZNF76 (if available)

Paralogs for ZNF76 Gene

(191) SIMAP similar genes for ZNF76 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF76: view

Variants for ZNF76 Gene

Sequence variations from dbSNP and Humsavar for ZNF76 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000057218 -- 35,259,759(+) ATGGC(C/G)CAGGC intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000138451 -- 35,268,851(+) AGATG(A/G)CCCTA intron-variant
rs1000177145 -- 35,288,352(+) GGATT(A/G)TGAGG intron-variant
rs1000359561 -- 35,295,892(+) GTTTT(G/T)TTTTT nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs1000409778 -- 35,281,841(+) GAGGC(-/A)AGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF76 Gene

Variant ID Type Subtype PubMed ID
esv2750621 CNV gain 17666407
esv2759419 CNV loss 17122850

Variation tolerance for ZNF76 Gene

Residual Variation Intolerance Score: 79.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.57; 77.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF76 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF76

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF76 Gene

Disorders for ZNF76 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF76 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cataract 1, multiple types
  • cataract 1 multiple types
- elite association - COSMIC cancer census association via MalaCards
Search ZNF76 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ZNF76

Genetic Association Database (GAD)
ZNF76
Human Genome Epidemiology (HuGE) Navigator
ZNF76
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF76
genes like me logo Genes that share disorders with ZNF76: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF76 Gene

Publications for ZNF76 Gene

  1. A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the T-complex gene tcp-11. (PMID: 1427894) Ragoussis J. … Trowsdale J. (Genomics 1992) 2 3 4 64
  2. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P. … Inskip P.D. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 46 64
  3. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S. … Kang D. (Hum. Immunol. 2010) 3 46 64
  4. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J. … Grant S.F. (BMC Med. Genet. 2010) 3 46 64
  5. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 46 64

Products for ZNF76 Gene

Sources for ZNF76 Gene

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