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Aliases for ZNF75D Gene

Aliases for ZNF75D Gene

  • Zinc Finger Protein 75D 2 3 5
  • Zinc Finger Protein 82 3 4
  • Zinc Finger Protein 75 3 4
  • ZNF75 3 4
  • ZNF82 3 4
  • Zinc Finger Protein 75 (D8C6) 2
  • ZKSCAN24 3
  • ZSCAN28 3
  • D8C6 3

External Ids for ZNF75D Gene

Previous HGNC Symbols for ZNF75D Gene

  • ZNF82
  • ZNF75

Previous GeneCards Identifiers for ZNF75D Gene

  • GC0XM134248
  • GC0XM134384
  • GC0XM123779

Summaries for ZNF75D Gene

Entrez Gene Summary for ZNF75D Gene

  • This gene encodes a protein that likely functions as a transcription factor. The protein, which belongs to the ZNF75 family, includes an N-terminal SCAN domain, a KRAB box, and five C2H2-type zinc finger motifs. Another functional gene belonging to this family is located on chromosome 16, while pseudogenes have been identified on chromosomes 11 and 12. Alternative splicing results in multiple transcripts variants. [provided by RefSeq, Jun 2010]

GeneCards Summary for ZNF75D Gene

ZNF75D (Zinc Finger Protein 75D) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF75A.

UniProtKB/Swiss-Prot for ZNF75D Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF75D Gene

Genomics for ZNF75D Gene

Regulatory Elements for ZNF75D Gene

Enhancers for ZNF75D Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF75D on UCSC Golden Path with GeneCards custom track

Promoters for ZNF75D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF75D on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF75D Gene

135,248,589 bp from pter
135,344,618 bp from pter
96,030 bases
Minus strand

Genomic View for ZNF75D Gene

Genes around ZNF75D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF75D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF75D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF75D Gene

Proteins for ZNF75D Gene

  • Protein details for ZNF75D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 75D
    Protein Accession:
    Secondary Accessions:
    • A6NK62
    • B3KRI7
    • Q5JPG0
    • Q6LDE0

    Protein attributes for ZNF75D Gene

    510 amino acids
    Molecular mass:
    59298 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF75D Gene


neXtProt entry for ZNF75D Gene

Proteomics data for ZNF75D Gene at MOPED

Post-translational modifications for ZNF75D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF75D Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for ZNF75

No data available for DME Specific Peptides for ZNF75D Gene

Domains & Families for ZNF75D Gene

Gene Families for ZNF75D Gene

Suggested Antigen Peptide Sequences for ZNF75D Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 5 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Contains 1 SCAN box domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF75D: view

Function for ZNF75D Gene

Molecular function for ZNF75D Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes for ZNF75D Gene

genes like me logo Genes that share phenotypes with ZNF75D: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF75D Gene

Localization for ZNF75D Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF75D Gene

Subcellular locations from

Jensen Localization Image for ZNF75D Gene COMPARTMENTS Subcellular localization image for ZNF75D gene
Compartment Confidence
nucleus 5
golgi apparatus 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF75D Gene

Pathways & Interactions for ZNF75D Gene

SuperPathways for ZNF75D Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF75D: view

Pathways by source for ZNF75D Gene

2 Reactome pathways for ZNF75D Gene

Interacting Proteins for ZNF75D Gene

Gene Ontology (GO) - Biological Process for ZNF75D Gene


No data available for SIGNOR curated interactions for ZNF75D Gene

Drugs & Compounds for ZNF75D Gene

(1) Drugs for ZNF75D Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 2102
genes like me logo Genes that share compounds with ZNF75D: view

Transcripts for ZNF75D Gene

Unigene Clusters for ZNF75D Gene

Zinc finger protein 75D:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF75D Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b
SP1: - - -
SP2: - - - -
SP3: - -

Relevant External Links for ZNF75D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF75D Gene

mRNA expression in normal human tissues for ZNF75D Gene

Protein differential expression in normal tissues from HIPED for ZNF75D Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF75D Gene

SOURCE GeneReport for Unigene cluster for ZNF75D Gene Hs.533540

genes like me logo Genes that share expression patterns with ZNF75D: view

Protein tissue co-expression partners for ZNF75D Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF75D Gene

Orthologs for ZNF75D Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF75D Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF75D 35
  • 83.47 (n)
  • 70.95 (a)
-- 36
  • 62 (a)
-- 36
  • 57 (a)
ZNF75 36
  • 61 (a)
ZNF75D 36
  • 69 (a)
(Canis familiaris)
Mammalia ZNF75D 35
  • 87.1 (n)
  • 76.82 (a)
ZNF75D 36
  • 71 (a)
(Pan troglodytes)
Mammalia ZNF75D 35
  • 99.74 (n)
  • 99.41 (a)
ZNF75D 36
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 38 (a)
Species with no ortholog for ZNF75D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF75D Gene

Gene Tree for ZNF75D (if available)
Gene Tree for ZNF75D (if available)

Paralogs for ZNF75D Gene

Paralogs for ZNF75D Gene Pseudogenes for ZNF75D Gene

genes like me logo Genes that share paralogs with ZNF75D: view

Variants for ZNF75D Gene

Sequence variations from dbSNP and Humsavar for ZNF75D Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs4589 -- 135,286,096(+) ACTTT(G/T)CTCTG intron-variant, utr-variant-3-prime
rs7042 -- 135,286,075(+) TCACT(C/G)TGAGC intron-variant, utr-variant-3-prime
rs14241 -- 135,286,291(+) TATGG(C/T)ACCAG intron-variant, utr-variant-3-prime
rs726546 -- 135,338,261(+) CAGAA(A/T)TGTCT intron-variant
rs884165 -- 135,324,813(-) TGTAC(C/T)GTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF75D Gene

Variant ID Type Subtype PubMed ID
dgv2476e1 CNV Complex 17122850
nsv7104 CNV Loss 18451855
nsv469871 CNV Loss 16826518

Variation tolerance for ZNF75D Gene

Residual Variation Intolerance Score: 49.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 9.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF75D Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF75D Gene

Disorders for ZNF75D Gene

Relevant External Links for ZNF75D

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF75D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF75D Gene

Publications for ZNF75D Gene

  1. Isolation of a zinc finger motif (ZNF75) mapping on chromosome Xq26. (PMID: 1505955) Villa A. … Vezzoni P. (Genomics 1992) 2 3 4 67
  2. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZNF75D Gene

Sources for ZNF75D Gene