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Aliases for ZNF740 Gene

Aliases for ZNF740 Gene

  • Zinc Finger Protein 740 2 3 5
  • OriLyt TD-Element-Binding Protein 7 3 4
  • Zfp740 3
  • TB7 4

External Ids for ZNF740 Gene

Previous GeneCards Identifiers for ZNF740 Gene

  • GC12P051863
  • GC12P053574
  • GC12P050617

Summaries for ZNF740 Gene

GeneCards Summary for ZNF740 Gene

ZNF740 (Zinc Finger Protein 740) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF281.

UniProtKB/Swiss-Prot for ZNF740 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF740 Gene

Genomics for ZNF740 Gene

Regulatory Elements for ZNF740 Gene

Enhancers for ZNF740 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G053971 2.1 FANTOM5 Ensembl ENCODE dbSUPER 50.8 +809.5 809543 36.8 CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 SP3 ZNF740 MAP3K12 ENSG00000258344 LOC100652999 HOXC8 HOXC5 SP1 HOTAIR CBX5 HOXC4
GH12G053386 1.5 Ensembl ENCODE dbSUPER 57.5 +208.5 208471 6.3 ATF1 ZNF493 ZFP64 YY1 ZNF121 ZNF202 SP3 TSHZ1 REST ZNF623 ZNF740 SP1 AAAS CBX5 MAP3K12 ENSG00000258344 IGFBP6 LOC100652999 PRR13 PFDN5
GH12G053498 1.4 ENCODE dbSUPER 43.8 +319.9 319907 5.0 CREB3L1 AGO1 ZFP64 DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 NFYC ZNF740 SP1 MAP3K12 CBX5 ENSG00000258344 LOC100652999 PRR13 AAAS ATP5G2 SPRYD3
GH12G052894 2 FANTOM5 Ensembl ENCODE dbSUPER 27.8 -277.8 -277773 16.1 MLX CREB3L1 AGO1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 AAAS ZNF740 MAP3K12 KRT18 SP1 SPRYD3 EIF4B LOC100652999 KRT74 KRT78
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF740 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF740 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ZNF740 Gene

53,180,700 bp from pter
53,195,141 bp from pter
14,442 bases
Plus strand

Genomic View for ZNF740 Gene

Genes around ZNF740 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF740 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF740 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF740 Gene

Proteins for ZNF740 Gene

  • Protein details for ZNF740 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 740
    Protein Accession:
    Secondary Accessions:
    • A8K9M9

    Protein attributes for ZNF740 Gene

    193 amino acids
    Molecular mass:
    21857 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF740 Gene

Post-translational modifications for ZNF740 Gene

  • Ubiquitination at isoforms=96
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF740 Gene

No data available for DME Specific Peptides for ZNF740 Gene

Domains & Families for ZNF740 Gene

Gene Families for ZNF740 Gene

Protein Domains for ZNF740 Gene

Suggested Antigen Peptide Sequences for ZNF740 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF740: view

Function for ZNF740 Gene

Molecular function for ZNF740 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF740 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF740: view

Phenotypes for ZNF740 Gene

GenomeRNAi human phenotypes for ZNF740:
genes like me logo Genes that share phenotypes with ZNF740: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF740 Gene

Localization for ZNF740 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF740 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF740 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF740 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF740: view

Pathways & Interactions for ZNF740 Gene

SuperPathways for ZNF740 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF740: view

Pathways by source for ZNF740 Gene

2 Reactome pathways for ZNF740 Gene

Interacting Proteins for ZNF740 Gene

Gene Ontology (GO) - Biological Process for ZNF740 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF740: view

No data available for SIGNOR curated interactions for ZNF740 Gene

Drugs & Compounds for ZNF740 Gene

No Compound Related Data Available

Transcripts for ZNF740 Gene

Unigene Clusters for ZNF740 Gene

Zinc finger protein 740:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF740 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1: - -

Relevant External Links for ZNF740 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF740 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF740 Gene

Protein differential expression in normal tissues from HIPED for ZNF740 Gene

This gene is overexpressed in Heart (64.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF740 Gene

Protein tissue co-expression partners for ZNF740 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF740 Gene:


SOURCE GeneReport for Unigene cluster for ZNF740 Gene:


Evidence on tissue expression from TISSUES for ZNF740 Gene

  • Skin(4.4)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with ZNF740: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF740 Gene

Orthologs for ZNF740 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF740 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF740 34 35
  • 100 (n)
(Bos Taurus)
Mammalia ZNF740 34 35 35
  • 96.2 (n)
(Canis familiaris)
Mammalia ZNF740 34 35
  • 96.03 (n)
(Rattus norvegicus)
Mammalia Znf740 34
  • 93.78 (n)
(Mus musculus)
Mammalia Zfp740 35
  • 91 (a)
(Gallus gallus)
Aves ZNF740 34 35
  • 72.58 (n)
(Anolis carolinensis)
Reptilia ZNF740 35
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia znf740 34
  • 57.84 (n)
(Danio rerio)
Actinopterygii znf740b 35
  • 32 (a)
Species where no ortholog for ZNF740 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF740 Gene

Gene Tree for ZNF740 (if available)
Gene Tree for ZNF740 (if available)

Paralogs for ZNF740 Gene

Paralogs for ZNF740 Gene

(311) SIMAP similar genes for ZNF740 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF740: view

Variants for ZNF740 Gene

Sequence variations from dbSNP and Humsavar for ZNF740 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000085610 -- 53,181,394(+) AAAGG(C/G)TCTCC intron-variant, upstream-variant-2KB
rs1000651417 -- 53,184,804(+) GCAGG(A/G)TGTAA intron-variant
rs1000833153 -- 53,185,773(+) CTTAC(-/CCACT)CCACT intron-variant
rs1001303148 -- 53,188,101(+) GTTGC(A/G)GTAGC intron-variant, utr-variant-3-prime
rs1001444508 -- 53,190,984(+) TTCTC(C/T)ACAGA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ZNF740 Gene

Variant ID Type Subtype PubMed ID
dgv2644n54 CNV loss 21841781
dgv2645n54 CNV loss 21841781
nsv469404 CNV loss 19166990
nsv470295 CNV gain 18288195
nsv517066 CNV loss 19592680
nsv558994 CNV loss 21841781
nsv832417 CNV gain 17160897

Variation tolerance for ZNF740 Gene

Residual Variation Intolerance Score: 75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF740 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF740 Gene

Disorders for ZNF740 Gene

Relevant External Links for ZNF740

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF740 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF740 Gene

Publications for ZNF740 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3 64
  4. Probing nuclear pore complex architecture with proximity-dependent biotinylation. (PMID: 24927568) Kim D.I. … Roux K.J. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 64
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64

Products for ZNF740 Gene

Sources for ZNF740 Gene

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