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Aliases for ZNF75D Gene

Aliases for ZNF75D Gene

  • Zinc Finger Protein 75D 2 3 5
  • Zinc Finger Protein 82 3 4
  • Zinc Finger Protein 75 3 4
  • ZNF75 3 4
  • ZNF82 3 4
  • Zinc Finger Protein 75 (D8C6) 2
  • ZKSCAN24 3
  • ZSCAN28 3
  • D8C6 3

External Ids for ZNF75D Gene

Previous HGNC Symbols for ZNF75D Gene

  • ZNF82
  • ZNF75

Previous GeneCards Identifiers for ZNF75D Gene

  • GC0XM134248
  • GC0XM134384
  • GC0XM123779

Summaries for ZNF75D Gene

Entrez Gene Summary for ZNF75D Gene

  • This gene encodes a protein that likely functions as a transcription factor. The protein, which belongs to the ZNF75 family, includes an N-terminal SCAN domain, a KRAB box, and five C2H2-type zinc finger motifs. Another functional gene belonging to this family is located on chromosome 16, while pseudogenes have been identified on chromosomes 11 and 12. Alternative splicing results in multiple transcripts variants. [provided by RefSeq, Jun 2010]

GeneCards Summary for ZNF75D Gene

ZNF75D (Zinc Finger Protein 75D) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF75A.

UniProtKB/Swiss-Prot for ZNF75D Gene

  • May be involved in transcriptional regulation.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF75D Gene

Genomics for ZNF75D Gene

Regulatory Elements for ZNF75D Gene

Enhancers for ZNF75D Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG135342 1.1 ENCODE 0.7 +0.2 203 3.4 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF766 RTL8B ZNF75D PIR55917
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF75D on UCSC Golden Path with GeneCards custom track

Promoters for ZNF75D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000249007 1318 5001 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF766

Genomic Location for ZNF75D Gene

Chromosome:
X
Start:
135,248,589 bp from pter
End:
135,344,618 bp from pter
Size:
96,030 bases
Orientation:
Minus strand

Genomic View for ZNF75D Gene

Genes around ZNF75D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF75D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF75D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF75D Gene

Proteins for ZNF75D Gene

  • Protein details for ZNF75D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51815-ZN75D_HUMAN
    Recommended name:
    Zinc finger protein 75D
    Protein Accession:
    P51815
    Secondary Accessions:
    • A6NK62
    • B3KRI7
    • Q5JPG0
    • Q6LDE0

    Protein attributes for ZNF75D Gene

    Size:
    510 amino acids
    Molecular mass:
    59298 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF75D Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF75D Gene

Post-translational modifications for ZNF75D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF75D Gene

Domains & Families for ZNF75D Gene

Gene Families for ZNF75D Gene

Suggested Antigen Peptide Sequences for ZNF75D Gene

Graphical View of Domain Structure for InterPro Entry

P51815

UniProtKB/Swiss-Prot:

ZN75D_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF75D: view

Function for ZNF75D Gene

Molecular function for ZNF75D Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF75D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0008270 zinc ion binding NAS 8288223
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF75D: view

Phenotypes for ZNF75D Gene

genes like me logo Genes that share phenotypes with ZNF75D: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF75D Gene

Localization for ZNF75D Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF75D Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF75D gene
Compartment Confidence
nucleus 5
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for ZNF75D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF75D: view

Pathways & Interactions for ZNF75D Gene

SuperPathways for ZNF75D Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF75D: view

Pathways by source for ZNF75D Gene

2 Reactome pathways for ZNF75D Gene

Interacting Proteins for ZNF75D Gene

Gene Ontology (GO) - Biological Process for ZNF75D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF75D: view

No data available for SIGNOR curated interactions for ZNF75D Gene

Drugs & Compounds for ZNF75D Gene

(1) Drugs for ZNF75D Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 2296
genes like me logo Genes that share compounds with ZNF75D: view

Transcripts for ZNF75D Gene

Unigene Clusters for ZNF75D Gene

Zinc finger protein 75D:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF75D Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b
SP1: - - -
SP2: - - - -
SP3: - -
SP4:
SP5:

Relevant External Links for ZNF75D Gene

GeneLoc Exon Structure for
ZNF75D
ECgene alternative splicing isoforms for
ZNF75D

Expression for ZNF75D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF75D Gene

Protein differential expression in normal tissues from HIPED for ZNF75D Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF75D Gene



Protein tissue co-expression partners for ZNF75D Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF75D Gene:

ZNF75D

SOURCE GeneReport for Unigene cluster for ZNF75D Gene:

Hs.533540

Evidence on tissue expression from TISSUES for ZNF75D Gene

  • Nervous system(4.3)
  • Lung(4.2)
  • Lymph node(4.2)
genes like me logo Genes that share expression patterns with ZNF75D: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF75D Gene

Orthologs for ZNF75D Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF75D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF75D 34 35
  • 99.74 (n)
dog
(Canis familiaris)
Mammalia ZNF75D 34 35
  • 87.1 (n)
cow
(Bos Taurus)
Mammalia ZNF75D 34 35
  • 83.47 (n)
-- 35
  • 62 (a)
OneToMany
ZNF75 35
  • 61 (a)
OneToMany
-- 35
  • 57 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 38 (a)
OneToMany
Species where no ortholog for ZNF75D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF75D Gene

ENSEMBL:
Gene Tree for ZNF75D (if available)
TreeFam:
Gene Tree for ZNF75D (if available)

Paralogs for ZNF75D Gene

Paralogs for ZNF75D Gene

Pseudogenes.org Pseudogenes for ZNF75D Gene

genes like me logo Genes that share paralogs with ZNF75D: view

Variants for ZNF75D Gene

Sequence variations from dbSNP and Humsavar for ZNF75D Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs782539023 Benign 135,287,570(+) CCTGA(C/T)ACTTA intron-variant, reference, missense
rs1000015206 -- 135,285,173(+) TAGTC(A/G)CCATT intron-variant
rs1000123787 -- 135,275,937(+) TTTCT(A/C)AAAAA intron-variant
rs1000125013 -- 135,345,515(+) GACAA(A/G)CAATA intron-variant, upstream-variant-2KB
rs1000236163 -- 135,284,526(+) AGGGA(G/T)GAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF75D Gene

Variant ID Type Subtype PubMed ID
esv2758894 CNV gain 17122850
nsv469825 CNV loss 16826518
nsv469871 CNV loss 16826518
nsv7104 CNV deletion 18451855
nsv7458 OTHER inversion 18451855

Variation tolerance for ZNF75D Gene

Residual Variation Intolerance Score: 49.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 9.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF75D Gene

Human Gene Mutation Database (HGMD)
ZNF75D
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF75D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF75D Gene

Disorders for ZNF75D Gene

Relevant External Links for ZNF75D

Genetic Association Database (GAD)
ZNF75D
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF75D

No disorders were found for ZNF75D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF75D Gene

Publications for ZNF75D Gene

  1. Isolation of a zinc finger motif (ZNF75) mapping on chromosome Xq26. (PMID: 1505955) Villa A. … Vezzoni P. (Genomics 1992) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. ZNF75: isolation of a cDNA clone of the KRAB zinc finger gene subfamily mapped in YACs 1 Mb telomeric of HPRT. (PMID: 8288223) Villa A. … Vezzoni P. (Genomics 1993) 3 4 64
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 64
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64

Products for ZNF75D Gene

Sources for ZNF75D Gene

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