Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF749 Gene

Aliases for ZNF749 Gene

  • Zinc Finger Protein 749 2 3

External Ids for ZNF749 Gene

Previous GeneCards Identifiers for ZNF749 Gene

  • GC19P062646
  • GC19P057946
  • GC19P054263

Summaries for ZNF749 Gene

GeneCards Summary for ZNF749 Gene

ZNF749 (Zinc Finger Protein 749) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF17.

UniProtKB/Swiss-Prot for ZNF749 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF749 Gene

Genomics for ZNF749 Gene

Regulatory Elements for ZNF749 Gene

Transcription factor binding sites by QIAGEN in the ZNF749 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF749 Gene

Start:
57,435,325 bp from pter
End:
57,445,923 bp from pter
Size:
10,599 bases
Orientation:
Plus strand

Genomic View for ZNF749 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF749 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF749 Gene

Proteins for ZNF749 Gene

  • Protein details for ZNF749 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43361-ZN749_HUMAN
    Recommended name:
    Zinc finger protein 749
    Protein Accession:
    O43361
    Secondary Accessions:

    Protein attributes for ZNF749 Gene

    Size:
    778 amino acids
    Molecular mass:
    90364 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB97932.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for ZNF749 Gene

Proteomics data for ZNF749 Gene at MOPED

Post-translational modifications for ZNF749 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF749 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF749 Gene

Domains for ZNF749 Gene

Gene Families for ZNF749 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF749 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43361

UniProtKB/Swiss-Prot:

ZN749_HUMAN :
  • O43361
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 19 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF749: view

Function for ZNF749 Gene

Molecular function for ZNF749 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF749 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF749: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF749 Gene

Localization for ZNF749 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF749 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF749 Gene COMPARTMENTS Subcellular localization image for ZNF749 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF749 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF749: view

Pathways for ZNF749 Gene

SuperPathways for ZNF749 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF749: view

Pathways by source for ZNF749 Gene

2 Reactome pathways for ZNF749 Gene

Interacting Proteins for ZNF749 Gene

Gene Ontology (GO) - Biological Process for ZNF749 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF749: view

Transcripts for ZNF749 Gene

Unigene Clusters for ZNF749 Gene

Zinc finger protein 749:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF749

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZNF749
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF749 Gene

No ASD Table

Relevant External Links for ZNF749 Gene

GeneLoc Exon Structure for
ZNF749
ECgene alternative splicing isoforms for
ZNF749

Expression for ZNF749 Gene

mRNA expression in normal human tissues for ZNF749 Gene

SOURCE GeneReport for Unigene cluster for ZNF749 Gene Hs.467358

genes like me logo Genes that share expressions with ZNF749: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for ZNF749 Gene

Orthologs for ZNF749 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF749 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF749 35
  • 98 (n)
  • 97.28 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 45 (a)
ManyToMany
Species with no ortholog for ZNF749:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF749 Gene

ENSEMBL:
Gene Tree for ZNF749 (if available)
TreeFam:
Gene Tree for ZNF749 (if available)

Paralogs for ZNF749 Gene

Selected SIMAP similar genes for ZNF749 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF749: view

Variants for ZNF749 Gene

Sequence variations from dbSNP and Humsavar for ZNF749 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs726260 -- 57,440,667(-) TCTAA(C/T)GCCTC intron-variant
rs2240037 -- 57,444,351(+) CACCA(A/G)AGAGT synonymous-codon, reference
rs2240038 - 57,444,361(+) TTCAT(A/G)CTGGC missense, reference
rs2240039 -- 57,444,603(+) ACATG(C/T)AGTGA reference, synonymous-codon, intron-variant
rs2240040 -- 57,444,818(+) TTATG(C/T)GTGTA missense, reference

Relevant External Links for ZNF749 Gene

HapMap Linkage Disequilibrium report
ZNF749

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF749 Gene

Disorders for ZNF749 Gene

No disorders were found for ZNF749 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF749 Gene

Publications for ZNF749 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Distinct class of putative "non-conserved" promoters in humans: comparative studies of alternative promoters of human and mouse genes. (PMID: 17567985) Tsuritani K. … Suzuki Y. (Genome Res. 2007) 3
  5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3

Products for ZNF749 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZNF749
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF749
    • Block miRNA regulation of ZNF749 using miScript Target Protectors

    Sources for ZNF749 Gene

    Back to Top

    Content