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ZNF721 Gene

protein-coding   GIFtS: 40
GCID: GC04M000427

Zinc Finger Protein 721

  Search for ZNF721
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 7211 2
KIAA19823

External Ids:    HGNC: 294251   Entrez Gene: 1709602   Ensembl: ENSG000001829037   UniProtKB: Q8TF203   

Export aliases for ZNF721 gene to outside databases

Previous GC identifers: GC04U900481 GC04M000425


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF721 Gene:
ZNF721 (zinc finger protein 721) is a protein-coding gene. An important paralog of this gene is ZNF616.

UniProtKB/Swiss-Prot: ZN721_HUMAN, Q8TF20
Function: May be involved in transcriptional regulation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_006051.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF721 gene promoter:
         SRF   FOXF2   AML1a   Pbx1a   SRF (504 AA)   LUN-1   FOXL1   CREB   deltaCREB   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZNF721 promoter sequence
   Search Chromatin IP Primers for ZNF721

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF721


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

ZNF721 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF721 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M000427:  view genomic region     (about GC identifiers)

Start:
419,604 bp from pter      End:
493,442 bp from pter
Size:
73,839 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN721_HUMAN, Q8TF20 (See protein sequence)
Recommended Name: Zinc finger protein 721  
Size: 911 amino acids; 105084 Da
Sequence caution: Sequence=CAH10687.1; Type=Frameshift; Positions=246, 250, 392, 394, 401, 409, 416, 418, 426,
444, 454, 492, 500, 540, 553, 690, 779, 782;
Secondary accessions: Q69YG7
Alternative splicing: 2 isoforms:  Q8TF20-1   Q8TF20-2   

Explore the universe of human proteins at neXtProt for ZNF721: NX_Q8TF20

Explore proteomics data for ZNF721 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys160
  • Modification sites at PhosphoSitePlus

  • See ZNF721 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_597731.2  
    ENSEMBL proteins: 
     ENSP00000430163   ENSP00000423586   ENSP00000340524   ENSP00000428878   ENSP00000421325  
    Reactome Protein details: Q8TF20

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8TF20

    ProtoNet protein and cluster: Q8TF20

    UniProtKB/Swiss-Prot: ZN721_HUMAN, Q8TF20
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 30 C2H2-type zinc fingers


    ZNF721 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN721_HUMAN, Q8TF20
    Function: May be involved in transcriptional regulation (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    ZNF721 for ontologies           About GeneDecksing


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN721_HUMAN, Q8TF20: Nucleus (Probable)

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF721 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF721 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF721
        Generic Transcription Pathway



    ZNF721 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF721
    Interactions:

        Search GeneGlobe Interaction Network for ZNF721

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    ZNF721 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for ZNF721 (ZN721)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF721 gene: 
    NM_133474.3  

    Unigene Cluster for ZNF721:

    Zinc finger protein 721
    Hs.428360  [show with all ESTs]
    Unigene Representative Sequence: AL834155
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000515578(uc011buv.2 uc003gae.3) ENST00000506646 ENST00000507078
    ENST00000338977(uc003gaf.4 uc003gag.3 uc010ibe.3) ENST00000511833(uc003gah.1)
    ENST00000505900
    miRNA
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    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat ZNF721

    Additional mRNA sequence: 

    AB075862.1 AK092362.1 AK095558.1 AK095689.1 AK127067.1 AK128499.1 AL834155.1 

    11 DOTS entries:

    DT.411536  DT.411539  DT.100022745  DT.91985931  DT.100020145  DT.100664887  DT.100777107  DT.411538 
    DT.414041  DT.91815210  DT.95076829 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF721 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACCTCCATA
    ZNF721 Expression
    About this image


    ZNF721 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Blood (Cardiovascular System)
             Double Positive Thymocytes Thymus
    ZNF721 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF721 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.428360
        Custom PCR Arrays for ZNF721
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF721

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF721 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017321821 oocyte zinc finger protein XlCOF7.1-like 54.45(n)
    54.45(a)
      101732182  XM_004913877.1  XP_004913934.1 
            Species with no ortholog for ZNF721

    ENSEMBL Gene Tree for ZNF721 (if available)
    TreeFam Gene Tree for ZNF721 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF721 gene
    ZNF6162  ZNF4732  ZNF1602  ZNF4932  ZNF5462  ZNF992  ZNF8362  ZNF5942  
    ZFP622  ZNF8412  ZNF432  ZNF780B2  ZNF1972  ZNF1072  ZNF585A2  ZNF8082  
    ZNF3472  ZNF8452  ZNF585B2  ZNF6582  ZNF6292  ZNF6242  ZNF2682  ZNF8142  
    Selected SIMAP similar genes for ZNF721 using alignment to 4 protein entries:     ZN721_HUMAN (see all proteins) (see all similar genes):
    ZNF525    ZNF83    ZNF519    ZNF616    ZNF880    ZNF761
    ZNF624    ZNF546    ZNF595    ZNF283    ZNF91    ZNF766
    ZNF707    FIK    ZNF610    ZNF614    ZNF818P    ZNF534

    ZNF721 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for ZNF721 (see all 6)
    PGOHUM00000259398 PGOHUM00000234820 PGOHUM00000258179 PGOHUM00000250742 PGOHUM00000250744


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF721 (see all 455)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs752425231,2
    C,F--470044(+) AAATAG/AGACCC 1 -- int14Minor allele frequency- A:0.20NA EA 244
    rs65993481,2
    C,F,A,H--470103(+) CAACTG/ATATTG 1 -- int126Minor allele frequency- A:0.44NA NS EA WA CSA 2482
    rs788194361,2
    C,F--470312(+) GGTGAT/CGCTTC 1 -- int11Minor allele frequency- C:0.09EA 120
    rs1428215221,2
    --470343(+) CCACAC/TCATTT 1 -- int10--------
    rs1510285611,2
    --470374(+) TACCCA/TCACCA 1 -- int10--------
    rs785374061,2
    C,F--470391(+) CTGAGC/AAGTTG 1 -- int11Minor allele frequency- A:0.04WA 118
    rs68254521,2
    C,F,A,H--470463(+) tattaT/Ctgcct 1 -- int118Minor allele frequency- C:0.14NS EA NA CSA WA 2342
    rs1394226421,2
    --470605(+) TGGCTA/GCAGCT 1 -- int10--------
    rs1851756041,2
    C--470647(+) AATGCG/TGTTTC 1 -- int10--------
    rs777571841,2
    C,F--470747(+) CAGGGT/GGCCAC 1 -- int12Minor allele frequency- G:0.06WA NA 238

    HapMap Linkage Disequilibrium report for ZNF721 (419604 - 493442 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ZNF721:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2671108CNV Deletion23128226
    nsv517948CNV Loss19592680
    nsv461144CNV Loss19166990
    nsv461146CNV Gain19166990
    nsv469997CNV Gain18288195
    nsv461145CNV Gain19166990
    esv4769CNV Complex18987735

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF721 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF721)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2001)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    7. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 170960 HGNC: 29425 Ensembl:ENSG00000182903 euGenes: HUgn170960 ECgene: ZNF721
    H-InvDB: ZNF721

    (According to HUGE)
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    HUGE: KIAA1982

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF721 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF721 gene:
    Search GeneIP for patents involving ZNF721

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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