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ZNF747 Gene

protein-coding   GIFtS: 47
GCID: GC16M030541

Zinc Finger Protein 747

  Search for ZNF747
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 7471 2
KRAB Domain-Containing Protein ZNF7472

External Ids:    HGNC: 283501   Entrez Gene: 659882   Ensembl: ENSG000001699557   UniProtKB: Q9BV973   

Export aliases for ZNF747 gene to outside databases

Previous GC identifers: GC16M030452 GC16M030453 GC16M028106


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF747 Gene:
ZNF747 (zinc finger protein 747) is a protein-coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF764.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_187260.1  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF747 gene promoter:
         NF-1   p53   Nkx2-5   GATA-1   HNF-1A   c-Ets-1   HNF-1   PPAR-gamma2   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF747 promoter sequence
   Search Chromatin IP Primers for ZNF747

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF747


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

ZNF747 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF747 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M030541:  view genomic region     (about GC identifiers)

Start:
30,537,244 bp from pter      End:
30,546,668 bp from pter
Size:
9,425 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN747_HUMAN, Q9BV97 (See protein sequence)
Recommended Name: KRAB domain-containing protein ZNF747  
Size: 191 amino acids; 20610 Da
Caution: Despite its name, it does not contain a canonical C2H2-type zinc-finger
Sequence caution: Sequence=BAB70760.1; Type=Erroneous termination; Positions=172; Note=Translated as Lys;
Secondary accessions: A8K827 B7WNU3 Q59FB4 Q96NW0
Alternative splicing: 2 isoforms:  Q9BV97-1   Q9BV97-2   

Explore the universe of human proteins at neXtProt for ZNF747: NX_Q9BV97

Explore proteomics data for ZNF747 at MOPED


See ZNF747 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_076420.1  
ENSEMBL proteins: 
 ENSP00000378528   ENSP00000252799   ENSP00000457274   ENSP00000441702  
Reactome Protein details: Q9BV97

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ZNF: Zinc fingers, C2H2-type

2 InterPro protein domains:
 IPR001909 Krueppel-associated_box
 IPR026613 KRAB_dom_C2H2_Znf_fam

Graphical View of Domain Structure for InterPro Entry Q9BV97

ProtoNet protein and cluster: Q9BV97

1 Blocks protein domain: IPB001909 KRAB box

UniProtKB/Swiss-Prot: ZN747_HUMAN, Q9BV97
Similarity: Contains 1 KRAB domain


Find genes that share domains with ZNF747           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003676nucleic acid binding IEA--
GO:0046872metal ion binding ----
     
Find genes that share ontologies with ZNF747           About GenesLikeMe


Animal Models:
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miRNA
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hsa-mir-181b-5p (MIRT047268), hsa-mir-335-5p (MIRT018802)

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Selected qRT-PCR Assays for microRNAs that regulate ZNF747 (see all 16):
hsa-miR-3690 hsa-miR-4254 hsa-miR-588 hsa-miR-622 hsa-miR-1236 hsa-miR-548s hsa-miR-3907 hsa-miR-3158-3p
SwitchGear 3'UTR luciferase reporter plasmidZNF747 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat ZNF747

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF747


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol2
extracellular2
nucleus2

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular IEA--

Find genes that share ontologies with ZNF747           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ZNF747 About    
See pathways by source

SuperPathContained pathways About
1Gene Expression
Generic Transcription Pathway0.40
Gene Expression0.40


Find genes that share SuperPaths with ZNF747           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for ZNF747
    Generic Transcription Pathway


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF747
Interactions:

    Search GeneGlobe Interaction Network for ZNF747

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

Selected Interacting proteins for ZNF747 (Q9BV972, 3 ENSP000002527994) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
InteractantInteraction Details
GeneCardExternal ID(s)
PARP2Q9UGN52, 3, ENSP000002504164MINT-8201948 I2D: score=1 STRING: ENSP00000250416
SUFUQ9UMX13, ENSP000003589184I2D: score=1 STRING: ENSP00000358918
APPBP2Q926243I2D: score=1 
CBX5ENSP000002098754STRING: ENSP00000209875
ELAVL1ENSP000003852694STRING: ENSP00000385269
About this table

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006355regulation of transcription, DNA-templated IEA--

Find genes that share ontologies with ZNF747           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ZNF747 (ZN747)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ZNF747 gene: 
NM_023931.2  

Unigene Cluster for ZNF747:

Zinc finger protein 747
Hs.592032  [show with all ESTs]
Unigene Representative Sequence: NM_023931
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000395094(uc002dyo.1 uc010vey.1) ENST00000252799(uc002dyn.3)
ENST00000568028 ENST00000535210
miRNA
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Selected qRT-PCR Assays for microRNAs that regulate ZNF747 (see all 16):
hsa-miR-3690 hsa-miR-4254 hsa-miR-588 hsa-miR-622 hsa-miR-1236 hsa-miR-548s hsa-miR-3907 hsa-miR-3158-3p
SwitchGear 3'UTR luciferase reporter plasmidZNF747 3' UTR sequence
Inhib. RNA
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Primer
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  QuantiTect SYBR Green Assays in human, mouse, rat ZNF747
  QuantiFast Probe-based Assays in human, mouse, rat ZNF747

Additional mRNA sequence: 

AB209546.1 AK054567.1 AK292192.1 AK299308.1 AK316254.1 BC001361.2 

5 DOTS entries:

DT.425655  DT.97826970  DT.97788304  DT.70105414  DT.95086049 

Selected AceView cDNA sequences (see all 43):

AW301238 BC001361 CR591695 AI589884 BM665031 AW337902 BE328001 AA316824 
BM984722 BM695384 BP359683 BQ025937 BM557226 NM_023931 BM461939 CR599858 
BE327668 BF063940 AI764970 AI914742 AV698149 AI421665 AU280254 BE465016 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZNF747 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCCAAGCACC
ZNF747 Expression
About this image


ZNF747 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Heart (Cardiovascular System)
         Atrioventricular Node
ZNF747 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ZNF747 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.592032
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF747

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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ENSEMBL Gene Tree for ZNF747 (if available)
TreeFam Gene Tree for ZNF747 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ZNF747 gene
ZNF7642  ZNF6882  ENSG000002614592  ENSG000002608692  ZNF6892  ZNF7852  
Selected SIMAP similar genes for ZNF747 using alignment to 2 protein entries:     ZN747_HUMAN (see all proteins) (see all similar genes):
smap-7    ZFS-4    ZNF28    ZNF761    ZNF78L1    ZNF283
ZNF420    ZNF669    ZNF826P    ZNF331    LOC101928664    ZNF101
ZNF808    ZNF688    ZNF224    ZNF501    ZNF559    ZNF850

Find genes that share paralogs with ZNF747           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZNF747 (see all 37)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1486142391,2
--30542434(+) TTTGAC/TACAGA 1 -- int10--------
rs1431567181,2
--30542509(+) AAAAGA/CAAGCC 1 -- int10--------
rs1162985311,2
C,F--30542594(+) GGCTCC/TGGCCC 1 -- int11Minor allele frequency- T:0.06WA 118
rs65651901,2
C,F,A,H--30542609(+) cccaaC/Aaactg 1 -- int111Minor allele frequency- A:0.07NS EA NA CSA WA 684
rs11378881,2
C--30542706(-) aagatC/Ttaaag 1 -- int12Minor allele frequency- T:0.00NA 4
rs1158331491,2
F--30542766(+) CAGCAA/GCTGCA 1 -- int11Minor allele frequency- G:0.01WA 118
rs1819420031,2
--30542775(+) CAGGCA/GAGATC 1 -- int10--------
rs1142741861,2
C,F--30542805(+) TTTTAG/AGTTGT 1 -- ut311Minor allele frequency- A:0.05WA 118
rs1849815501,2
--30542830(+) ATGAAA/GGCCAG 1 -- ut310--------
rs1897337261,2
--30543191(+) GGCCAC/GGTGAG 1 -- ut310--------

HapMap Linkage Disequilibrium report for ZNF747 (30537244 - 30546668 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for ZNF747:    About this table    
Variant IDTypeSubtypePubMed ID
nsv1784CNV Insertion18451855
nsv905726CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing ZNF747
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ZNF747 gene integrated from 10 sources:
(articles sorted by number of sources associating them with ZNF747)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  2. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 3 Loftus B.J.... Adams M.D. (Genomics 1999)
  3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
  4. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (Cell 2010)
  5. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PubMed id 20562864)1 Nozawa R.S.... Obuse C. (Nat. Cell Biol. 2010)
  6. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
  7. Genome-scale RNAi screen for host factors required for HIV replication. (PubMed id 18976975)1 Zhou H....Espeseth A.S. (amp 2008)
  8. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (Nature 2004)
  9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 65988 HGNC: 28350 AceView: MGC2474 Ensembl:ENSG00000169955 euGenes: HUgn65988
ECgene: ZNF747 H-InvDB: ZNF747

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ZNF747 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ZNF747 gene:
Search GeneIP for patents involving ZNF747

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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