ZNF749 Gene
protein-coding GIFtS: 40
GCID: GC19P057946
|
|
zinc finger protein 749
| |
Aliases
for ZNF749 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 7491 2 | | FLJ163601 |
Export aliases for ZNF749 gene to outside databasesPrevious GC identifers: GC19P062646 GC19P054263 |
Summaries
for ZNF749 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN749_HUMAN, O43361Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF749 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF749 gene promoter:
HTF XBP-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF749
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF749 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.43 Ensembl cytogenetic band: 19q13.43 HGNC cytogenetic band: 19q13.43ZNF749 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P057946: view genomic region
(about GC identifiers)
Start:
|
57,946,693 bp from pter |
End:
|
57,957,191 bp from pter |
Size:
|
10,499 bases |
Orientation:
|
plus strand |
|
Proteins
for ZNF749 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN749_HUMAN, O43361 (See
protein sequence)Recommended Name: Zinc finger protein 749 Size: 778 amino acids; 90364 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAB97932.1; Type=Erroneous gene model prediction;Explore the universe of human proteins at neXtProt for ZNF749: NX_O43361
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O43361
ZNF749 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001018855.2
ENSEMBL proteins: ENSP00000333980 ENSP00000397745 Reactome Protein details: O43361
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZNF749 for ontologies About GeneDecksing
ZNF749 Antibody Products:
Assay Products for ZNF749: |
Protein
Domains /
Families
for ZNF749 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF749 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O43361ProtoNet protein and cluster: O43361 1 Blocks protein family: IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZN749_HUMAN, O43361Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 19 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF749 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN749_HUMAN, O43361Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF749
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF749
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF749 (NM_001023561) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF749 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZNF749 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF749 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZNF749 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF749 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF749
ZNF749 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF749
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF749 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF749 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF749
Search CenterWatch for drugs/clinical trials and news about ZNF749 / ZN749
|
Transcripts
for ZNF749 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF749 gene: NM_001023561.2 Unigene Cluster for ZNF749: Zinc finger protein 749 Hs.467358 [show with all ESTs]Unigene Representative Sequence: NM_0010235612 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000334181(uc002qoq.2) ENST00000415248
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF749
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF749
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF749 (NM_001023561) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF749 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZNF749 |
Additional cDNA sequence: AF021946.1 AK122740.1 AK122794.1 1 DOTS entry: DT.91713131 24/93 AceView cDNA sequences (see all 93): AA335875 BE045934 N67859 BE892698 AI125173 CR601614 AK026886 NM_024691 AI279074 AW594524 BU155438 AA447637 BF312592 AK122794 BF512550 BF110540 BE261125 AI301017 AI350944 CB161375 AA906574 BG391293 AA530978 BP336834
GeneLoc Exon Structure
|
Expression
for ZNF749 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF749 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAAAATCCA
About this image
See ZNF749 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF749
SOURCE GeneReport for Unigene cluster: Hs.467358
SABiosciences Custom PCR Arrays for ZNF749
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF749
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF749 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF749 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF749 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF749 |
Orthologs
for ZNF749 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZNF749 (if available)
TreeFam Gene Tree for ZNF749 (if available) |
Paralogs
for ZNF749 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF749 gene
- ZNF5492 ZNF2112 ZNF4172 ZNF7922 ZNF5512 ZNF7762 ZNF5472 ZNF172
- ZNF4162 ZNF5482 ZNF3042 ZNF587B2 ZNF7732 ZNF1322 ZIK12 ZNF1342
- ZNF6712 ZNF4182 ZNF2562 ZNF1542 ZNF5522 ZNF7722 ZNF5302 ZNF4192
18/382 SIMAP similar genes for ZNF749 using alignment to 2 protein entries: ZN749_HUMAN (see all proteins)
(see all similar genes):ZNF78L1 ZNF818P kr-znf3 ZFS-5 ZNF232 ZNF55
ZFP41 ZNF697 ZNF702P ZNF17 ZNF22 ZNF
ZNF586 ZFP92 ZNF844 ZNF662 ZNF696 DKFZp313M0722
ZNF749 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF749 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF749 (57946693 - 57957191 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF749: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF749 |
|
Disorders
/ Diseases
for ZNF749 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZNF749 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF749 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF749) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
- Distinct class of putative 'non-conserved' promoters in humans: comparative studies of alternative promoters of human and mouse genes. (PubMed id 17567985)1 Tsuritani K....Suzuki Y. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
|
External Searches for ZNF749 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF749 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF749 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF749 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF749 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF749 gene:
Search GeneIP for patents involving ZNF749
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF749 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF749 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF749 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF749 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF749 | | OriGene 3'-UTR Clone for ZNF749 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF749 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF749 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF749 | | OriGene Custom Protein Services for ZNF749 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF749 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF749 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF749 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF749 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF749 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF749 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for ZNF749 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | ZNF749 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF749 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF749 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZNF749 |
|
|
|
|
