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Aliases for ZNF75A Gene

Aliases for ZNF75A Gene

  • Zinc Finger Protein 75a 2 3 5

External Ids for ZNF75A Gene

Previous GeneCards Identifiers for ZNF75A Gene

  • GC16U990066
  • GC16P003389
  • GC16P003355
  • GC16P003295
  • GC16P003325
  • GC16P003306
  • GC16P003318

Summaries for ZNF75A Gene

GeneCards Summary for ZNF75A Gene

ZNF75A (Zinc Finger Protein 75a) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF75D.

UniProtKB/Swiss-Prot for ZNF75A Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF75A Gene

Genomics for ZNF75A Gene

Regulatory Elements for ZNF75A Gene

Enhancers for ZNF75A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F003266 0.4 Ensembl 29.3 -38.4 -38406 0.4 GATAD2A CTCF CBX3 PKNOX1 MAX ZNF644 ZNF2 RAD21 TEAD3 ADNP ZNF75A ZNF200 TIGD7 NAA60 ZNF597 ZNF174 ZSCAN32 OR2C1 ZNF263 ENSG00000279330
GH16F003304 0.4 ENCODE 18.2 +0.0 4 2.0 HDGF PKNOX1 ATF1 CREB3L1 SIN3A ZNF2 ETS1 YY1 ELK1 CBX5 ZNF75A CREBBP ZNF263 LOC105371055 ZNF597 THOC6 MEFV ENSG00000262899 GC16P003350
GH16F003281 0.6 ENCODE 17.5 -21.8 -21825 3.6 HDGF PKNOX1 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF75A MMP25 ENSG00000279031 ENSG00000279330
GH16F003262 0.5 ENCODE 16.3 -41.5 -41499 2.9 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF143 FOS CREBBP THOC6 LOC105371055 ZNF597 ZNF75A RNPS1 ZNF205 PDPK2P ZNF263 MTCO1P28
GH16F003254 1.4 FANTOM5 Ensembl ENCODE 13.8 -48.0 -48009 6.8 HDGF ATF1 PKNOX1 CREB3L1 SIN3A ZNF2 YY1 ZNF766 ELK1 CBX5 MEFV MMP25 ZNF263 CREBBP ZNF75A LOC105371055 ZNF597 ZNF200 THOC6 OR2C1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF75A on UCSC Golden Path with GeneCards custom track

Promoters for ZNF75A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001503122 -5 2399 HDGF PKNOX1 ATF1 CREB3L1 SIN3A ZNF2 ETS1 YY1 ELK1 CBX5

Genomic Location for ZNF75A Gene

Chromosome:
16
Start:
3,305,406 bp from pter
End:
3,318,852 bp from pter
Size:
13,447 bases
Orientation:
Plus strand

Genomic View for ZNF75A Gene

Genes around ZNF75A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF75A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF75A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF75A Gene

Proteins for ZNF75A Gene

  • Protein details for ZNF75A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96N20-ZN75A_HUMAN
    Recommended name:
    Zinc finger protein 75A
    Protein Accession:
    Q96N20
    Secondary Accessions:
    • Q0VDI8
    • Q92669

    Protein attributes for ZNF75A Gene

    Size:
    296 amino acids
    Molecular mass:
    34694 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF75A Gene

Post-translational modifications for ZNF75A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF75A Gene

Domains & Families for ZNF75A Gene

Gene Families for ZNF75A Gene

Suggested Antigen Peptide Sequences for ZNF75A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96N20

UniProtKB/Swiss-Prot:

ZN75A_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 5 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF75A: view

Function for ZNF75A Gene

Molecular function for ZNF75A Gene

GENATLAS Biochemistry:
zinc finger protein 75,related sequence A
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF75A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF75A: view
genes like me logo Genes that share phenotypes with ZNF75A: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF75A Gene

Localization for ZNF75A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF75A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF75A Gene COMPARTMENTS Subcellular localization image for ZNF75A gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF75A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF75A: view

Pathways & Interactions for ZNF75A Gene

SuperPathways for ZNF75A Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF75A: view

Pathways by source for ZNF75A Gene

2 Reactome pathways for ZNF75A Gene

Interacting Proteins for ZNF75A Gene

Gene Ontology (GO) - Biological Process for ZNF75A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZNF75A: view

No data available for SIGNOR curated interactions for ZNF75A Gene

Transcripts for ZNF75A Gene

Unigene Clusters for ZNF75A Gene

Zinc finger protein 75a:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF75A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - -
SP4: - - -
SP5: - - -
SP6:
SP7:
SP8:
SP9: -

Relevant External Links for ZNF75A Gene

GeneLoc Exon Structure for
ZNF75A
ECgene alternative splicing isoforms for
ZNF75A

Expression for ZNF75A Gene

mRNA expression in normal human tissues for ZNF75A Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF75A Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF75A Gene:

ZNF75A

SOURCE GeneReport for Unigene cluster for ZNF75A Gene:

Hs.513292
genes like me logo Genes that share expression patterns with ZNF75A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF75A Gene

Orthologs for ZNF75A Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF75A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF75A 34 35
  • 99.21 (n)
dog
(Canis familiaris)
Mammalia ZNF75A 34
  • 89.94 (n)
-- 35
  • 50 (a)
OneToMany
-- 35
  • 49 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ZNF75A 34 35
  • 88.36 (n)
-- 35
  • 53 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ZNF75A 35
  • 34 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 4 (a)
OneToMany
Species where no ortholog for ZNF75A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF75A Gene

ENSEMBL:
Gene Tree for ZNF75A (if available)
TreeFam:
Gene Tree for ZNF75A (if available)

Paralogs for ZNF75A Gene

Paralogs for ZNF75A Gene

(445) SIMAP similar genes for ZNF75A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF75A: view

Variants for ZNF75A Gene

Sequence variations from dbSNP and Humsavar for ZNF75A Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_035570 A breast cancer sample
rs111249127 -- 3,306,941(+) CATAA(A/G)TTTTA intron-variant, upstream-variant-2KB
rs111252204 -- 3,319,403(+) AGCCA(C/T)TGTGC intron-variant, utr-variant-3-prime
rs111333503 -- 3,307,866(+) TCACA(A/G)GAGGA intron-variant, upstream-variant-2KB
rs111333926 -- 3,311,250(+) TTGAC(C/G)AACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF75A Gene

Variant ID Type Subtype PubMed ID
nsv1036149 CNV gain 25217958
nsv1044147 CNV loss 25217958

Variation tolerance for ZNF75A Gene

Residual Variation Intolerance Score: 22.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF75A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF75A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF75A Gene

Disorders for ZNF75A Gene

Relevant External Links for ZNF75A

Genetic Association Database (GAD)
ZNF75A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF75A

No disorders were found for ZNF75A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF75A Gene

Publications for ZNF75A Gene

  1. The ZNF75 zinc finger gene subfamily: isolation and mapping of the four members in humans and great apes. (PMID: 8661144) Villa A. … Vezzoni P. (Genomics 1996) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 64

Products for ZNF75A Gene

Sources for ZNF75A Gene

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