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Aliases for ZNF718 Gene

Aliases for ZNF718 Gene

  • Zinc Finger Protein 718 2 3 5

External Ids for ZNF718 Gene

Previous GeneCards Identifiers for ZNF718 Gene

  • GC04P000115
  • GC04P000047
  • GC04P000117
  • GC04P000050

Summaries for ZNF718 Gene

GeneCards Summary for ZNF718 Gene

ZNF718 (Zinc Finger Protein 718) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF141.

UniProtKB/Swiss-Prot for ZNF718 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF718 Gene

Genomics for ZNF718 Gene

Regulatory Elements for ZNF718 Gene

Enhancers for ZNF718 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F000123 1 ENCODE 61.9 +0.5 546 2.4 HDGF ATF1 PKNOX1 SIN3A FEZF1 ZNF2 YY1 GLIS2 ZNF143 ZNF207 ZNF718 SNX18P15
GH04F000120 0.6 Ensembl ENCODE 50.8 -3.3 -3311 1.9 NR2F2 ZNF718 ENSG00000274847
GH04F000472 0.7 ENCODE 22 +349.3 349318 2.1 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 ZNF721 ZNF718 PIGG CTBP1-AS2 ENSG00000272588 CRIPAK ABCA11P PIR50641
GH04F000212 0.5 ENCODE 16.8 +88.3 88343 1.6 PKNOX1 CREB3L1 TSC22D4 YBX1 POLR2H POLR2A TARDBP PBX2 ZFX ZNF718 PDE6B ZNF876P GC04P000228 GC04P000229 GC04P000230 PIR59219
GH04F000050 1.5 FANTOM5 Ensembl ENCODE 15.1 -70.8 -70818 6.1 HDAC1 CBX3 PKNOX1 TBL1XR1 ARNT WRNIP1 SIN3A ETS1 YY1 ELK1 ENSG00000272588 ZNF718 ZNF141 LOC100129917 IDUA ENSG00000251535 ZNF595 LOC105379580
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF718 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF718 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001428665 425 2200 HDGF ATF1 PKNOX1 SIN3A FEZF1 ZNF2 YY1 ZNF143 ZNF207 KLF7

Genomic Location for ZNF718 Gene

Chromosome:
4
Start:
124,476 bp from pter
End:
202,306 bp from pter
Size:
77,831 bases
Orientation:
Plus strand

Genomic View for ZNF718 Gene

Genes around ZNF718 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF718 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF718 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF718 Gene

Proteins for ZNF718 Gene

  • Protein details for ZNF718 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3SXZ3-ZN718_HUMAN
    Recommended name:
    Zinc finger protein 718
    Protein Accession:
    Q3SXZ3
    Secondary Accessions:
    • Q3SXZ4
    • Q3SXZ5

    Protein attributes for ZNF718 Gene

    Size:
    478 amino acids
    Molecular mass:
    55404 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF718 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF718 Gene

Post-translational modifications for ZNF718 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF718 Gene

No data available for DME Specific Peptides for ZNF718 Gene

Domains & Families for ZNF718 Gene

Gene Families for ZNF718 Gene

Protein Domains for ZNF718 Gene

Suggested Antigen Peptide Sequences for ZNF718 Gene

Graphical View of Domain Structure for InterPro Entry

Q3SXZ3

UniProtKB/Swiss-Prot:

ZN718_HUMAN :
  • Contains 1 KRAB domain.
  • Contains 11 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Similarity:
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF718: view

Function for ZNF718 Gene

Molecular function for ZNF718 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF718 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF718: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF718 Gene

Localization for ZNF718 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF718 Gene

Gene Ontology (GO) - Cellular Components for ZNF718 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ZNF718: view

No data available for Subcellular locations from COMPARTMENTS for ZNF718 Gene

Pathways & Interactions for ZNF718 Gene

SuperPathways for ZNF718 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF718: view

Pathways by source for ZNF718 Gene

2 Reactome pathways for ZNF718 Gene

Interacting Proteins for ZNF718 Gene

Gene Ontology (GO) - Biological Process for ZNF718 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
genes like me logo Genes that share ontologies with ZNF718: view

No data available for SIGNOR curated interactions for ZNF718 Gene

Transcripts for ZNF718 Gene

Unigene Clusters for ZNF718 Gene

Zinc finger protein 718:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF718 Gene

No ASD Table

Relevant External Links for ZNF718 Gene

GeneLoc Exon Structure for
ZNF718
ECgene alternative splicing isoforms for
ZNF718

Expression for ZNF718 Gene

mRNA expression in normal human tissues for ZNF718 Gene

Protein differential expression in normal tissues from HIPED for ZNF718 Gene

This gene is overexpressed in Monocytes (54.3) and Adipocyte (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF718 Gene



Protein tissue co-expression partners for ZNF718 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF718 Gene:

ZNF718

SOURCE GeneReport for Unigene cluster for ZNF718 Gene:

Hs.636638
genes like me logo Genes that share expression patterns with ZNF718: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF718 Gene

Orthologs for ZNF718 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ZNF718 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF718 34
  • 99.37 (n)
Species where no ortholog for ZNF718 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF718 Gene

ENSEMBL:
Gene Tree for ZNF718 (if available)
TreeFam:
Gene Tree for ZNF718 (if available)

Paralogs for ZNF718 Gene

(541) SIMAP similar genes for ZNF718 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF718: view

Variants for ZNF718 Gene

Sequence variations from dbSNP and Humsavar for ZNF718 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10003260 -- 191,053(+) TATAT(A/T)TTTTT intron-variant
rs10004179 -- 137,767(+) TCTTA(C/G)TCGGG intron-variant
rs10005766 -- 124,343(+) gcctg(A/T)cactc upstream-variant-2KB, utr-variant-5-prime
rs10005767 -- 124,347(+) gtcac(G/T)ctcgc upstream-variant-2KB, utr-variant-5-prime
rs10005847 -- 135,806(+) gcttc(C/G)ttttc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF718 Gene

Variant ID Type Subtype PubMed ID
dgv1447e212 CNV gain 25503493
dgv1448e212 CNV loss 25503493
dgv1449e212 CNV gain 25503493
dgv2697n106 CNV deletion 24896259
dgv5059n100 CNV gain 25217958
dgv5060n100 CNV gain 25217958
dgv5065n100 CNV loss 25217958
dgv5070n100 CNV gain 25217958
dgv5071n100 CNV gain 25217958
dgv5072n100 CNV loss 25217958
dgv5073n100 CNV loss 25217958
dgv5074n100 CNV loss 25217958
dgv5075n100 CNV loss 25217958
dgv8874n54 CNV loss 21841781
esv2456521 CNV deletion 19546169
esv2762401 CNV loss 21179565
esv2762402 CNV loss 21179565
esv2763816 CNV gain+loss 21179565
esv3304624 CNV mobile element insertion 20981092
esv33512 CNV gain 17666407
esv3355 OTHER sequence alteration 18987735
esv3360440 CNV insertion 20981092
esv3599345 CNV loss 21293372
esv3599346 CNV gain 21293372
esv3599347 CNV loss 21293372
esv3599353 CNV loss 21293372
esv3599354 CNV gain 21293372
esv3599355 CNV loss 21293372
esv3599357 CNV loss 21293372
esv3599358 CNV gain 21293372
esv3599359 CNV gain 21293372
esv3893860 CNV loss 25118596
esv3893861 CNV gain 25118596
esv3893862 CNV gain 25118596
esv5403 OTHER complex 18987735
esv7180 CNV loss 19470904
nsv1001192 CNV loss 25217958
nsv1001533 CNV gain 25217958
nsv1001899 CNV loss 25217958
nsv1011039 CNV loss 25217958
nsv1013934 CNV gain 25217958
nsv1074123 CNV deletion 25765185
nsv1150471 CNV deletion 26484159
nsv4193 CNV insertion 18451855
nsv461141 CNV gain 19166990
nsv461142 CNV loss 19166990
nsv508985 CNV insertion 20534489
nsv515005 CNV loss 21397061
nsv516451 CNV gain+loss 19592680
nsv593189 CNV gain 21841781
nsv593190 CNV gain 21841781
nsv593192 CNV loss 21841781
nsv593193 CNV gain 21841781
nsv593194 CNV loss 21841781
nsv593197 CNV gain 21841781
nsv829833 CNV gain 17160897
nsv967716 CNV duplication 23825009

Relevant External Links for ZNF718 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF718

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ZNF718 Gene

Disorders for ZNF718 Gene

Relevant External Links for ZNF718

Genetic Association Database (GAD)
ZNF718
Human Genome Epidemiology (HuGE) Navigator
ZNF718
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF718

No disorders were found for ZNF718 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF718 Gene

Publications for ZNF718 Gene

  1. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PMID: 20080650) Xu J. … Isaacs W.B. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 46 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for ZNF718 Gene

Sources for ZNF718 Gene

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