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Aliases for ZNF730 Gene

Aliases for ZNF730 Gene

  • Zinc Finger Protein 730 2 3 5

External Ids for ZNF730 Gene

Previous GeneCards Identifiers for ZNF730 Gene

  • GC19P023299
  • GC19P022840
  • GC19P023248

Summaries for ZNF730 Gene

GeneCards Summary for ZNF730 Gene

ZNF730 (Zinc Finger Protein 730) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF98.

UniProtKB/Swiss-Prot for ZNF730 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF730 Gene

Genomics for ZNF730 Gene

Regulatory Elements for ZNF730 Gene

Enhancers for ZNF730 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F023074 0.6 ENCODE 17.3 +0.4 438 2.1 BRD4 GTF2F1 ZNF133 SIN3A REST TFDP1 E2F1 POLR2A MLLT1 ZNF730 ZNF492 ZNF728 ENSG00000267924 GC19P023094
GH19F023170 0.2 ENCODE 12 +95.5 95484 0.2 ZNF730 GC19P023157 ENSG00000269471
GH19F023070 0.5 ENCODE 4.5 -3.9 -3931 0.6 TBP SUZ12 POLR2A HLF ZNF730 ENSG00000269543 GC19P023066
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF730 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF730 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000641333 491 2200 BRD4 CTCF ZNF133 SIN3A REST RAD21 TFDP1 E2F1 POLR2A MLLT1

Genomic Location for ZNF730 Gene

23,075,210 bp from pter
23,147,219 bp from pter
72,010 bases
Plus strand

Genomic View for ZNF730 Gene

Genes around ZNF730 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF730 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF730 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF730 Gene

Proteins for ZNF730 Gene

  • Protein details for ZNF730 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative zinc finger protein 730
    Protein Accession:

    Protein attributes for ZNF730 Gene

    503 amino acids
    Molecular mass:
    59040 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF730 Gene

Post-translational modifications for ZNF730 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF730 Gene

No data available for DME Specific Peptides for ZNF730 Gene

Domains & Families for ZNF730 Gene

Gene Families for ZNF730 Gene

Protein Domains for ZNF730 Gene

Suggested Antigen Peptide Sequences for ZNF730 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF730: view

Function for ZNF730 Gene

Molecular function for ZNF730 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF730 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF730: view

Animal Model Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF730 Gene

Localization for ZNF730 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF730 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF730 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF730 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IBA --
genes like me logo Genes that share ontologies with ZNF730: view

Pathways & Interactions for ZNF730 Gene

SuperPathways for ZNF730 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF730: view

Pathways by source for ZNF730 Gene

2 Reactome pathways for ZNF730 Gene

Interacting Proteins for ZNF730 Gene

Gene Ontology (GO) - Biological Process for ZNF730 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
genes like me logo Genes that share ontologies with ZNF730: view

No data available for SIGNOR curated interactions for ZNF730 Gene

Transcripts for ZNF730 Gene

mRNA/cDNA for ZNF730 Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF730 Gene

Zinc finger protein 730:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF730 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1: -
SP3: - -

Relevant External Links for ZNF730 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF730 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF730 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF730 Gene

This gene is overexpressed in Testis (x15.3).

NURSA nuclear receptor signaling pathways regulating expression of ZNF730 Gene:


SOURCE GeneReport for Unigene cluster for ZNF730 Gene:

genes like me logo Genes that share expression patterns with ZNF730: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF730 Gene

Orthologs for ZNF730 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF730 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF730 34 35
  • 98.28 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 53 (a)
-- 35
  • 35 (a)
(Bos Taurus)
Mammalia -- 35
  • 51 (a)
(Mus musculus)
Mammalia Rsl1 35
  • 42 (a)
(Canis familiaris)
Mammalia -- 35
  • 36 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 49 (a)
-- 35
  • 38 (a)
-- 35
  • 35 (a)
-- 35
  • 31 (a)
-- 35
  • 29 (a)
-- 35
  • 29 (a)
-- 35
  • 28 (a)
-- 35
  • 26 (a)
Species where no ortholog for ZNF730 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF730 Gene

Gene Tree for ZNF730 (if available)
Gene Tree for ZNF730 (if available)

Paralogs for ZNF730 Gene

(497) SIMAP similar genes for ZNF730 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF730: view

Variants for ZNF730 Gene

Sequence variations from dbSNP and Humsavar for ZNF730 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1037993 -- 23,124,004(+) ATACT(G/T)CTCCC intron-variant, upstream-variant-2KB
rs1037994 -- 23,124,241(+) CTGCA(C/T)GTTCT intron-variant, upstream-variant-2KB
rs1037995 -- 23,124,353(+) AGAGC(C/G)ATAAC intron-variant, upstream-variant-2KB
rs10402689 -- 23,109,475(+) gagat(C/G)tcgac intron-variant
rs10405359 -- 23,113,279(+) aagca(C/T)gcttc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF730 Gene

Variant ID Type Subtype PubMed ID
nsv9686 CNV gain+loss 18304495
nsv963031 CNV duplication 23825009
nsv961200 CNV duplication 23825009
nsv961199 CNV duplication 23825009
nsv956607 CNV deletion 24416366
nsv833789 CNV gain+loss 17160897
nsv833788 CNV gain 17160897
nsv817826 CNV gain 17921354
nsv579032 CNV loss 21841781
nsv469842 CNV gain+loss 16826518
nsv458527 CNV loss 19166990
nsv1072873 CNV deletion 25765185
nsv1060295 CNV loss 25217958
nsv1057420 CNV gain 25217958
esv8775 CNV loss 19470904
esv5233 OTHER inversion 18987735
esv3643986 CNV gain 21293372
esv3643985 CNV loss 21293372
esv3643984 CNV gain 21293372
esv3643983 CNV loss 21293372
esv3556206 CNV deletion 23714750
esv2934 CNV loss 18987735
esv2758750 CNV gain+loss 17122850
esv2751784 CNV gain 17911159
esv2718367 CNV deletion 23290073
esv2511687 CNV deletion 19546169
esv2436547 CNV deletion 19546169
esv1932531 CNV deletion 18987734
esv1572676 CNV deletion 17803354
dgv511e201 CNV deletion 23290073
dgv1739n106 CNV deletion 24896259
dgv138e55 CNV gain 17911159

Variation tolerance for ZNF730 Gene

Residual Variation Intolerance Score: 91.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.81; 58.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF730 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF730 Gene

Disorders for ZNF730 Gene

Relevant External Links for ZNF730

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF730 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF730 Gene

Publications for ZNF730 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for ZNF730 Gene

Sources for ZNF730 Gene

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