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ZNF720 Gene

protein-coding   GIFtS: 49
GCID: GC16P031725

Zinc Finger Protein 720

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Protein 7201 2
Putative Protein ZNF7202

External Ids:    HGNC: 269871   Entrez Gene: 1244112   Ensembl: ENSG000001973027   UniProtKB: Q7Z2F63   
ORGUL members:         

Export aliases for ZNF720 gene to outside databases

Previous GC identifers: GC16P031635 GC16P029284


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF720 Gene:
ZNF720 (zinc finger protein 720) is a protein-coding gene. Diseases associated with ZNF720 include hiv-1. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF267.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_187260.1  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF720 gene promoter:
         NF-1/L   NF-1   Tal-1   Lmo2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   E47   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF720 promoter sequence
   Search Chromatin IP Primers for ZNF720

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF720


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

ZNF720 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF720 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P031725:  view genomic region     (about GC identifiers)

Start:
31,724,550 bp from pter      End:
31,806,190 bp from pter
Size:
81,641 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN720_HUMAN, Q7Z2F6 (See protein sequence)
Recommended Name: Putative protein ZNF720  
Size: 126 amino acids; 14454 Da
Caution: Despite its name, it does not contain a canonical C2H2-type zinc-finger
Secondary accessions: Q6ZQX1
Alternative splicing: 2 isoforms:  Q7Z2F6-1   Q7Z2F6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF720: NX_Q7Z2F6

Explore proteomics data for ZNF720 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF720 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001124385.1  
    ENSEMBL proteins: 
     ENSP00000445614   ENSP00000441893   ENSP00000319222   ENSP00000434091   ENSP00000381694  
     ENSP00000443758   ENSP00000431546   ENSP00000435171   ENSP00000437310   ENSP00000440701  
    Reactome Protein details: Q7Z2F6

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    2 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR026613 KRAB_dom_C2H2_Znf_fam

    Graphical View of Domain Structure for InterPro Entry Q7Z2F6

    ProtoNet protein and cluster: Q7Z2F6

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN720_HUMAN, Q7Z2F6
    Similarity: Contains 1 KRAB domain


    ZNF720 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0046872metal ion binding ----
         
    ZNF720 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF720:
     Decreased p24 protein expressi 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton2
    cytosol2
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--

    ZNF720 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF720 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF720
        Generic Transcription Pathway



    ZNF720 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF720
    Interactions:

        Search GeneGlobe Interaction Network for ZNF720

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IEA--

    ZNF720 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF720 (ZN720)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF720 gene (2 alternative transcripts): 
    NM_001004300.1  NM_001130913.1  

    Unigene Cluster for ZNF720:

    Zinc finger protein 720
    Hs.528826  [show with all ESTs]
    Unigene Representative Sequence: NM_001130913
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000529943 ENST00000539915 ENST00000316491(uc002ecn.4) ENST00000534277(uc010vfs.2 uc002ecq.3)
    ENST00000531864 ENST00000398707 ENST00000533488 ENST00000398696(uc002ecp.1)
    ENST00000534369 ENST00000542684 ENST00000544044 ENST00000530881 ENST00000529515
    ENST00000399681
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat ZNF720

    Additional mRNA sequence: 

    AK128671.1 AK299345.1 BC018134.1 BC055408.1 

    8 DOTS entries:

    DT.75123582  DT.95097638  DT.120690452  DT.97815758  DT.100665831  DT.120690428  DT.102823425  DT.92068113 

    Selected AceView cDNA sequences (see all 62):

    BX097026 NM_001004300 BX279886 BX444393 AA810258 BQ129174 CR611323 BC018134 
    BX117290 BM893942 BM728611 CB243738 AA417854 AW014458 BQ129310 BM477614 
    BX103176 BQ775135 BM852456 CD514053 BQ446015 BQ926558 BM967285 BF183230 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF720 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGTTTCTG
    ZNF720 Expression
    About this image

    ZNF720 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF720 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.528826
        Custom PCR Arrays for ZNF720
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF720

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    ENSEMBL Gene Tree for ZNF720 (if available)
    TreeFam Gene Tree for ZNF720 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF720 gene
    ZNF2672  
    Selected SIMAP similar genes for ZNF720 using alignment to 8 protein entries:     ZN720_HUMAN (see all proteins) (see all similar genes):
    POM121C    ZNF78L1    ZNF267    ZNF818P    kr-znf3    ZNF529
    ZNF420    ZNF780B    ZNF12    ZNF81    ZNF283    ZFP1
    ZNF551    ZFS-6    ZNF826P    ZNF701    ZNF527    ZNF317

    ZNF720 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ZNF720
    PGOHUM00000259048 PGOHUM00000259049


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF720 (see all 830)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1494555331,2
    --31722617(+) TGAAGC/GCTGCA 1 -- us2k10--------
    rs1916378431,2
    C--31722704(+) GATGTC/TCCTGT 1 -- us2k10--------
    rs22399691,2
    C,F,O,H--31722770(-) GACGCC/TAGTCA 1 -- us2k112Minor allele frequency- T:0.18EA NA NS CSA WA 2414
    rs10454831,2
    C,F,A,H--31722952(+) TTGTCA/TCCTCT 1 -- us2k122Minor allele frequency- T:0.39EA MN NS NA WA CSA 2647
    rs1834904401,2
    --31723038(+) CCATGG/TCCACT 1 -- us2k10--------
    rs178395201,2
    C,F,H--31723156(+) CTTTAC/TAGAGA 1 -- us2k111Minor allele frequency- T:0.03NA NS EA WA 1346
    rs1170654221,2
    C--31723253(+) TTTCTC/AATTTT 1 -- us2k11Minor allele frequency- A:0.01EA 120
    rs1127544361,2
    C,F--31723281(+) ATTTCG/ACATTG 1 -- us2k11Minor allele frequency- A:0.00CSA 1
    rs1887769331,2
    --31723455(+) AGCTGA/GGATTT 1 -- us2k10--------
    rs1912064811,2
    --31723463(+) TTTACC/GTGGCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF720 (31724550 - 31806190 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ZNF720:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2658959CNV Deletion23128226
    esv2714195CNV Deletion23290073
    nsv833195CNV Loss17160897
    nsv905761CNV Gain21882294
    nsv905747CNV Gain21882294
    dgv848e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF720

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for ZNF720:    
    About MalaCards
    hiv-1


    ZNF720 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF720
    Human Genome Epidemiology (HuGE) Navigator: ZNF720 (1 document)

    Export disorders for ZNF720 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF720 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF720)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    2. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    3. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PubMed id 21083371)4 Chinn L.W....O'Brien S.J. (J. Infect. Dis. 2010)
    4. Identification of host proteins required for HIV infection through a functional genomic screen. (PubMed id 18187620)1 Brass A.L....Elledge S.J. (Science 2008)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 124411 HGNC: 26987 AceView: LOC124411 Ensembl:ENSG00000197302 euGenes: HUgn124411
    ECgene: ZNF720 H-InvDB: ZNF720

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF720 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF720 gene:
    Search GeneIP for patents involving ZNF720

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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