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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF736 Gene

protein-coding GIFtS: 35
GCID: GC07P063767

zinc finger protein 736

Search for ZNF736
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger Protein 736¹ ²
KRAB-Containing Zinc-Finger Repressor Protein²

External Ids:	HGNC: 32467¹	Entrez Gene: 728927²	Ensembl: ENSG00000234444⁷	UniProtKB: B4DX44³

Export aliases for ZNF736 gene to outside databases

Previous GC identifers: GC00U922630 GC07P060153

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN736_HUMAN, B4DX44

Function: May be involved in transcriptional regulation (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007933.15 NT_079593.2

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for ZNF736
Other transcription factors

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF736

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.21 Ensembl cytogenetic band: 7q11.21 HGNC cytogenetic band: 7q11.21

ZNF736 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF736 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P063767: view genomic region (about GC identifiers)

Start:	63,767,837 bp from pter	End:	63,810,017 bp from pter
Size:	42,181 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 63,110,780-63,147,611

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN736_HUMAN, B4DX44 (See protein sequence)

Recommended Name: Zinc finger protein 736

Size: 427 amino acids; 49868 Da

Subcellular location: Nucleus (By similarity)

Explore the universe of human proteins at neXtProt for ZNF736: NX_B4DX44

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_B4DX44

ZNF736 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001164376.1

ENSEMBL proteins:

ENSP00000391083 ENSP00000400852 ENSP00000347210

Reactome Protein details: B4DX44
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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

ZNF736 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF736 for domains About GeneDecksing

4 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR001909 Krueppel-associated_box

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry B4DX44

ProtoNet protein and cluster: B4DX44

UniProtKB/Swiss-Prot: ZN736_HUMAN, B4DX44

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 10 C2H2-type zinc fingers

Similarity: Contains 1 KRAB domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZN736_HUMAN, B4DX44

Function: May be involved in transcriptional regulation (By similarity)

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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZNF736 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Generic Transcription Pathway

Generic Transcription Pathway

1.00

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Reactome Pathways for ZNF736

	Generic Transcription Pathway
	Gene Expression

ZNF736 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF736

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZNF736 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Browse Tocris compounds for ZNF736
Search CenterWatch for drugs/clinical trials and news about ZNF736 / ZN736

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for ZNF736 gene:

NM_001170905.1

Unigene Cluster for ZNF736:

Zinc finger protein 736

Hs.734771 [show with all ESTs]

Unigene Representative Sequence: NM_001170905

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000493036 ENST00000465343 ENST00000492322 ENST00000438373 ENST00000488621

ENST00000423484 ENST00000355095(uc011kdo.2)

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Additional cDNA sequence:

AK301806.1 BC031335.1

8 DOTS entries:

DT.101970897 DT.40259039 DT.95326739 DT.121100403 DT.121100456 DT.121421758 DT.40127351 DT.95081594

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF736 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

ZNF736 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Spermatid

Germ Cells, Male Gametocytes

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ZNF736 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF736

SOURCE GeneReport for Unigene cluster: Hs.734771

SABiosciences Custom PCR Arrays for ZNF736

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ZNF736 gene from 1/4 species (see all 4) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 7)	--	42(a) 39(a) (see all 7)	many ↔ many many ↔ many (see all 7)	GL343330.1(1093706-1292239) AAWZ02037240(11818-13836)

ENSEMBL Gene Tree for ZNF736 (if available)
TreeFam Gene Tree for ZNF736 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF736 gene

ZNF727²

18/482 SIMAP similar genes for ZNF736 using alignment to 1 protein entry: ZN736_HUMAN(see all similar genes):

ZNF727 ZNF78L1 MGC12518 ZFS-4 ZFS-6 ZNF232

ZNF826P ZNF283 DKFZp686M04222 ZFS-5 ZNF808 ZNF273

ZNF81 ZNF DKFZp686H10254 HZF30 HZF36 ZNF66

ZNF736 for paralogs About GeneDecksing

5/20 Pseudogenes.org Pseudogenes for ZNF736 (see all 20)
PGOHUM00000259390 PGOHUM00000245422 PGOHUM00000245966 PGOHUM00000235346 PGOHUM00000232730

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs638873^1,2	C,F,A,H,	--	63771235(-)	`ACCCCG/AGGGGC`	1	--	us2k¹		6		NA WA EA	364
rs61000688^1,2	C,F,	--	63771242(+)	`GGGTCA/GCCATG`	1	--	us2k¹		1		WA	118
rs6947268^1,2	C,	--	63771269(+)	`TGACCC/AGGGAG`	1	--	us2k¹		1		NA	2
rs6947294^1,2	C,F,H,	--	63771321(+)	`TCTCCA/GTAACC`	1	--	us2k¹		7		NS EA NA WA	652
rs192461541^1,2		--	63771332(+)	`TCTGCC/GGATCT`	1	--	us2k¹		0	--	--	--	--
rs6951617^1,2	C,F,H,	--	63771372(+)	`GCCACT/CCCGTT`	1	--	us2k¹		7		NS EA NA WA	632
rs184389254^1,2		--	63771373(+)	`CCACTC/TCGTTA`	1	--	us2k¹		0	--	--	--	--
rs62463884^1,2		--	63771374(+)	`CACTCC/TGTTAA`	1	--	us2k¹		0	--	--	--	--
rs149473370^1,2	C,	--	63771483(+)	`CTAAA-/GGGGGG`	1	--	us2k¹		0	--	--	--	--
rs71060583^1,2	C	--	63771484(+)	`TAAAGG/-GGGGG`	1	--	us2k¹		1		NA	2

HapMap Linkage Disequilibrium report for ZNF736 (63767837 - 63810017 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZNF736
1 CNV: 5239

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF736 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF736)

Utopia: connect your pdf to the dynamic
world of online information

Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
The DNA sequence of human chromosome 7. (PubMed id 12853948)² Hillier L.W.... Wilson R.K. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 728927	HGNC: 32467	Ensembl:ENSG00000234444	euGenes: HUgn728927	ECgene: ZNF736
H-InvDB: ZNF736

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF736	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF736 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF736 gene:
Search GeneIP for patents involving ZNF736

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
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About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZNF736 gene at Home site.

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ZNF736 Gene

zinc finger protein 736

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ZNF736 Gene

zinc finger protein 736

Aliasesfor ZNF736 gene

Summariesfor ZNF736 gene

Genomic Viewsfor ZNF736 gene

Proteinsfor ZNF736 gene

Protein Domains /Familiesfor ZNF736 gene

Functionfor ZNF736 gene

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Transcriptsfor ZNF736 gene

Expression for ZNF736 gene

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Genomic Variantsfor ZNF736 gene

Disorders / Diseasesfor ZNF736 gene

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External Searches for ZNF736 gene

Genome Databases showing ZNF736 gene

Other Databases showing ZNF736 gene

Specialized Databases showing ZNF736 gene

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Aliases
for ZNF736 gene

Summaries
for ZNF736 gene

Genomic Views
for ZNF736 gene

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for ZNF736 gene

Protein Domains /
Families
for ZNF736 gene

Function
for ZNF736 gene

Pathways & Interactions
for ZNF736 gene

Drugs & Compounds
for ZNF736 gene

Transcripts
for ZNF736 gene

Expression
for ZNF736 gene

Orthologs
for ZNF736 gene

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for ZNF736 gene

Genomic Variants
for ZNF736 gene

Disorders / Diseases
for ZNF736 gene

Publications
for ZNF736 gene

Intellectual Property
for ZNF736 gene

Products
for ZNF736 gene