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Aliases for ZNF726 Gene

Aliases for ZNF726 Gene

  • Zinc Finger Protein 726 2 3 5

External Ids for ZNF726 Gene

Previous GeneCards Identifiers for ZNF726 Gene

  • GC19U900614
  • GC19P023891
  • GC19P024092
  • GC19P023647

Summaries for ZNF726 Gene

GeneCards Summary for ZNF726 Gene

ZNF726 (Zinc Finger Protein 726) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF254.

UniProtKB/Swiss-Prot for ZNF726 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF726 Gene

Genomics for ZNF726 Gene

Regulatory Elements for ZNF726 Gene

Enhancers for ZNF726 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F023801 0.6 ENCODE 7.8 -112.7 -112700 1.8 ZNF316 MAFK ZNF726 ZNF675 BNIP3P39 GC19P023828
GH19F023798 0.2 ENCODE 4.7 -114.9 -114916 2.4 DPF2 GATA3 CTBP1 ATF3 POLR2A SMARCA4 CUX1 FOS ENSG00000233836 ZNF681 ENSG00000268362 ENSG00000269397 ZNF726 ZNF675 ZNF91 BNIP3P39 GC19P023828
GH19F023917 0.2 ENCODE 0.8 +3.1 3138 0.2 GC19P023918 ZNF726
GH19F023916 0.2 Ensembl 0.8 +1.6 1625 0.2 GC19P023918 ZNF726
GH19F023914 0.5 ENCODE 0.8 +0.1 85 1.6 TBP HDAC1 PKNOX1 ATF1 NFRKB SIN3A ZBTB40 YY1 FOS KDM4B GC19P023918 ZNF726
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF726 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF726 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001418515 225 1799 TBP HDAC1 PKNOX1 ATF1 NFRKB SIN3A ZBTB40 CHAMP1 YY1 FOS

Genomic Location for ZNF726 Gene

Chromosome:
19
Start:
23,914,876 bp from pter
End:
23,945,159 bp from pter
Size:
30,284 bases
Orientation:
Plus strand

Genomic View for ZNF726 Gene

Genes around ZNF726 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF726 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF726 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF726 Gene

Proteins for ZNF726 Gene

  • Protein details for ZNF726 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NNF4-ZN726_HUMAN
    Recommended name:
    Zinc finger protein 726
    Protein Accession:
    A6NNF4
    Secondary Accessions:
    • M0R0X8
    • Q86Y87

    Protein attributes for ZNF726 Gene

    Size:
    738 amino acids
    Molecular mass:
    85539 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF726 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF726 Gene

Post-translational modifications for ZNF726 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF726 Gene

No data available for DME Specific Peptides for ZNF726 Gene

Domains & Families for ZNF726 Gene

Gene Families for ZNF726 Gene

Protein Domains for ZNF726 Gene

Suggested Antigen Peptide Sequences for ZNF726 Gene

Graphical View of Domain Structure for InterPro Entry

A6NNF4

UniProtKB/Swiss-Prot:

ZN726_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 20 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 20 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF726: view

Function for ZNF726 Gene

Molecular function for ZNF726 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF726 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF726: view

Animal Model Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF726 Gene

Localization for ZNF726 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF726 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF726 Gene COMPARTMENTS Subcellular localization image for ZNF726 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF726 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF726: view

Pathways & Interactions for ZNF726 Gene

SuperPathways for ZNF726 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF726: view

Pathways by source for ZNF726 Gene

2 Reactome pathways for ZNF726 Gene

Interacting Proteins for ZNF726 Gene

Gene Ontology (GO) - Biological Process for ZNF726 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
genes like me logo Genes that share ontologies with ZNF726: view

No data available for SIGNOR curated interactions for ZNF726 Gene

Transcripts for ZNF726 Gene

mRNA/cDNA for ZNF726 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF726 Gene

Zinc finger protein 726:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF726 Gene

No ASD Table

Relevant External Links for ZNF726 Gene

GeneLoc Exon Structure for
ZNF726
ECgene alternative splicing isoforms for
ZNF726

Expression for ZNF726 Gene

mRNA expression in normal human tissues for ZNF726 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF726 Gene:

ZNF726

SOURCE GeneReport for Unigene cluster for ZNF726 Gene:

Hs.655305
genes like me logo Genes that share expression patterns with ZNF726: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF726 Gene

Orthologs for ZNF726 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF726 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF726 34
  • 93.56 (n)
mouse
(Mus musculus)
Mammalia Zfp712 34 16
  • 67.05 (n)
Gm9894 35
  • 52 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 57 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 51 (a)
ManyToMany
-- 35
  • 43 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 40 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 55 (a)
ManyToMany
-- 35
  • 45 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
-- 35
  • 37 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
Species where no ortholog for ZNF726 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF726 Gene

ENSEMBL:
Gene Tree for ZNF726 (if available)
TreeFam:
Gene Tree for ZNF726 (if available)

Paralogs for ZNF726 Gene

(541) SIMAP similar genes for ZNF726 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF726: view

Variants for ZNF726 Gene

Sequence variations from dbSNP and Humsavar for ZNF726 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10403746 -- 23,924,452(+) ATTTC(C/T)TTTGT intron-variant
rs10405341 -- 23,924,450(+) ATATT(C/T)CCTTT intron-variant
rs10409825 -- 23,924,654(+) aggcc(A/G)ggaca intron-variant
rs10410153 -- 23,932,000(+) GAAAT(C/G)AAGAG intron-variant
rs10411782 -- 23,934,172(+) TAATC(A/T)TTCTC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ZNF726 Gene

Variant ID Type Subtype PubMed ID
dgv3481n100 CNV gain 25217958
dgv515e201 CNV deletion 23290073
esv2633716 CNV deletion 19546169
esv2662304 CNV deletion 23128226
esv2670676 CNV deletion 23128226
esv2751784 CNV gain 17911159
esv2763201 CNV gain 21179565
esv3574386 CNV gain 25503493
esv3644029 CNV gain 21293372
esv3893187 CNV gain 25118596
esv8359 CNV loss 19470904
nsv1057420 CNV gain 25217958
nsv1057875 CNV gain 25217958
nsv1072875 CNV deletion 25765185
nsv458530 CNV gain 19166990
nsv470136 CNV gain 18288195
nsv524183 CNV gain 19592680
nsv579076 CNV gain 21841781
nsv579077 CNV gain 21841781
nsv960820 CNV duplication 23825009

Variation tolerance for ZNF726 Gene

Residual Variation Intolerance Score: 72.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.39; 63.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF726 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF726

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF726 Gene

Disorders for ZNF726 Gene

Relevant External Links for ZNF726

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF726

No disorders were found for ZNF726 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF726 Gene

Publications for ZNF726 Gene

  1. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PMID: 21697133) Oshikawa M. … Kato S. (Invest. Ophthalmol. Vis. Sci. 2011) 3 64
  2. A scan for positively selected genes in the genomes of humans and chimpanzees. (PMID: 15869325) Nielsen R. … Cargill M. (PLoS Biol. 2005) 3 64
  3. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3 64
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for ZNF726 Gene

Sources for ZNF726 Gene

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