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ZNF74 Gene

protein-coding   GIFtS: 60
GCID: GC22P020748

Zinc Finger Protein 74

(Previous name: zinc finger protein 74 (Cos52))
  See ZNF74-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 741 2     Zinc Finger Protein 74 (Cos52)1
Zinc Finger Protein 5202 3     COS522
ZNF5202 3     ZFP5202
hZNF72 3     

External Ids:    HGNC: 131441   Entrez Gene: 76252   Ensembl: ENSG000001852527   OMIM: 1945485   UniProtKB: Q165873   

Export aliases for ZNF74 gene to outside databases

Previous GC identifers: GC22P017450 GC22P019073 GC22P004012


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF74 Gene:
ZNF74 (zinc finger protein 74) is a protein-coding gene. Diseases associated with ZNF74 include atrioventricular septal defect, and tetralogy of fallot. GO annotations related to this gene include RNA binding. An important paralog of this gene is ZNF79.

UniProtKB/Swiss-Prot: ZNF74_HUMAN, Q16587
Function: May play a role in RNA metabolism

Gene Wiki entry for ZNF74 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF74 gene promoter:
         RP58   HTF   FOXD1   SEF-1 (1)   Cdc5   YY1   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF74 promoter sequence
   Search Chromatin IP Primers for ZNF74

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF74


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11.2

ZNF74 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF74 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P020748:  view genomic region     (about GC identifiers)

Start:
20,748,405 bp from pter      End:
20,762,752 bp from pter
Size:
14,348 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZNF74_HUMAN, Q16587 (See protein sequence)
Recommended Name: Zinc finger protein 74  
Size: 644 amino acids; 72207 Da
Sequence caution: Sequence=AAF21777.1; Type=Frameshift; Positions=164, 173; Sequence=AAF21778.1; Type=Frameshift;
Positions=164, 173; Sequence=AAF21779.1; Type=Frameshift; Positions=164, 173; Sequence=AAF21780.1;
Type=Frameshift; Positions=164, 173; Sequence=CAA50632.1; Type=Frameshift; Positions=164, 173;
Sequence=CAA63379.1; Type=Frameshift; Positions=164, 173;
Secondary accessions: B5MCE3 B7Z5Y2 Q6IBV2 Q6PJP1 Q9UC04 Q9UF05 Q9UF06 Q9UF07
Alternative splicing: 5 isoforms:  Q16587-1   Q16587-2   Q16587-3   Q16587-4   Q16587-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF74: NX_Q16587

Explore proteomics data for ZNF74 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF74 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001243452.1  NP_001243453.1  NP_001243454.1  NP_003417.2  

    ENSEMBL proteins: 
     ENSP00000383301   ENSP00000384750   ENSP00000350101   ENSP00000397011   ENSP00000395437  
     ENSP00000385855   ENSP00000349098  
    Reactome Protein details: Q16587

    ZNF74 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ZNF74

     
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    antibodies-online proteins for ZNF74 (2 products) 

     
    antibodies-online peptides for ZNF74

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q16587

    ProtoNet protein and cluster: Q16587

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZNF74_HUMAN, Q16587
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 12 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF74           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZNF74_HUMAN, Q16587
    Function: May play a role in RNA metabolism

         Genatlas biochemistry entry for ZNF74:
    zinc finger protein 74,64kDa (C2H2 type,Kruppel associated box),commonly deleted in DiGeorge syndrome,including
    ZNF74-1 and ZNF74-2,expressed only in neural crest-derived tissues and neuroepithelium of spinal cord as well as
    to foregut endoderm epithelia (esophagus,respiratory tract,putatively involved in the DiGeorge

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0003723RNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF74           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF74:
     Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF74

    miRNA
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    miRTarBase miRNAs that target ZNF74:
    hsa-mir-98-5p (MIRT027535)

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    1 qRT-PCR Assays for microRNA that regulate ZNF74:
    hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmidZNF74 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZNF74

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF74


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZNF74_HUMAN, Q16587: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0015629actin cytoskeleton IDA--

    Find genes that share ontologies with ZNF74           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF74 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF74           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF74
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF74
    Interactions:

        GeneGlobe Interaction Network for ZNF74

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ZNF74 (Q165873 ENSP000003833014) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIM28Q132633, ENSP000002530244I2D: score=2 STRING: ENSP00000253024
    POLR2AP249283, ENSP000003149494I2D: score=2 STRING: ENSP00000314949
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IBA--
    GO:0007275multicellular organismal development TAS1639391

    Find genes that share ontologies with ZNF74           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF74



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF74 gene (4 alternative transcripts): 
    NM_001256523.1  NM_001256524.1  NM_001256525.1  NM_003426.3  

    Unigene Cluster for ZNF74:

    Zinc finger protein 74
    Hs.517418  [show with all ESTs]
    Unigene Representative Sequence: NR_046282
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000400451 ENST00000403682 ENST00000357502 ENST00000493734 ENST00000420626
    ENST00000437275(uc010gsm.3 uc002zsg.3 uc002zsh.3 uc002zsi.3 uc010gsn.3)
    ENST00000405993 ENST00000476678 ENST00000356671
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZNF74 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ZNF74:
    hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmidZNF74 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ZNF74
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF74
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF74
      QuantiFast Probe-based Assays in human, mouse, rat ZNF74

    Additional mRNA sequence: 

    AB209663.1 AK291358.1 AK299569.1 BC013395.2 BC013741.1 BC048295.1 BC056902.1 CR456616.1 
    NR_046282.1 X71623.1 

    15 DOTS entries:

    DT.102831036  DT.95363766  DT.120668553  DT.100794776  DT.100794780  DT.406294  DT.120667844  DT.100696419 
    DT.100711361  DT.91919580  DT.95363767  DT.100683339  DT.100691788  DT.100843198  DT.102831037 

    Selected AceView cDNA sequences (see all 82):

    CR594912 BC056902 BM917893 CR601515 AA865061 BU584856 BC013741 BE017950 
    CR456616 AU103408 BQ045162 BM703607 BX281584 AI791359 BC013395 BX347559 
    AI732963 BU736501 AI791724 AI457800 AL524733 AA954136 AU125227 CB265673 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF74 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d
    SP1:                                -           -                                                               
    SP2:              -     -     -     -           -     -                                                         
    SP3:                                -           -     -                                                         
    SP4:                                -     -     -     -                                                         
    SP5:                    -     -     -           -     -                                                         


    ECgene alternative splicing isoforms for ZNF74

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF74 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTTTAATCA
    ZNF74 Expression
    About this image


    ZNF74 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Rockefeller University embryonic stem cell line 2
    ZNF74 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF74 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.517418

    UniProtKB/Swiss-Prot: ZNF74_HUMAN, Q16587
    Tissue specificity: Highly expressed in the fetal brain

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZNF74 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF741 zinc finger protein 74 81.54(n)
    78.29(a)
      100684862  XM_005636601.1  XP_005636658.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG97973   -- 38(a)   85A9   --


    ENSEMBL Gene Tree for ZNF74 (if available)
    TreeFam Gene Tree for ZNF74 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF74 gene
    ZNF792  ZNF5702  ZFP302  ZNF5292  ZNF286B2  ZNF7902  ZNF3832  ZNF1812  
    ZNF2872  ZNF5822  ZNF4712  ZFP822  ZNF286A2  ZNF2502  ZNF8792  ZNF354C2  
    ZNF5832  ZNF3912  ZNF5542  ZNF4542  ZFP902  ENSG000001876072  ZFP142  ZNF3312  
    ZNF354A2  ZNF4612  ZNF354B2  ZNF342  ZNF5272  ZNF5652  
    Selected SIMAP similar genes for ZNF74 using alignment to 6 protein entries:     ZNF74_HUMAN (see all proteins) (see all similar genes):
    AURA2    FKBP3    RTBDN    SYPL1    BTBD2    EDRF1
    APOD    CFLAR    PLEKHH2    RARS2    DNMT1    NEK4
    NSRP1    PLA2G6    ZNF212    DCTN5    FAM210A    ZNF78L1

    Find genes that share paralogs with ZNF74           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF74 (see all 399)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1854922551,2
    --20747255(+) TAACCA/GGGCGT 5 -- us2k10--------
    rs1882963921,2
    --20747265(+) TGGTGA/GTGCAT 5 -- us2k10--------
    rs1386142771,2
    C--20747347(+) TGAGCC/TGTGAT 5 -- us2k10--------
    rs1493253331,2
    --20747391(+) GAGACA/CCAGTC 5 -- us2k10--------
    rs1151953781,2
    F--20747533(+) TGAAGG/AGTTTG 5 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1817986751,2
    --20747562(+) ACCACC/TTCTCA 5 -- us2k10--------
    rs1115078061,2
    F--20747682(+) ATGACT/AGTAGT 5 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1480390681,2
    --20747685(+) ACAGTA/GGTTAG 5 -- us2k10--------
    rs8870211,2
    C,F,A,H--20747763(+) GGCGTG/TTGGTT 5 -- us2k132Minor allele frequency- T:0.38EA NA NS WA CSA 4394
    rs612614751,2
    C,F--20747863(+) CAGACC/TTTCCT 5 -- us2k12Minor allele frequency- T:0.08WA 120

    HapMap Linkage Disequilibrium report for ZNF74 (20748405 - 20762752 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZNF74 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv436864CNV Insertion17901297
    nsv509809CNV Insertion20534489
    nsv436867CNV Insertion17901297
    dgv4868n71CNV Loss21882294
    nsv834138CNV Loss17160897
    nsv523162CNV Loss19592680
    nsv914395CNV Loss21882294
    nsv834136CNV Loss17160897
    nsv828952CNV Gain20364138
    nsv914390CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 194548    OMIM disorders: --

    2 diseases for ZNF74:    
    About MalaCards
    atrioventricular septal defect    tetralogy of fallot

    4 diseases from the University of Copenhagen DISEASES database for ZNF74:
    DiGeorge syndrome     Velocardiofacial syndrome     Atrioventricular septal defect     Tetralogy of Fallot

    Find genes that share disorders with ZNF74           About GenesLikeMe

    Genetic Association Database (GAD): ZNF74
    Human Genome Epidemiology (HuGE) Navigator: ZNF74 (1 document)

    Export disorders for ZNF74 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF74 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with ZNF74)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of ZNF74 gene genotypes with age-at-onset of schizophrenia. (PubMed id 11705709)1, 2, 4 Takase K.... Arinami T. (Schizophr. Res. 2001)
    2. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2, 3 Dunham I.... Wright H. (Nature 1999)
    3. Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2). (PubMed id 1639391)1, 2, 3 Aubry M.... Rouleau G.A. (Genomics 1992)
    4. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    5. The KRAB zinc finger gene ZNF74 encodes an RNA-binding protein tightly associated with the nuclear matrix. (PubMed id 8663113)1, 2 Grondin B.... Aubry M. (J. Biol. Chem. 1996)
    6. Isolation of a zinc finger gene consistently deleted in DiGeorge syndrome. (PubMed id 8268910)1, 2 Aubry M....Rouleau G.A. (Hum. Mol. Genet. 1993)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7625 HGNC: 13144 AceView: ZNF74 Ensembl:ENSG00000185252 euGenes: HUgn7625
    ECgene: ZNF74 H-InvDB: ZNF74

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF74 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ZNF74 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF74 gene:
    Search GeneIP for patents involving ZNF74

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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