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Aliases for ZNF716 Gene

Aliases for ZNF716 Gene

  • Zinc Finger Protein 716 2 3 5

External Ids for ZNF716 Gene

Previous GeneCards Identifiers for ZNF716 Gene

  • GC07P057321
  • GC07P057501
  • GC07P057110
  • GC07P057513
  • GC07P057506
  • GC07P057524

Summaries for ZNF716 Gene

GeneCards Summary for ZNF716 Gene

ZNF716 (Zinc Finger Protein 716) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF718.

UniProtKB/Swiss-Prot for ZNF716 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF716 Gene

Genomics for ZNF716 Gene

Regulatory Elements for ZNF716 Gene

Genomic Location for ZNF716 Gene

57,450,177 bp from pter
57,473,559 bp from pter
23,383 bases
Plus strand

Genomic View for ZNF716 Gene

Genes around ZNF716 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF716 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF716 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF716 Gene

Proteins for ZNF716 Gene

  • Protein details for ZNF716 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 716
    Protein Accession:

    Protein attributes for ZNF716 Gene

    495 amino acids
    Molecular mass:
    57006 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF716 Gene

Proteomics data for ZNF716 Gene at MOPED

Post-translational modifications for ZNF716 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF716 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF716 Gene

Domains & Families for ZNF716 Gene

Gene Families for ZNF716 Gene

Protein Domains for ZNF716 Gene

Suggested Antigen Peptide Sequences for ZNF716 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF716: view

Function for ZNF716 Gene

Molecular function for ZNF716 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes for ZNF716 Gene

genes like me logo Genes that share phenotypes with ZNF716: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF716 Gene

Localization for ZNF716 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF716 Gene

Subcellular locations from

Jensen Localization Image for ZNF716 Gene COMPARTMENTS Subcellular localization image for ZNF716 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF716 Gene

Pathways & Interactions for ZNF716 Gene

SuperPathways for ZNF716 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF716: view

Pathways by source for ZNF716 Gene

2 Reactome pathways for ZNF716 Gene

Interacting Proteins for ZNF716 Gene

Gene Ontology (GO) - Biological Process for ZNF716 Gene


No data available for SIGNOR curated interactions for ZNF716 Gene

Drugs & Compounds for ZNF716 Gene

No Compound Related Data Available

Transcripts for ZNF716 Gene

mRNA/cDNA for ZNF716 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF716 Gene

Zinc finger protein 716:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF716 Gene

No ASD Table

Relevant External Links for ZNF716 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF716 Gene

mRNA expression in normal human tissues for ZNF716 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF716 Gene

This gene is overexpressed in Testis (x47.4).

SOURCE GeneReport for Unigene cluster for ZNF716 Gene Hs.533121

genes like me logo Genes that share expression patterns with ZNF716: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF716 Gene

Orthologs for ZNF716 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF716 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF716 35
  • 99.06 (n)
  • 98.38 (a)
ZNF716 36
  • 98 (a)
(Bos Taurus)
Mammalia -- 36
  • 47 (a)
(Canis familiaris)
Mammalia -- 36
  • 35 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 34 (a)
-- 36
  • 47 (a)
(Mus musculus)
Mammalia Zfp493 36
  • 55 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
-- 36
  • 30 (a)
-- 36
  • 36 (a)
-- 36
  • 35 (a)
-- 36
  • 28 (a)
-- 36
  • 29 (a)
-- 36
  • 28 (a)
-- 36
  • 26 (a)
Species with no ortholog for ZNF716:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF716 Gene

Gene Tree for ZNF716 (if available)
Gene Tree for ZNF716 (if available)

Paralogs for ZNF716 Gene

(502) SIMAP similar genes for ZNF716 Gene using alignment to 1 proteins: Pseudogenes for ZNF716 Gene

genes like me logo Genes that share paralogs with ZNF716: view

Variants for ZNF716 Gene

Sequence variations from dbSNP and Humsavar for ZNF716 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1851773 -- 57,459,845(+) TTGTT(C/G)TTCTC intron-variant
rs1851774 -- 57,460,035(+) TTCAG(C/G)GAAAG intron-variant
rs2103101 -- 57,459,289(+) TCCTG(A/G)GCACA intron-variant
rs2396950 -- 57,457,438(+) ctccc(A/G)ggttc intron-variant
rs2894770 -- 57,457,834(+) ctcag(A/T)gtctg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF716 Gene

Variant ID Type Subtype PubMed ID
nsv464484 CNV Gain 19166990
nsv520659 CNV Gain 19592680
esv2752161 CNV Gain 17911159
esv2752162 CNV Gain 17911159
dgv816n27 CNV Gain 19166990
dgv2083e1 CNV Complex 17122850
esv2752163 CNV Gain 17911159
nsv464486 CNV Gain 19166990

Variation tolerance for ZNF716 Gene

Residual Variation Intolerance Score: 47.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.99; 74.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF716 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF716 Gene

Disorders for ZNF716 Gene

Relevant External Links for ZNF716

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF716 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF716 Gene

Publications for ZNF716 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3
  3. Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9. (PMID: 24376456) Simino J. … Rao D.C. (Front Genet 2013) 3
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3

Products for ZNF716 Gene

Sources for ZNF716 Gene

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