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Aliases for ZNF716 Gene

Aliases for ZNF716 Gene

  • Zinc Finger Protein 716 2 3 5

External Ids for ZNF716 Gene

Previous GeneCards Identifiers for ZNF716 Gene

  • GC07P057321
  • GC07P057501
  • GC07P057110
  • GC07P057513
  • GC07P057506
  • GC07P057524
  • GC07P057533
  • GC07P057545

Summaries for ZNF716 Gene

GeneCards Summary for ZNF716 Gene

ZNF716 (Zinc Finger Protein 716) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF479.

UniProtKB/Swiss-Prot for ZNF716 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF716 Gene

Genomics for ZNF716 Gene

Regulatory Elements for ZNF716 Gene

Enhancers for ZNF716 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F057646 0.5 FANTOM5 2.8 +196.7 196728 0.4 NRF1 LOC100420545 ZNF716 GC07M057647 GC07M057648 PIR45164
GH07F057579 0.4 FANTOM5 1.3 +129.6 129630 0.4 ZNF479 ZNF716 NCOR1P3 LOC105375301
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF716 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF716 Gene

Chromosome:
7
Start:
57,450,177 bp from pter
End:
57,473,559 bp from pter
Size:
23,383 bases
Orientation:
Plus strand

Genomic View for ZNF716 Gene

Genes around ZNF716 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF716 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF716 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF716 Gene

Proteins for ZNF716 Gene

  • Protein details for ZNF716 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NP11-ZN716_HUMAN
    Recommended name:
    Zinc finger protein 716
    Protein Accession:
    A6NP11

    Protein attributes for ZNF716 Gene

    Size:
    495 amino acids
    Molecular mass:
    57006 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF716 Gene

Post-translational modifications for ZNF716 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF716 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF716 Gene

Domains & Families for ZNF716 Gene

Gene Families for ZNF716 Gene

Protein Domains for ZNF716 Gene

Suggested Antigen Peptide Sequences for ZNF716 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NP11

UniProtKB/Swiss-Prot:

ZN716_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF716: view

Function for ZNF716 Gene

Molecular function for ZNF716 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF716 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF716: view

Phenotypes for ZNF716 Gene

genes like me logo Genes that share phenotypes with ZNF716: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF716 Gene

Localization for ZNF716 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF716 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF716 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF716 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ZNF716: view

Pathways & Interactions for ZNF716 Gene

SuperPathways for ZNF716 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF716: view

Pathways by source for ZNF716 Gene

2 Reactome pathways for ZNF716 Gene

Gene Ontology (GO) - Biological Process for ZNF716 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF716: view

No data available for SIGNOR curated interactions for ZNF716 Gene

Transcripts for ZNF716 Gene

mRNA/cDNA for ZNF716 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF716 Gene

Zinc finger protein 716:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF716 Gene

No ASD Table

Relevant External Links for ZNF716 Gene

GeneLoc Exon Structure for
ZNF716
ECgene alternative splicing isoforms for
ZNF716

Expression for ZNF716 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF716 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF716 Gene

This gene is overexpressed in Testis (x47.4).

NURSA nuclear receptor signaling pathways regulating expression of ZNF716 Gene:

ZNF716

SOURCE GeneReport for Unigene cluster for ZNF716 Gene:

Hs.533121
genes like me logo Genes that share expression patterns with ZNF716: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF716 Gene

Orthologs for ZNF716 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF716 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF716 34 35
  • 99.06 (n)
mouse
(Mus musculus)
Mammalia Zfp493 35
  • 55 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 47 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 47 (a)
ManyToMany
-- 35
  • 34 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 35 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 47 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 26 (a)
ManyToMany
Species where no ortholog for ZNF716 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF716 Gene

ENSEMBL:
Gene Tree for ZNF716 (if available)
TreeFam:
Gene Tree for ZNF716 (if available)

Paralogs for ZNF716 Gene

(502) SIMAP similar genes for ZNF716 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ZNF716 Gene

genes like me logo Genes that share paralogs with ZNF716: view

Variants for ZNF716 Gene

Sequence variations from dbSNP and Humsavar for ZNF716 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10215781 -- 57,468,524(+) GTTAC(C/T)TTACT intron-variant
rs10225979 -- 57,462,955(+) GTTAC(G/T)AATCA intron-variant
rs10228135 -- 57,458,673(+) acctc(A/G)gcctc intron-variant
rs10230602 -- 57,464,364(+) gatct(G/T)cccag intron-variant
rs10231707 -- 57,450,998(+) ttttt(C/T)ttcaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF716 Gene

Variant ID Type Subtype PubMed ID
nsv970848 CNV duplication 23825009
nsv970847 CNV duplication 23825009
nsv607057 CNV gain 21841781
nsv607055 CNV gain 21841781
nsv607048 CNV gain 21841781
nsv520659 CNV gain 19592680
nsv464486 CNV gain 19166990
nsv464484 CNV gain 19166990
nsv1032246 CNV loss 25217958
nsv1027062 CNV gain 25217958
nsv1021062 CNV gain 25217958
nsv1016541 CNV gain 25217958
esv3613301 CNV gain 21293372
esv3613300 CNV loss 21293372
esv3576359 CNV gain 25503493
esv2761119 CNV gain+loss 21179565
esv2759531 CNV gain 17122850
esv2752163 CNV gain 17911159
esv2752162 CNV gain 17911159
esv2752161 CNV gain 17911159
dgv816n27 CNV gain 19166990
dgv6372n100 CNV gain 25217958
dgv6371n100 CNV gain 25217958
dgv6370n100 CNV loss 25217958
dgv6369n100 CNV gain 25217958
dgv6368n100 CNV loss 25217958
dgv6367n100 CNV gain 25217958
dgv11355n54 CNV gain 21841781
dgv11354n54 CNV gain 21841781

Variation tolerance for ZNF716 Gene

Residual Variation Intolerance Score: 47.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.99; 74.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF716 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF716

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF716 Gene

Disorders for ZNF716 Gene

Relevant External Links for ZNF716

Genetic Association Database (GAD)
ZNF716
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF716

No disorders were found for ZNF716 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF716 Gene

Publications for ZNF716 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64
  3. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3 64
  4. Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9. (PMID: 24376456) Simino J. … Rao D.C. (Front Genet 2013) 3 64
  5. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PMID: 17903300) Fox C.S. … Atwood L.D. (BMC Med. Genet. 2007) 46 64

Products for ZNF716 Gene

Sources for ZNF716 Gene

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