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ZNF737 Gene

protein-coding   GIFtS: 41
GCID: GC19M020957

Zinc Finger Protein 737

  Search for ZNF737
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 7371 2
ZNF1022 3 5
Zinc Finger Protein 102 (Y3)2
Zinc Finger Protein 1023

External Ids:    HGNC: 324681   Entrez Gene: 1001298422   Ensembl: ENSG000002374407   OMIM: 6039845   UniProtKB: O753733   

Export aliases for ZNF737 gene to outside databases

Previous GC identifers: GC19U900745 GC19M020524 GC19M020720 GC19M020211 GC19M020804


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF737 Gene:
ZNF737 (zinc finger protein 737) is a protein-coding gene. An important paralog of this gene is ZNF85.

UniProtKB/Swiss-Prot: ZN737_HUMAN, O75373
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ZNF737
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ZNF737

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF737


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p12   Ensembl cytogenetic band:  19p12   HGNC cytogenetic band: 19p12

ZNF737 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF737 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M020957:  view genomic region     (about GC identifiers)

Start:
20,718,631 bp from pter      End:
20,748,626 bp from pter
Size:
29,996 bases      Orientation:
minus strand

1 alternative location:
Chr19-,NW_003571053 455,245-483,073     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN737_HUMAN, O75373 (See protein sequence)
Recommended Name: Zinc finger protein 737  
Size: 536 amino acids; 61931 Da
Secondary accessions: C9JHM3

Explore the universe of human proteins at neXtProt for ZNF737: NX_O75373

Explore proteomics data for ZNF737 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys286
  • Modification sites at PhosphoSitePlus

  • See ZNF737 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001152765.1  
    ENSEMBL proteins: 
     ENSP00000471995   ENSP00000395733   ENSP00000471784   ENSP00000470737   ENSP00000471973  
    Reactome Protein details: O75373

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry O75373

    ProtoNet protein and cluster: O75373

    UniProtKB/Swiss-Prot: ZN737_HUMAN, O75373
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 13 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF737           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN737_HUMAN, O75373
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF737           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF737:
     Decreased influenza A virus in 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN737_HUMAN, O75373: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF737           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF737 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF737           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF737
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF737
    Interactions:

        Search GeneGlobe Interaction Network for ZNF737

    1 Interacting protein for ZNF737 (O753733) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SREBF2Q127723I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF737           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF737 (ZN737)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF737 gene: 
    NM_001159293.1  

    Unigene Cluster for ZNF737:

    Zinc finger protein 737
    Hs.515696  [show with all ESTs]
    Unigene Representative Sequence: NM_001159293
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000596530 ENST00000427401(uc002npa.3) ENST00000594419 ENST00000597940
    ENST00000596797
    miRNA
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    Additional mRNA sequence: BC015765.1 

    17 DOTS entries:

    DT.91918341  DT.104717  DT.101961053  DT.100008579  DT.100649883  DT.101970160  DT.106754  DT.121496621 
    DT.306919  DT.40120431  DT.95301598  DT.75136851  DT.92326694  DT.95202290  DT.100035550  DT.75129798 
    DT.91969012 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF737 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCATCAAGC
    ZNF737 Expression
    About this image

    ZNF737 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF737 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515696
        Custom PCR Arrays for ZNF737
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF737

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF737 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 8)
    Uncharacterized protein
    (see all 8)
    54(a)
    42(a)
    (see all 8)
    many ↔ many
    many ↔ many
    (see all 8)
    AAWZ02037240(11818-13836)
    GL343434.1(292314-296903)
            Species with no ortholog for ZNF737

    ENSEMBL Gene Tree for ZNF737 (if available)
    TreeFam Gene Tree for ZNF737 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF737 gene
    ZNF852  ZNF4862  ZNF1952  ZNF922  ZNF1002  ZNF7322  ZNF6752  ZNF1382  
    ZNF5062  ZNF662  ZNF2732  ZNF6952  ZNF6262  ZNF6802  ZNF4792  ZNF2532  
    ZNF932  ZNF6822  ZNF4922  ZNF6762  ZNF6812  ZNF1412  ZNF7362  ZNF6792  
    ZNF2572  ZNF2542  ZNF724P2  ZNF982  ZNF7162  ZNF7142  ZNF4292  ZNF5192  
    ZNF4302  ZNF7302  ZNF7082  ZNF1172  ZNF4312  ZNF902  ZNF7262  ZNF7282  
    Selected SIMAP similar genes for ZNF737 using alignment to 5 protein entries:     ZN737_HUMAN (see all proteins) (see all similar genes):
    PLEKHH2    DNMT1    MGC12518    AURA2    BECN1    BTBD2
    CTSS    RTBDN    FOPNL    ZNF98    IMPA1    ZNF93
    ZNF506    ZNF90    ERBB2    NEK4    NF2    TMEM14B

    Find genes that share paralogs with ZNF737           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ZNF737
    PGOHUM00000233378


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF737 (see all 833)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1482361751,2
    C--20685617(+) AACCCC/TAGTAA 1 -- us2k10--------
    rs1459681631,2
    C--20720362(+) CTGTCA/GCCCAG 1 -- int10--------
    rs1398857671,2
    --20720434(+) TCTTCC/TGCCTC 1 -- int10--------
    rs431911,2
    C,F,A--20720479(-) cgggcG/Atagtg 1 -- int14Minor allele frequency- A:0.43NA WA CSA 7
    rs771836931,2
    C,F--20720655(+) TAAAAT/CTCTTC 1 -- int12Minor allele frequency- C:0.06WA 120
    rs730105121,2
    C--20720660(+) TTCTTC/TGCTAA 1 -- int13Minor allele frequency- T:0.12CSA WA EA 240
    rs758920721,2
    C,F--20720681(+) TCTTAT/CTCAAA 1 -- int12Minor allele frequency- C:0.07WA 120
    rs755054741,2
    C,F--20720767(+) ACATAA/GTCTTT 1 -- int12Minor allele frequency- G:0.04WA 120
    rs1860590601,2
    --20720938(+) AATTAC/TGAATA 1 -- ut310--------
    rs1921072181,2
    --20721026(+) ATCAAC/TGTACT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF737 (20718631 - 20748626 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZNF737 (see all 41):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718314CNV Deletion23290073
    esv2422114CNV Deletion20811451
    dgv550e201CNV Deletion23290073
    dgv630e199CNV Deletion23128226
    esv2658579CNV Deletion23128226
    esv2718315CNV Deletion23290073
    esv2718311CNV Deletion23290073
    esv267467CNV Insertion20981092
    esv1696645CNV Insertion17803354
    esv274568CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603984    OMIM disorders: --


    Find genes that share disorders with ZNF737           About GenesLikeMe


    Export disorders for ZNF737 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF737 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF737)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. (PubMed id 8467795)1, 2 Bellefroid E.J.... Martial J.A. (EMBO J. 1993)
    3. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (Science 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 100129842 HGNC: 32468 Ensembl:ENSG00000237440 euGenes: HUgn100129842 ECgene: ZNF737
    H-InvDB: ZNF737

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF737 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF737 gene:
    Search GeneIP for patents involving ZNF737

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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