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Aliases for ZNF740 Gene

Aliases for ZNF740 Gene

  • Zinc Finger Protein 740 2 3
  • OriLyt TD-Element-Binding Protein 7 3 4
  • Zfp740 3
  • TB7 4

External Ids for ZNF740 Gene

Previous GeneCards Identifiers for ZNF740 Gene

  • GC12P051863
  • GC12P053574
  • GC12P050617

Summaries for ZNF740 Gene

GeneCards Summary for ZNF740 Gene

ZNF740 (Zinc Finger Protein 740) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF148.

UniProtKB/Swiss-Prot for ZNF740 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF740 Gene

Genomics for ZNF740 Gene

Regulatory Elements for ZNF740 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF740 Gene

Start:
53,180,700 bp from pter
End:
53,195,141 bp from pter
Size:
14,442 bases
Orientation:
Plus strand

Genomic View for ZNF740 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF740 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF740 Gene

Proteins for ZNF740 Gene

  • Protein details for ZNF740 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDX6-ZN740_HUMAN
    Recommended name:
    Zinc finger protein 740
    Protein Accession:
    Q8NDX6
    Secondary Accessions:
    • A8K9M9

    Protein attributes for ZNF740 Gene

    Size:
    193 amino acids
    Molecular mass:
    21857 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF740 Gene

Proteomics data for ZNF740 Gene at MOPED

Post-translational modifications for ZNF740 Gene

  • Ubiquitination at Lys96
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF740 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ZNF740 Gene

Domains for ZNF740 Gene

Gene Families for ZNF740 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF740 Gene

Suggested Antigen Peptide Sequences for ZNF740 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NDX6

UniProtKB/Swiss-Prot:

ZN740_HUMAN :
  • Q8NDX6
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF740: view

Function for ZNF740 Gene

Molecular function for ZNF740 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF740 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF740: view

Animal Model Products

CRISPR Products

miRNA for ZNF740 Gene

miRTarBase miRNAs that target ZNF740

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF740

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF740 Gene

Localization for ZNF740 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF740 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF740 Gene COMPARTMENTS Subcellular localization image for ZNF740 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF740 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF740: view

Pathways for ZNF740 Gene

SuperPathways for ZNF740 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF740: view

Pathways by source for ZNF740 Gene

2 Reactome pathways for ZNF740 Gene

Interacting Proteins for ZNF740 Gene

Gene Ontology (GO) - Biological Process for ZNF740 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF740: view

Transcripts for ZNF740 Gene

Unigene Clusters for ZNF740 Gene

Zinc finger protein 740:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF740

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF740 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1: - -
SP2:
SP3:

Relevant External Links for ZNF740 Gene

GeneLoc Exon Structure for
ZNF740
ECgene alternative splicing isoforms for
ZNF740

Expression for ZNF740 Gene

mRNA expression in normal human tissues for ZNF740 Gene

Protein differential expression in normal tissues for ZNF740 Gene

This gene is overexpressed in Heart (64.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF740 Gene

SOURCE GeneReport for Unigene cluster for ZNF740 Gene Hs.524458

genes like me logo Genes that share expressions with ZNF740: view

Expression partners for ZNF740 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF740 Gene

Orthologs for ZNF740 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF740 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF740 35
  • 96.2 (n)
  • 98.96 (a)
ZNF740 36
  • 98 (a)
OneToMany
ZNF740 36
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ZNF740 35
  • 96.03 (n)
  • 98.45 (a)
ZNF740 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF740 35
  • 100 (n)
  • 100 (a)
ZNF740 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Znf740 35
  • 93.78 (n)
  • 96.89 (a)
mouse
(Mus musculus)
Mammalia Zfp740 16
Zfp740 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF740 35
  • 72.58 (n)
  • 76.88 (a)
ZNF740 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF740 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf740 35
  • 57.84 (n)
  • 51.35 (a)
zebrafish
(Danio rerio)
Actinopterygii znf740b 36
  • 32 (a)
OneToOne
Species with no ortholog for ZNF740:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF740 Gene

ENSEMBL:
Gene Tree for ZNF740 (if available)
TreeFam:
Gene Tree for ZNF740 (if available)

Paralogs for ZNF740 Gene

Paralogs for ZNF740 Gene

Selected SIMAP similar genes for ZNF740 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF740: view

Variants for ZNF740 Gene

Sequence variations from dbSNP and Humsavar for ZNF740 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1052712 -- 53,190,602(+) CCCCA(A/G)ATGCC utr-variant-3-prime
rs1801641 -- 53,189,617(+) CTATG(C/G)TGACA utr-variant-3-prime
rs2272298 -- 53,188,711(+) ACAAG(A/G)TCTCG utr-variant-3-prime
rs3101059 -- 53,187,592(-) CTTGC(A/G)CCTAT utr-variant-3-prime, intron-variant
rs3108404 -- 53,189,447(+) ACCTA(A/T)TCTGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF740 Gene

Variant ID Type Subtype PubMed ID
nsv517066 CNV Loss 19592680
nsv832417 CNV Gain 17160897
nsv470295 CNV Gain 18288195
nsv469404 CNV Loss 19166990

Relevant External Links for ZNF740 Gene

HapMap Linkage Disequilibrium report
ZNF740

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF740 Gene

Disorders for ZNF740 Gene

No disorders were found for ZNF740 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ZNF740 Gene

Publications for ZNF740 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3
  4. Protein microarray analysis identifies human cellular prion protein interactors. (PMID: 18482256) Satoh J. … Tabunoki H. (Neuropathol. Appl. Neurobiol. 2009) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for ZNF740 Gene

Sources for ZNF740 Gene

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