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Aliases for ZNF732 Gene

Aliases for ZNF732 Gene

  • Zinc Finger Protein 732 2 3

External Ids for ZNF732 Gene

Previous GeneCards Identifiers for ZNF732 Gene

  • GC00U922461
  • GC04U900973
  • GC04P000197
  • GC04M000262
  • GC04M000267
  • GC04M000269
  • GC04M000274
  • GC04M000280
  • GC04M000285
  • GC04M000291
  • GC04M000296

Summaries for ZNF732 Gene

GeneCards Summary for ZNF732 Gene

ZNF732 (Zinc Finger Protein 732) is a Protein Coding gene. Diseases associated with ZNF732 include anonychia congenita. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF253.

UniProtKB/Swiss-Prot for ZNF732 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF732 Gene

Genomics for ZNF732 Gene

Regulatory Elements for ZNF732 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF732 Gene

Chromosome:
4
Start:
270,675 bp from pter
End:
305,321 bp from pter
Size:
34,647 bases
Orientation:
Minus strand

Genomic View for ZNF732 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF732 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF732 Gene

Proteins for ZNF732 Gene

  • Protein details for ZNF732 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B4DXR9-ZN732_HUMAN
    Recommended name:
    Zinc finger protein 732
    Protein Accession:
    B4DXR9

    Protein attributes for ZNF732 Gene

    Size:
    585 amino acids
    Molecular mass:
    67839 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF732 Gene

Proteomics data for ZNF732 Gene at MOPED

Post-translational modifications for ZNF732 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF732 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF732 Gene

Domains & Families for ZNF732 Gene

Gene Families for ZNF732 Gene

Protein Domains for ZNF732 Gene

Suggested Antigen Peptide Sequences for ZNF732 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

B4DXR9

UniProtKB/Swiss-Prot:

ZN732_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 16 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 16 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF732: view

Function for ZNF732 Gene

Molecular function for ZNF732 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF732 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF732: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF732 Gene

Localization for ZNF732 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF732 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF732 Gene COMPARTMENTS Subcellular localization image for ZNF732 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF732 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ZNF732: view

Pathways & Interactions for ZNF732 Gene

SuperPathways for ZNF732 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF732: view

Pathways by source for ZNF732 Gene

2 Reactome pathways for ZNF732 Gene

Interacting Proteins for ZNF732 Gene

Gene Ontology (GO) - Biological Process for ZNF732 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF732: view

No data available for SIGNOR curated interactions for ZNF732 Gene

Drugs & Compounds for ZNF732 Gene

No Compound Related Data Available

Transcripts for ZNF732 Gene

mRNA/cDNA for ZNF732 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF732 Gene

Zinc finger protein 732:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF732

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF732 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8
SP1: - -
SP2: - -
SP3: - - -
SP4:
SP5: - - - -

Relevant External Links for ZNF732 Gene

GeneLoc Exon Structure for
ZNF732
ECgene alternative splicing isoforms for
ZNF732

Expression for ZNF732 Gene

mRNA expression in normal human tissues for ZNF732 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF732 Gene

This gene is overexpressed in Brain - Cerebellum (x4.1).

Protein differential expression in normal tissues from HIPED for ZNF732 Gene

This gene is overexpressed in Liver (68.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF732 Gene



SOURCE GeneReport for Unigene cluster for ZNF732 Gene Hs.698668

genes like me logo Genes that share expression patterns with ZNF732: view

Protein tissue co-expression partners for ZNF732 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZNF732 Gene

Orthologs for ZNF732 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF732 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF732 35
  • 99.2 (n)
  • 98.12 (a)
ZNF732 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 52 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 37 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 41 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zfp493 36
  • 57 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
Species with no ortholog for ZNF732:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF732 Gene

ENSEMBL:
Gene Tree for ZNF732 (if available)
TreeFam:
Gene Tree for ZNF732 (if available)

Paralogs for ZNF732 Gene

(517) SIMAP similar genes for ZNF732 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ZNF732 Gene

genes like me logo Genes that share paralogs with ZNF732: view

Variants for ZNF732 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF732 Gene

Variant ID Type Subtype PubMed ID
nsv878233 CNV Gain 21882294
nsv878236 CNV Loss 21882294
nsv829833 CNV Gain 17160897
dgv914e199 CNV Deletion 23128226
dgv5386n71 CNV Gain 21882294
esv4769 CNV Complex 18987735
nsv878244 CNV Loss 21882294
nsv469996 CNV Gain 18288195
nsv469736 CNV Loss 16826518
esv2462495 CNV Deletion 19546169
esv2673769 CNV Deletion 23128226

Variation tolerance for ZNF732 Gene

Residual Variation Intolerance Score: 98.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.95; 68.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF732 Gene

HapMap Linkage Disequilibrium report
ZNF732

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for ZNF732 Gene

Disorders for ZNF732 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF732 Gene - From: DISEASES

Disorder Aliases PubMed IDs
anonychia congenita
  • hyponychia congenita
- elite association

Relevant External Links for ZNF732

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF732
genes like me logo Genes that share disorders with ZNF732: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF732 Gene

Publications for ZNF732 Gene

  1. Genome-wide association study of antibody response to smallpox vaccine. (PMID: 22542470) Ovsyannikova I.G. … Poland G.A. (Vaccine 2012) 67
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 67
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67
  4. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 67

Products for ZNF732 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZNF732
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF732
  • Block miRNA regulation of ZNF732 using miScript Target Protectors

Sources for ZNF732 Gene

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