Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF721 Gene

Aliases for ZNF721 Gene

  • Zinc Finger Protein 721 2 3 5
  • KIAA1982 4

External Ids for ZNF721 Gene

Previous GeneCards Identifiers for ZNF721 Gene

  • GC04U900481
  • GC04M000427

Summaries for ZNF721 Gene

GeneCards Summary for ZNF721 Gene

ZNF721 (Zinc Finger Protein 721) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF729.

UniProtKB/Swiss-Prot for ZNF721 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF721 Gene

Genomics for ZNF721 Gene

Regulatory Elements for ZNF721 Gene

Genomic Location for ZNF721 Gene

425,815 bp from pter
499,171 bp from pter
73,357 bases
Minus strand

Genomic View for ZNF721 Gene

Genes around ZNF721 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF721 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF721 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF721 Gene

Proteins for ZNF721 Gene

  • Protein details for ZNF721 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 721
    Protein Accession:
    Secondary Accessions:
    • Q69YG7

    Protein attributes for ZNF721 Gene

    911 amino acids
    Molecular mass:
    105084 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAH10687.1; Type=Frameshift; Positions=246, 250, 392, 394, 401, 409, 416, 418, 426, 444, 454, 492, 500, 540, 553, 690, 779, 782; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF721 Gene


neXtProt entry for ZNF721 Gene

Proteomics data for ZNF721 Gene at MOPED

Post-translational modifications for ZNF721 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF721 Gene

No data available for DME Specific Peptides for ZNF721 Gene

Domains & Families for ZNF721 Gene

Gene Families for ZNF721 Gene

Protein Domains for ZNF721 Gene

Suggested Antigen Peptide Sequences for ZNF721 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 30 C2H2-type zinc fingers.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 30 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF721: view

Function for ZNF721 Gene

Molecular function for ZNF721 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF721: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF721 Gene

Localization for ZNF721 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF721 Gene

Subcellular locations from

Jensen Localization Image for ZNF721 Gene COMPARTMENTS Subcellular localization image for ZNF721 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF721 Gene

Pathways & Interactions for ZNF721 Gene

SuperPathways for ZNF721 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF721: view

Pathways by source for ZNF721 Gene

2 Reactome pathways for ZNF721 Gene

Interacting Proteins for ZNF721 Gene

Gene Ontology (GO) - Biological Process for ZNF721 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF721: view

No data available for SIGNOR curated interactions for ZNF721 Gene

Drugs & Compounds for ZNF721 Gene

No Compound Related Data Available

Transcripts for ZNF721 Gene

mRNA/cDNA for ZNF721 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF721 Gene

Zinc finger protein 721:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF721 Gene

No ASD Table

Relevant External Links for ZNF721 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF721 Gene

mRNA expression in normal human tissues for ZNF721 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF721 Gene

SOURCE GeneReport for Unigene cluster for ZNF721 Gene Hs.428360

genes like me logo Genes that share expression patterns with ZNF721: view

Protein tissue co-expression partners for ZNF721 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF721 Gene

Orthologs for ZNF721 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF721 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF721 35
  • 99.46 (n)
  • 99.35 (a)
(Bos Taurus)
Mammalia -- 36
  • 46 (a)
(Canis familiaris)
Mammalia -- 36
  • 40 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 47 (a)
(Mus musculus)
Mammalia A530054K11Rik 36
  • 40 (a)
AA987161 36
  • 36 (a)
Zfp457 36
  • 47 (a)
Zfp458 36
  • 49 (a)
Zfp738 36
  • 45 (a)
Zfp748 36
  • 39 (a)
Zfp759 36
  • 48 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732182 35
  • 54.45 (n)
  • 54.45 (a)
Species with no ortholog for ZNF721:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF721 Gene

Gene Tree for ZNF721 (if available)
Gene Tree for ZNF721 (if available)

Paralogs for ZNF721 Gene

(467) SIMAP similar genes for ZNF721 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF721: view

Variants for ZNF721 Gene

Sequence variations from dbSNP and Humsavar for ZNF721 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1052218 -- 487,902(+) CTGTC(A/G/T)CTACA intron-variant
rs1055982 -- 480,761(+) ATGCA(C/T)ATGCC intron-variant
rs1838040 -- 481,998(+) CATTA(A/T)ATATA intron-variant
rs2120092 -- 481,926(+) TAAAC(A/G)GAACT intron-variant
rs4110694 -- 484,435(+) tgacc(A/G)ctggt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF721 Gene

Variant ID Type Subtype PubMed ID
esv4769 CNV Complex 18987735
nsv461144 CNV Loss 19166990
nsv461145 CNV Gain 19166990
nsv517948 CNV Loss 19592680
nsv469997 CNV Gain 18288195
nsv461146 CNV Gain 19166990
esv2671108 CNV Deletion 23128226

Variation tolerance for ZNF721 Gene

Residual Variation Intolerance Score: 92.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.57; 72.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF721 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF721 Gene

Disorders for ZNF721 Gene

Relevant External Links for ZNF721

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF721 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF721 Gene

Publications for ZNF721 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ZNF721 Gene

Sources for ZNF721 Gene

Back to Top