ZNF75D Gene
protein-coding GIFtS: 49
GCID: GC0XM134384
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|
zinc finger protein 75D(Previous name: zinc finger protein 75 (D8C6) )
(Previous symbols: ZNF82, ZNF75)
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Aliases
for ZNF75D gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 75D1 2 | | ZSCAN281 2 | | ZNF751 2 3 5 | | Zinc Finger Protein 752 3 | | ZNF821 2 3 | | Zinc Finger Protein 822 3 | | D8C61 2 | | Zinc Finger Protein 75 (D8C6)1 | | ZKSCAN241 2 | | |
Export aliases for ZNF75D gene to outside databasesPrevious GC identifers: GC0XM134248 GC0XM123779 |
Summaries
for ZNF75D gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZNF75D:
This gene encodes a protein that likely functions as a transcription factor. The protein, which belongs to the ZNF75family, includes an N-terminal SCAN domain, a KRAB box, and five C2H2-type zinc finger motifs. Another functional genebelonging to this family is located on chromosome 16, while pseudogenes have been identified on chromosomes 11 and 12.Alternative splicing results in multiple transcripts variants. (provided by RefSeq, Jun 2010)
UniProtKB/Swiss-Prot: ZN75D_HUMAN, P51815Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF75D gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011786.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF75D gene promoter:
AhR STAT1 Nkx2-2 STAT1beta Arnt STAT1alpha HEN1 AREB6 ZID
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF75D
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF75D |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq26.3 Ensembl cytogenetic band: Xq26.3 HGNC cytogenetic band: Xq26ZNF75D Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM134384: view genomic region
(about GC identifiers)
Start:
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134,382,867 bp from pter |
End:
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134,478,012 bp from pter |
Size:
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95,146 bases |
Orientation:
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minus strand |
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Proteins
for ZNF75D gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN75D_HUMAN, P51815 (See
protein sequence)Recommended Name: Zinc finger protein 75D Size: 510 amino acids; 59298 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: A6NK62 B3KRI7 Q5JPG0 Q6LDE0Alternative splicing: 2 isoforms: P51815-1 P51815-2 Explore the universe of human proteins at neXtProt for ZNF75D: NX_P51815
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P51815
ZNF75D Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001171992.1 NP_009062.2
ENSEMBL proteins: ENSP00000359802 ENSP00000359800 Reactome Protein details: P51815
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
NAS | -- |
ZNF75D for ontologies About GeneDecksing
ZNF75D Antibody Products:
Assay Products for ZNF75D: |
Protein
Domains /
Families
for ZNF75D gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF75D for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry P51815ProtoNet protein and cluster: P51815 2 Blocks protein families: IPB001909 KRAB box IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZN75D_HUMAN, P51815Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 5 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domainSimilarity: Contains 1 SCAN box domain |
Function
for ZNF75D gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN75D_HUMAN, P51815Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF75D (see all 2)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF75D |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
ZNF75D for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZNF75D:
|
Pathways & Interactions
for ZNF75D gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF75D
ZNF75D for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF75D
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
NAS | -- | | GO:0016032 | viral reproduction |
IEA | -- |
ZNF75D for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF75D gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF75D
1 HMDB Compound for ZNF75D About this table
Search CenterWatch for drugs/clinical trials and news about ZNF75D / ZN75D
|
Transcripts
for ZNF75D gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF75D gene (2 alternative transcripts): NM_001185063.1 NM_007131.3 Unigene Cluster for ZNF75D: Zinc finger protein 75D Hs.533540 [show with all ESTs]Unigene Representative Sequence: AL8319844 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000494295(uc022cep.1) ENST00000370766(uc022ceq.1 uc004eyo.3 uc004eym.3)
ENST00000370764 ENST00000469456
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF75D (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF75D (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ZNF75D (NM_007131) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF75D | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF75D |
Additional cDNA sequence: AK091687.1 AK092347.1 AK290215.1 AL831984.2 AL832801.1 BC109100.2 S67970.1 8 DOTS entries: DT.452918 DT.100023108 DT.100776955 DT.121313700 DT.100023105 DT.121313676 DT.100776956 DT.121313713 24/108 AceView cDNA sequences (see all 108): AX747490 BM789646 AI127026 BQ012594 BX106424 AI333111 BC029893 BQ012093 BQ882079 CR624208 CF529959 CF530049 CA392171 AL832801 CA419845 AA604941 AA761146 BC029787 AK092347 BM789656 AA913348 CB241691 NM_007131 BX453632
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF75D About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9a | · | 9b |
|---|
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| SP1: | | | - | | - | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF75D
|
Expression
for ZNF75D gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF75D expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATTTATATC
About this image
See ZNF75D Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF75D
SOURCE GeneReport for Unigene cluster: Hs.533540
SABiosciences Custom PCR Arrays for ZNF75D
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF75D
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF75D | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF75D | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF75D | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF75D |
Orthologs
for ZNF75D gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZNF75D gene from 2/10 species (see all 10) About this table
Species with no ortholog for ZNF75D
ENSEMBL Gene Tree for ZNF75D (if available)
TreeFam Gene Tree for ZNF75D (if available) |
Paralogs
for ZNF75D gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF75D gene
- ZNF75A2
18/147 SIMAP similar genes for ZNF75D using alignment to 2 protein entries: ZN75D_HUMAN (see all proteins)
(see all similar genes):DKFZp451F083 SCAND1 ZNF818P ZNF761 ZNF573 LOC100128510
ZNF28 ZNF75A ZNF226 ZNF718 ZNF78L1 kr-znf3
HZF16 MGC12518 ZNF273 ZNF75CP ZNF789 ZNF
ZNF75D for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for ZNF75D
PGOHUM00000250413 PGOHUM00000239428 PGOHUM00000250670
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Genomic Variants
for ZNF75D gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF75D (134382867 - 134478012 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for ZNF75D
3 CNVs: 2280 4173 2130
Human Gene Mutation Database (HGMD): ZNF75D
Locus Specific Mutation Databases (LSDB): ZNF75D
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF75D |
|
Disorders
/ Diseases
for ZNF75D gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZNF75D for disorders About MalaCards
ZNF75D for disorders About GeneDecksing
OMIM gene information: 314997
OMIM disorders: --
Export disorders for ZNF75D gene to outside databases
|
Publications
for ZNF75D gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF75D gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with ZNF75D) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation of a zinc finger motif (ZNF75) mapping on chromosome Xq26. (PubMed id 1505955)1, 2, 3 Villa A.... Vezzoni P. (1992)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- ZNF75: isolation of a cDNA clone of the KRAB zinc finger gene subfamily mapped in YACs 1 Mb telomeric of HPRT. (PubMed id 8288223)1, 2 Villa A.... Vezzoni P. (1993)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZNF75D gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF75D gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF75D gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF75D gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF75D | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF75D gene:
Search GeneIP for patents involving ZNF75D
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF75D gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF75D | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF75D | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF75D | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF75D | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF75D | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF75D |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF75D |
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