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Aliases for ZNF732 Gene

Aliases for ZNF732 Gene

  • Zinc Finger Protein 732 2 3 5

External Ids for ZNF732 Gene

Previous GeneCards Identifiers for ZNF732 Gene

  • GC00U922461
  • GC04U900973
  • GC04P000197
  • GC04M000262
  • GC04M000267
  • GC04M000269
  • GC04M000274
  • GC04M000280
  • GC04M000285
  • GC04M000291
  • GC04M000296
  • GC04M000300
  • GC04M000305
  • GC04M000310
  • GC04M000314
  • GC04M000318
  • GC04M000323

Summaries for ZNF732 Gene

Entrez Gene Summary for ZNF732 Gene

  • This gene encodes a kruppel-associated box-containing zinc finger protein (KRAB-ZFP). The encoded protein contains an N-terminal kruppel-associated box (KRAB) domain and sixteen C-terminal C2H2-type zinc finger domains. The KRAB-ZFPs represent the largest family of mammalian transcriptional repressors, which function through the recruitment of the nuclear co-factor KRAB-Associated Protein 1 (KAP1), to engage histone modifiers and induce heterochromatin formation. [provided by RefSeq, Jul 2017]

GeneCards Summary for ZNF732 Gene

ZNF732 (Zinc Finger Protein 732) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF141.

UniProtKB/Swiss-Prot for ZNF732 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF732 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF732 Gene

Genomics for ZNF732 Gene

GeneHancer (GH) Regulatory Elements for ZNF732 Gene

Promoters and enhancers for ZNF732 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I000304 Promoter/Enhancer 1.1 Ensembl ENCODE 560.1 +0.1 70 1.7 MXI1 PKNOX1 DDX20 MAX SIN3A SP1 POLR2A CHD2 ZNF732 ZNF718 ENSG00000251689
GH04I001009 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 12.4 -705.9 -705917 3.8 HDGF PKNOX1 ZFP64 ARID4B SIN3A ZNF48 GLIS2 CBX5 ZNF143 FOS FGFRL1 LOC100129917 ZNF141 ZNF718 ZNF876P CTBP1-AS2 ZNF732 LOC100288172 ABCA11P IDUA
GH04I000704 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.3 -400.9 -400934 2.6 HDGF PKNOX1 CLOCK SMAD1 ARNT SIN3A YBX1 ZNF2 POLR2B ZNF207 PCGF3 CRIPAK LOC100129917 ZNF718 PIGG ZNF141 ENSG00000272588 PDE6B ENSG00000281016 ZNF732
GH04I001240 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 9.9 -940.7 -940702 10.5 HDGF PKNOX1 ATF1 ARNT SIN3A YY1 ZNF766 GLIS2 ZNF207 ZNF143 CTBP1 MAEA CTBP1-AS2 UVSSA CRIPAK ZNF732 PIR37123 CTBP1-AS
GH04I001041 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 12.4 -736.5 -736465 1.6 PKNOX1 ATF1 RB1 ZSCAN4 EGR1 ATF7 EGR2 HDAC8 ZNF592 SP1 GC04M001019 LOC105374343 CRIPAK LOC100129917 ZNF141 CTBP1-AS2 ZNF718 ZNF876P ZNF732 LOC100288172
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF732 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF732 gene promoter:

Genomic Locations for ZNF732 Gene

Genomic Locations for ZNF732 Gene
chr4:270,675-305,321
(GRCh38/hg38)
Size:
34,647 bases
Orientation:
Minus strand
chr4:264,464-299,110
(GRCh37/hg19)

Genomic View for ZNF732 Gene

Genes around ZNF732 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF732 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF732 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF732 Gene

Proteins for ZNF732 Gene

  • Protein details for ZNF732 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B4DXR9-ZN732_HUMAN
    Recommended name:
    Zinc finger protein 732
    Protein Accession:
    B4DXR9

    Protein attributes for ZNF732 Gene

    Size:
    585 amino acids
    Molecular mass:
    67839 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF732 Gene

Post-translational modifications for ZNF732 Gene

No Post-translational modifications

Other Protein References for ZNF732 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF732 Gene

Domains & Families for ZNF732 Gene

Gene Families for ZNF732 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF732 Gene

Suggested Antigen Peptide Sequences for ZNF732 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

B4DXR9

UniProtKB/Swiss-Prot:

ZN732_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF732: view

Function for ZNF732 Gene

Molecular function for ZNF732 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF732 Gene

Gene Ontology (GO) - Molecular Function for ZNF732 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF732: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF732 Gene

Localization for ZNF732 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF732 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF732 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF732 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF732: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF732 Gene

Pathways & Interactions for ZNF732 Gene

SuperPathways for ZNF732 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF732: view

Pathways by source for ZNF732 Gene

2 Reactome pathways for ZNF732 Gene

Interacting Proteins for ZNF732 Gene

Gene Ontology (GO) - Biological Process for ZNF732 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF732: view

No data available for SIGNOR curated interactions for ZNF732 Gene

Drugs & Compounds for ZNF732 Gene

No Compound Related Data Available

Transcripts for ZNF732 Gene

mRNA/cDNA for ZNF732 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF732 Gene

Zinc finger protein 732:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF732 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8
SP1: - -
SP2: - -
SP3: - - -
SP4:
SP5: - - - -

Relevant External Links for ZNF732 Gene

GeneLoc Exon Structure for
ZNF732
ECgene alternative splicing isoforms for
ZNF732

Expression for ZNF732 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF732 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF732 Gene

This gene is overexpressed in Brain - Cerebellum (x4.1).

Protein differential expression in normal tissues from HIPED for ZNF732 Gene

This gene is overexpressed in Liver (68.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF732 Gene



Protein tissue co-expression partners for ZNF732 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF732 Gene:

ZNF732

SOURCE GeneReport for Unigene cluster for ZNF732 Gene:

Hs.698668
genes like me logo Genes that share expression patterns with ZNF732: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF732 Gene

Orthologs for ZNF732 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF732 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF732 33 34
  • 99.2 (n)
mouse
(Mus musculus)
Mammalia Zfp493 34
  • 57 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 52 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 50 (a)
ManyToMany
-- 34
  • 41 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 37 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 51 (a)
ManyToMany
-- 34
  • 44 (a)
ManyToMany
-- 34
  • 39 (a)
ManyToMany
-- 34
  • 36 (a)
ManyToMany
-- 34
  • 35 (a)
ManyToMany
-- 34
  • 33 (a)
ManyToMany
-- 34
  • 33 (a)
ManyToMany
-- 34
  • 29 (a)
ManyToMany
Species where no ortholog for ZNF732 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF732 Gene

ENSEMBL:
Gene Tree for ZNF732 (if available)
TreeFam:
Gene Tree for ZNF732 (if available)

Paralogs for ZNF732 Gene

(517) SIMAP similar genes for ZNF732 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ZNF732 Gene

genes like me logo Genes that share paralogs with ZNF732: view

Variants for ZNF732 Gene

Sequence variations from dbSNP and Humsavar for ZNF732 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000035875 -- 287,108(-) G/A intron_variant
rs1000091614 -- 295,889(-) C/T intron_variant
rs1000189243 -- 289,891(-) T/G intron_variant
rs1000237308 -- 283,861(-) A/G intron_variant
rs10002733 -- 285,607(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF732 Gene

Variant ID Type Subtype PubMed ID
dgv2697n106 CNV deletion 24896259
dgv5074n100 CNV loss 25217958
dgv914e199 CNV deletion 23128226
esv2462495 CNV deletion 19546169
esv2673769 CNV deletion 23128226
esv2763816 CNV gain+loss 21179565
esv3599366 CNV gain 21293372
esv3893860 CNV loss 25118596
esv3893862 CNV gain 25118596
esv4769 OTHER complex 18987735
nsv1001899 CNV loss 25217958
nsv1004032 CNV loss 25217958
nsv1009336 CNV gain 25217958
nsv1011039 CNV loss 25217958
nsv1011981 CNV loss 25217958
nsv1074123 CNV deletion 25765185
nsv1150471 CNV deletion 26484159
nsv469736 CNV loss 16826518
nsv469996 CNV gain 18288195
nsv593190 CNV gain 21841781
nsv593198 CNV loss 21841781
nsv829833 CNV gain 17160897
nsv956428 CNV deletion 24416366
nsv966244 CNV duplication 23825009

Variation tolerance for ZNF732 Gene

Residual Variation Intolerance Score: 98.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.95; 68.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF732 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF732

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF732 Gene

Disorders for ZNF732 Gene

Additional Disease Information for ZNF732

No disorders were found for ZNF732 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF732 Gene

Publications for ZNF732 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks. (PMID: 28273063) Imbeault M … Trono D (Nature 2017) 3 58
  3. Evolution of KRAB-containing zinc finger proteins and their roles in species evolution. (PMID: 27867147) Wang J … Tian CY (Yi chuan = Hereditas 2016) 3 58
  4. Zinc fingers function cooperatively with KRAB domain for nuclear localization of KRAB-containing zinc finger proteins. (PMID: 24647005) Wang W … Li W (PloS one 2014) 3 58
  5. Cys2His2 zinc finger protein family: classification, functions, and major members. (PMID: 22803940) Razin SV … Kantidze OL (Biochemistry. Biokhimiia 2012) 3 58

Products for ZNF732 Gene

Sources for ZNF732 Gene

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