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Aliases for ZNF727 Gene

Aliases for ZNF727 Gene

  • Zinc Finger Protein 727 2 3 5
  • Zinc Finger Protein 727 Pseudogene 3 4
  • ZNF727P 3 4
  • Zinc Finger Protein 727, Pseudogene 2

External Ids for ZNF727 Gene

Previous HGNC Symbols for ZNF727 Gene

  • ZNF727P

Previous GeneCards Identifiers for ZNF727 Gene

  • GC00U922770
  • GC07P063104
  • GC07P063475
  • GC07P062843
  • GC07P063506

Summaries for ZNF727 Gene

GeneCards Summary for ZNF727 Gene

ZNF727 (Zinc Finger Protein 727) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF718.

UniProtKB/Swiss-Prot for ZNF727 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF727 Gene

Genomics for ZNF727 Gene

Regulatory Elements for ZNF727 Gene

Enhancers for ZNF727 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF727 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF727 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF727 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF727 Gene

Chromosome:
7
Start:
64,044,801 bp from pter
End:
64,085,184 bp from pter
Size:
40,384 bases
Orientation:
Plus strand

Genomic View for ZNF727 Gene

Genes around ZNF727 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF727 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF727 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF727 Gene

Proteins for ZNF727 Gene

  • Protein details for ZNF727 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MUV8-ZN727_HUMAN
    Recommended name:
    Putative zinc finger protein 727
    Protein Accession:
    A8MUV8

    Protein attributes for ZNF727 Gene

    Size:
    499 amino acids
    Molecular mass:
    57972 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF727 Gene

Proteomics data for ZNF727 Gene at MOPED

Post-translational modifications for ZNF727 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF727 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF727 Gene

Domains & Families for ZNF727 Gene

Gene Families for ZNF727 Gene

Protein Domains for ZNF727 Gene

Suggested Antigen Peptide Sequences for ZNF727 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A8MUV8

UniProtKB/Swiss-Prot:

ZN727_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF727: view

Function for ZNF727 Gene

Molecular function for ZNF727 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF727 Gene

Localization for ZNF727 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF727 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF727 Gene COMPARTMENTS Subcellular localization image for ZNF727 gene
Compartment Confidence
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for ZNF727 Gene

Pathways & Interactions for ZNF727 Gene

SuperPathways for ZNF727 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF727: view

Pathways by source for ZNF727 Gene

2 Reactome pathways for ZNF727 Gene

Interacting Proteins for ZNF727 Gene

Gene Ontology (GO) - Biological Process for ZNF727 Gene

None

No data available for SIGNOR curated interactions for ZNF727 Gene

Drugs & Compounds for ZNF727 Gene

No Compound Related Data Available

Transcripts for ZNF727 Gene

mRNA/cDNA for ZNF727 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF727 Gene

Zinc finger protein 727:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF727 Gene

No ASD Table

Relevant External Links for ZNF727 Gene

GeneLoc Exon Structure for
ZNF727
ECgene alternative splicing isoforms for
ZNF727

Expression for ZNF727 Gene

mRNA expression in normal human tissues for ZNF727 Gene

SOURCE GeneReport for Unigene cluster for ZNF727 Gene Hs.640774

genes like me logo Genes that share expression patterns with ZNF727: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF727 Gene

Orthologs for ZNF727 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ZNF727 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF727 35
  • 99.27 (n)
  • 99.2 (a)
Species with no ortholog for ZNF727:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF727 Gene

ENSEMBL:
Gene Tree for ZNF727 (if available)
TreeFam:
Gene Tree for ZNF727 (if available)

Paralogs for ZNF727 Gene

(496) SIMAP similar genes for ZNF727 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF727: view

Variants for ZNF727 Gene

Sequence variations from dbSNP and Humsavar for ZNF727 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs893623 -- 64,081,030(-) agcca(C/G)agaac intron-variant
rs978661 -- 64,085,396(-) GTATT(A/G)CTTTT downstream-variant-500B
rs978662 -- 64,085,269(-) CTAAA(C/T)GAAAA downstream-variant-500B
rs981084 -- 64,049,771(+) gagat(A/G)atcta intron-variant
rs981085 -- 64,050,073(+) tttct(A/C)tatat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF727 Gene

Variant ID Type Subtype PubMed ID
nsv464513 CNV Gain 19166990
nsv888255 CNV Loss 21882294
dgv1147e201 CNV Deletion 23290073
nsv888258 CNV Gain 21882294
nsv888259 CNV Gain 21882294
nsv888260 CNV Loss 21882294
nsv888263 CNV Loss 21882294
esv2734573 CNV Deletion 23290073
dgv1212e199 CNV Deletion 23128226
nsv888264 CNV Gain 21882294

Variation tolerance for ZNF727 Gene

Gene Damage Index Score: 3.47; 54.97% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF727 Gene

Disorders for ZNF727 Gene

Relevant External Links for ZNF727

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF727

No disorders were found for ZNF727 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF727 Gene

Publications for ZNF727 Gene

  1. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. Toward a complete human genome sequence. (PMID: 9847074) Sulston J.E. … Waterston R. (Genome Res. 1998) 3

Products for ZNF727 Gene

Sources for ZNF727 Gene

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