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Aliases for ZNF76 Gene

Aliases for ZNF76 Gene

  • Zinc Finger Protein 76 2 3 5
  • Zinc Finger Protein 76 (Expressed In Testis) 2 3
  • Zinc Finger Protein 523 3 4
  • D6S229E 3 4
  • ZNF523 3 4
  • Zfp523 3

External Ids for ZNF76 Gene

Previous HGNC Symbols for ZNF76 Gene

  • D6S229E

Previous GeneCards Identifiers for ZNF76 Gene

  • GC06P035229
  • GC06P035274
  • GC06P035335
  • GC06P034948
  • GC06P035227
  • GC06P035323
  • GC06P035779
  • GC06P036306
  • GC06P037292
  • GC06P035481
  • GC06P035534

Summaries for ZNF76 Gene

GeneCards Summary for ZNF76 Gene

ZNF76 (Zinc Finger Protein 76) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZIC3.

UniProtKB/Swiss-Prot for ZNF76 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF76 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF76 Gene

Genomics for ZNF76 Gene

Regulatory Elements for ZNF76 Gene

Enhancers for ZNF76 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF76 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF76 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF76 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF76 Gene

Chromosome:
6
Start:
35,258,909 bp from pter
End:
35,295,987 bp from pter
Size:
37,079 bases
Orientation:
Plus strand

Genomic View for ZNF76 Gene

Genes around ZNF76 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF76 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF76 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF76 Gene

Proteins for ZNF76 Gene

  • Protein details for ZNF76 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36508-ZNF76_HUMAN
    Recommended name:
    Zinc finger protein 76
    Protein Accession:
    P36508
    Secondary Accessions:
    • Q9BQB2

    Protein attributes for ZNF76 Gene

    Size:
    570 amino acids
    Molecular mass:
    61831 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF76 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF76 Gene

Proteomics data for ZNF76 Gene at MOPED

Post-translational modifications for ZNF76 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF76 Gene

No data available for DME Specific Peptides for ZNF76 Gene

Domains & Families for ZNF76 Gene

Gene Families for ZNF76 Gene

Protein Domains for ZNF76 Gene

Suggested Antigen Peptide Sequences for ZNF76 Gene

Graphical View of Domain Structure for InterPro Entry

P36508

UniProtKB/Swiss-Prot:

ZNF76_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 7 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 7 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF76: view

Function for ZNF76 Gene

Molecular function for ZNF76 Gene

GENATLAS Biochemistry:
zinc finger protein 76 (C2H2 type,Kruppel-like),transactivator protein,DNA protein related to Xenopus laevis STAF and ZNF143
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF76: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF76 Gene

Localization for ZNF76 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF76 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF76 Gene COMPARTMENTS Subcellular localization image for ZNF76 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF76 Gene

Pathways & Interactions for ZNF76 Gene

SuperPathways for ZNF76 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF76 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006359 regulation of transcription from RNA polymerase III promoter TAS 9705341
genes like me logo Genes that share ontologies with ZNF76: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF76 Gene

Drugs & Compounds for ZNF76 Gene

No Compound Related Data Available

Transcripts for ZNF76 Gene

Unigene Clusters for ZNF76 Gene

Zinc finger protein 76:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF76 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c · 13d ^ 14 ^ 15 ^
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: - - - - - -
SP5: - - -
SP6: -
SP7: - - -
SP8: -
SP9: - -
SP10:

ExUns: 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for ZNF76 Gene

GeneLoc Exon Structure for
ZNF76
ECgene alternative splicing isoforms for
ZNF76

Expression for ZNF76 Gene

mRNA expression in normal human tissues for ZNF76 Gene

Protein differential expression in normal tissues from HIPED for ZNF76 Gene

This gene is overexpressed in Plasma (61.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF76 Gene



SOURCE GeneReport for Unigene cluster for ZNF76 Gene Hs.388024

mRNA Expression by UniProt/SwissProt for ZNF76 Gene

P36508-ZNF76_HUMAN
Tissue specificity: Testis.
genes like me logo Genes that share expression patterns with ZNF76: view

Protein tissue co-expression partners for ZNF76 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF76 Gene

Orthologs for ZNF76 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF76 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF76 35
  • 90.92 (n)
  • 93.5 (a)
ZNF76 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF76 35
  • 90.76 (n)
  • 94.74 (a)
ZNF76 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp523 35
  • 88.91 (n)
  • 92.43 (a)
Zfp523 16
Zfp523 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF76 35
  • 99.24 (n)
  • 98.95 (a)
ZNF76 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp523 35
  • 89.08 (n)
  • 92.25 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNF76 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF76 35
  • 68.25 (n)
  • 62.36 (a)
ZNF76 36
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zgc:153635 35
  • 66.14 (n)
  • 67.06 (a)
ZNF76 36
  • 63 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8333 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToMany
Species with no ortholog for ZNF76:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF76 Gene

ENSEMBL:
Gene Tree for ZNF76 (if available)
TreeFam:
Gene Tree for ZNF76 (if available)

Paralogs for ZNF76 Gene

(191) SIMAP similar genes for ZNF76 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF76: view

Variants for ZNF76 Gene

Sequence variations from dbSNP and Humsavar for ZNF76 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs2228265 - 35,286,197(+) GGTGA(C/T)GGTAC nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs33959228 - 35,291,620(+) ACATC(C/T)GCAAG nc-transcript-variant, reference, missense
rs35582935 - 35,292,923(+) ACCCC(A/G)GATAG nc-transcript-variant, downstream-variant-500B, reference, missense
rs5875514 -- 35,280,517(+) ATGAT(-/C)CCCCC intron-variant
rs6457812 -- 35,277,343(+) TGGTT(A/C)TTCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF76 Gene

Variant ID Type Subtype PubMed ID
dgv1939e1 CNV Complex 17122850
esv2750621 CNV Gain 17666407
esv32738 CNV Gain 17666407

Variation tolerance for ZNF76 Gene

Residual Variation Intolerance Score: 79.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.57; 77.97% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF76 Gene

Disorders for ZNF76 Gene

Relevant External Links for ZNF76

Genetic Association Database (GAD)
ZNF76
Human Genome Epidemiology (HuGE) Navigator
ZNF76
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF76

No disorders were found for ZNF76 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF76 Gene

Publications for ZNF76 Gene

  1. A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the T-complex gene tcp-11. (PMID: 1427894) Ragoussis J. … Trowsdale J. (Genomics 1992) 2 3 4 67
  2. ZNF76, a novel transcriptional repressor targeting TATA-binding protein, is modulated by sumoylation. (PMID: 15280358) Zheng G. … Yang Y.C. (J. Biol. Chem. 2004) 3 23
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  4. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P. … Inskip P.D. (Cancer Epidemiol. Biomarkers Prev. 2010) 3
  5. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S. … Kang D. (Hum. Immunol. 2010) 3

Products for ZNF76 Gene

Sources for ZNF76 Gene

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