ZNF76 Gene
protein-coding GIFtS: 53
GCID: GC06P035779
|
|
zinc finger protein 76(Previous name: zinc finger protein 76 (expressed in testis) )
(Previous symbol: D6S229E)
| |
Aliases
for ZNF76 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 761 2 | | D6S229E1 2 3 5 | | ZNF5231 2 3 | | Zfp5231 2 | | Zinc Finger Protein 76 (Expressed In Testis)1 2 | | Zinc Finger Protein 5232 3 |
Export aliases for ZNF76 gene to outside databasesPrevious GC identifers: GC06P035229 GC06P035274 GC06P035335 GC06P034948 GC06P035227 GC06P035323 |
Summaries
for ZNF76 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZNF76_HUMAN, P36508Function: May be involved in transcriptional regulation
Gene Wiki entry for ZNF76
|
Genomic Views
for ZNF76 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF76 gene promoter:
HFH-3 TBP NF-1/L NF-1 USF1 p53 p300 GATA-2 FOXI1 USF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF76
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF76 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.31 Ensembl cytogenetic band: 6p21.31 HGNC cytogenetic band: 6p21.31ZNF76 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P035779: view genomic region
(about GC identifiers)
Start:
|
35,226,686 bp from pter |
End:
|
35,263,762 bp from pter |
Size:
|
37,077 bases |
Orientation:
|
plus strand |
|
Proteins
for ZNF76 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZNF76_HUMAN, P36508 (See
protein sequence)Recommended Name: Zinc finger protein 76 Size: 570 amino acids; 61831 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: Q9BQB2Alternative splicing: 2 isoforms: P36508-1 P36508-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZNF76: NX_P36508
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P36508
ZNF76 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003418.2
ENSEMBL proteins: ENSP00000229405 ENSP00000419106 ENSP00000363064 ENSP00000344097 ENSP00000418749 ENSP00000392243
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF76 for ontologies About GeneDecksing
ZNF76 Antibody Products:
Assay Products for ZNF76: |
Protein
Domains /
Families
for ZNF76 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF76 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P36508ProtoNet protein and cluster: P36508 1 Blocks protein family: IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZNF76_HUMAN, P36508Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 7 C2H2-type zinc fingers |
Function
for ZNF76 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZNF76_HUMAN, P36508Function: May be involved in transcriptional regulation Genatlas biochemistry entry for ZNF76:zinc finger protein 76 (C2H2 type,Kruppel-like),transactivator protein,DNA protein related to Xenopus laevis STAF andZNF143
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF76
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF76 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
ZNF76 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for ZNF76:
|
Pathways & Interactions
for ZNF76 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZNF76
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/6 Interacting proteins for ZNF76 (P365082, 3 ENSP000003630644) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006357 | regulation of transcription from RNA polymerase II promoter |
TAS | 9705341 | | GO:0006359 | regulation of transcription from RNA polymerase III promoter |
TAS | 9705341 |
ZNF76 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF76 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF76
Search CenterWatch for drugs/clinical trials and news about ZNF76
|
Transcripts
for ZNF76 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF76 gene: NM_003427.3 Unigene Cluster for ZNF76: Zinc finger protein 76 Hs.388024 [show with all ESTs]Unigene Representative Sequence: NM_00342712 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000491400(uc011dsx.2) ENST00000229405 ENST00000469195(uc011dsz.1)
ENST00000486891(uc011dsy.1) ENST00000484932 ENST00000460229 ENST00000373953(uc003oki.1 uc003okj.1)
ENST00000339411 ENST00000482946 ENST00000479226 ENST00000498555 ENST00000440666
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF76 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF76
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
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Synthesis Service for ZNF76 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF76 |
Additional cDNA sequence: AK294605.1 AK295276.1 AK302903.1 AK304626.1 AK310877.1 BC000133.2 BC002549.2 BT007316.1 M91592.1 12 DOTS entries: DT.215030 DT.100818833 DT.100818831 DT.91752500 DT.40316328 DT.446245 DT.121386804 DT.97822063 DT.101956077 DT.91755432 DT.95261276 DT.95278275 24/189 AceView cDNA sequences (see all 189): BQ777334 BQ059510 BX095537 BM743659 CR614742 BM712364 BM854905 BM790806 AA486210 BM928406 BM854991 BM810280 BE390417 BI870145 BQ007602 BM724427 AA335667 BQ216715 BU741686 CD617098 BI711849 BQ186111 BM980146 BG758274
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF76 (see all 10) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · | 13c | · | 13d | ^ | 14 | ^ | 15 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | - | | | | | | | | | | - | | |
| SP3: | | | | | | | | | - | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 16 | ^ | 17 |
|---|
|
| SP1: | | | | | |
| SP2: | | | | | |
| SP3: | | | | | |
| SP4: | | | | | |
| SP5: | | | | |
ECgene alternative splicing isoforms for ZNF76
|
Expression
for ZNF76 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF76 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATGAATGAG
About this image
See ZNF76 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF76
SOURCE GeneReport for Unigene cluster: Hs.388024
UniProtKB/Swiss-Prot: ZNF76_HUMAN, P36508Tissue specificity: Testis
SABiosciences Custom PCR Arrays for ZNF76
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF76
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF76 |
Orthologs
for ZNF76 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ZNF76 gene from 5/16 species (see all 16) About this table
ENSEMBL Gene Tree for ZNF76 (if available)
TreeFam Gene Tree for ZNF76 (if available) |
Paralogs
for ZNF76 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF76 gene
- GLI12 ZIC22 YY12 ZIC12 GLIS22 GLI22 ZNF1432 GLI32
- YY22 MTF12 ZIC32 ZNF4102 ZFP422 GLIS12 ZIC42 GLIS32
- ZIC52
18/198 SIMAP similar genes for ZNF76 using alignment to 5 protein entries: ZNF76_HUMAN (see all proteins)
(see all similar genes):ZNF143 ZNF826P ZFP112 ZFS-5 ZNF878 DKFZp434J0650
ZNF500 ZNF664 HZF16 ZNF211 ZNF778 ZFP2
ZNF124 ZNF239 ZNF544 ZNF558 ZNF668 ZNF700
ZNF76 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF76 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF76 (35226686 - 35263762 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZNF76
1 CNV: 3606 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF76 |
|
Disorders
/ Diseases
for ZNF76 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF76 for disorders About GeneDecksing
OMIM gene information: 194549
OMIM disorders: --
2  diseases for ZNF76: About MalaCardsmeningioma leukemia
Human Genome Epidemiology (HuGE) Navigator: ZNF76 (5 documents)
Export disorders for ZNF76 gene to outside databases
|
Publications
for ZNF76 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF76 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with ZNF76) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the t-complex gene tcp-11. (PubMed id 1427894)1, 2, 3 Ragoussis J.... Trowsdale J. (1992)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- ZNF76, a novel transcriptional repressor targeting TATA-binding protein, is modulated by sumoylation. (PubMed id 15280358)1, 9 Zheng G. and Yang Y.C. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- The role of height-associated loci identified in geno me wide association studies in the determination of pediatric stature. (PubMed id 20546612)1 Zhao J....Grant S.F. (2010)
- Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1 Han S....Kang D. (2010)
- Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1 Rajaraman P....Inskip P.D. (2010)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Common variation in genes related to innate immunity and risk of adult glioma. (PubMed id 19423540)1 Rajaraman P....Chanock S.J. (2009)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
|
External Searches for ZNF76 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF76 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF76 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF76 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF76 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF76 gene:
Search GeneIP for patents involving ZNF76
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF76 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF76 |
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