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ZNF75A Gene

protein-coding   GIFtS: 48
GCID: GC16P003355

Zinc Finger Protein 75a

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 75a1 2

External Ids:    HGNC: 131461   Entrez Gene: 76272   Ensembl: ENSG000001620867   OMIM: 6014735   UniProtKB: Q96N203   

Export aliases for ZNF75A gene to outside databases

Previous GC identifers: GC16U990066 GC16P003389 GC16P003295 GC16P003325


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF75A Gene:
ZNF75A (zinc finger protein 75a) is a protein-coding gene. An important paralog of this gene is ZNF75D.

UniProtKB/Swiss-Prot: ZN75A_HUMAN, Q96N20
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010393.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF75A gene promoter:
         MZF-1   Ik-2   Meis-1a   FOXL1   GATA-1   Meis-1   Meis-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF75A promoter sequence
   Search Chromatin IP Primers for ZNF75A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF75A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.11

ZNF75A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF75A gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P003355:  view genomic region     (about GC identifiers)

Start:
3,355,406 bp from pter      End:
3,368,852 bp from pter
Size:
13,447 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN75A_HUMAN, Q96N20 (See protein sequence)
Recommended Name: Zinc finger protein 75A  
Size: 296 amino acids; 34694 Da
Secondary accessions: Q0VDI8 Q92669

Explore the universe of human proteins at neXtProt for ZNF75A: NX_Q96N20

Explore proteomics data for ZNF75A at MOPED


See ZNF75A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_694573.1  
ENSEMBL proteins: 
 ENSP00000459566   ENSP00000459707  
Reactome Protein details: Q96N20

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ZNF: Zinc fingers, C2H2-type

4 InterPro protein domains:
 IPR001909 Krueppel-associated_box
 IPR015880 Znf_C2H2-like
 IPR013087 Znf_C2H2/integrase_DNA-bd
 IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q96N20

ProtoNet protein and cluster: Q96N20

2 Blocks protein domains:
IPB001909 KRAB box
IPB007086 C2H2-type zinc finger signature


UniProtKB/Swiss-Prot: ZN75A_HUMAN, Q96N20
Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
Similarity: Contains 5 C2H2-type zinc fingers
Similarity: Contains 1 KRAB domain


Find genes that share domains with ZNF75A           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ZN75A_HUMAN, Q96N20
Function: May be involved in transcriptional regulation

     Genatlas biochemistry entry for ZNF75A:
zinc finger protein 75,related sequence A

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003674molecular_function ND--
GO:0003676nucleic acid binding ----
GO:0003677DNA binding IEA--
GO:0046872metal ion binding IEA--
     
Find genes that share ontologies with ZNF75A           About GenesLikeMe


Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for ZNF75A

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ZN75A_HUMAN, Q96N20: Nucleus (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular ----
GO:0005634nucleus IEA--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ZNF75A About    
See pathways by source

SuperPathContained pathways About
1Gene Expression
Generic Transcription Pathway0.40
Gene Expression0.40


Find genes that share SuperPaths with ZNF75A           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for ZNF75A
    Generic Transcription Pathway


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Interactions:

    Search GeneGlobe Interaction Network for ZNF75A

Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated IEA--
GO:0008150biological_process ND--

Find genes that share ontologies with ZNF75A           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for ZNF75A (ZN75A)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ZNF75A gene: 
NM_153028.2  

Unigene Cluster for ZNF75A:

Zinc finger protein 75a
Hs.513292  [show with all ESTs]
Unigene Representative Sequence: AK093979
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000498240(uc002cuv.4) ENST00000575234 ENST00000574298(uc002cut.4)
ENST00000571101 ENST00000575812 ENST00000573828 ENST00000572999 ENST00000575253

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hsa-miR-33a*
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Inhib. RNA
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Additional mRNA sequence: 

AK056091.1 AK093979.1 BC119652.1 BC119653.1 CR749782.1 

11 DOTS entries:

DT.413448  DT.120672483  DT.100745633  DT.40113378  DT.204411  DT.120672458  DT.100717723  DT.120672488 
DT.92417086  DT.95203949  DT.120672495 

Selected AceView cDNA sequences (see all 91):

BX101232 AA969310 AA829635 AI745304 AA884695 CA413716 CR749782 AX748391 
BM746950 R85696 BU101946 BE208132 AK093979 AA423932 AW628313 AI648586 
BC051366 AI572250 AI313421 BU145762 AA279687 AI263181 BV186604 BG943048 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF75A (see all 9)    About this scheme

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
SP1:                          -     -     -     -     -     -                                   -                           
SP2:                          -     -     -     -     -     -                       -     -     -                           
SP3:                                            -     -     -                       -     -     -                           
SP4:                                            -     -     -                                                               
SP5:                                            -     -     -                                                               


ECgene alternative splicing isoforms for ZNF75A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZNF75A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GAATATATAT
ZNF75A Expression
About this image

ZNF75A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ZNF75A Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.513292
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of mammals.

Orthologs for ZNF75A gene from Selected species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia ZNF75A1 zinc finger protein 75a 89.94(n)
88.47(a)
  100687710  XM_003434814.2  XP_003434862.2 


ENSEMBL Gene Tree for ZNF75A (if available)
TreeFam Gene Tree for ZNF75A (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ZNF75A gene
ZNF75D2  
Selected SIMAP similar genes for ZNF75A using alignment to 2 protein entries:     ZN75A_HUMAN (see all proteins) (see all similar genes):
DKFZp686A1965    ZNF471    ZNF627    ZNF229    ZNF528    DKFZp547L155
LOC101928664    ZNF16    ZNF677    ZNF616    ZNF607    ZNF83
ZNF320    ZNF793    ZNF415    ZNF212    ZNF688    ZNF761

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZNF75A (see all 316)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0355704
A breast cancer sample4--see VAR_0355702 Q E mis40--------
rs1926605511,2
--3357450(+) CTCACC/TGTCTC 1 -- int10--------
rs797287581,2
C,F--3357598(+) CTGCAA/TCCTTG 1 -- int12Minor allele frequency- T:0.14WA 120
rs779060121,2
C,F--3357620(+) TCAGGC/TGACTC 1 -- int14Minor allele frequency- T:0.21WA CSA 123
rs1432292731,2
--3357628(+) CTCTCC/TCACCT 1 -- int10--------
rs2015708341,2
C--3357680(+) GGCTA-/TTTTTT 1 -- int10--------
rs727744971,2
C--3357694(+) TTTTTT/CTTCAA 1 -- int12Minor allele frequency- C:0.00CSA 2
rs2007574241,2
--3357694(+) TTTTT-/CTTCAA 1 -- int10--------
rs1152071011,2
C,F--3357728(+) GTCTCG/ACTATG 1 -- int11Minor allele frequency- A:0.03WA 118
rs1483059131,2
--3357782(+) ACCTCC/GGTCTC 1 -- int10--------

HapMap Linkage Disequilibrium report for ZNF75A (3355406 - 3368852 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for ZNF75A:    About this table    
Variant IDTypeSubtypePubMed ID
dgv2583n71CNV Loss21882294
nsv905212CNV Gain21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 601473    OMIM disorders: --


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Genetic Association Database (GAD): ZNF75A

Export disorders for ZNF75A gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ZNF75A gene integrated from 10 sources:
(articles sorted by number of sources associating them with ZNF75A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The ZNF75 zinc finger gene subfamily: isolation and mapping of the four members in humans and great apes. (PubMed id 8661144)1, 2, 3 Villa A.... Vezzoni P. (Genomics 1996)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
  5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
  6. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
  7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7627 HGNC: 13146 AceView: OR2C1andZNF75A Ensembl:ENSG00000162086 euGenes: HUgn7627
ECgene: ZNF75A H-InvDB: ZNF75A

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ZNF75A Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ZNF75A gene:
Search GeneIP for patents involving ZNF75A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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