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Aliases for ZNF718 Gene

Aliases for ZNF718 Gene

  • Zinc Finger Protein 718 2 3 5

External Ids for ZNF718 Gene

Previous GeneCards Identifiers for ZNF718 Gene

  • GC04P000115
  • GC04P000047
  • GC04P000117
  • GC04P000050

Summaries for ZNF718 Gene

GeneCards Summary for ZNF718 Gene

ZNF718 (Zinc Finger Protein 718) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF138.

UniProtKB/Swiss-Prot for ZNF718 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF718 Gene

Genomics for ZNF718 Gene

Regulatory Elements for ZNF718 Gene

Enhancers for ZNF718 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF718 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF718 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF718 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF718 Gene

124,476 bp from pter
202,306 bp from pter
77,831 bases
Plus strand

Genomic View for ZNF718 Gene

Genes around ZNF718 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF718 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF718 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF718 Gene

Proteins for ZNF718 Gene

  • Protein details for ZNF718 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 718
    Protein Accession:
    Secondary Accessions:
    • Q3SXZ4
    • Q3SXZ5

    Protein attributes for ZNF718 Gene

    478 amino acids
    Molecular mass:
    55404 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF718 Gene


neXtProt entry for ZNF718 Gene

Proteomics data for ZNF718 Gene at MOPED

Post-translational modifications for ZNF718 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF718 Gene

No data available for DME Specific Peptides for ZNF718 Gene

Domains & Families for ZNF718 Gene

Gene Families for ZNF718 Gene

Protein Domains for ZNF718 Gene

Suggested Antigen Peptide Sequences for ZNF718 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Contains 11 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF718: view

Function for ZNF718 Gene

Molecular function for ZNF718 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF718 Gene

Localization for ZNF718 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF718 Gene

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ZNF718 Gene

Pathways & Interactions for ZNF718 Gene

SuperPathways for ZNF718 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF718: view

Pathways by source for ZNF718 Gene

2 Reactome pathways for ZNF718 Gene

Interacting Proteins for ZNF718 Gene

Gene Ontology (GO) - Biological Process for ZNF718 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF718: view

No data available for SIGNOR curated interactions for ZNF718 Gene

Drugs & Compounds for ZNF718 Gene

No Compound Related Data Available

Transcripts for ZNF718 Gene

Unigene Clusters for ZNF718 Gene

Zinc finger protein 718:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF718 Gene

No ASD Table

Relevant External Links for ZNF718 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF718 Gene

mRNA expression in normal human tissues for ZNF718 Gene

Protein differential expression in normal tissues from HIPED for ZNF718 Gene

This gene is overexpressed in Monocytes (54.3) and Adipocyte (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF718 Gene

SOURCE GeneReport for Unigene cluster for ZNF718 Gene Hs.636638

genes like me logo Genes that share expression patterns with ZNF718: view

Protein tissue co-expression partners for ZNF718 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF718 Gene

Orthologs for ZNF718 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ZNF718 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF718 35
  • 99.37 (n)
  • 98.54 (a)
Species with no ortholog for ZNF718:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF718 Gene

Gene Tree for ZNF718 (if available)
Gene Tree for ZNF718 (if available)

Paralogs for ZNF718 Gene

(541) SIMAP similar genes for ZNF718 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF718: view

Variants for ZNF718 Gene

Sequence variations from dbSNP and Humsavar for ZNF718 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs9684215 - 161,105(+) CAGAA(A/C/G)AAAAC intron-variant, nc-transcript-variant, reference, synonymous-codon, missense
rs9684214 - 161,104(+) CCAGA(A/G)AAAAA intron-variant, nc-transcript-variant, reference, missense
rs7677201 - 161,575(+) CTCAT(A/C)CCTTA intron-variant, nc-transcript-variant, reference, missense
rs7440274 - 161,923(+) TAATC(A/G)TAAGA intron-variant, nc-transcript-variant, reference, missense
rs3829 -- 141,070(-) tggat(A/G)tggac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF718 Gene

Variant ID Type Subtype PubMed ID
nsv10409 CNV Loss 18304495
nsv821633 CNV Gain 15273396
dgv1563e1 CNV Complex 17122850
esv2752043 CNV Gain 17911159
esv33512 CNV Gain 17666407
essv5613 CNV CNV 17122850
nsv878233 CNV Gain 21882294
esv2420576 CNV Deletion 18987734
nsv878234 CNV Gain 21882294
dgv5384n71 CNV Loss 21882294
nsv878236 CNV Loss 21882294
esv2460685 CNV Deletion 19546169
esv2671718 CNV Deletion 23128226
esv7180 CNV Loss 19470904
esv5403 CNV Complex 18987735
nsv818206 CNV Loss 17921354
nsv461141 CNV Gain 19166990
nsv516451 CNV Gain+Loss 19592680
dgv5385n71 CNV Gain 21882294
esv2663599 CNV Deletion 23128226
esv2672719 CNV Deletion 23128226
esv271141 CNV Insertion 20981092
nsv4193 CNV Insertion 18451855
esv2456521 CNV Deletion 19546169
esv3355 CNV Duplication 18987735
nsv508985 CNV Insertion 20534489
nsv461142 CNV Loss 19166990
esv268902 CNV Insertion 20981092
nsv829833 CNV Gain 17160897
nsv515005 CNV Complex 21397061

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for ZNF718 Gene

Disorders for ZNF718 Gene

Relevant External Links for ZNF718

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF718 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF718 Gene

Publications for ZNF718 Gene

  1. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PMID: 20080650) Xu J. … Isaacs W.B. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 48 67
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZNF718 Gene

Sources for ZNF718 Gene