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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF721 Gene

protein-coding   GIFtS: 38
GCID: GC04M000425

Zinc Finger Protein 721

  Search for ZNF721
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 7211 2
KIAA19823

External Ids:    HGNC: 294251   Entrez Gene: 1709602   Ensembl: ENSG000001829037   UniProtKB: Q8TF203   

Export aliases for ZNF721 gene to outside databases

Previous GC identifer: GC04U900481


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF721 Gene: 
ZNF721 (zinc finger protein 721) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF91.

UniProtKB/Swiss-Prot: ZN721_HUMAN, Q8TF20
Function: May be involved in transcriptional regulation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_037622.5  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF721 gene promoter:
         SRF   FOXF2   AML1a   Pbx1a   SRF (504 AA)   LUN-1   FOXL1   CREB   deltaCREB   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZNF721 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF721

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF721


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

ZNF721 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF721 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M000425:  view genomic region     (about GC identifiers)

Start:
419,604 bp from pter      End:
493,442 bp from pter
Size:
73,839 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN721_HUMAN, Q8TF20 (See protein sequence)
Recommended Name: Zinc finger protein 721  
Size: 911 amino acids; 105084 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=CAH10687.1; Type=Frameshift; Positions=246, 250, 392, 394, 401, 409, 416, 418, 426,
444, 454, 492, 500, 540, 553, 690, 779, 782;
Secondary accessions: Q69YG7
Alternative splicing: 2 isoforms:  Q8TF20-1   Q8TF20-2   

Explore the universe of human proteins at neXtProt for ZNF721: NX_Q8TF20

Explore proteomics data for ZNF721 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TF20

  • ZNF721 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF721 Protein Expression
    REFSEQ proteins: NP_597731.2  
    ENSEMBL proteins: 
     ENSP00000430163   ENSP00000423586   ENSP00000340524   ENSP00000428878   ENSP00000421325  
    Reactome Protein details: Q8TF20
    Human Recombinant Protein Products for ZNF721: 
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF721 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8TF20

    ProtoNet protein and cluster: Q8TF20

    UniProtKB/Swiss-Prot: ZN721_HUMAN, Q8TF20
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 30 C2H2-type zinc fingers


    ZNF721 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN721_HUMAN, Q8TF20
    Function: May be involved in transcriptional regulation (By similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF721 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF721 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF721
        Generic Transcription Pathway
    Gene Expression



    ZNF721 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF721

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF721 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF721 (ZN721)

    Search CenterWatch for drugs/clinical trials and news about ZNF721 / ZN721

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF721 gene: 
    NM_133474.3  

    Unigene Clusters for ZNF721:

    Zinc finger protein 721
    Hs.428360  [show with all ESTs], Hs.724168  [show with all ESTs]
    Unigene Representative Sequences: AL834155, AK021514
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000515578(uc011buv.2 uc003gae.3) ENST00000506646 ENST00000507078
    ENST00000338977(uc003gaf.4 uc003gag.3 uc010ibe.3) ENST00000511833(uc003gah.1)
    ENST00000505900
    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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                         Customized lentivirus expression plasmids for stable overexpression of ZNF721 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF721
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF721

    Additional mRNA sequence: AK021514.1 

    12 DOTS entries:

    DT.411536  DT.411539  DT.100022745  DT.91954556  DT.91985931  DT.100020145  DT.100664887  DT.100777107 
    DT.411538  DT.414041  DT.91815210  DT.95076829 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF721 expression in normal human tissues (normalized intensities)      ZNF721 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACCTCCATA
    ZNF721 Expression
    About this image


    ZNF721 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Blood (Cardiovascular System)
             Double Positive Thymocytes Thymus

    See ZNF721 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF721

    SOURCE GeneReport for Unigene clusters: Hs.428360 Hs.724168
        SABiosciences Custom PCR Arrays for ZNF721
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF721
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF721

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for ZNF721 (if available)
    TreeFam Gene Tree for ZNF721 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF721 gene
    ZNF912  ZNF5212  ZNF6462  ZNF8502  ZNF7292  ZNF4232  ZNF2082  
    18/465 SIMAP similar genes for ZNF721 using alignment to 4 protein entries:     ZN721_HUMAN (see all proteins) (see all similar genes):
    ZNF525    ZNF83    ZNF616    ZNF519    ZNF546    ZNF880
    ZNF761    ZNF624    ZNF766    ZNF595    ZNF91    ZNF283
    ZNF177    ZNF707    FIK    ZNF610    ZNF614    ZNF818P

    ZNF721 for paralogs           About GeneDecksing


    5/6 Pseudogenes.org Pseudogenes for ZNF721 (see all 6)
    PGOHUM00000259398 PGOHUM00000234820 PGOHUM00000258179 PGOHUM00000250742 PGOHUM00000250744


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/455 SNPs in ZNF721 are shown (see all 455)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs752425231,2
    C,F--470044(+) AAATAG/AGACCC 1 -- int14Minor allele frequency- A:0.20NA EA 244
    rs65993481,2
    C,F,A,H--470103(+) CAACTG/ATATTG 1 -- int126Minor allele frequency- A:0.44NA NS EA WA CSA 2482
    rs788194361,2
    C,F--470312(+) GGTGAT/CGCTTC 1 -- int11Minor allele frequency- C:0.09EA 120
    rs1428215221,2
    --470343(+) CCACAC/TCATTT 1 -- int10--------
    rs1510285611,2
    --470374(+) TACCCA/TCACCA 1 -- int10--------
    rs785374061,2
    C,F--470391(+) CTGAGC/AAGTTG 1 -- int11Minor allele frequency- A:0.04WA 118
    rs68254521,2
    C,F,A,H--470463(+) tattaT/Ctgcct 1 -- int118Minor allele frequency- C:0.14NS EA NA CSA WA 2342
    rs1394226421,2
    --470605(+) TGGCTA/GCAGCT 1 -- int10--------
    rs1851756041,2
    C--470647(+) AATGCG/TGTTTC 1 -- int10--------
    rs777571841,2
    C,F--470747(+) CAGGGT/GGCCAC 1 -- int12Minor allele frequency- G:0.06WA NA 238

    HapMap Linkage Disequilibrium report for ZNF721 (419604 - 493442 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ZNF721:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2671108CNV Deletion23128226
    nsv517948CNV Loss19592680
    nsv461144CNV Loss19166990
    nsv461146CNV Gain19166990
    nsv469997CNV Gain18288195
    nsv461145CNV Gain19166990
    esv4769CNV Complex18987735

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF721 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF721)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2, 3 Nagase T.... Ohara O. (2001)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    4. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    7. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 170960 HGNC: 29425 Ensembl:ENSG00000182903 euGenes: HUgn170960 ECgene: ZNF721
    H-InvDB: ZNF721

    (According to HUGE)
    About This Section
    HUGE: KIAA1982

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF721 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF721 gene:
    Search GeneIP for patents involving ZNF721

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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