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Aliases for ZNF718 Gene

Aliases for ZNF718 Gene

  • Zinc Finger Protein 718 2 3

External Ids for ZNF718 Gene

Previous GeneCards Identifiers for ZNF718 Gene

  • GC04P000115
  • GC04P000047
  • GC04P000117
  • GC04P000050

Summaries for ZNF718 Gene

GeneCards Summary for ZNF718 Gene

ZNF718 (Zinc Finger Protein 718) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression.

UniProtKB/Swiss-Prot for ZNF718 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF718 Gene

Genomics for ZNF718 Gene

Regulatory Elements for ZNF718 Gene

Genomic Location for ZNF718 Gene

Start:
124,452 bp from pter
End:
163,989 bp from pter
Size:
39,538 bases
Orientation:
Plus strand

Genomic View for ZNF718 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF718 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF718 Gene

Proteins for ZNF718 Gene

  • Protein details for ZNF718 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3SXZ3-ZN718_HUMAN
    Recommended name:
    Zinc finger protein 718
    Protein Accession:
    Q3SXZ3
    Secondary Accessions:
    • Q3SXZ4
    • Q3SXZ5

    Protein attributes for ZNF718 Gene

    Size:
    478 amino acids
    Molecular mass:
    55404 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF718 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF718 Gene

Proteomics data for ZNF718 Gene at MOPED

Post-translational modifications for ZNF718 Gene

  • Ubiquitination at Lys337 and Lys340
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF718 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF718 Gene

Domains for ZNF718 Gene

Gene Families for ZNF718 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF718 Gene

Suggested Antigen Peptide Sequences for ZNF718 Gene

Graphical View of Domain Structure for InterPro Entry

Q3SXZ3

UniProtKB/Swiss-Prot:

ZN718_HUMAN :
  • Q3SXZ3
Domain:
  • Contains 1 KRAB domain.
Similarity:
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF718: view

Function for ZNF718 Gene

Molecular function for ZNF718 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF718 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF718: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF718

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF718 Gene

Localization for ZNF718 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF718 Gene

Gene Ontology (GO) - Cellular Components for ZNF718 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF718: view

No data available for Subcellular locations from COMPARTMENTS for ZNF718 Gene

Pathways for ZNF718 Gene

SuperPathways for ZNF718 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF718: view

Pathways by source for ZNF718 Gene

2 Reactome pathways for ZNF718 Gene

Interacting Proteins for ZNF718 Gene

Gene Ontology (GO) - Biological Process for ZNF718 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF718: view

Transcripts for ZNF718 Gene

Unigene Clusters for ZNF718 Gene

Zinc finger protein 718:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF718

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF718 Gene

No ASD Table

Relevant External Links for ZNF718 Gene

GeneLoc Exon Structure for
ZNF718
ECgene alternative splicing isoforms for
ZNF718

Expression for ZNF718 Gene

mRNA expression in normal human tissues for ZNF718 Gene

Protein differential expression in normal tissues for ZNF718 Gene

This gene is overexpressed in Monocytes (54.3) and Adipocyte (14.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ZNF718 Gene

SOURCE GeneReport for Unigene cluster for ZNF718 Gene Hs.636638

genes like me logo Genes that share expressions with ZNF718: view

Expression partners for ZNF718 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF718 Gene

Orthologs for ZNF718 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ZNF718 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF718 35
  • 99.37 (n)
  • 98.54 (a)
Species with no ortholog for ZNF718:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF718 Gene

ENSEMBL:
Gene Tree for ZNF718 (if available)
TreeFam:
Gene Tree for ZNF718 (if available)

Paralogs for ZNF718 Gene

Selected SIMAP similar genes for ZNF718 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF718: view

No data available for Paralogs for ZNF718 Gene

Variants for ZNF718 Gene

Sequence variations from dbSNP and Humsavar for ZNF718 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs3829 -- 141,070(-) tggat(A/G)tggac intron-variant
rs1135336 -- 141,093(+) ttttt(A/G/T)ttttt intron-variant
rs3747693 -- 124,493(+) CGGGA(G/T)CTGGC utr-variant-5-prime, nc-transcript-variant
rs3747694 -- 124,549(+) TCGCT(C/G)TGCTC utr-variant-5-prime, nc-transcript-variant
rs3935553 -- 199,265(+) CCCTT(C/G)ACATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF718 Gene

Variant ID Type Subtype PubMed ID
nsv10409 CNV Loss 18304495
nsv821633 CNV Gain 15273396
dgv1563e1 CNV Complex 17122850
esv2752043 CNV Gain 17911159
esv33512 CNV Gain 17666407
essv5613 CNV CNV 17122850
nsv878233 CNV Gain 21882294
esv2420576 CNV Deletion 18987734
nsv878234 CNV Gain 21882294
dgv5384n71 CNV Loss 21882294
nsv878236 CNV Loss 21882294
esv2460685 CNV Deletion 19546169
esv2671718 CNV Deletion 23128226
esv7180 CNV Loss 19470904
esv5403 CNV Complex 18987735
nsv818206 CNV Loss 17921354
nsv461141 CNV Gain 19166990
nsv516451 CNV Gain+Loss 19592680
dgv5385n71 CNV Gain 21882294
esv2663599 CNV Deletion 23128226
esv2672719 CNV Deletion 23128226
esv271141 CNV Insertion 20981092
nsv4193 CNV Insertion 18451855
esv2456521 CNV Deletion 19546169
esv3355 CNV Duplication 18987735
nsv508985 CNV Insertion 20534489
nsv461142 CNV Loss 19166990
esv268902 CNV Insertion 20981092
nsv829833 CNV Gain 17160897
nsv515005 CNV Complex 21397061

Relevant External Links for ZNF718 Gene

HapMap Linkage Disequilibrium report
ZNF718

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF718 Gene

Disorders for ZNF718 Gene

Relevant External Links for ZNF718

Genetic Association Database (GAD)
ZNF718
Human Genome Epidemiology (HuGE) Navigator
ZNF718

No disorders were found for ZNF718 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ZNF718 Gene

Publications for ZNF718 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PMID: 20080650) Xu J. … Isaacs W.B. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 48
  3. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ZNF718 Gene

Sources for ZNF718 Gene

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