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Aliases for ZNF749 Gene

Aliases for ZNF749 Gene

  • Zinc Finger Protein 749 2 3 5

External Ids for ZNF749 Gene

Previous GeneCards Identifiers for ZNF749 Gene

  • GC19P062646
  • GC19P057946
  • GC19P054263

Summaries for ZNF749 Gene

GeneCards Summary for ZNF749 Gene

ZNF749 (Zinc Finger Protein 749) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF17.

UniProtKB/Swiss-Prot for ZNF749 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF749 Gene

Genomics for ZNF749 Gene

Regulatory Elements for ZNF749 Gene

Enhancers for ZNF749 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF749 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ZNF749 gene promoter:

Genomic Location for ZNF749 Gene

57,428,568 bp from pter
57,447,485 bp from pter
18,918 bases
Plus strand

Genomic View for ZNF749 Gene

Genes around ZNF749 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF749 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF749 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF749 Gene

Proteins for ZNF749 Gene

  • Protein details for ZNF749 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 749
    Protein Accession:

    Protein attributes for ZNF749 Gene

    778 amino acids
    Molecular mass:
    90364 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAB97932.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for ZNF749 Gene

Proteomics data for ZNF749 Gene at MOPED

Post-translational modifications for ZNF749 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF749 Gene

No data available for DME Specific Peptides for ZNF749 Gene

Domains & Families for ZNF749 Gene

Gene Families for ZNF749 Gene

Protein Domains for ZNF749 Gene

Suggested Antigen Peptide Sequences for ZNF749 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 19 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 19 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF749: view

Function for ZNF749 Gene

Molecular function for ZNF749 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF749: view

Animal Model Products

CRISPR Products

miRNA for ZNF749 Gene

miRTarBase miRNAs that target ZNF749

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF749 Gene

Localization for ZNF749 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF749 Gene

Subcellular locations from

Jensen Localization Image for ZNF749 Gene COMPARTMENTS Subcellular localization image for ZNF749 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF749 Gene

Pathways & Interactions for ZNF749 Gene

SuperPathways for ZNF749 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF749: view

Pathways by source for ZNF749 Gene

2 Reactome pathways for ZNF749 Gene

Interacting Proteins for ZNF749 Gene

Gene Ontology (GO) - Biological Process for ZNF749 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF749: view

No data available for SIGNOR curated interactions for ZNF749 Gene

Drugs & Compounds for ZNF749 Gene

No Compound Related Data Available

Transcripts for ZNF749 Gene

Unigene Clusters for ZNF749 Gene

Zinc finger protein 749:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF749 Gene

No ASD Table

Relevant External Links for ZNF749 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF749 Gene

mRNA expression in normal human tissues for ZNF749 Gene

SOURCE GeneReport for Unigene cluster for ZNF749 Gene Hs.467358

genes like me logo Genes that share expression patterns with ZNF749: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF749 Gene

Orthologs for ZNF749 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF749 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF749 35
  • 98 (n)
  • 97.28 (a)
(Bos Taurus)
Mammalia -- 36
  • 45 (a)
Species with no ortholog for ZNF749:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF749 Gene

Gene Tree for ZNF749 (if available)
Gene Tree for ZNF749 (if available)

Paralogs for ZNF749 Gene

(375) SIMAP similar genes for ZNF749 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF749: view

Variants for ZNF749 Gene

Sequence variations from dbSNP and Humsavar for ZNF749 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12986235 - 57,443,876(+) ATATC(A/G)GCAAA reference, missense
rs2240038 - 57,444,361(+) TTCAT(A/G)CTGGC reference, missense
rs7246856 - 57,445,460(+) TCAGA(G/T)AATTC reference, missense
rs7258248 -- 57,444,860(+) TCATC(C/T)AGATG reference, missense
rs7260039 -- 57,427,574(+) TGGGG(A/G)GGTGG upstream-variant-2KB

Variation tolerance for ZNF749 Gene

Residual Variation Intolerance Score: 67.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.06; 75.25% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ZNF749 Gene

Disorders for ZNF749 Gene

Relevant External Links for ZNF749

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF749 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF749 Gene

Publications for ZNF749 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 67
  2. Distinct class of putative "non-conserved" promoters in humans: comparative studies of alternative promoters of human and mouse genes. (PMID: 17567985) Tsuritani K. … Suzuki Y. (Genome Res. 2007) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ZNF749 Gene

Sources for ZNF749 Gene