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Aliases for ZNF727 Gene

Aliases for ZNF727 Gene

  • Zinc Finger Protein 727 2 3 5
  • Zinc Finger Protein 727 Pseudogene 3 4
  • ZNF727P 3 4
  • Zinc Finger Protein 727, Pseudogene 2
  • Putative Zinc Finger Protein 727 3

External Ids for ZNF727 Gene

Previous HGNC Symbols for ZNF727 Gene

  • ZNF727P

Previous GeneCards Identifiers for ZNF727 Gene

  • GC00U922770
  • GC07P063104
  • GC07P063475
  • GC07P062843
  • GC07P063506
  • GC07P064047

Summaries for ZNF727 Gene

GeneCards Summary for ZNF727 Gene

ZNF727 (Zinc Finger Protein 727) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF736.

UniProtKB/Swiss-Prot for ZNF727 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF727 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF727 Gene

Genomics for ZNF727 Gene

Regulatory Elements for ZNF727 Gene

Enhancers for ZNF727 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H064312 0.9 ENCODE 9.7 +269.2 269152 3 PKNOX1 SIN3A YY1 ZNF121 GATA2 ELK1 ZNF207 ATF7 FOS RUNX3 ZNF736 GTF2IP14 ENSG00000227113 YWHAEP1 ZNF727 GUSBP6 SEPHS1P1 GC07M064314 LOC105375322
GH07H063932 0.4 FANTOM5 4.4 -112.7 -112690 0.1 MNT ZNF727 VN1R34P SLC25A1P3
GH07H064044 0.4 ENCODE 0.7 +0.6 611 1.2 SP2 BNIP3P11 ZNF727 PIR33294
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF727 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF727 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000212803 1000 799 GATA3

Genomic Locations for ZNF727 Gene

Genomic Locations for ZNF727 Gene
40,384 bases
Plus strand

Genomic View for ZNF727 Gene

Genes around ZNF727 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF727 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF727 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF727 Gene

Proteins for ZNF727 Gene

  • Protein details for ZNF727 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative zinc finger protein 727
    Protein Accession:

    Protein attributes for ZNF727 Gene

    499 amino acids
    Molecular mass:
    57972 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF727 Gene

Post-translational modifications for ZNF727 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF727 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF727 Gene

Domains & Families for ZNF727 Gene

Gene Families for ZNF727 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF727 Gene


Suggested Antigen Peptide Sequences for ZNF727 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF727: view

Function for ZNF727 Gene

Molecular function for ZNF727 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF727 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF727: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF727 Gene

Localization for ZNF727 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF727 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF727 gene
Compartment Confidence
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF727 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF727: view

Pathways & Interactions for ZNF727 Gene

SuperPathways for ZNF727 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF727: view

Pathways by source for ZNF727 Gene

2 Reactome pathways for ZNF727 Gene

Interacting Proteins for ZNF727 Gene

Gene Ontology (GO) - Biological Process for ZNF727 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF727: view

No data available for SIGNOR curated interactions for ZNF727 Gene

Drugs & Compounds for ZNF727 Gene

No Compound Related Data Available

Transcripts for ZNF727 Gene

mRNA/cDNA for ZNF727 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF727 Gene

Zinc finger protein 727:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF727 Gene

No ASD Table

Relevant External Links for ZNF727 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF727 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF727 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF727 Gene:


SOURCE GeneReport for Unigene cluster for ZNF727 Gene:

genes like me logo Genes that share expression patterns with ZNF727: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF727 Gene

Orthologs for ZNF727 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ZNF727 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF727 33
  • 99.27 (n)
Species where no ortholog for ZNF727 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF727 Gene

Gene Tree for ZNF727 (if available)
Gene Tree for ZNF727 (if available)

Paralogs for ZNF727 Gene

(496) SIMAP similar genes for ZNF727 Gene using alignment to 1 proteins: Pseudogenes for ZNF727 Gene

genes like me logo Genes that share paralogs with ZNF727: view

Variants for ZNF727 Gene

Sequence variations from dbSNP and Humsavar for ZNF727 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000097312 -- 64,073,496(+) GTATC(A/G)TTATT intron-variant
rs1000258034 -- 64,073,308(+) TGTGT(-/G)GTTTT intron-variant
rs1000288701 -- 64,049,660(+) GAATA(A/G)GACAT intron-variant
rs1000415597 -- 64,043,955(+) AGCTG(A/G)CCTCC upstream-variant-2KB
rs1000549975 -- 64,062,696(+) TATAT(A/G)TATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF727 Gene

Variant ID Type Subtype PubMed ID
nsv981494 CNV duplication 23825009
nsv607304 CNV gain 21841781
nsv607299 CNV gain 21841781
nsv464513 CNV gain 19166990
nsv1019909 CNV gain 25217958
nsv1018445 CNV gain 25217958
nsv1016645 CNV gain+loss 25217958
esv3891132 CNV gain 25118596
dgv6434n100 CNV loss 25217958
dgv1212e199 CNV deletion 23128226
dgv11415n54 CNV loss 21841781
dgv1099e201 CNV deletion 23290073

Variation tolerance for ZNF727 Gene

Gene Damage Index Score: 3.47; 54.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF727 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF727 Gene

Disorders for ZNF727 Gene

Relevant External Links for ZNF727

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF727 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF727 Gene

Publications for ZNF727 Gene

  1. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 60
  2. Evolution of KRAB-containing zinc finger proteins and their roles in species evolution. (PMID: 27867147) Wang J … Tian CY (Yi chuan = Hereditas 2016) 3 60
  3. Zinc fingers function cooperatively with KRAB domain for nuclear localization of KRAB-containing zinc finger proteins. (PMID: 24647005) Wang W … Li W (PloS one 2014) 3 60
  4. Cys2His2 zinc finger protein family: classification, functions, and major members. (PMID: 22803940) Razin SV … Kantidze OL (Biochemistry. Biokhimiia 2012) 3 60
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60

Products for ZNF727 Gene

Sources for ZNF727 Gene

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