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Aliases for ZNF726 Gene

Aliases for ZNF726 Gene

  • Zinc Finger Protein 726 2 3 5

External Ids for ZNF726 Gene

Previous GeneCards Identifiers for ZNF726 Gene

  • GC19U900614
  • GC19P023891
  • GC19P024092
  • GC19P023647

Summaries for ZNF726 Gene

GeneCards Summary for ZNF726 Gene

ZNF726 (Zinc Finger Protein 726) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF254.

UniProtKB/Swiss-Prot for ZNF726 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF726 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF726 Gene

Genomics for ZNF726 Gene

GeneHancer (GH) Regulatory Elements for ZNF726 Gene

Promoters and enhancers for ZNF726 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I023914 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +0.2 192 1.9 PKNOX1 ATF1 SIN3A YY1 POLR2B E2F8 FOS ATF7 ZNF202 SP3 ZNF726 GC19P023918
GH19I023801 Enhancer 0.4 ENCODE 7.8 -112.7 -112700 1.8 ZNF316 MAFK ZNF726 ZNF675 BNIP3P39 GC19P023828 RPSAP58 ENSG00000233836
GH19I023798 Enhancer 0.3 ENCODE 4.7 -114.9 -114915 2.4 POLR2A BNIP3P39 ENSG00000233836 ZNF681 ENSG00000268362 ENSG00000269397 ZNF726 ZNF675 ZNF91 GC19P023828 RPSAP58
GH19I023917 Enhancer 0.2 ENCODE 0.8 +3.1 3138 0.2 GC19P023918 ZNF726
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF726 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF726 Gene

Genomic Locations for ZNF726 Gene
chr19:23,914,876-23,945,159
(GRCh38/hg38)
Size:
30,284 bases
Orientation:
Plus strand
chr19:24,097,678-24,127,961
(GRCh37/hg19)

Genomic View for ZNF726 Gene

Genes around ZNF726 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF726 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF726 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF726 Gene

Proteins for ZNF726 Gene

  • Protein details for ZNF726 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NNF4-ZN726_HUMAN
    Recommended name:
    Zinc finger protein 726
    Protein Accession:
    A6NNF4
    Secondary Accessions:
    • M0R0X8
    • Q86Y87

    Protein attributes for ZNF726 Gene

    Size:
    738 amino acids
    Molecular mass:
    85539 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF726 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF726 Gene

Post-translational modifications for ZNF726 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZNF726 Gene

Domains & Families for ZNF726 Gene

Gene Families for ZNF726 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF726 Gene

Suggested Antigen Peptide Sequences for ZNF726 Gene

Graphical View of Domain Structure for InterPro Entry

A6NNF4

UniProtKB/Swiss-Prot:

ZN726_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF726: view

Function for ZNF726 Gene

Molecular function for ZNF726 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF726 Gene

Gene Ontology (GO) - Molecular Function for ZNF726 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF726: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF726 Gene

Localization for ZNF726 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF726 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF726 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF726 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF726: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF726 Gene

Pathways & Interactions for ZNF726 Gene

SuperPathways for ZNF726 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF726: view

Pathways by source for ZNF726 Gene

2 Reactome pathways for ZNF726 Gene

Interacting Proteins for ZNF726 Gene

Gene Ontology (GO) - Biological Process for ZNF726 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA,IEA --
genes like me logo Genes that share ontologies with ZNF726: view

No data available for SIGNOR curated interactions for ZNF726 Gene

Drugs & Compounds for ZNF726 Gene

No Compound Related Data Available

Transcripts for ZNF726 Gene

mRNA/cDNA for ZNF726 Gene

(5) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF726 Gene

Zinc finger protein 726:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF726 Gene

No ASD Table

Relevant External Links for ZNF726 Gene

GeneLoc Exon Structure for
ZNF726
ECgene alternative splicing isoforms for
ZNF726

Expression for ZNF726 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF726 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF726 Gene:

ZNF726

SOURCE GeneReport for Unigene cluster for ZNF726 Gene:

Hs.655305
genes like me logo Genes that share expression patterns with ZNF726: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF726 Gene

Orthologs for ZNF726 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF726 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF726 33
  • 93.56 (n)
mouse
(Mus musculus)
Mammalia Zfp712 33 16
  • 67.05 (n)
Gm9894 34
  • 52 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 57 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 51 (a)
ManyToMany
-- 34
  • 43 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 40 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 55 (a)
ManyToMany
-- 34
  • 45 (a)
ManyToMany
-- 34
  • 41 (a)
ManyToMany
-- 34
  • 37 (a)
ManyToMany
-- 34
  • 36 (a)
ManyToMany
-- 34
  • 35 (a)
ManyToMany
-- 34
  • 33 (a)
ManyToMany
-- 34
  • 31 (a)
ManyToMany
Species where no ortholog for ZNF726 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF726 Gene

ENSEMBL:
Gene Tree for ZNF726 (if available)
TreeFam:
Gene Tree for ZNF726 (if available)

Paralogs for ZNF726 Gene

(541) SIMAP similar genes for ZNF726 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF726: view

Variants for ZNF726 Gene

Sequence variations from dbSNP and Humsavar for ZNF726 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000150617 -- 23,926,318(+) G/T intron_variant
rs1000164484 -- 23,926,378(+) C/T intron_variant
rs1000329483 -- 23,931,624(+) G/A intron_variant
rs1000402922 -- 23,931,349(+) T/C intron_variant
rs1000561162 -- 23,924,952(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF726 Gene

Variant ID Type Subtype PubMed ID
dgv3481n100 CNV gain 25217958
dgv515e201 CNV deletion 23290073
esv2633716 CNV deletion 19546169
esv2662304 CNV deletion 23128226
esv2670676 CNV deletion 23128226
esv2751784 CNV gain 17911159
esv2763201 CNV gain 21179565
esv3574386 CNV gain 25503493
esv3644029 CNV gain 21293372
esv3893187 CNV gain 25118596
esv8359 CNV loss 19470904
nsv1057420 CNV gain 25217958
nsv1057875 CNV gain 25217958
nsv1072875 CNV deletion 25765185
nsv458530 CNV gain 19166990
nsv470136 CNV gain 18288195
nsv524183 CNV gain 19592680
nsv579076 CNV gain 21841781
nsv579077 CNV gain 21841781
nsv960820 CNV duplication 23825009

Variation tolerance for ZNF726 Gene

Residual Variation Intolerance Score: 72.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.39; 63.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF726 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF726

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF726 Gene

Disorders for ZNF726 Gene

Additional Disease Information for ZNF726

No disorders were found for ZNF726 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF726 Gene

Publications for ZNF726 Gene

  1. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PMID: 21697133) Oshikawa M … Kato S (Investigative ophthalmology & visual science 2011) 3 58
  2. A scan for positively selected genes in the genomes of humans and chimpanzees. (PMID: 15869325) Nielsen R … Cargill M (PLoS biology 2005) 3 58
  3. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R … Stanton LW (Nature biotechnology 2004) 3 58
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for ZNF726 Gene

Sources for ZNF726 Gene

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