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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF76 Gene

protein-coding   GIFtS: 56
GCID: GC06P036306

Zinc Finger Protein 76

(Previous name: zinc finger protein 76 (expressed in testis))
(Previous symbol: D6S229E)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 761 2
D6S229E1 2 3 5
Zinc Finger Protein 76 (Expressed In Testis)1 2
Zinc Finger Protein 5232 3
ZNF5232 3
Zfp5232

External Ids:    HGNC: 131491   Entrez Gene: 76292   Ensembl: ENSG000000650297   OMIM: 1945495   UniProtKB: P365083   

Export aliases for ZNF76 gene to outside databases

Previous GC identifers: GC06P035229 GC06P035274 GC06P035335 GC06P034948 GC06P035227 GC06P035323 GC06P035779


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF76 Gene: 
ZNF76 (zinc finger protein 76) is a protein-coding gene. Diseases associated with ZNF76 include meningioma, and leukemia. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is MTF1.

UniProtKB/Swiss-Prot: ZNF76_HUMAN, P36508
Function: May be involved in transcriptional regulation

Gene Wiki entry for ZNF76 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF76 gene promoter:
         HFH-3   TBP   NF-1/L   NF-1   USF1   p53   p300   GATA-2   FOXI1   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF76 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF76

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF76


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.31   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21.31

ZNF76 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF76 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P036306:  view genomic region     (about GC identifiers)

Start:
35,226,686 bp from pter      End:
35,263,762 bp from pter
Size:
37,077 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZNF76_HUMAN, P36508 (See protein sequence)
Recommended Name: Zinc finger protein 76  
Size: 570 amino acids; 61831 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: Q9BQB2
Alternative splicing: 2 isoforms:  P36508-1   P36508-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF76: NX_P36508

Explore proteomics data for ZNF76 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P36508

  • ZNF76 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF76 Protein Expression
    REFSEQ proteins: NP_003418.2  
    ENSEMBL proteins: 
     ENSP00000229405   ENSP00000419106   ENSP00000363064   ENSP00000344097   ENSP00000418749  
     ENSP00000392243  

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    Cloud-Clone Corp. Proteins for ZNF76 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZNF76 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P36508

    ProtoNet protein and cluster: P36508

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZNF76_HUMAN, P36508
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 7 C2H2-type zinc fingers


    ZNF76 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZNF76_HUMAN, P36508
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF76:
    zinc finger protein 76 (C2H2 type,Kruppel-like),transactivator protein,DNA protein related to Xenopus laevis STAF
    and ZNF143

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF76 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for ZNF76:
     G0/1 arrest  Increased G1 DNA content  Increased cell number in G1, s  Synthetic lethal with Ras 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidZNF76 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZNF76

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for ZNF76 (P365082, 3 ENSP000003630644) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD1Q157972, 3MINT-62026 I2D: score=3 
    PIAS1O759253, ENSP000002496364I2D: score=2 STRING: ENSP00000249636
    TBPP202263, ENSP000002303544I2D: score=2 STRING: ENSP00000230354
    EP300Q094723, ENSP000002632534I2D: score=1 STRING: ENSP00000263253
    HDAC1Q135473, ENSP000003626494I2D: score=1 STRING: ENSP00000362649
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS9705341
    GO:0006359regulation of transcription from RNA polymerase III promoter TAS9705341

    ZNF76 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF76

    Search CenterWatch for drugs/clinical trials and news about ZNF76

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF76 gene: 
    NM_003427.3  

    Unigene Cluster for ZNF76:

    Zinc finger protein 76
    Hs.388024  [show with all ESTs]
    Unigene Representative Sequence: NM_003427
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000491400(uc011dsx.2) ENST00000229405 ENST00000469195(uc011dsz.1)
    ENST00000486891(uc011dsy.1) ENST00000484932 ENST00000460229 ENST00000373953(uc003oki.1 uc003okj.1)
    ENST00000339411 ENST00000482946 ENST00000479226 ENST00000498555 ENST00000440666

    miRNA
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    hsa-miR-125a-5p hsa-miR-2114 hsa-miR-137 hsa-miR-2278 hsa-miR-1285 hsa-miR-3605-5p hsa-miR-2355-5p hsa-miR-612
    SwitchGear 3'UTR luciferase reporter plasmidZNF76 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK294605.1 AK295276.1 AK302903.1 AK304626.1 AK310877.1 BC000133.2 BC002549.2 BT007316.1 
    M91592.1 

    12 DOTS entries:

    DT.215030  DT.100818833  DT.100818831  DT.91752500  DT.40316328  DT.446245  DT.121386804  DT.97822063 
    DT.101956077  DT.91755432  DT.95261276  DT.95278275 

    24/189 AceView cDNA sequences (see all 189):

    BQ059510 BE390417 BQ007602 BI870145 BU741686 BQ216715 BM928406 BM810280 
    BX095537 BM743659 BM790806 BM712364 BM724427 BQ777334 BM854991 CR614742 
    BM854905 AA486210 AA335667 BE617478 BM670667 BC000133 CD617098 BQ186111 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF76 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c · 13d ^ 14 ^ 15 ^
    SP1:                                                                          -                                         -     -                                 
    SP2:                                                                          -                                         -     -                             -   
    SP3:                          -     -                                         -                                                                                 
    SP4:        -     -     -     -     -                                         -                                                                                 
    SP5:                          -     -                 -                                                                                                         

    ExUns: 16 ^ 17
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for ZNF76

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF76 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGAATGAG
    ZNF76 Expression
    About this image


    See ZNF76 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF76

    SOURCE GeneReport for Unigene cluster: Hs.388024

    UniProtKB/Swiss-Prot: ZNF76_HUMAN, P36508
    Tissue specificity: Testis

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZNF76 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp5231 , 5 zinc finger protein 5231, 5 88.91(n)1
    92.43(a)1
      17 (14.63 cM)5
    2246561  NM_172617.31  NP_766205.11 
     281772075 
    chicken
    (Gallus gallus)
    Aves ZNF761 zinc finger protein 76 68.97(n)
    62.91(a)
      772107  XM_001235292.2  XP_001235293.2 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1536351 zgc:153635 66.4(n)
    67.06(a)
      564210  NM_001077610.1  NP_001071078.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tra-16
    Sex-determining transformer protein 1
    8(a)
    1 → many
    III(11172092-11195207)


    ENSEMBL Gene Tree for ZNF76 (if available)
    TreeFam Gene Tree for ZNF76 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF76 gene
    MTF12  ZIC32  ZNF4102  GLI12  ZIC22  ZIC12  GLIS22  GLI22  
    ZIC42  GLIS12  ZNF1432  GLIS32  ZIC52  GLI32  
    18/191 SIMAP similar genes for ZNF76 using alignment to 5 protein entries:     ZNF76_HUMAN (see all proteins) (see all similar genes):
    ZNF143    ZNF826P    ZFS-5    ZNF112    ZNF878    DKFZp434J0650
    ZNF500    ZNF664    HZF16    ZNF211    ZNF778    ZFP2
    ZNF124    ZNF239    ZNF544    ZNF558    ZNF668    ZNF700

    ZNF76 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/806 SNPs in ZNF76 are shown (see all 806)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs737451411,2
    C,F--35140141(+) CGATCC/G/TGTAAG 1 -- us2k11WA 2
    rs788190731,2
    C,F--35140142(+) GATCCG/ATAAGG 1 -- us2k12Minor allele frequency- A:0.03CSA NA 122
    rs1482677411,2
    --35140159(+) AGAAAA/CGACAG 1 -- us2k10--------
    rs1417972711,2
    --35140262(+) ACCCTC/TAATTC 1 -- us2k10--------
    rs1462412021,2
    C--35140273(+) ATATTA/GTAAGA 1 -- us2k10--------
    rs1396298371,2
    C--35140344(+) CTTTTC/TTTGAG 1 -- us2k10--------
    rs1841308131,2
    --35140413(+) CCTCCA/GCCTCC 1 -- us2k10--------
    rs1870542831,2
    --35140519(+) AGAGGG/TGGGGT 1 -- us2k10--------
    rs1428210021,2
    --35140550(+) GGTCTC/GGAACT 1 -- us2k10--------
    rs1921961511,2
    --35140616(+) TTAAGC/TCACGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF76 (35226686 - 35263762 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZNF76:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv32738CNV Gain17666407
    esv2750621CNV Gain17666407
    dgv1939e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 194549    OMIM disorders: --

    2 diseases for ZNF76:    About MalaCards
    meningioma    leukemia


    ZNF76 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF76
    Human Genome Epidemiology (HuGE) Navigator: ZNF76 (5 documents)

    Export disorders for ZNF76 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF76 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with ZNF76)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the t-complex gene tcp-11. (PubMed id 1427894)1, 2, 3 Ragoussis J.... Trowsdale J. (1992)
    2. The role of height-associated loci identified in geno me wide association studies in the determination of pediatric stature. (PubMed id 20546612)1, 4 Zhao J....Grant S.F. (2010)
    3. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    4. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    5. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. ZNF76, a novel transcriptional repressor targeting TATA-binding protein, is modulated by sumoylation. (PubMed id 15280358)1, 9 Zheng G. and Yang Y.C. (2004)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    10. Common variation in genes related to innate immunity and risk of adult glioma. (PubMed id 19423540)1 Rajaraman P....Chanock S.J. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7629 HGNC: 13149 AceView: ZNF76 Ensembl:ENSG00000065029 euGenes: HUgn7629
    ECgene: ZNF76 H-InvDB: ZNF76

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF76 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF76 gene:
    Search GeneIP for patents involving ZNF76

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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