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ZNF729 Gene

protein-coding   GIFtS: 34
GCID: GC19P022486

Zinc Finger Protein 729

  Search for ZNF729
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 7291 2

External Ids:    HGNC: 324641   Entrez Gene: 1002872262   Ensembl: ENSG000001963507   UniProtKB: A6NN143   

Export aliases for ZNF729 gene to outside databases

Previous GC identifers: GC00U921783 GC19U900716 GC19P022264


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF729 Gene:
ZNF729 (zinc finger protein 729) is a protein-coding gene. An important paralog of this gene is ZNF91.

UniProtKB/Swiss-Prot: ZN729_HUMAN, A6NN14
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ZNF729
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ZNF729

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF729


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p12   Ensembl cytogenetic band:  19p12   HGNC cytogenetic band: 19p12

ZNF729 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF729 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P022486:  view genomic region     (about GC identifiers)

Start:
22,469,210 bp from pter      End:
22,499,978 bp from pter
Size:
30,769 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN729_HUMAN, A6NN14 (See protein sequence)
Recommended Name: Zinc finger protein 729  
Size: 1173 amino acids; 135747 Da

Explore the universe of human proteins at neXtProt for ZNF729: NX_A6NN14

Explore proteomics data for ZNF729 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys887
  • Modification sites at PhosphoSitePlus

  • See ZNF729 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001229609.1  
    ENSEMBL proteins: 
     ENSP00000469582   ENSP00000350085  
    Reactome Protein details: A6NN14

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry A6NN14

    ProtoNet protein and cluster: A6NN14

    UniProtKB/Swiss-Prot: ZN729_HUMAN, A6NN14
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 35 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF729 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN729_HUMAN, A6NN14
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    ZNF729 for ontologies           About GeneDecksing


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN729_HUMAN, A6NN14: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF729 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF729 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF729
        Generic Transcription Pathway



    ZNF729 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF729
    Interactions:

        Search GeneGlobe Interaction Network for ZNF729

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    ZNF729 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF729 (ZN729)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF729 gene: 
    NM_001242680.1  

    Unigene Cluster for ZNF729:

    Zinc finger protein 729
    Hs.531629  [show with all ESTs]
    Unigene Representative Sequence: NM_001242680
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000601693 ENST00000357491(uc021urs.1)
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    2 DOTS entries:

    DT.121421676  DT.92023614 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF729 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF729 Expression
    About this image

    ZNF729 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF729 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.531629
        Custom PCR Arrays for ZNF729
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZNF729 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia A530054K11Rik1 , 5 RIKEN cDNA A530054K11 gene1, 5 67.31(n)1
    59.42(a)1
      13 (34.62 cM)5
    2122811  NM_183146.31  NP_898969.21 
     676170015 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 57)
    Uncharacterized protein
    (see all 57)
    58(a)
    57(a)
    (see all 57)
    many ↔ many
    many ↔ many
    (see all 57)
    GL343676.1(133636-262720)
    GL343786.1(58917-170574)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017328371 zinc finger protein 208-like 55.99(n)
    48.13(a)
      101732837  XM_004919060.1  XP_004919117.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005379891 zinc finger protein 41-like 66.09(n)
    59.77(a)
      100537989  XM_003198460.2  XP_003198508.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Oaz6
    O/E-associated zinc finger protein
    13(a)
    1 → many
    2R(10323404-10353386)


    ENSEMBL Gene Tree for ZNF729 (if available)
    TreeFam Gene Tree for ZNF729 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF729 gene
    ZNF912  ZNF5212  PEG32  ZNF8502  ZNF4232  ZNF2082  
    Selected SIMAP similar genes for ZNF729 using alignment to 2 protein entries:     ZN729_HUMAN (see all proteins) (see all similar genes):
    MGC12518    ZNF273    ZFS-6    ZNF701    DKFZp686M04222    DKFZp762K012
    ZNF78L1    ZFS-4    ZNF506    smap-7    HZF30    ZFS-1
    ZNF85    ZNF257    ZNF300P1    ZNF429    ZNF430    ZNF431

    ZNF729 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for ZNF729
    PGOHUM00000234219 PGOHUM00000234222 PGOHUM00000245112 PGOHUM00000232756


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF729 (see all 863)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs586858021,2
    C--22414700(+) TATAT-/ATAT  
            
    GGTCT
    1 -- int10--------
    rs1870668481,2
    --22467286(+) TGTGGA/CGGGGC 1 -- us2k10--------
    rs104214441,2
    C--22467290(+) gagggA/Gcaacc 1 -- us2k10--------
    rs1163498241,2
    F--22467319(+) GGTCTT/CGAATG 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1910312201,2
    --22467347(+) GAATGC/GTACCA 1 -- us2k10--------
    rs1181613781,2
    C,F--22467370(+) ATGGCC/GGATGT 1 -- us2k11Minor allele frequency- G:0.03NA 120
    rs1460652101,2
    --22467427(+) CCCTGC/TTGACA 1 -- us2k10--------
    rs1821136331,2
    C--22467451(+) AAGCTC/TATCCC 1 -- us2k10--------
    rs40855631,2
    C--22467472(+) gctgcC/Ttattc 1 -- us2k12Minor allele frequency- T:0.00NA 4
    rs739228601,2
    C,F--22467547(+) GCCCAG/CCCTAA 1 -- us2k11Minor allele frequency- C:0.50WA 2

    HapMap Linkage Disequilibrium report for ZNF729 (22469210 - 22499978 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZNF729 (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv552e201CNV Deletion23290073
    esv2718335CNV Deletion23290073
    dgv553e201CNV Deletion23290073
    dgv633e199CNV Deletion23128226
    nsv436853CNV Insertion17901297
    esv34340CNV Loss17911159
    nsv911441CNV Gain21882294
    nsv833786CNV Gain17160897
    dgv3813n71CNV Gain21882294
    dgv3n43CNV Gain19587683

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF729 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF729)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)1, 2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    2. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 100287226 HGNC: 32464 Ensembl:ENSG00000196350 euGenes: HUgn100287226 ECgene: ZNF729
    H-InvDB: ZNF729

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF729 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF729 gene:
    Search GeneIP for patents involving ZNF729

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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