ZNF721 Gene
protein-coding GIFtS: 38
GCID: GC04M000425
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zinc finger protein 721
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Aliases
for ZNF721 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 7211 2 | | KIAA19821 3 |
Export aliases for ZNF721 gene to outside databasesPrevious GC identifer: GC04U900481 |
Summaries
for ZNF721 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN721_HUMAN, Q8TF20Function: May be involved in transcriptional regulation (By similarity)
|
Genomic Views
for ZNF721 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_037622.5
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF721 gene promoter:
SRF FOXF2 AML1a Pbx1a SRF (504 AA) LUN-1 FOXL1 CREB deltaCREB Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF721
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF721 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p16.3 Ensembl cytogenetic band: 4p16.3 HGNC cytogenetic band: 4p16.3ZNF721 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M000425: view genomic region
(about GC identifiers)
Start:
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419,604 bp from pter |
End:
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493,442 bp from pter |
Size:
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73,839 bases |
Orientation:
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minus strand |
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Proteins
for ZNF721 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN721_HUMAN, Q8TF20 (See
protein sequence)Recommended Name: Zinc finger protein 721 Size: 911 amino acids; 105084 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=CAH10687.1; Type=Frameshift; Positions=246, 250, 392, 394, 401, 409, 416, 418, 426, 444,454, 492, 500, 540, 553, 690, 779, 782;
Secondary accessions: Q69YG7Alternative splicing: 2 isoforms: Q8TF20-1 Q8TF20-2 Explore the universe of human proteins at neXtProt for ZNF721: NX_Q8TF20
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TF20
ZNF721 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_597731.2
ENSEMBL proteins: ENSP00000430163 ENSP00000423586 ENSP00000340524 ENSP00000428878 ENSP00000421325 Reactome Protein details: Q8TF20
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF721 for ontologies About GeneDecksing
ZNF721 Antibody Products:
Assay Products for ZNF721: |
Protein
Domains /
Families
for ZNF721 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF721 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8TF20ProtoNet protein and cluster: Q8TF20 UniProtKB/Swiss-Prot: ZN721_HUMAN, Q8TF20Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 30 C2H2-type zinc fingers |
Function
for ZNF721 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN721_HUMAN, Q8TF20Function: May be involved in transcriptional regulation (By similarity)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF721
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for ZNF721 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZNF721 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF721 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF721 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF721 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF721
ZNF721 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF721
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF721 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF721 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF721
Search CenterWatch for drugs/clinical trials and news about ZNF721 / ZN721
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Transcripts
for ZNF721 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF721 gene: NM_133474.2 Unigene Cluster for ZNF721: Zinc finger protein 721 Hs.724168 [show with all ESTs]Unigene Representative Sequence: AK0215146 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000515578(uc011buv.2 uc003gae.3) ENST00000506646 ENST00000507078
ENST00000338977(uc003gaf.4 uc003gag.3 uc010ibe.3) ENST00000511833(uc003gah.1)
ENST00000505900
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF721
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF721
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF721 (NM_133474) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF721 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZNF721 |
Additional cDNA sequence: AK021514.1 1 DOTS entry: DT.91954556
GeneLoc Exon Structure
|
Expression
for ZNF721 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF721 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACCTCCATA
About this image
See ZNF721 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF721
SOURCE GeneReport for Unigene cluster: Hs.724168
SABiosciences Custom PCR Arrays for ZNF721
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF721
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF721 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF721 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF721 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF721 |
Orthologs
for ZNF721 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZNF721 gene from 3/14 species (see all 14) About this table
ENSEMBL Gene Tree for ZNF721 (if available)
TreeFam Gene Tree for ZNF721 (if available) |
Paralogs
for ZNF721 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF721 gene
- ZNF6162 ZNF1602 ZNF8502 ZNF992 ZNF5462 ZNF6652 ZNF8362 ZNF8412
- ZNF912 ZNF432 ZNF780B2 ZNF1972 ZNF585A2 ZNF8082 ZNF7292 ZNF3472
- ZNF8452 ZNF1842 ZNF585B2 ZNF6582 ZNF6242 ZNF2082
18/452 SIMAP similar genes for ZNF721 using alignment to 4 protein entries: ZN721_HUMAN (see all proteins)
(see all similar genes):ZNF525 ZNF519 ZNF761 ZNF624 ZNF595 ZNF283
ZNF177 ZNF880 ZNF707 ZNF818P ZNF534 ZNF565
ZFP90 MGC12518 ZNF267 ZNF583 ZNF471 ZNF554
ZNF721 for paralogs About GeneDecksing
5/6 Pseudogenes.org Pseudogenes for ZNF721 (see all 6)
PGOHUM00000259398 PGOHUM00000234820 PGOHUM00000258179 PGOHUM00000250742 PGOHUM00000250744
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Genomic Variants
for ZNF721 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF721 |
|
Disorders
/ Diseases
for ZNF721 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZNF721 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF721 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF721) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2, 3 Nagase T.... Ohara O. (2001)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
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External Searches for ZNF721 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing ZNF721 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing ZNF721 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ZNF721 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF721 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for ZNF721 gene:
Search GeneIP for patents involving ZNF721
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF721 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF721 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF721 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF721 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF721 | | OriGene 3'-UTR Clone for ZNF721 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF721 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF721 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for ZNF721 |
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 | | | ZNF721 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF721 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF721 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZNF721 |
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