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Aliases for ZNF717 Gene

Aliases for ZNF717 Gene

  • Zinc Finger Protein 717 2 3
  • Krueppel-Like Factor X17 3 4
  • Zinc Finger Protein 838 2 3
  • Kruppel-Like Zinc Finger Factor X17 3
  • ZNF838 3
  • X17 3

External Ids for ZNF717 Gene

Previous HGNC Symbols for ZNF717 Gene

  • ZNF838

Previous GeneCards Identifiers for ZNF717 Gene

  • GC03M075870
  • GC03U900858
  • GC03M075758

Summaries for ZNF717 Gene

GeneCards Summary for ZNF717 Gene

ZNF717 (Zinc Finger Protein 717) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF630.

UniProtKB/Swiss-Prot for ZNF717 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF717 Gene

Genomics for ZNF717 Gene

Genomic Location for ZNF717 Gene

75,709,643 bp from pter
75,785,583 bp from pter
75,941 bases
Minus strand

Genomic View for ZNF717 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF717 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF717 Gene

No data available for Regulatory Elements for ZNF717 Gene

Proteins for ZNF717 Gene

  • Protein details for ZNF717 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 717
    Protein Accession:

    Protein attributes for ZNF717 Gene

    904 amino acids
    Molecular mass:
    105251 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAK28319.1; Type=Frameshift; Positions=685; Evidence={ECO:0000305};

neXtProt entry for ZNF717 Gene

Proteomics data for ZNF717 Gene at MOPED

Post-translational modifications for ZNF717 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF717 Gene

No data available for DME Specific Peptides for ZNF717 Gene

Domains & Families for ZNF717 Gene

Gene Families for ZNF717 Gene

Protein Domains for ZNF717 Gene

Suggested Antigen Peptide Sequences for ZNF717 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 22 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 22 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF717: view

Function for ZNF717 Gene

Molecular function for ZNF717 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF717 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF717: view

Phenotypes for ZNF717 Gene

GenomeRNAi human phenotypes for ZNF717:
genes like me logo Genes that share phenotypes with ZNF717: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF717 Gene

Localization for ZNF717 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF717 Gene

Subcellular locations from

Jensen Localization Image for ZNF717 Gene COMPARTMENTS Subcellular localization image for ZNF717 gene
Compartment Confidence
nucleus 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ZNF717 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF717: view

Pathways & Interactions for ZNF717 Gene

SuperPathways for ZNF717 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF717: view

Pathways by source for ZNF717 Gene

2 Reactome pathways for ZNF717 Gene

Interacting Proteins for ZNF717 Gene

Gene Ontology (GO) - Biological Process for ZNF717 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF717: view

No data available for SIGNOR curated interactions for ZNF717 Gene

Drugs & Compounds for ZNF717 Gene

No Compound Related Data Available

Transcripts for ZNF717 Gene

mRNA/cDNA for ZNF717 Gene

(16) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF717 Gene

Zinc finger protein 717:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF717 Gene

No ASD Table

Relevant External Links for ZNF717 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF717 Gene

mRNA expression in normal human tissues for ZNF717 Gene

Protein differential expression in normal tissues from HIPED for ZNF717 Gene

This gene is overexpressed in Brain (43.3) and Platelet (25.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ZNF717 Gene

SOURCE GeneReport for Unigene cluster for ZNF717 Gene Hs.556877

genes like me logo Genes that share expression patterns with ZNF717: view

Protein tissue co-expression partners for ZNF717 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF717 Gene

Orthologs for ZNF717 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF717 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Zfp39 35
  • 67.69 (n)
  • 54.43 (a)
Gm13212 36
  • 40 (a)
(Rattus norvegicus)
Mammalia Zfp39 35
  • 67.44 (n)
  • 50.93 (a)
(Bos Taurus)
Mammalia -- 36
  • 37 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 43 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 38 (a)
(Gallus gallus)
Aves -- 36
  • 36 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 54 (a)
(Danio rerio)
Actinopterygii si:ch211-209n20.58 36
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
-- 36
  • 44 (a)
-- 36
  • 38 (a)
-- 36
  • 42 (a)
Species with no ortholog for ZNF717:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF717 Gene

Gene Tree for ZNF717 (if available)
Gene Tree for ZNF717 (if available)

Paralogs for ZNF717 Gene

(530) SIMAP similar genes for ZNF717 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZNF717: view

Variants for ZNF717 Gene

Sequence variations from dbSNP and Humsavar for ZNF717 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs460187 -- 75,735,379(+) GCCAC(A/G/T)ATACC intron-variant, downstream-variant-500B
rs1052377 -- 75,730,313(-) CATCT(C/T)CTGAT utr-variant-3-prime, intron-variant
rs1812646 -- 75,752,584(-) attca(A/G)acccc intron-variant
rs1813512 -- 75,718,854(+) gccac(A/G)ggcaa intron-variant
rs1821925 -- 75,724,082(+) ctctc(C/T)ccacc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF717 Gene

Variant ID Type Subtype PubMed ID
esv2422315 CNV Deletion 17116639
esv614 CNV CNV 17122850
nsv529016 CNV Gain 19592680
esv26581 CNV Gain+Loss 19812545
dgv1469e1 CNV Complex 17122850
nsv876983 CNV Gain 21882294
nsv876984 CNV Gain 21882294
dgv1472e1 CNV Complex 17122850
dgv1473e1 CNV Complex 17122850
essv18298 CNV CNV 17122850
nsv428418 CNV Loss 18775914
nsv10283 CNV Gain+Loss 18304495
nsv876987 CNV Gain 21882294
dgv1474e1 CNV Complex 17122850
nsv821408 CNV Duplication 20802225
nsv822138 CNV Gain 20364138
nsv876988 CNV Loss 21882294
esv2436311 CNV Gain 19546169
dgv812n67 CNV Gain 20364138
nsv822140 CNV Loss 20364138
esv2671489 CNV Deletion 23128226
esv33470 CNV Loss 17666407
esv2725476 CNV Deletion 23290073
nsv471427 CNV Duplication 19718026
esv2725478 CNV Deletion 23290073
nsv513053 CNV Loss 21212237
esv2725479 CNV Deletion 23290073
esv9630 CNV Loss 19470904
esv2725480 CNV Deletion 23290073
esv2725481 CNV Deletion 23290073
esv2725482 CNV Deletion 23290073
esv2725483 CNV Deletion 23290073
esv2004829 CNV Deletion 18987734
esv2725484 CNV Deletion 23290073
esv2725486 CNV Deletion 23290073
esv2725487 CNV Deletion 23290073
esv2725488 CNV Deletion 23290073
dgv820e201 CNV Deletion 23290073
dgv821e201 CNV Deletion 23290073
dgv822e201 CNV Deletion 23290073
esv2725494 CNV Deletion 23290073
esv2725498 CNV Deletion 23290073
esv2661069 CNV Deletion 23128226
dgv5169n71 CNV Gain 21882294
esv2725500 CNV Deletion 23290073
esv2725501 CNV Deletion 23290073
esv2725502 CNV Deletion 23290073
esv1200496 CNV Insertion 17803354
esv2241639 CNV Deletion 18987734
esv2725503 CNV Deletion 23290073
esv2725504 CNV Deletion 23290073

Variation tolerance for ZNF717 Gene

Gene Damage Index Score: 2.86; 48.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF717 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF717 Gene

Disorders for ZNF717 Gene

Relevant External Links for ZNF717

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ZNF717: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF717 Gene

Publications for ZNF717 Gene

  1. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells. (PMID: 21282530) Vandamme J. … Angrand P.O. (Mol. Cell. Proteomics 2011) 67
  2. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PMID: 17903297) Seshadri S. … Wolf P.A. (BMC Med. Genet. 2007) 67
  3. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S. … Cupples L.A. (BMC Med. Genet. 2007) 67
  4. Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study. (PMID: 17903303) O'Donnell C.J. … Demissie S. (BMC Med. Genet. 2007) 67
  5. Genome-wide association with diabetes-related traits in the Framingham Heart Study. (PMID: 17903298) Meigs J.B. … Dupuis J. (BMC Med. Genet. 2007) 67

Products for ZNF717 Gene

Sources for ZNF717 Gene

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