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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF738 Gene

protein-coding   GIFtS: 39
GCID: GC19P021541

Zinc Finger Protein 738

  Search for ZNF738
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Protein 7381 2

External Ids:    HGNC: 324691   Entrez Gene: 1482032   Ensembl: ENSG000001726877   UniProtKB: Q8NE653   
ORGUL members:         
NONCODE14:n407661      

Export aliases for ZNF738 gene to outside databases

Previous GC identifers: GC19P021334 GC19P021032


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF738 Gene: 
ZNF738 (zinc finger protein 738) is a protein-coding gene, and is affiliated with the lncRNA class. Among its related super-pathways are Gene Expression. GO annotations related to this gene include ubiquitin-protein ligase activity and DNA binding. An important paralog of this gene is ZNF720.

UniProtKB/Swiss-Prot: ZN738_HUMAN, Q8NE65
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF738 gene promoter:
         GATA-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ZNF738

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF738


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p12   Ensembl cytogenetic band:  19p12   HGNC cytogenetic band: 19p12

ZNF738 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF738 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P021541:  view genomic region     (about GC identifiers)

Start:
21,541,732 bp from pter      End:
21,571,384 bp from pter
Size:
29,653 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN738_HUMAN, Q8NE65 (See protein sequence)
Recommended Name: Protein ZNF738  
Size: 137 amino acids; 15884 Da
Subcellular location: Nucleus (Probable)
Caution: Despite its name, it does not contain a canonical C2H2-type zinc-finger
Secondary accessions: A8K4N7

Explore the universe of human proteins at neXtProt for ZNF738: NX_Q8NE65

Explore proteomics data for ZNF738 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NE65

  • ZNF738 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF738 Protein Expression

    ENSEMBL proteins: 
     ENSP00000311957   ENSP00000370252   ENSP00000471336   ENSP00000473241   ENSP00000470939  
    Reactome Protein details: Q8NE65
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF738 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR026613 KRAB_dom_C2H2_Znf_fam

    Graphical View of Domain Structure for InterPro Entry Q8NE65

    ProtoNet protein and cluster: Q8NE65

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN738_HUMAN, Q8NE65
    Similarity: Contains 1 KRAB domain


    ZNF738 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN738_HUMAN, Q8NE65
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0004842ubiquitin-protein ligase activity ISS--
         
    ZNF738 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF738 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF738
        Generic Transcription Pathway
    Gene Expression



    ZNF738 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF738

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZNF738 (ENSP000003119574) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination ISS--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0042981regulation of apoptotic process ----

    ZNF738 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF738 (ZN738)

    Search CenterWatch for drugs/clinical trials and news about ZNF738 / ZN738

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    Unigene Cluster for ZNF738:

    Zinc finger protein 738
    Hs.124384  [show with all ESTs]
    Unigene Representative Sequence: NR_027130
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311015(uc002npt.3 uc002nps.4) ENST00000380870 ENST00000597810
    ENST00000597492 ENST00000594245
    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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    Additional mRNA sequence: 

    AJ004948.1 AK027579.1 AK291002.1 AK291193.1 BC034499.1 NR_027130.1 

    14 DOTS entries:

    DT.101957044  DT.102831340  DT.408247  DT.100655529  DT.101922  DT.121496622  DT.40122199  DT.95356385 
    DT.102831338  DT.40290520  DT.65285221  DT.100039458  DT.75129029  DT.95179084 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF738 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTATAATGA
    ZNF738 Expression
    About this image


    See ZNF738 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF738

    SOURCE GeneReport for Unigene cluster: Hs.124384
        SABiosciences Custom PCR Arrays for ZNF738
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF738

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for ZNF738 (if available)
    TreeFam Gene Tree for ZNF738 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF738 gene
    ZNF7202  ZNF6072  ENSG000002684612  ENSG000002692372  ZNF5952  ENSG000002675522  
    18/405 SIMAP similar genes for ZNF738 using alignment to 5 protein entries:     ZN738_HUMAN (see all proteins) (see all similar genes):
    COX7A2    DRG2    MTA3    NUSAP1    CFLAR    IFT122
    CES4A    C18orf8    DYM    MGC12518    NSRP1    CCPG1
    MKRN1    SCIMP    THADA    MYO15B    TNFRSF17    WDR6

    ZNF738 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ZNF738
    PGOHUM00000234226 PGOHUM00000234602


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/729 SNPs in ZNF738 are shown (see all 729)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1433670501,2
    --21539750(+) GCCCCA/GGAAGC 1 -- us2k10--------
    rs1890432901,2
    --21539759(+) GCAGAA/TGATCA 1 -- us2k10--------
    rs1148912011,2
    F--21539760(+) CAGAAG/CATCAC 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1930011261,2
    --21539762(+) GAAGAC/TCACCC 1 -- us2k10--------
    rs1856120361,2
    --21539833(+) TGATAC/TCAGAA 1 -- us2k10--------
    rs72522611,2
    C,F,A,H--21539835(+) ATACCG/AGAAGA 1 -- us2k123Minor allele frequency- A:0.40NS EA NA WA CSA 2352
    rs1173649171,2
    F--21539843(+) AGAACG/AGCCCC 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs23589831,2
    C,F,A,H--21539849(+) GCCCCG/ACTCAC 1 -- us2k110Minor allele frequency- A:0.38NA WA CSA EA 374
    rs1902381331,2
    --21539961(+) GCCAGA/GATTCA 1 -- us2k10--------
    rs1824625031,2
    --21540003(+) AGTGGA/GCACCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF738 (21541732 - 21571384 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for ZNF738 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2718333CNV Deletion23290073
    esv2718331CNV Deletion23290073
    esv2663001CNV Deletion23128226
    esv2718330CNV Deletion23290073
    esv2718332CNV Deletion23290073
    esv2665276CNV Deletion23128226
    esv2718325CNV Deletion23290073
    nsv911420CNV Loss21882294
    esv2751783CNV Loss17911159
    dgv3807n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF738 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF738)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 148203 HGNC: 32469 Ensembl:ENSG00000172687 euGenes: HUgn148203 ECgene: ZNF738
    H-InvDB: ZNF738

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF738 gene:
    Search GeneIP for patents involving ZNF738

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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