Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF728 Gene

Aliases for ZNF728 Gene

  • Zinc Finger Protein 728 2 3 5

External Ids for ZNF728 Gene

Previous GeneCards Identifiers for ZNF728 Gene

  • GC19U900615
  • GC19M023157

Summaries for ZNF728 Gene

GeneCards Summary for ZNF728 Gene

ZNF728 (Zinc Finger Protein 728) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF726.

Additional gene information for ZNF728 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF728 Gene

Genomics for ZNF728 Gene

Regulatory Elements for ZNF728 Gene

Enhancers for ZNF728 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H023074 0.6 ENCODE 5.3 -72.4 -72440 2.1 GTF2F1 MXI1 ESRRA ZBTB5 CC2D1A E2F1 TFDP1 POLR2A MLLT1 ZNF730 ZNF492 ZNF728 ENSG00000267924 GC19P023094
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF728 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ZNF728 gene promoter:

Genomic Locations for ZNF728 Gene

Genomic Locations for ZNF728 Gene
28,326 bases
Minus strand

Genomic View for ZNF728 Gene

Genes around ZNF728 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF728 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF728 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF728 Gene

Proteins for ZNF728 Gene

  • Protein details for ZNF728 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 728
    Protein Accession:

    Protein attributes for ZNF728 Gene

    622 amino acids
    Molecular mass:
    71801 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF728 Gene

Post-translational modifications for ZNF728 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF728 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF728 Gene

Domains & Families for ZNF728 Gene

Gene Families for ZNF728 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF728 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF728: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ZNF728 Gene

Function for ZNF728 Gene

Phenotypes From GWAS Catalog for ZNF728 Gene

Gene Ontology (GO) - Molecular Function for ZNF728 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF728: view

Phenotypes for ZNF728 Gene

genes like me logo Genes that share phenotypes with ZNF728: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF728 Gene

Localization for ZNF728 Gene

Gene Ontology (GO) - Cellular Components for ZNF728 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with ZNF728: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for ZNF728 Gene

Pathways & Interactions for ZNF728 Gene

SuperPathways for ZNF728 Gene

No Data Available

Interacting Proteins for ZNF728 Gene

Gene Ontology (GO) - Biological Process for ZNF728 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF728: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF728 Gene

Drugs & Compounds for ZNF728 Gene

No Compound Related Data Available

Transcripts for ZNF728 Gene

mRNA/cDNA for ZNF728 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF728 Gene

Zinc finger protein 728:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF728 Gene

No ASD Table

Relevant External Links for ZNF728 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF728 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF728 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF728 Gene

This gene is overexpressed in Testis (x14.0).

NURSA nuclear receptor signaling pathways regulating expression of ZNF728 Gene:


SOURCE GeneReport for Unigene cluster for ZNF728 Gene:

genes like me logo Genes that share expression patterns with ZNF728: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF728 Gene

Orthologs for ZNF728 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF728 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 67 (a)
(Mus musculus)
Mammalia Zfp273 34
  • 59 (a)
(Bos Taurus)
Mammalia -- 34
  • 55 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 51 (a)
-- 34
  • 40 (a)
(Canis familiaris)
Mammalia -- 34
  • 40 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 53 (a)
-- 34
  • 46 (a)
-- 34
  • 39 (a)
-- 34
  • 38 (a)
-- 34
  • 36 (a)
-- 34
  • 35 (a)
-- 34
  • 34 (a)
-- 34
  • 29 (a)
Species where no ortholog for ZNF728 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF728 Gene

Gene Tree for ZNF728 (if available)
Gene Tree for ZNF728 (if available)

Paralogs for ZNF728 Gene

(530) SIMAP similar genes for ZNF728 Gene using alignment to 3 proteins: Pseudogenes for ZNF728 Gene

genes like me logo Genes that share paralogs with ZNF728: view

Variants for ZNF728 Gene

Sequence variations from dbSNP and Humsavar for ZNF728 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000010482 -- 22,998,216(+) TGGTA(C/G)ACTGG intron-variant
rs1000064182 -- 22,997,998(+) GAGAA(C/T)GGCCA intron-variant
rs1000334976 -- 23,003,330(+) ACTGA(A/G)GAAAG upstream-variant-2KB
rs1001040311 -- 22,978,911(+) CCAGT(A/G)TAAAA intron-variant
rs1001052970 -- 22,979,275(+) GAAGA(A/T)CAACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF728 Gene

Variant ID Type Subtype PubMed ID
nsv978796 CNV duplication 23825009
nsv9686 CNV gain+loss 18304495
nsv833788 CNV gain 17160897
nsv817826 CNV gain 17921354
nsv579013 CNV loss 21841781
nsv578989 CNV gain 21841781
nsv525240 CNV gain 19592680
nsv519744 CNV gain+loss 19592680
nsv469842 CNV gain+loss 16826518
nsv1067397 CNV loss 25217958
esv3893182 CNV gain 25118596
esv3643978 CNV gain 21293372
esv3643977 CNV loss 21293372
esv2758750 CNV gain+loss 17122850
esv2751784 CNV gain 17911159
dgv633e199 CNV deletion 23128226
dgv6326n54 CNV loss 21841781
dgv512e201 CNV deletion 23290073
dgv511e201 CNV deletion 23290073
dgv3n43 CNV gain 19587683
dgv3478n100 CNV loss 25217958
dgv140n111 CNV duplication 26073780
dgv138e55 CNV gain 17911159

Variation tolerance for ZNF728 Gene

Residual Variation Intolerance Score: 79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.76; 91.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF728 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF728 Gene

Disorders for ZNF728 Gene

Relevant External Links for ZNF728

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF728 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF728 Gene

Publications for ZNF728 Gene

  1. A genome-wide association study (GWAS) for bronchopulmonary dysplasia. (PMID: 23897914) Wang H … O'Brodovich HM (Pediatrics 2013) 3 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 60
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for ZNF728 Gene

Sources for ZNF728 Gene

Loading form....