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Aliases for ZNF749 Gene

Aliases for ZNF749 Gene

  • Zinc Finger Protein 749 2 3 5

External Ids for ZNF749 Gene

Previous GeneCards Identifiers for ZNF749 Gene

  • GC19P062646
  • GC19P057946
  • GC19P054263

Summaries for ZNF749 Gene

GeneCards Summary for ZNF749 Gene

ZNF749 (Zinc Finger Protein 749) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF17.

UniProtKB/Swiss-Prot for ZNF749 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF749 Gene

Genomics for ZNF749 Gene

Regulatory Elements for ZNF749 Gene

Enhancers for ZNF749 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F057681 1.1 ENCODE 20.3 +253.6 253579 1.6 PKNOX1 ATF1 CREB3L1 ARID4B SIN3A GLI4 DMAP1 ETS1 YY1 ELK1 ZNF17 ZNF549 ZNF134 ZNF773 ZNF211 ZNF544 ZNF551 ZNF749 ZNF606 ZNF543
GH19F057809 1.5 FANTOM5 ENCODE 10.8 +384.7 384650 7.2 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF134 ZNF805 ZNF264 TRIM28 ZNF256 ZNF543 ZNF417 ZNF773 ZNF17 ENSG00000269867
GH19F057434 1.1 ENCODE 14.6 +7.0 6968 2.4 PKNOX1 CREB3L1 MLX ARID4B SIN3A ZNF2 YY1 CBX5 ZNF207 ZNF143 ZNF749 ZNF805 ZNF304 RPS5 PIR33363
GH19F057818 1.1 ENCODE 13.7 +391.2 391217 3.3 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 FOS ENSG00000269867 ZNF587 ZNF749 ZNF549 ZNF324 ZNF586 ZNF776 ZNF551 MZF1-AS1 ZNF324B
GH19F057849 1.2 ENCODE 11.2 +422.1 422092 3.0 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ENSG00000269867 LOC105372483 ZNF587 ZNF805 ZNF17 ZNF749 RPS5 ZNF550 ZNF586 ZNF671
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF749 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ZNF749 gene promoter:

Genomic Location for ZNF749 Gene

Chromosome:
19
Start:
57,428,568 bp from pter
End:
57,447,485 bp from pter
Size:
18,918 bases
Orientation:
Plus strand

Genomic View for ZNF749 Gene

Genes around ZNF749 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF749 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF749 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF749 Gene

Proteins for ZNF749 Gene

  • Protein details for ZNF749 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43361-ZN749_HUMAN
    Recommended name:
    Zinc finger protein 749
    Protein Accession:
    O43361

    Protein attributes for ZNF749 Gene

    Size:
    778 amino acids
    Molecular mass:
    90364 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB97932.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for ZNF749 Gene

Post-translational modifications for ZNF749 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF749 Gene

No data available for DME Specific Peptides for ZNF749 Gene

Domains & Families for ZNF749 Gene

Gene Families for ZNF749 Gene

Protein Domains for ZNF749 Gene

Suggested Antigen Peptide Sequences for ZNF749 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43361

UniProtKB/Swiss-Prot:

ZN749_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 19 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 19 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF749: view

Function for ZNF749 Gene

Molecular function for ZNF749 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF749 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF749: view
genes like me logo Genes that share phenotypes with ZNF749: view

Animal Model Products

miRNA for ZNF749 Gene

miRTarBase miRNAs that target ZNF749

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF749 Gene

Localization for ZNF749 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF749 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF749 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF749 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF749: view

Pathways & Interactions for ZNF749 Gene

SuperPathways for ZNF749 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF749: view

Pathways by source for ZNF749 Gene

2 Reactome pathways for ZNF749 Gene

Gene Ontology (GO) - Biological Process for ZNF749 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF749: view

No data available for SIGNOR curated interactions for ZNF749 Gene

Transcripts for ZNF749 Gene

Unigene Clusters for ZNF749 Gene

Zinc finger protein 749:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF749 Gene

No ASD Table

Relevant External Links for ZNF749 Gene

GeneLoc Exon Structure for
ZNF749
ECgene alternative splicing isoforms for
ZNF749

Expression for ZNF749 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF749 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF749 Gene:

ZNF749

SOURCE GeneReport for Unigene cluster for ZNF749 Gene:

Hs.467358
genes like me logo Genes that share expression patterns with ZNF749: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF749 Gene

Orthologs for ZNF749 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF749 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF749 34
  • 98 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 45 (a)
ManyToMany
Species where no ortholog for ZNF749 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF749 Gene

ENSEMBL:
Gene Tree for ZNF749 (if available)
TreeFam:
Gene Tree for ZNF749 (if available)

Paralogs for ZNF749 Gene

(375) SIMAP similar genes for ZNF749 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF749: view

Variants for ZNF749 Gene

Sequence variations from dbSNP and Humsavar for ZNF749 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10084129 -- 57,428,979(+) aatat(C/T)ccatt intron-variant
rs10403000 -- 57,428,441(+) ttttt(G/T)gttta upstream-variant-2KB
rs10408471 -- 57,429,179(+) accaa(A/C)acgcc intron-variant
rs10408717 -- 57,429,364(+) tggct(A/G)ctgtg intron-variant
rs10408747 -- 57,430,604(+) gtcca(A/G)ggttt intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF749 Gene

Variant ID Type Subtype PubMed ID
esv3583608 CNV loss 25503493

Variation tolerance for ZNF749 Gene

Residual Variation Intolerance Score: 67.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.06; 75.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF749 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF749

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF749 Gene

Disorders for ZNF749 Gene

Relevant External Links for ZNF749

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF749

No disorders were found for ZNF749 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF749 Gene

Publications for ZNF749 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
  3. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PMID: 19608861) Choudhary C. … Mann M. (Science 2009) 4 64
  4. Distinct class of putative "non-conserved" promoters in humans: comparative studies of alternative promoters of human and mouse genes. (PMID: 17567985) Tsuritani K. … Suzuki Y. (Genome Res. 2007) 3 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for ZNF749 Gene

Sources for ZNF749 Gene

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