ZNF746 Gene
protein-coding GIFtS: 48
GCID: GC07M149169
|
|
zinc finger protein 746
| |
Aliases
for ZNF746 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 7461 2 | | Parkin-Interacting Substrate2 3 | | PARIS2 3 | | FLJ314131 | | Parkin-Interacting Sustrate2 |
Export aliases for ZNF746 gene to outside databasesPrevious GC identifers: GC07M148800 GC07M143246 |
Summaries
for ZNF746 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN746_HUMAN, Q6NUN9Function: Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters andrepress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death
|
Genomic Views
for ZNF746 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF746 gene promoter:
RFX1 GCNF ATF-2 Nkx2-5 E47 CRE-BP1 Pax-3 POU2F1 GCNF-1 POU2F1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF746
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF746 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q36.1 Ensembl cytogenetic band: 7q36.1 HGNC cytogenetic band: 7q36.1ZNF746 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M149169: view genomic region
(about GC identifiers)
Start:
|
149,169,884 bp from pter |
End:
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149,194,908 bp from pter |
Size:
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25,025 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 148,507,917-148,532,930 |
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Proteins
for ZNF746 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN746_HUMAN, Q6NUN9 (See
protein sequence)Recommended Name: Zinc finger protein 746 Size: 644 amino acids; 69136 Da
Subunit: Interacts (via C2H2-type zinc fingers) with PARK2
Subcellular location: Cytoplasm. Nucleus (Probable). Note=Mainly localizes to the cytoplasm; probably translocates tothe nucleus to repress selected genes
Miscellaneous: May act as a downstream effector of PARK2 and contribute to neurodegeneration in Parkinson disease casescaused by defects in PARK2: its accumulation due to the absence of PARK2, followed by up-regulation of PPARGC1A, couldlead to the selective loss of dopamine neurons in the substantia nigra (PubMed:21376232)
Secondary accessions: A8K6Z9 Q6ZRF9Alternative splicing: 3 isoforms: Q6NUN9-1 Q6NUN9-2 Q6NUN9-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZNF746: NX_Q6NUN9
Post-translational modifications:
Ubiquitinated by PARK2. 'Lys-48'-linked polyubiquitination by PARK2 leads to degradation by the proteasome and may playa key role in regulation of neuron death1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6NUN9
ZNF746 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001156946.1 NP_689770.3
ENSEMBL proteins: ENSP00000345140 ENSP00000420329 ENSP00000395007 Reactome Protein details: Q6NUN9
Human Recombinant Protein Products for ZNF746:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
ZNF746 for ontologies About GeneDecksing
ZNF746 Antibody Products:
Assay Products for ZNF746: |
Protein
Domains /
Families
for ZNF746 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF746 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6NUN9ProtoNet protein and cluster: Q6NUN9 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZN746_HUMAN, Q6NUN9Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 4 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF746 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ZN746_HUMAN, Q6NUN9Function: Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters andrepress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
ZNF746 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF746 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF746 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for ZNF746 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF746 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF746 |
|
Pathways & Interactions
for ZNF746 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF746
ZNF746 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF746
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/18 Interacting proteins for ZNF746 (Q6NUN91, 2, 3 ENSP000003451404) via UniProtKB, MINT, STRING, and/or I2D (see all 18)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- | | GO:0010941 | regulation of cell death |
IDA | -- | | GO:0045892 | negative regulation of transcription, DNA-dependent |
IDA | -- | | GO:0070997 | neuron death |
IDA | -- |
ZNF746 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF746 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF746
Search CenterWatch for drugs/clinical trials and news about ZNF746 / ZN746
|
Transcripts
for ZNF746 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF746 gene (2 alternative transcripts): NM_001163474.1 NM_152557.4 Unigene Cluster for ZNF746: Zinc finger protein 746 Hs.24643 [show with all ESTs]Unigene Representative Sequence: BC0355864 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000340622(uc003wfw.2) ENST00000471735 ENST00000461958 ENST00000458143(uc010lpi.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF746 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF746 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ZNF746 (NM_152557) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF746 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF746 |
Additional cDNA sequence: AK055975.1 AK128244.1 AK291814.1 BC031968.1 BC035586.1 BC068505.1 9 DOTS entries: DT.97761942 DT.214576 DT.95202735 DT.121051077 DT.97802102 DT.100774575 DT.91683046 DT.92424622 DT.100813858 24/98 AceView cDNA sequences (see all 98): NM_152557 AW770381 BQ184531 BG152601 BC031968 BM564984 BC068505 CK301095 BQ025901 AA461114 AI348533 BF432218 AA257139 BM682239 AA461431 BM479839 BQ024147 BQ024797 N62819 AK128244 BQ682902 CR592744 AA460655 BF224162
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF746 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF746
|
Expression
for ZNF746 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF746 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CATACTTTTA
About this image
See ZNF746 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF746
SOURCE GeneReport for Unigene cluster: Hs.24643
SABiosciences Custom PCR Arrays for ZNF746
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF746
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF746 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF746 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF746 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF746 |
Orthologs
for ZNF746 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for ZNF746 gene from 1/6 species (see all 6) About this table
ENSEMBL Gene Tree for ZNF746 (if available)
TreeFam Gene Tree for ZNF746 (if available) |
Paralogs
for ZNF746 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF746 gene
- ZNF2822 ZNF7772 ZNF2122 ZNF3982 ZNF7832
18/48 SIMAP similar genes for ZNF746 using alignment to 2 protein entries: ZN746_HUMAN (see all proteins)
(see all similar genes):ZNF767 LOC155060 ZNF66 ZNF273 MGC12518 ZNF569
ZNF718 ZNF697 ZNF254 ZNF133 ZNF506 ZNF212
ZNF514 ZNF90 kr-znf3 ZNF783 ZNF248 ZNF78L1
ZNF746 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF746 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF746 (149169884 - 149194908 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF746: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF746 |
|
Disorders
/ Diseases
for ZNF746 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF746 for disorders About GeneDecksing
OMIM gene information: 613914
OMIM disorders: --
5  diseases for ZNF746: About MalaCardsamyotrophic lateral sclerosis lateral sclerosis parkinson's disease neurodegeneration
neuronitis
Export disorders for ZNF746 gene to outside databases
|
Publications
for ZNF746 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF746 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF746) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- PARIS (ZNF746) repression of PGC-1alpha contributes to neurodegeneration in Parkinson's disease. (PubMed id 21376232)1, 2 Shin J.H.... Dawson T.M. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Genetic risk and a primary role for cell-mediated immu ne mechanisms in multiple sclerosis. (PubMed id 21833088)1 ....Compston A. (2011)
- Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. (PubMed id 19451621)1 Landers J.E....Brown R.H. (2009)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZNF746 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF746 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF746 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF746 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF746 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF746 gene:
Search GeneIP for patents involving ZNF746
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF746 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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 | | | ZNF746 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF746 |
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