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Aliases for ZNF721 Gene

Aliases for ZNF721 Gene

  • Zinc Finger Protein 721 2 3
  • KIAA1982 4

External Ids for ZNF721 Gene

Previous GeneCards Identifiers for ZNF721 Gene

  • GC04U900481
  • GC04M000427

Summaries for ZNF721 Gene

GeneCards Summary for ZNF721 Gene

ZNF721 (Zinc Finger Protein 721) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF268.

UniProtKB/Swiss-Prot for ZNF721 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF721 Gene

Genomics for ZNF721 Gene

Regulatory Elements for ZNF721 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF721 Gene

Chromosome:
4
Start:
425,815 bp from pter
End:
499,171 bp from pter
Size:
73,357 bases
Orientation:
Minus strand

Genomic View for ZNF721 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for ZNF721 Gene

Proteins for ZNF721 Gene

  • Protein details for ZNF721 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF20-ZN721_HUMAN
    Recommended name:
    Zinc finger protein 721
    Protein Accession:
    Q8TF20
    Secondary Accessions:
    • Q69YG7

    Protein attributes for ZNF721 Gene

    Size:
    911 amino acids
    Molecular mass:
    105084 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAH10687.1; Type=Frameshift; Positions=246, 250, 392, 394, 401, 409, 416, 418, 426, 444, 454, 492, 500, 540, 553, 690, 779, 782; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF721 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF721 Gene

Proteomics data for ZNF721 Gene at MOPED

Post-translational modifications for ZNF721 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF721 Gene

No data available for DME Specific Peptides for ZNF721 Gene

Domains & Families for ZNF721 Gene

Gene Families for ZNF721 Gene

Protein Domains for ZNF721 Gene

Suggested Antigen Peptide Sequences for ZNF721 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TF20

UniProtKB/Swiss-Prot:

ZN721_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 30 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 30 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF721: view

Function for ZNF721 Gene

Molecular function for ZNF721 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF721 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF721: view

Phenotypes for ZNF721 Gene

GenomeRNAi human phenotypes for ZNF721:
genes like me logo Genes that share phenotypes with ZNF721: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF721

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF721 Gene

Localization for ZNF721 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF721 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF721 Gene COMPARTMENTS Subcellular localization image for ZNF721 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF721 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF721: view

Pathways & Interactions for ZNF721 Gene

SuperPathways for ZNF721 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF721: view

Pathways by source for ZNF721 Gene

2 Reactome pathways for ZNF721 Gene

Interacting Proteins for ZNF721 Gene

Gene Ontology (GO) - Biological Process for ZNF721 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF721: view

No data available for SIGNOR curated interactions for ZNF721 Gene

Drugs & Compounds for ZNF721 Gene

No Compound Related Data Available

Transcripts for ZNF721 Gene

mRNA/cDNA for ZNF721 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF721 Gene

Zinc finger protein 721:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF721

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF721 Gene

No ASD Table

Relevant External Links for ZNF721 Gene

GeneLoc Exon Structure for
ZNF721
ECgene alternative splicing isoforms for
ZNF721

Expression for ZNF721 Gene

mRNA expression in normal human tissues for ZNF721 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF721 Gene



SOURCE GeneReport for Unigene cluster for ZNF721 Gene Hs.428360

genes like me logo Genes that share expression patterns with ZNF721: view

Protein tissue co-expression partners for ZNF721 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF721 Gene

Orthologs for ZNF721 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF721 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF721 35
  • 99.46 (n)
  • 99.35 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 46 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 40 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 47 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia A530054K11Rik 36
  • 40 (a)
ManyToMany
AA987161 36
  • 36 (a)
ManyToMany
Zfp457 36
  • 47 (a)
ManyToMany
Zfp458 36
  • 49 (a)
ManyToMany
Zfp738 36
  • 45 (a)
ManyToMany
Zfp748 36
  • 39 (a)
ManyToMany
Zfp759 36
  • 48 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 53 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732182 35
  • 54.45 (n)
  • 54.45 (a)
Species with no ortholog for ZNF721:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF721 Gene

ENSEMBL:
Gene Tree for ZNF721 (if available)
TreeFam:
Gene Tree for ZNF721 (if available)

Paralogs for ZNF721 Gene

(467) SIMAP similar genes for ZNF721 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF721: view

Variants for ZNF721 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF721 Gene

Variant ID Type Subtype PubMed ID
esv4769 CNV Complex 18987735
nsv461144 CNV Loss 19166990
nsv461145 CNV Gain 19166990
nsv517948 CNV Loss 19592680
nsv469997 CNV Gain 18288195
nsv461146 CNV Gain 19166990
esv2671108 CNV Deletion 23128226

Variation tolerance for ZNF721 Gene

Residual Variation Intolerance Score: 92.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.57; 72.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF721 Gene

HapMap Linkage Disequilibrium report
ZNF721
Human Gene Mutation Database (HGMD)
ZNF721

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for ZNF721 Gene

Disorders for ZNF721 Gene

Relevant External Links for ZNF721

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF721
genes like me logo Genes that share disorders with ZNF721: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF721 Gene

Publications for ZNF721 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T. … Ohara O. (DNA Res. 2001) 2 67
  2. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 67
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 67
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 67
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67

Products for ZNF721 Gene

Sources for ZNF721 Gene

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