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ZNF717 Gene

protein-coding   GIFtS: 42
GCID: GC03M075758

Zinc Finger Protein 717

(Previous name: zinc finger protein 838)
(Previous symbol: ZNF838)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 7171 2
ZNF8381 2
Zinc Finger Protein 8381 2
Krueppel-Like Factor X172 3
X172
Kruppel-Like Zinc Finger Factor X172

External Ids:    HGNC: 294481   Entrez Gene: 1001318272   Ensembl: ENSG000002271247   UniProtKB: Q9BY313   

Export aliases for ZNF717 gene to outside databases

Previous GC identifers: GC03M075870 GC03U900858


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF717 Gene:
ZNF717 (zinc finger protein 717) is a protein-coding gene. An important paralog of this gene is ZNF334.

UniProtKB/Swiss-Prot: ZN717_HUMAN, Q9BY31
Function: May be involved in transcriptional regulation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ZNF717
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ZNF717

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF717


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p12.3   Ensembl cytogenetic band:  3p12.3   HGNC cytogenetic band: 3p12.3

ZNF717 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF717 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M075758:  view genomic region     (about GC identifiers)

Start:
75,758,794 bp from pter      End:
75,834,734 bp from pter
Size:
75,941 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN717_HUMAN, Q9BY31 (See protein sequence)
Recommended Name: Zinc finger protein 717  
Size: 904 amino acids; 105251 Da
Sequence caution: Sequence=AAK28319.1; Type=Frameshift; Positions=685;

Explore the universe of human proteins at neXtProt for ZNF717: NX_Q9BY31

Explore proteomics data for ZNF717 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF717 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001121695.1  NP_001277137.1  NP_001277138.1  NP_001277139.1  

    ENSEMBL proteins: 
     ENSP00000417902   ENSP00000419377   ENSP00000418187   ENSP00000420241   ENSP00000409514  
     ENSP00000383643  
    Reactome Protein details: Q9BY31

    ZNF717 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ZNF717

     
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    Search antibodies-online for antibodies for ZNF717 

    ZNF717 Assay Products:

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    Cloud-Clone Corp. ELISAs for ZNF717
    Cloud-Clone Corp. CLIAs for ZNF717
    Search eBioscience for ELISAs for ZNF717 
    antibodies-online kits for ZNF717 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9BY31

    ProtoNet protein and cluster: Q9BY31

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZN717_HUMAN, Q9BY31
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 22 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF717           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN717_HUMAN, Q9BY31
    Function: May be involved in transcriptional regulation (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF717           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF717

    miRNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN717_HUMAN, Q9BY31: Nucleus (Potential)

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF717           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF717 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF717           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF717
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF717
    Interactions:

        Search GeneGlobe Interaction Network for ZNF717

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ZNF717 (ENSP000004095144) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZAKENSP000003643614STRING: ENSP00000364361
    CBX8ENSP000002693854STRING: ENSP00000269385
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IBA--

    Find genes that share ontologies with ZNF717           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF717 (ZN717)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF717 gene (4 alternative transcripts): 
    NM_001128223.1  NM_001290208.1  NM_001290209.1  NM_001290210.1  

    Unigene Cluster for ZNF717:

    Zinc finger protein 717
    Hs.556877  [show with all ESTs]
    Unigene Representative Sequence: NM_001128223
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000491507(uc003dpw.3) ENST00000477374 ENST00000478296 ENST00000468296
    ENST00000471541 ENST00000422325(uc011bgi.2) ENST00000400845
    miRNA
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: ZNF717 (NM_001128223)
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZNF717
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF717
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF717
      QuantiFast Probe-based Assays in human, mouse, rat ZNF717

    Additional mRNA sequence: 

    AF226994.1 AK123776.1 

    4 DOTS entries:

    DT.120909827  DT.40133341  DT.92037391  DT.97806644 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF717 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGCAAAAA
    ZNF717 Expression
    About this image

    ZNF717 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF717 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.556877
        Custom PCR Arrays for ZNF717
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF717

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF717 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp391 zinc finger protein 39 67.69(n)
    54.43(a)
      22698  NM_011758.2  NP_035888.2 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    36(a)
    1 → many
    2(350396-358052)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    54(a)
    many ↔ many
    GL343935.1(22548-104429)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-209n20.586
    si:ch211-209n20.58
    39(a)
    many ↔ many
    4(36662631-36857756) ENSDARG00000088888


    ENSEMBL Gene Tree for ZNF717 (if available)
    TreeFam Gene Tree for ZNF717 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF717 gene
    ZNF3342  ZNF4202  ZNF780A2  ZNF6652  ZNF72  ZNF232  ZNF33A2  RBAK2  
    ZNF302  ZNF5732  ZNF33B2  ZNF5402  ZNF2512  ZNF6052  ZNF842  ZNF1892  
    ZNF5712  ZNF6302  ZNF3372  ZNF2832  ZNF4042  ZNF1352  ZNF4842  ZNF122  
    ZNF3452  ZNF1842  ZNF6992  ZNF412  ZNF6152  ZNF4702  ZNF5692  
    Selected SIMAP similar genes for ZNF717 using alignment to 6 protein entries:     ZN717_HUMAN (see all proteins) (see all similar genes):
    ZNF73    ZNF320    FIK    ZNF78L1    ZNF300P1    ZNF56
    kr-znf3    ZNF577    MGC12518    ZNF26    DKFZp666M039    ZNF93
    ZNF32    ZNF83    ZNF420    ZNF664    ZNF331    ZNF525

    Find genes that share paralogs with ZNF717           About GenesLikeMe


    5 Pseudogenes.org Pseudogenes for ZNF717
    PGOHUM00000238653 PGOHUM00000239584 PGOHUM00000244465 PGOHUM00000250546 PGOHUM00000233526


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF717 (see all 3459)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs773010611,2
    C,Funtested175788273(+) ATAGGA/G/TAAAAG 2 F syn13NA 12
    rs758111701,2
    C,Funtested175790837(+) TCCTGC/ACACTC 2 /W /C mis12Minor allele frequency- A:0.50WA CSA 4
    rs1393654471,2
    C--75788023(+) AATAAC/TAGCTG 2 I V mis10--------
    rs1506898081,2
    C--75788028(+) CAGCTA/C/GAGTTA 3 S * L stg1 mis10--------
    rs1443554571,2
    C--75788040(+) TACAGA/GCTTTC 2 A V mis10--------
    rs1442623251,2
    C--75788068(+) ACCAAA/CGGTCT 2 V F mis10--------
    rs1512166711,2
    C--75788088(+) GAACCC/TTCTTA 2 K R mis10--------
    rs1458298781,2
    C--75788130(+) TTTTCA/CCTTGT 2 G V mis10--------
    rs1438718341,2
    C--75788150(+) GAAAA-/GAGTCT 2 Q S fra10--------
    rs1483721201,2
    --75788152(+) AAAAGC/G/TCTGCA 3 T P A mis10--------

    HapMap Linkage Disequilibrium report for ZNF717 (75758794 - 75834734 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZNF717 (see all 51):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv822e201CNV Deletion23290073
    esv2725503CNV Deletion23290073
    esv2725482CNV Deletion23290073
    esv2422315CNV Deletion17116639
    esv2725480CNV Deletion23290073
    esv2725498CNV Deletion23290073
    esv2725484CNV Deletion23290073
    esv2725504CNV Deletion23290073
    esv2661069CNV Deletion23128226
    esv2725502CNV Deletion23290073

    Human Gene Mutation Database (HGMD): ZNF717
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF717
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF717

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ZNF717           About GenesLikeMe

    Genetic Association Database (GAD): ZNF717

    Export disorders for ZNF717 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF717 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with ZNF717)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)1, 2 Muzny D.M....Gibbs R.A. (Nature 2006)
    2. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    3. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    4. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells. (PubMed id 21282530)1 Vandamme J.... Angrand P.O. (Mol. Cell. Proteomics 2011)
    5. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PubMed id 17903297)4 Seshadri S....Wolf P.A. (BMC Med. Genet. 2007)
    6. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    7. Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study. (PubMed id 17903303)4 O'Donnell C.J....Demissie S. (BMC Med. Genet. 2007)
    8. Genome-wide association with diabetes-related traits in the Framingham Heart Study. (PubMed id 17903298)4 Meigs J.B....Dupuis J. (BMC Med. Genet. 2007)
    9. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)4 Benjamin E.J....Vasan R.S. (BMC Med. Genet. 2007)
    10. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)4 Yang Q....O'Donnell C.J. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 100131827 HGNC: 29448 Ensembl:ENSG00000227124 euGenes: HUgn100131827 ECgene: ZNF717
    H-InvDB: ZNF717

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF717 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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