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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF75A Gene

protein-coding GIFtS: 45
GCID: GC16P003355

zinc finger protein 75a

Search for ZNF75A
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger Protein 75a¹ ²
FLJ31529¹

External Ids:	HGNC: 13146¹	Entrez Gene: 7627²	Ensembl: ENSG00000162086⁷	OMIM: 601473⁵	UniProtKB: Q96N20³

Export aliases for ZNF75A gene to outside databases

Previous GC identifers: GC16U990066 GC16P003389 GC16P003295 GC16P003325

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN75A_HUMAN, Q96N20

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF75A gene promoter:
MZF-1 Ik-2 Meis-1a FOXL1 GATA-1 Meis-1 Meis-1b
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF75A promoter sequence

Search SABiosciences Chromatin IP Primers for ZNF75A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF75A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.11

ZNF75A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF75A gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P003355: view genomic region (about GC identifiers)

Start:	3,355,406 bp from pter	End:	3,368,852 bp from pter
Size:	13,447 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN75A_HUMAN, Q96N20 (See protein sequence)

Recommended Name: Zinc finger protein 75A

Size: 296 amino acids; 34694 Da

Subcellular location: Nucleus (Potential)

Secondary accessions: Q0VDI8 Q92669

Explore the universe of human proteins at neXtProt for ZNF75A: NX_Q96N20

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96N20

ZNF75A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_694573.1

ENSEMBL proteins:

ENSP00000459566 ENSP00000293995 ENSP00000460317 ENSP00000459707

Reactome Protein details: Q96N20
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	Uscn Proteins for ZNF75A

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IEA	--

ZNF75A for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF75A for domains About GeneDecksing

4 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR001909 Krueppel-associated_box

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q96N20

ProtoNet protein and cluster: Q96N20

2 Blocks protein families:

IPB001909 KRAB box

IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: ZN75A_HUMAN, Q96N20

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 5 C2H2-type zinc fingers

Similarity: Contains 1 KRAB domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZN75A_HUMAN, Q96N20

Function: May be involved in transcriptional regulation

Genatlas biochemistry entry for ZNF75A:

zinc finger protein 75,related sequence A

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In Situ Assay
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Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZNF75A for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Generic Transcription Pathway

Generic Transcription Pathway

1.00

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Reactome Pathways for ZNF75A

	Generic Transcription Pathway
	Gene Expression

ZNF75A for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF75A

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0008150	biological_process	ND	--

ZNF75A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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Browse Tocris compounds for ZNF75A
Search CenterWatch for drugs/clinical trials and news about ZNF75A / ZN75A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for ZNF75A gene:

NM_153028.2

Unigene Cluster for ZNF75A:

Zinc finger protein 75a

Hs.513292 [show with all ESTs]

Unigene Representative Sequence: AK093979

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000498240(uc002cuv.4) ENST00000575234 ENST00000574298(uc002cut.4)

ENST00000293995 ENST00000571101 ENST00000573594 ENST00000575812 ENST00000573828

ENST00000572999 ENST00000575253

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Additional cDNA sequence:

AK056091.1 AK093979.1 BC119652.1 BC119653.1 CR749782.1

11 DOTS entries:

DT.413448 DT.120672483 DT.100745633 DT.40113378 DT.204411 DT.120672458 DT.100717723 DT.92417086

DT.95203949 DT.120672488 DT.120672495

24/91 AceView cDNA sequences (see all 91):

AX748391 BU101946 CA413716 AA829635 AI572250 AI313421 CR749782 AI648586

AI745304 AK093979 AA884695 AW628313 AA423932 AA969310 BX101232 AI263181

AA279687 R85696 BM746950 BC051366 BU145762 BE208132 BI836429 H88041

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF75A (see all 9) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	·	2c	·	2d	^	3	^	4a	·	4b	·	4c	^	5	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	·	8c
SP1:									-		-		-		-		-		-												-
SP2:									-		-		-		-		-		-								-		-		-
SP3:															-		-		-								-		-		-
SP4:															-		-		-
SP5:															-		-		-

ECgene alternative splicing isoforms for ZNF75A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF75A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAATATATAT

About this image
See ZNF75A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF75A

SOURCE GeneReport for Unigene cluster: Hs.513292

SABiosciences Custom PCR Arrays for ZNF75A

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ZNF75A gene from 2/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	-- REPIN1⁶ (see all 3)	--	32(a) 30(a) (see all 3)	many ↔ many many ↔ many (see all 3)	AAWZ02040501(4060-6499) AAWZ02039384(4666-5910)
fruit fly (Drosophila melanogaster)	Insecta	CG1832⁶ CG3407⁶	--	15(a) 11(a)	many ↔ many many ↔ many	2L(22165720-22169143) 2L(3810799-3813407)

ENSEMBL Gene Tree for ZNF75A (if available)
TreeFam Gene Tree for ZNF75A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF75A gene

ZNF75D²

18/501 SIMAP similar genes for ZNF75A using alignment to 4 protein entries: ZN75A_HUMAN (see all proteins) (see all similar genes):

DKFZp686A1965 ZNF471 ZNF229 ZNF761 ZNF667 DKFZp547L155

ZNF16 ZNF607 ZNF573 DKFZp451F083 ZNF230 ZNF75D

ZNF793 ZNF195 ZNF212 ZNF267 ZNF383 ZNF818P

ZNF75A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs114753618^1,2	F,	--	3353474(+)	`ATCTTA/TATGCT`	2	--	us2k¹ int¹		1		WA	118
rs189375487^1,2		--	3353592(+)	`AATTCA/CAGTGA`	2	--	int¹ us2k¹		0	--	--	--	--
rs115122676^1,2	F,	--	3353845(+)	`TTTTGT/CTTTTT`	2	--	int¹ us2k¹		1		WA	118
rs2680232^1,2	C,A,H	--	3353901(+)	`gaactC/CG /G/GAggctc`	2	--	us2k¹ int¹		0	--	--	--	--
rs77490617^1,2		--	3353901(+)	`GAACTG/CGGCTC`	2	--	int¹ us2k¹		1		NA	2
rs2524313^1,2	F,A,	--	3353902(+)	`AACTCG/AGCTCA`	2	--	int¹ us2k¹		2		NA	4
rs185029733^1,2		--	3354003(+)	`AATTTG/TTTTTT`	2	--	us2k¹ int¹		0	--	--	--	--
rs189401493^1,2		--	3354125(+)	`GCCACC/TGCGCC`	2	--	us2k¹ int¹		0	--	--	--	--
rs74482707^1,2	C,F,	--	3354207(+)	`AAACTC/TGTTTT`	2	--	us2k¹ int¹		1		WA	118
rs8182183^1,2	C	--	3354234(+)	`TTCCTC/ATAAAT`	2	--	int¹ us2k¹ trp³		2		NA	4

HapMap Linkage Disequilibrium report for ZNF75A (3355406 - 3368852 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF75A: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZNF75A for disorders About MalaCards

ZNF75A for disorders About GeneDecksing

OMIM gene information: 601473 OMIM disorders: --

Export disorders for ZNF75A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF75A gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF75A)

Utopia: connect your pdf to the dynamic
world of online information

The ZNF75 zinc finger gene subfamily: isolation and mapping of the four members in humans and great apes. (PubMed id 8661144)^{1, 2, 3} Villa A.... Vezzoni P. (1996)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)² Sjoeblom T.... Velculescu V.E. (2006)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7627	HGNC: 13146	AceView: OR2C1andZNF75A	Ensembl:ENSG00000162086	euGenes: HUgn7627
ECgene: ZNF75A	H-InvDB: ZNF75A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF75A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF75A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF75A gene:
Search GeneIP for patents involving ZNF75A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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ZNF75A Gene

zinc finger protein 75a

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ZNF75A Gene

zinc finger protein 75a

Aliasesfor ZNF75A gene

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