Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF746 Gene

protein-coding   GIFtS: 52
GCID: GC07M149169

Zinc Finger Protein 746

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 7461 2
Parkin-Interacting Substrate2 3
PARIS2 3
Parkin-Interacting Sustrate2

External Ids:    HGNC: 219481   Entrez Gene: 1550612   Ensembl: ENSG000001812207   OMIM: 6139145   UniProtKB: Q6NUN93   

Export aliases for ZNF746 gene to outside databases

Previous GC identifers: GC07M148800 GC07M143246


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF746 Gene: 
ZNF746 (zinc finger protein 746) is a protein-coding gene. Diseases associated with ZNF746 include lateral sclerosis, and amyotrophic lateral sclerosis, and among its related super-pathways are Gene Expression. GO annotations related to this gene include transcription regulatory region DNA binding and ubiquitin protein ligase binding. An important paralog of this gene is ZNF282.

UniProtKB/Swiss-Prot: ZN746_HUMAN, Q6NUN9
Function: Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters
and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007914.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF746 gene promoter:
         RFX1   GCNF   ATF-2   Nkx2-5   E47   CRE-BP1   Pax-3   POU2F1   GCNF-1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZNF746 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF746

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF746


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.1   Ensembl cytogenetic band:  7q36.1   HGNC cytogenetic band: 7q36.1

ZNF746 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF746 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M149169:  view genomic region     (about GC identifiers)

Start:
149,169,884 bp from pter      End:
149,194,908 bp from pter
Size:
25,025 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 148,507,917-148,532,930     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN746_HUMAN, Q6NUN9 (See protein sequence)
Recommended Name: Zinc finger protein 746  
Size: 644 amino acids; 69136 Da
Subunit: Interacts (via C2H2-type zinc fingers) with PARK2
Subcellular location: Cytoplasm. Nucleus (Probable). Note=Mainly localizes to the cytoplasm; probably translocates
to the nucleus to repress selected genes
Miscellaneous: May act as a downstream effector of PARK2 and contribute to neurodegeneration in Parkinson disease
cases caused by defects in PARK2: its accumulation due to the absence of PARK2, followed by up-regulation of
PPARGC1A, could lead to the selective loss of dopamine neurons in the substantia nigra (PubMed:21376232)
Secondary accessions: A8K6Z9 Q6ZRF9
Alternative splicing: 3 isoforms:  Q6NUN9-1   Q6NUN9-2   Q6NUN9-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF746: NX_Q6NUN9

Explore proteomics data for ZNF746 at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated by PARK2. 'Lys-48'-linked polyubiquitination by PARK2 leads to degradation by the proteasome and may
    play a key role in regulation of neuron death
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6NUN9

  • ZNF746 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF746 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001156946.1  NP_689770.3  

    ENSEMBL proteins: 
     ENSP00000345140   ENSP00000420329   ENSP00000395007  
    Reactome Protein details: Q6NUN9
    Human Recombinant Protein Products for ZNF746: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ZNF746
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ZNF746
    GenScript Custom Purified and Recombinant Proteins Services for ZNF746
    Novus Biologicals ZNF746 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF746 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--

    ZNF746 for ontologies           About GeneDecksing



    ZNF746 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ZNF746
    GenScript Custom Superior Antibodies Services for ZNF746
    Novus Biologicals ZNF746 Antibody
    Abcam antibodies for ZNF746
    Cloud-Clone Corp. Antibodies for ZNF746 
    Search ThermoFisher Antibodies for ZNF746
    LSBio Antibodies in human, mouse, rat for ZNF746 

    Assay Products for ZNF746: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ZNF746
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ZNF746
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ZNF746 
    Cloud-Clone Corp. CLIAs for ZNF746


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    5 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR022137 DUF3669_Znf
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q6NUN9

    ProtoNet protein and cluster: Q6NUN9

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN746_HUMAN, Q6NUN9
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 4 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF746 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN746_HUMAN, Q6NUN9
    Function: Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters
    and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding ----
    GO:0031625ubiquitin protein ligase binding IPI--
    GO:0044212transcription regulatory region DNA binding IDA--
         
    ZNF746 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF746 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZNF746

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF746 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZNF746 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZNF746
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF746 (see all 26):
    hsa-miR-194* hsa-miR-30c hsa-miR-4307 hsa-miR-607 hsa-miR-16-2* hsa-miR-3074-3p hsa-miR-30d hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidZNF746 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZNF746
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF746

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ZNF746
    Sirion Biotech Customized adenovirus for overexpression of ZNF746

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ZNF746 (see all 13)
    OriGene ORF clones in mouse, rat for ZNF746
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ZNF746 (NM_152557)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF746
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF746
    Sirion Biotech Customized lentivirus for stable overexpression of ZNF746 
                         Customized lentivirus expression plasmids for stable overexpression of ZNF746 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ZNF746
    Search LifeMap BioReagents cell lines for ZNF746
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF746


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF746 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF746
        Generic Transcription Pathway
    Gene Expression



    ZNF746 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF746

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/18 Interacting proteins for ZNF746 (Q6NUN91, 2, 3 ENSP000003451404) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DIABLOQ9NR282, 3, ENSP000002671694MINT-8254133 I2D: score=2 STRING: ENSP00000267169
    EPHA8P293222, 3, ENSP000001662444MINT-8254974 I2D: score=2 STRING: ENSP00000166244
    PARK2O602601, 3, ENSP000003558654EBI-3862525,EBI-716346 I2D: score=1 STRING: ENSP00000355865
    DUSP23Q9BVJ72, 3MINT-8254800 I2D: score=2 
    FAM118BQ9BPY32, 3MINT-8255277 I2D: score=2 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0010941regulation of cell death IDA--
    GO:0045892negative regulation of transcription, DNA-dependent IDA--
    GO:0070997neuron death IDA--

    ZNF746 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF746 (ZN746)

    Search CenterWatch for drugs/clinical trials and news about ZNF746 / ZN746

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF746 gene (2 alternative transcripts): 
    NM_001163474.1  NM_152557.4  

    Unigene Cluster for ZNF746:

    Zinc finger protein 746
    Hs.24643  [show with all ESTs]
    Unigene Representative Sequence: BC035586
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000340622(uc003wfw.2) ENST00000471735 ENST00000461958 ENST00000458143(uc010lpi.2)


    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZNF746
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF746 (see all 26):
    hsa-miR-194* hsa-miR-30c hsa-miR-4307 hsa-miR-607 hsa-miR-16-2* hsa-miR-3074-3p hsa-miR-30d hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidZNF746 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZNF746
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF746
    Clone
    Products:
         
    OriGene clones in human, mouse for ZNF746 (see all 13)
    OriGene ORF clones in mouse, rat for ZNF746
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ZNF746 (NM_152557)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF746
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF746
    Sirion Biotech Customized lentivirus for stable overexpression of ZNF746 
                         Customized lentivirus expression plasmids for stable overexpression of ZNF746 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF746
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF746
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF746
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF746

    Additional mRNA sequence: 

    AK055975.1 AK128244.1 AK291814.1 BC031968.1 BC035586.1 BC068505.1 

    9 DOTS entries:

    DT.97761942  DT.214576  DT.95202735  DT.121051077  DT.97802102  DT.100774575  DT.91683046  DT.92424622 
    DT.100813858 

    24/98 AceView cDNA sequences (see all 98):

    CR592744 AW770381 AA460655 AA461431 BM479839 BM682239 AA461114 AA257139 
    N62819 BF224162 BQ184531 AK128244 NM_152557 BQ024147 BQ024797 BF432218 
    BC068505 BM564984 AI348533 BG152601 BQ682902 BC031968 BQ025901 CK301095 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF746    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
    SP1:                    -                           
    SP2:                                                
    SP3:                                                


    ECgene alternative splicing isoforms for ZNF746

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF746 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATACTTTTA
    ZNF746 Expression
    About this image


    See ZNF746 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF746

    SOURCE GeneReport for Unigene cluster: Hs.24643
        SABiosciences Custom PCR Arrays for ZNF746
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF746
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF746
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF746
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF746
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF746

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF746 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp7461 , 5 zinc finger protein 7461, 5 87.66(n)1
    94.4(a)1
      6 (23.04 cM)5
    692281  NM_001163475.11  NP_001156947.11 
     480623955 
    chicken
    (Gallus gallus)
    Aves --
    ZNF7676
    (see all 4)
    zinc finger family member 767
    (see all 4)
    48(a)
    35(a)
    (see all 4)
    possible ortholog
    possible ortholog
    (see all 4)
    2(539156-543542)
    2(504467-519631)


    ENSEMBL Gene Tree for ZNF746 (if available)
    TreeFam Gene Tree for ZNF746 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF746 gene
    ZNF2822  ZNF7772  ZNF2122  ZNF3982  ZNF7832  
    18/103 SIMAP similar genes for ZNF746 using alignment to 2 protein entries:     ZN746_HUMAN (see all proteins) (see all similar genes):
    ZNF767    LOC155060    ZNF66    ZNF10    ZNF273    ZNF595
    MGC12518    ZFP30    ZNF569    ZNF718    ZNF274    ZNF212
    ZNF141    ZNF257    ZNF267    ZNF540    ZNF573    ZNF682

    ZNF746 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/639 SNPs in ZNF746 are shown (see all 639)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1914284001,2
    --149169384(+) TACTCA/GGGAGG 2 -- int10--------
    rs1164898191,2
    --149169525(+) AGAAGA/CAAGCA 2 -- int10--------
    rs78084161,2
    C,F,A,H--149169534(+) CATCCA/GACATC 2 -- int19Minor allele frequency- G:0.07NS EA NA WA 546
    rs748179011,2
    C--149169558(+) TACTCC/TGCAAT 2 -- int10--------
    rs1414173281,2
    --149169633(+) AACCAC/TGTTTA 2 -- int10--------
    rs1839109211,2
    --149169653(+) GGAAAC/GTGATT 2 -- int10--------
    rs64649771,2
    C,F,A,H--149169736(+) CTTAGT/ATCTCA 2 -- int114Minor allele frequency- A:0.31NS EA WA NA CSA 786
    rs802965301,2
    F--149169748(+) GGTCAG/TTTACC 2 -- int11Minor allele frequency- T:0.04EA 120
    rs1504218021,2
    --149169775(+) GACCAA/CGCCTA 2 -- int10--------
    rs1899411911,2
    --149169823(+) TGGAGA/GGCATG 2 -- int10--------

    HapMap Linkage Disequilibrium report for ZNF746 (149169884 - 149194908 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF746:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2735330CNV Deletion23290073

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF746
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF746

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613914    OMIM disorders: --

    5 diseases for ZNF746:    About MalaCards
    lateral sclerosis    amyotrophic lateral sclerosis    parkinson's disease    multiple sclerosis
    neuronitis


    ZNF746 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): ZNF746

    Export disorders for ZNF746 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF746 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF746)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PARIS (ZNF746) repression of PGC-1alpha contributes to neurodegeneration in Parkinson's disease. (PubMed id 21376232)1, 2 Shin J.H.... Dawson T.M. (2011)
    2. Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. (PubMed id 19451621)1, 4 Landers J.E....Brown R.H. (2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Genetic risk and a primary role for cell-mediated immu ne mechanisms in multiple sclerosis. (PubMed id 21833088)1  ....Compston A. (2011)
    6. Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
    7. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    9. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 155061 HGNC: 21948 AceView: FLJ31413 Ensembl:ENSG00000181220 euGenes: HUgn155061
    ECgene: ZNF746 H-InvDB: ZNF746

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF746 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF746 gene:
    Search GeneIP for patents involving ZNF746

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ZNF746  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ZNF746  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ZNF746  
     OriGene qSTAR qPCR primer pairs in human, mouse for ZNF746   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ZNF746   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ZNF746   OriGene Custom Protein Services for ZNF746  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF746
     QIAGEN SeqTarget long-range PCR primers for resequencing ZNF746
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF746
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF746
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF746
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF746
     GenScript Custom Purified and Recombinant Proteins Services for ZNF746 GenScript cDNA clones with any tag delivered in your preferred vector for ZNF746
     GenScript Custom Assay Services for ZNF746 GenScript Custom Superior Antibodies Services for ZNF746
     GenScript Custom overexpressing Cell Line Services for ZNF746 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ZNF746 promoter
     Search Chromatin IP Primers for ZNF746
     RT2 qPCR Primer Assay in human, mouse, rat ZNF746
     Search GNC Networks for ZNF746
     SABiosciences Custom PCR Arrays for ZNF746
     Search Tocris compounds for ZNF746 (ZN746)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ZNF746 antibodies
     ZNF746 lysates
     Antibodies for ZNF746
     See all of Abcam's Antibodies, Kits and Proteins for ZNF746
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ZNF746
     Antibodies for ZNF746
     ELISAs for ZNF746
     CLIAs for ZNF746
     Search LifeMap BioReagents cell lines for ZNF746
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF746
     SwitchGear 3'UTR luciferase reporter plasmids for ZNF746
     SwitchGear Promoter luciferase reporter plasmids for ZNF746
     Search ThermoFisher Antibodies for ZNF746
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF746
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF746
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZNF746
    Customized:
     lentivirus for stable overexpression of ZNF746
     lentivirus expression plasmids for stable overexpression of ZNF746
     adenovirus for overexpression of ZNF746
     LSBio Antibodies in human, mouse, rat for ZNF746
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ZNF746 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4