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Aliases for ZNF718 Gene

Aliases for ZNF718 Gene

  • Zinc Finger Protein 718 2 3 5

External Ids for ZNF718 Gene

Previous GeneCards Identifiers for ZNF718 Gene

  • GC04P000115
  • GC04P000047
  • GC04P000117
  • GC04P000050

Summaries for ZNF718 Gene

GeneCards Summary for ZNF718 Gene

ZNF718 (Zinc Finger Protein 718) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF595.

UniProtKB/Swiss-Prot for ZNF718 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF718 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF718 Gene

Genomics for ZNF718 Gene

Regulatory Elements for ZNF718 Gene

Enhancers for ZNF718 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H000123 1 ENCODE 61.5 +0.5 546 2 HDGF PKNOX1 ATF1 SIN3A FEZF1 ZNF2 YY1 GLIS2 ZNF143 ATF7 ZNF718 PIGG PCGF3 GAK ZNF141 SNX18P15
GH04H000050 1.7 FANTOM5 Ensembl ENCODE dbSUPER 24.7 -70.8 -70818 6 PKNOX1 CBX3 TBL1XR1 ZSCAN4 YY1 ETS1 ZNF350 ZNF143 FOS RCOR1 PIGG PCGF3 ZNF718 ZNF141 GAK ENSG00000272588 LOC100129917 IDUA ZNF595 LOC105379580
GH04H000120 0.7 Ensembl ENCODE 50.7 -3.3 -3311 1 RUNX3 NR2F2 ZNF718 ENSG00000274847
GH04H000704 1.3 ENCODE dbSUPER 24.2 +581.8 581779 2 HDGF PKNOX1 ARNT ZNF493 SIN3A YBX1 ZNF2 GLIS2 ZNF143 ZNF207 PIGG ZNF718 PCGF3 LOC100129917 ENSG00000207009 ZNF141 ENSG00000272588 PDE6B ZNF732 CTBP1
GH04H001041 1.6 FANTOM5 Ensembl ENCODE dbSUPER 14 +917.3 917311 1 PKNOX1 ATF1 RB1 ZSCAN4 EGR1 ATF7 EGR2 HDAC8 ZNF592 SMARCA4 CRIPAK LOC100129917 ZNF141 CTBP1-AS2 ZNF718 ZNF876P ZNF732 LOC100288172 ABCA11P IDUA
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF718 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF718 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000164660 425 1800 HDGF PKNOX1 ATF1 SIN3A FEZF1 ZNF2 YY1 CBX5 ZNF143 ATF7

Genomic Location for ZNF718 Gene

124,476 bp from pter
202,306 bp from pter
77,831 bases
Plus strand

Genomic View for ZNF718 Gene

Genes around ZNF718 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF718 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF718 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF718 Gene

Proteins for ZNF718 Gene

  • Protein details for ZNF718 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 718
    Protein Accession:
    Secondary Accessions:
    • Q3SXZ4
    • Q3SXZ5

    Protein attributes for ZNF718 Gene

    478 amino acids
    Molecular mass:
    55404 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF718 Gene


neXtProt entry for ZNF718 Gene

Post-translational modifications for ZNF718 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF718 Gene

No data available for DME Specific Peptides for ZNF718 Gene

Domains & Families for ZNF718 Gene

Gene Families for ZNF718 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF718 Gene

Suggested Antigen Peptide Sequences for ZNF718 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF718: view

No data available for UniProtKB/Swiss-Prot for ZNF718 Gene

Function for ZNF718 Gene

Molecular function for ZNF718 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF718 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF718: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF718
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF718 Gene

Localization for ZNF718 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF718 Gene

Gene Ontology (GO) - Cellular Components for ZNF718 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF718: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for ZNF718 Gene

Pathways & Interactions for ZNF718 Gene

SuperPathways for ZNF718 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF718: view

Pathways by source for ZNF718 Gene

2 Reactome pathways for ZNF718 Gene

Interacting Proteins for ZNF718 Gene

Gene Ontology (GO) - Biological Process for ZNF718 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF718: view

No data available for SIGNOR curated interactions for ZNF718 Gene

Drugs & Compounds for ZNF718 Gene

No Compound Related Data Available

Transcripts for ZNF718 Gene

Unigene Clusters for ZNF718 Gene

Zinc finger protein 718:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF718
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF718 Gene

No ASD Table

Relevant External Links for ZNF718 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF718 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF718 Gene

Protein differential expression in normal tissues from HIPED for ZNF718 Gene

This gene is overexpressed in Monocytes (54.3) and Adipocyte (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF718 Gene

Protein tissue co-expression partners for ZNF718 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF718 Gene:


SOURCE GeneReport for Unigene cluster for ZNF718 Gene:

genes like me logo Genes that share expression patterns with ZNF718: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF718 Gene

Orthologs for ZNF718 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ZNF718 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF718 33
  • 99.37 (n)
Species where no ortholog for ZNF718 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF718 Gene

Gene Tree for ZNF718 (if available)
Gene Tree for ZNF718 (if available)

Paralogs for ZNF718 Gene

(541) SIMAP similar genes for ZNF718 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF718: view

Variants for ZNF718 Gene

Sequence variations from dbSNP and Humsavar for ZNF718 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000051503 -- 140,455(+) ATGGC(A/T)TTGTA intron-variant
rs1000140070 -- 146,815(+) TTCTC(G/T)TAAAT intron-variant
rs1000150962 -- 189,607(+) TGAAG(G/T)TTTTA intron-variant
rs1000164771 -- 126,022(+) AGCCC(C/T)GCCTG intron-variant
rs10003260 -- 191,053(+) TATAT(A/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF718 Gene

Variant ID Type Subtype PubMed ID
dgv1447e212 CNV gain 25503493
dgv1448e212 CNV loss 25503493
dgv1449e212 CNV gain 25503493
dgv2697n106 CNV deletion 24896259
dgv5059n100 CNV gain 25217958
dgv5060n100 CNV gain 25217958
dgv5065n100 CNV loss 25217958
dgv5070n100 CNV gain 25217958
dgv5071n100 CNV gain 25217958
dgv5072n100 CNV loss 25217958
dgv5073n100 CNV loss 25217958
dgv5074n100 CNV loss 25217958
dgv5075n100 CNV loss 25217958
dgv8874n54 CNV loss 21841781
esv2456521 CNV deletion 19546169
esv2762401 CNV loss 21179565
esv2762402 CNV loss 21179565
esv2763816 CNV gain+loss 21179565
esv3304624 CNV mobile element insertion 20981092
esv33512 CNV gain 17666407
esv3355 OTHER sequence alteration 18987735
esv3360440 CNV insertion 20981092
esv3599345 CNV loss 21293372
esv3599346 CNV gain 21293372
esv3599347 CNV loss 21293372
esv3599353 CNV loss 21293372
esv3599354 CNV gain 21293372
esv3599355 CNV loss 21293372
esv3599357 CNV loss 21293372
esv3599358 CNV gain 21293372
esv3599359 CNV gain 21293372
esv3893860 CNV loss 25118596
esv3893861 CNV gain 25118596
esv3893862 CNV gain 25118596
esv5403 OTHER complex 18987735
esv7180 CNV loss 19470904
nsv1001192 CNV loss 25217958
nsv1001533 CNV gain 25217958
nsv1001899 CNV loss 25217958
nsv1011039 CNV loss 25217958
nsv1013934 CNV gain 25217958
nsv1074123 CNV deletion 25765185
nsv1150471 CNV deletion 26484159
nsv4193 CNV insertion 18451855
nsv461141 CNV gain 19166990
nsv461142 CNV loss 19166990
nsv508985 CNV insertion 20534489
nsv515005 CNV loss 21397061
nsv516451 CNV gain+loss 19592680
nsv593189 CNV gain 21841781
nsv593190 CNV gain 21841781
nsv593192 CNV loss 21841781
nsv593193 CNV gain 21841781
nsv593194 CNV loss 21841781
nsv593197 CNV gain 21841781
nsv829833 CNV gain 17160897
nsv967716 CNV duplication 23825009

Relevant External Links for ZNF718 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ZNF718 Gene

Disorders for ZNF718 Gene

Relevant External Links for ZNF718

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF718 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF718 Gene

Publications for ZNF718 Gene

  1. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PMID: 20080650) Xu J … Isaacs WB (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 45 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for ZNF718 Gene

Sources for ZNF718 Gene

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