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Aliases for ZNF746 Gene

Aliases for ZNF746 Gene

  • Zinc Finger Protein 746 2 3 5
  • Parkin-Interacting Substrate 3 4
  • PARIS 3 4
  • Parkin Interacting Substrate 2
  • Parkin-Interacting Sustrate 3

External Ids for ZNF746 Gene

Previous GeneCards Identifiers for ZNF746 Gene

  • GC07M148800
  • GC07M149169
  • GC07M143246

Summaries for ZNF746 Gene

GeneCards Summary for ZNF746 Gene

ZNF746 (Zinc Finger Protein 746) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is ZNF777.

UniProtKB/Swiss-Prot for ZNF746 Gene

  • Transcription repressor that specifically binds to the 5-TATTTT[T/G]-3 consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF746 Gene

Genomics for ZNF746 Gene

Regulatory Elements for ZNF746 Gene

Enhancers for ZNF746 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F149622 1.2 FANTOM5 ENCODE 24.9 -126.6 -126553 3.8 ARNT CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 CBX5 ZNF143 ZNF746 ZNF767P ZNF862 ZNF786 ZNF783 RARRES2 ZNF777 LOC155060 ZNF212 GC07M149614
GH07F149620 1 FANTOM5 ENCODE 22.7 -123.7 -123718 1.6 HDGF PKNOX1 CBX3 TBL1XR1 ARNT WRNIP1 CREM SMARCA5 ZNF263 CBFB ZNF746 ZNF767P ZNF862 ZNF786 ZNF783 ZNF777 LOC155060 ZNF212 SSPO GC07M149614
GH07F149493 1.2 FANTOM5 ENCODE 16.7 +1.8 1849 4.8 HDGF ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 ZNF212 ZNF777 ZNF282 ZNF398 LOC155060 ZNF783 ZNF746 ZNF767P ENSG00000271664 ZNF786
GH07F149566 0.2 ENCODE 12.8 -69.1 -69130 0.4 ZNF746 ZNF767P GC07P149558 PIR50394
GH07F149586 0.8 ENCODE 12.8 -89.4 -89446 0.8 ZNF335 CTBP1 RNF2 ZBTB8A ZBTB40 ZBTB26 ZNF746 GC07M149591 TRC-GCA15-1 TRC-GCA3-1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF746 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF746 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000159334 437 2400 HDGF CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 CBX5

Genomic Location for ZNF746 Gene

Chromosome:
7
Start:
149,472,793 bp from pter
End:
149,497,837 bp from pter
Size:
25,045 bases
Orientation:
Minus strand

Genomic View for ZNF746 Gene

Genes around ZNF746 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF746 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF746 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF746 Gene

Proteins for ZNF746 Gene

  • Protein details for ZNF746 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NUN9-ZN746_HUMAN
    Recommended name:
    Zinc finger protein 746
    Protein Accession:
    Q6NUN9
    Secondary Accessions:
    • A8K6Z9
    • Q6ZRF9

    Protein attributes for ZNF746 Gene

    Size:
    644 amino acids
    Molecular mass:
    69136 Da
    Quaternary structure:
    • Interacts (via C2H2-type zinc fingers) with PARK2.
    Miscellaneous:
    • May act as a downstream effector of PARK2 and contribute to neurodegeneration in Parkinson disease cases caused by defects in PARK2: its accumulation due to the absence of PARK2, followed by up-regulation of PPARGC1A, could lead to the selective loss of dopamine neurons in the substantia nigra.

    Alternative splice isoforms for ZNF746 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF746 Gene

Post-translational modifications for ZNF746 Gene

  • Ubiquitinated by PARK2. Lys-48-linked polyubiquitination by PARK2 leads to degradation by the proteasome and may play a key role in regulation of neuron death.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF746 Gene

No data available for DME Specific Peptides for ZNF746 Gene

Domains & Families for ZNF746 Gene

Gene Families for ZNF746 Gene

Protein Domains for ZNF746 Gene

Suggested Antigen Peptide Sequences for ZNF746 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6NUN9

UniProtKB/Swiss-Prot:

ZN746_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 4 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF746: view

Function for ZNF746 Gene

Molecular function for ZNF746 Gene

UniProtKB/Swiss-Prot Function:
Transcription repressor that specifically binds to the 5-TATTTT[T/G]-3 consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death.

Gene Ontology (GO) - Molecular Function for ZNF746 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 21376232
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 21376232
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IDA 21376232
genes like me logo Genes that share ontologies with ZNF746: view
genes like me logo Genes that share phenotypes with ZNF746: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF746 Gene

Localization for ZNF746 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF746 Gene

Cytoplasm. Nucleus. Note=Mainly localizes to the cytoplasm; probably translocates to the nucleus to repress selected genes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF746 Gene COMPARTMENTS Subcellular localization image for ZNF746 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF746 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IC 21376232
GO:0005737 cytoplasm IEA,IDA 21376232
genes like me logo Genes that share ontologies with ZNF746: view

Pathways & Interactions for ZNF746 Gene

SuperPathways for ZNF746 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF746: view

Pathways by source for ZNF746 Gene

2 Reactome pathways for ZNF746 Gene

Gene Ontology (GO) - Biological Process for ZNF746 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 21376232
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 21376232
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 21376232
genes like me logo Genes that share ontologies with ZNF746: view

No data available for SIGNOR curated interactions for ZNF746 Gene

Transcripts for ZNF746 Gene

Unigene Clusters for ZNF746 Gene

Zinc finger protein 746:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF746 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: -
SP2:
SP3:

Relevant External Links for ZNF746 Gene

GeneLoc Exon Structure for
ZNF746
ECgene alternative splicing isoforms for
ZNF746

Expression for ZNF746 Gene

mRNA expression in normal human tissues for ZNF746 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF746 Gene

This gene is overexpressed in Whole Blood (x6.9).

Protein differential expression in normal tissues from HIPED for ZNF746 Gene

This gene is overexpressed in Brain (54.6) and Urine (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF746 Gene



Protein tissue co-expression partners for ZNF746 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF746 Gene:

ZNF746

SOURCE GeneReport for Unigene cluster for ZNF746 Gene:

Hs.24643
genes like me logo Genes that share expression patterns with ZNF746: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ZNF746 Gene

Orthologs for ZNF746 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF746 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF746 34 35
  • 99.38 (n)
dog
(Canis familiaris)
Mammalia ZNF746 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF746 34 35
  • 89.17 (n)
mouse
(Mus musculus)
Mammalia Zfp746 34 16 35
  • 87.14 (n)
rat
(Rattus norvegicus)
Mammalia Zfp746 34
  • 86.63 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF746 35
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF746 35
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 25 (a)
OneToMany
-- 35
  • 23 (a)
OneToMany
Species where no ortholog for ZNF746 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF746 Gene

ENSEMBL:
Gene Tree for ZNF746 (if available)
TreeFam:
Gene Tree for ZNF746 (if available)

Paralogs for ZNF746 Gene

Paralogs for ZNF746 Gene

genes like me logo Genes that share paralogs with ZNF746: view

Variants for ZNF746 Gene

Sequence variations from dbSNP and Humsavar for ZNF746 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000678 -- 149,494,477(+) TGAAT(C/T)GTGGC reference, synonymous-codon
rs10231827 -- 149,484,218(+) ATACC(A/G)AAACC intron-variant
rs10236963 -- 149,493,154(+) ggttg(A/T)catgc intron-variant
rs10249044 -- 149,477,831(+) CGGAG(A/C)GATAG intron-variant
rs10252201 -- 149,478,088(+) TGAAC(A/G)AAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF746 Gene

Variant ID Type Subtype PubMed ID
dgv11713n54 CNV loss 21841781
dgv3693n106 CNV deletion 24896259
esv2735330 CNV deletion 23290073
nsv1033447 CNV loss 25217958
nsv1074558 CNV deletion 25765185
nsv608976 CNV loss 21841781
nsv970602 CNV duplication 23825009

Variation tolerance for ZNF746 Gene

Residual Variation Intolerance Score: 16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.83; 34.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF746 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF746

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF746 Gene

Disorders for ZNF746 Gene

Relevant External Links for ZNF746

Genetic Association Database (GAD)
ZNF746
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF746

No disorders were found for ZNF746 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF746 Gene

Publications for ZNF746 Gene

  1. PARIS (ZNF746) repression of PGC-1alpha contributes to neurodegeneration in Parkinson's disease. (PMID: 21376232) Shin J.H. … Dawson T.M. (Cell 2011) 2 3 4 64
  2. Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. (PMID: 19451621) Landers J.E. … Brown R.H. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for ZNF746 Gene

Sources for ZNF746 Gene

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