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ZNF75D Gene

protein-coding   GIFtS: 51
GCID: GC0XM134384

Zinc Finger Protein 75D

(Previous name: zinc finger protein 75 (D8C6))
(Previous symbols: ZNF82, ZNF75)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Protein 75D1 2     Zinc Finger Protein 75 (D8C6)1
ZNF751 2 3 5     D8C62
ZNF821 2 3     ZKSCAN242
Zinc Finger Protein 752 3     ZSCAN282
Zinc Finger Protein 822 3     

External Ids:    HGNC: 131451   Entrez Gene: 76262   Ensembl: ENSG000001863767   OMIM: 3149975   UniProtKB: P518153   
ORGUL members:         

Export aliases for ZNF75D gene to outside databases

Previous GC identifers: GC0XM134248 GC0XM123779


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZNF75D Gene:
This gene encodes a protein that likely functions as a transcription factor. The protein, which belongs to the
ZNF75 family, includes an N-terminal SCAN domain, a KRAB box, and five C2H2-type zinc finger motifs. Another
functional gene belonging to this family is located on chromosome 16, while pseudogenes have been identified on
chromosomes 11 and 12. Alternative splicing results in multiple transcripts variants. (provided by RefSeq, Jun
2010)

GeneCards Summary for ZNF75D Gene:
ZNF75D (zinc finger protein 75D) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF75A.

UniProtKB/Swiss-Prot: ZN75D_HUMAN, P51815
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_011786.17  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF75D gene promoter:
         AhR   STAT1   Nkx2-2   STAT1beta   Arnt   STAT1alpha   HEN1   AREB6   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF75D promoter sequence
   Search Chromatin IP Primers for ZNF75D

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF75D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26.3   Ensembl cytogenetic band:  Xq26.3   HGNC cytogenetic band: Xq26

ZNF75D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF75D gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM134384:  view genomic region     (about GC identifiers)

Start:
134,382,867 bp from pter      End:
134,478,012 bp from pter
Size:
95,146 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN75D_HUMAN, P51815 (See protein sequence)
Recommended Name: Zinc finger protein 75D  
Size: 510 amino acids; 59298 Da
Secondary accessions: A6NK62 B3KRI7 Q5JPG0 Q6LDE0
Alternative splicing: 2 isoforms:  P51815-1   P51815-2   

Explore the universe of human proteins at neXtProt for ZNF75D: NX_P51815

Explore proteomics data for ZNF75D at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF75D Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001171992.1  NP_009062.2  

    ENSEMBL proteins: 
     ENSP00000359802   ENSP00000359800  
    Reactome Protein details: P51815

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    antibodies-online proteins for ZNF75D (5 products) 

     
    antibodies-online peptides for ZNF75D

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    Selected InterPro protein domains (see all 6):
     IPR001909 Krueppel-associated_box
     IPR008916 Retrov_capsid_C
     IPR003309 Tscrpt_reg_SCAN
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd

    Graphical View of Domain Structure for InterPro Entry P51815

    ProtoNet protein and cluster: P51815

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN75D_HUMAN, P51815
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 5 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain
    Similarity: Contains 1 SCAN box domain


    Find genes that share domains with ZNF75D           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN75D_HUMAN, P51815
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0008270zinc ion binding NAS8288223
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with ZNF75D           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF75D:
     Increased circadian rhythm amp 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF75D

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN75D_HUMAN, P51815: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    golgi apparatus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF75D           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF75D About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF75D           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF75D
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF75D
    Interactions:

        Search GeneGlobe Interaction Network for ZNF75D

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----

    Find genes that share ontologies with ZNF75D           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF75D (ZN75D)

    1 HMDB Compound for ZNF75D    About this table
    CompoundSynonyms CAS #PubMed Ids
    ZincZinc (see all 2)7440-66-6--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF75D gene (2 alternative transcripts): 
    NM_001185063.2  NM_007131.4  

    Unigene Cluster for ZNF75D:

    Zinc finger protein 75D
    Hs.533540  [show with all ESTs]
    Unigene Representative Sequence: AL831984
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000494295(uc022cep.1) ENST00000370766(uc022ceq.1 uc004eyo.3 uc004eym.3)
    ENST00000370764 ENST00000469456
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    hsa-miR-1283 hsa-miR-1255a hsa-miR-3921 hsa-miR-340 hsa-miR-1255b
    SwitchGear 3'UTR luciferase reporter plasmidZNF75D 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF75D
      QuantiFast Probe-based Assays in human, mouse, rat ZNF75D

    Additional mRNA sequence: 

    AK091687.1 AK092347.1 AK290215.1 AL831984.2 AL832801.1 BC109100.2 S67970.1 

    9 DOTS entries:

    DT.452918  DT.100776955  DT.100023108  DT.121313700  DT.100023105  DT.101980776  DT.121313676  DT.100776956 
    DT.121313713 

    Selected AceView cDNA sequences (see all 108):

    AA761146 BC029787 AI127026 BQ012594 AI337790 BM789656 CR624208 CA419845 
    BC029893 AK092347 BQ882079 CB241691 BX090999 AA913348 AA604941 CF530049 
    AX747490 AL832801 BX453632 NM_007131 BQ012093 AI333111 CF529959 BX106424 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF75D    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b
    SP1:        -     -                             -                                 
    SP2:                                      -     -     -     -                     
    SP3:                                -           -                                 
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for ZNF75D

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF75D expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTTATATC
    ZNF75D Expression
    About this image

    ZNF75D Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF75D Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.533540
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF75D gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF75D1 zinc finger protein 75D 87.1(n)
    76.82(a)
      611850  XM_005641852.1  XP_005641909.1 


    ENSEMBL Gene Tree for ZNF75D (if available)
    TreeFam Gene Tree for ZNF75D (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF75D gene
    ZNF75A2  
    Selected SIMAP similar genes for ZNF75D using alignment to 2 protein entries:     ZN75D_HUMAN (see all proteins) (see all similar genes):
    DKFZp451F083    SCAND1    ZNF818P    LOC101928664    ZNF761    ZNF573
    LOC100128510    ZNF28    ZNF718    ZNF78L1    kr-znf3    HZF16
    MGC12518    ZNF273    ZNF75CP    ZNF    DKFZp434G1930    HZF36

    Find genes that share paralogs with ZNF75D           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for ZNF75D
    PGOHUM00000250413 PGOHUM00000239428 PGOHUM00000250670


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF75D (see all 180)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1856554221,2
    --134378013(+) TTTGGA/GAACAG 2 -- ds50010--------
    rs454575991,2
    C--134378143(+) AAATGC/TGTCAT 2 -- ut310--------
    rs1905612131,2
    --134378269(+) TTGACA/GTCACA 2 -- ut310--------
    rs70421,2
    C,F,O,A,H--134378379(+) TCACTG/CTGAGC 2 -- ut31 ese312Minor allele frequency- C:0.28MN NA NS EA 935
    rs45891,2
    C,F,O,A,H--134378400(+) ACTTTT/GCTCTG 2 -- ut31 ese38Minor allele frequency- G:0.31MN NS EA NA 700
    rs59781181,2
    C,F,H--134378491(+) AATCAG/TTTTTG 2 -- ut316Minor allele frequency- T:0.03NS NA WA 768
    rs1417576131,2
    --134378539(+) ATAGGG/TTTGTA 2 -- ut310--------
    rs142411,2
    C,F,H--134378595(+) TATGGC/TACCAG 2 -- ut319Minor allele frequency- T:0.32MN NS EA NA 795
    rs73580171,2
    C,H--134378790(+) CCCTAG/AGCCTG 2 -- ut316Minor allele frequency- A:0.00NS EA NA 424
    rs1914816451,2
    --134378809(+) TTCAGA/TCCTTC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF75D (134382867 - 134478012 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZNF75D:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv469871CNV Loss16826518
    nsv7104CNV Loss18451855
    dgv2476e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): ZNF75D
    Locus Specific Mutation Databases (LSDB): ZNF75D

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 314997    OMIM disorders: --


    Find genes that share disorders with ZNF75D           About GenesLikeMe

    Genetic Association Database (GAD): ZNF75D

    Export disorders for ZNF75D gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF75D gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with ZNF75D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a zinc finger motif (ZNF75) mapping on chromosome Xq26. (PubMed id 1505955)1, 2, 3 Villa A.... Vezzoni P. (Genomics 1992)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. ZNF75: isolation of a cDNA clone of the KRAB zinc finger gene subfamily mapped in YACs 1 Mb telomeric of HPRT. (PubMed id 8288223)1, 2 Villa A.... Vezzoni P. (Genomics 1993)
    4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    6. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PubMed id 17903292)4 Hwang S.J....Fox C.S. (BMC Med. Genet. 2007)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (Nature 2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7626 HGNC: 13145 AceView: ZNF75 Ensembl:ENSG00000186376 euGenes: HUgn7626
    ECgene: ZNF75D H-InvDB: ZNF75D

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF75D Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF75D gene:
    Search GeneIP for patents involving ZNF75D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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