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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF729 Gene

protein-coding   GIFtS: 32
GCID: GC19P022486

Zinc Finger Protein 729

  Search for ZNF729
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 7291 2

External Ids:    HGNC: 324641   Entrez Gene: 1002872262   Ensembl: ENSG000001963507   UniProtKB: A6NN143   

Export aliases for ZNF729 gene to outside databases

Previous GC identifers: GC00U921783 GC19U900716 GC19P022264


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF729 Gene: 
ZNF729 (zinc finger protein 729) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF91.

UniProtKB/Swiss-Prot: ZN729_HUMAN, A6NN14
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011295.11  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ZNF729
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ZNF729

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF729


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p12   Ensembl cytogenetic band:  19p12   HGNC cytogenetic band: 19p12

ZNF729 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF729 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P022486:  view genomic region     (about GC identifiers)

Start:
22,469,210 bp from pter      End:
22,499,978 bp from pter
Size:
30,769 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN729_HUMAN, A6NN14 (See protein sequence)
Recommended Name: Zinc finger protein 729  
Size: 1173 amino acids; 135747 Da
Subcellular location: Nucleus (Potential)

Explore the universe of human proteins at neXtProt for ZNF729: NX_A6NN14

Explore proteomics data for ZNF729 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A6NN14

  • ZNF729 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF729 Protein Expression
    REFSEQ proteins: NP_001229609.1  
    ENSEMBL proteins: 
     ENSP00000469582   ENSP00000350085  
    Reactome Protein details: A6NN14
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF729 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry A6NN14

    ProtoNet protein and cluster: A6NN14

    UniProtKB/Swiss-Prot: ZN729_HUMAN, A6NN14
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 35 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF729 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN729_HUMAN, A6NN14
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF729 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF729 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF729
        Generic Transcription Pathway
    Gene Expression



    ZNF729 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF729

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF729 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ZNF729 (ZN729)

    Search CenterWatch for drugs/clinical trials and news about ZNF729 / ZN729

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for ZNF729 gene: 
    NM_001242680.1  

    Unigene Cluster for ZNF729:

    Zinc finger protein 729
    Hs.531629  [show with all ESTs]
    Unigene Representative Sequence: NM_001242680
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000601693 ENST00000357491(uc021urs.1)
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    2 DOTS entries:

    DT.121421676  DT.92023614 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF729 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF729 Expression
    About this image


    See ZNF729 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.531629
        SABiosciences Custom PCR Arrays for ZNF729
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF729

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZNF729 gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia A530054K11Rik1 , 5 RIKEN cDNA A530054K11 gene1, 5 67.31(n)1
    59.42(a)1
      13 (34.62 cM)5
    2122811  NM_183146.31  NP_898969.21 
     676170015 


    ENSEMBL Gene Tree for ZNF729 (if available)
    TreeFam Gene Tree for ZNF729 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF729 gene
    ZNF2081 2  ZNF912  ZNF7212  ZNF5212  ZNF6462  ZNF8502  ZNF4232  
    18/495 SIMAP similar genes for ZNF729 using alignment to 2 protein entries:     ZN729_HUMAN (see all proteins) (see all similar genes):
    MGC12518    ZNF273    ZFS-6    ZNF701    DKFZp686M04222    DKFZp762K012
    ZNF78L1    ZFS-4    ZNF506    smap-7    HZF30    ZFS-1
    ZNF257    ZNF300P1    ZNF429    ZNF430    ZNF431    ZNF676

    ZNF729 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for ZNF729
    PGOHUM00000234219 PGOHUM00000234222 PGOHUM00000245112 PGOHUM00000232756


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/863 SNPs in ZNF729 are shown (see all 863)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs586858021,2
    C--22414700(+) TATAT-/ATAT  
            
    GGTCT
    1 -- int10--------
    rs1870668481,2
    --22467286(+) TGTGGA/CGGGGC 1 -- us2k10--------
    rs104214441,2
    C--22467290(+) gagggA/Gcaacc 1 -- us2k10--------
    rs1163498241,2
    F--22467319(+) GGTCTT/CGAATG 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1910312201,2
    --22467347(+) GAATGC/GTACCA 1 -- us2k10--------
    rs1181613781,2
    C,F--22467370(+) ATGGCC/GGATGT 1 -- us2k11Minor allele frequency- G:0.03NA 120
    rs1460652101,2
    --22467427(+) CCCTGC/TTGACA 1 -- us2k10--------
    rs1821136331,2
    C--22467451(+) AAGCTC/TATCCC 1 -- us2k10--------
    rs40855631,2
    C--22467472(+) gctgcC/Ttattc 1 -- us2k12Minor allele frequency- T:0.00NA 4
    rs739228601,2
    C,F--22467547(+) GCCCAG/CCCTAA 1 -- us2k11Minor allele frequency- C:0.50WA 2

    HapMap Linkage Disequilibrium report for ZNF729 (22469210 - 22499978 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/17 variations for ZNF729 (see all 17):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv552e201CNV Deletion23290073
    esv2718335CNV Deletion23290073
    dgv553e201CNV Deletion23290073
    dgv633e199CNV Deletion23128226
    nsv436853CNV Insertion17901297
    esv34340CNV Loss17911159
    nsv911441CNV Gain21882294
    nsv833786CNV Gain17160897
    dgv3813n71CNV Gain21882294
    dgv3n43CNV Gain19587683

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF729 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF729)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)1, 2 Bechtel S.... Schupp I. (2007)
    2. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 100287226 HGNC: 32464 Ensembl:ENSG00000196350 euGenes: HUgn100287226 ECgene: ZNF729
    H-InvDB: ZNF729

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF729 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF729 gene:
    Search GeneIP for patents involving ZNF729

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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