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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF716 Gene

protein-coding GIFtS: 37
GCID: GC07P057501

zinc finger protein 716

Search for ZNF716
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger Protein 716¹ ²
FLJ46189¹

External Ids:	HGNC: 32458¹	Entrez Gene: 441234²	Ensembl: ENSG00000182111⁷	UniProtKB: A6NP11³

Export aliases for ZNF716 gene to outside databases

Previous GC identifers: GC07P057321 GC07P057110

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN716_HUMAN, A6NP11

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_033968.6 NT_079592.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF716 gene promoter:
RORalpha1 POU2F1 POU2F1a c-Myb ZIC2/Zic2 AP-4 Nkx5-1 RORalpha2
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for ZNF716

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF716

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p11.2 Ensembl cytogenetic band: 7p11.2 HGNC cytogenetic band: 7p11.1

ZNF716 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF716 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P057501: view genomic region (about GC identifiers)

Start:	57,509,883 bp from pter	End:	57,533,265 bp from pter
Size:	23,383 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 57,513,988-57,537,370

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN716_HUMAN, A6NP11 (See protein sequence)

Recommended Name: Zinc finger protein 716

Size: 495 amino acids; 57006 Da

Subcellular location: Nucleus (Probable)

Explore the universe of human proteins at neXtProt for ZNF716: NX_A6NP11

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_A6NP11

ZNF716 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001152751.1

ENSEMBL proteins:

ENSP00000394248

Reactome Protein details: A6NP11
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	Uscn Proteins for ZNF716

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

ZNF716 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF716 for domains About GeneDecksing

4 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR001909 Krueppel-associated_box

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry A6NP11

ProtoNet protein and cluster: A6NP11

UniProtKB/Swiss-Prot: ZN716_HUMAN, A6NP11

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 12 C2H2-type zinc fingers

Similarity: Contains 1 KRAB domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZN716_HUMAN, A6NP11

Function: May be involved in transcriptional regulation

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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZNF716 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Generic Transcription Pathway

Generic Transcription Pathway

1.00

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Reactome Pathways for ZNF716

	Generic Transcription Pathway
	Gene Expression

ZNF716 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF716

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZNF716 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF716
Search CenterWatch for drugs/clinical trials and news about ZNF716 / ZN716

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZNF716 gene:

NM_001159279.1

Unigene Cluster for ZNF716:

Zinc finger protein 716

Hs.533121 [show with all ESTs]

Unigene Representative Sequence: NM_001159279

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000420713(uc011kdi.1)

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Additional cDNA sequence: AK131575.1

2 DOTS entries:

DT.102834270 DT.95373561

1 AceView cDNA sequence:

AK131575

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF716 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCCCAGTTA

About this image
See ZNF716 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.533121

SABiosciences Custom PCR Arrays for ZNF716

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ZNF716 gene from 1/4 species (see all 4) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 7)	--	41(a) 38(a) (see all 7)	many ↔ many many ↔ many (see all 7)	GL343330.1(1093706-1292239) AAWZ02037240(11818-13836)

ENSEMBL Gene Tree for ZNF716 (if available)
TreeFam Gene Tree for ZNF716 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF716 gene

ZNF85² ZNF493² ZNF486² ZNF100² ZNF92² ZNF732² ZNF138² ZNF675²

ZNF506² ZNF273² ZNF66P² ZNF695² ZNF626² ZNF680² ZNF253² ZNF479²

ZNF93² ZNF492² ZNF682² ZNF676² ZNF141² ZNF681² ZNF679² ZNF257²

ZNF254² ZNF737² ZNF724P² ZNF98² ZNF849P² ZNF714² ZNF429² ZNF430²

ZNF730² ZNF678² ZNF117² ZNF708² ZNF107² ZNF431² ZNF90²

18/499 SIMAP similar genes for ZNF716 using alignment to 1 protein entry: ZN716_HUMAN(see all similar genes):

ZNF679 ZNF735 MGC12518 ZNF818P ZNF66 ZNF78L1

ZNF273 ZNF479 kr-znf3 ZFS-4 ZNF429 ZNF826P

ZFS-1 ZNF431 ZNF492 ZNF708 ZNF92 ZNF98

ZNF716 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for ZNF716
PGOHUM00000232782 PGOHUM00000233320

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs77798333^1,2		--	57507915(+)	`TAGCAT/CGTAAT`	1	--	us2k¹		1		NA	120
rs187537875^1,2		--	57507931(+)	`GTGAGA/GACAAT`	1	--	us2k¹		0	--	--	--	--
rs199832210^1,2	C	--	57507986(+)	`GGCTTC/TTTTAC`	1	--	us2k¹		0	--	--	--	--
rs73343891^1,2	C,	--	57508031(+)	`TGTATG/CTTGCA`	1	--	us2k¹		3		WA EA	240
rs192005805^1,2		--	57508044(+)	`AATCTC/TCTATT`	1	--	us2k¹		0	--	--	--	--
rs73343893^1,2	C,	--	57508150(+)	`GGTTCA/GAACAC`	1	--	us2k¹		3		WA EA	240
rs117641203^1,2		--	57508152(+)	`TTCAAA/TCACCT`	1	--	us2k¹		1		NA	120
rs142280861^1,2		--	57508187(+)	`ATGTGA/GTTGGT`	1	--	us2k¹		0	--	--	--	--
rs113405050^1,2	C,	--	57508262(+)	`GTATAC/TGCTTT`	1	--	us2k¹		3		WA EA	240
rs183459194^1,2		--	57508290(+)	`AATCAC/TATATT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZNF716 (57509883 - 57533265 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for ZNF716
6 CNVs: 53442 8561 2695 8560 8559 52262

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF716 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF716)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{1, 2} Hillier L.W.... Wilson R.K. (2003)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 441234	HGNC: 32458	AceView: LOC441234	Ensembl:ENSG00000182111	euGenes: HUgn441234
ECgene: ZNF716	H-InvDB: ZNF716

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF716	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF716 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF716 gene:
Search GeneIP for patents involving ZNF716

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZNF716 gene at Home site.

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ZNF716 Gene

zinc finger protein 716

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ZNF716 Gene

zinc finger protein 716

Aliasesfor ZNF716 gene

Summariesfor ZNF716 gene

Genomic Viewsfor ZNF716 gene

Proteinsfor ZNF716 gene

Protein Domains /Familiesfor ZNF716 gene

Functionfor ZNF716 gene

Pathways & Interactionsfor ZNF716 gene

Drugs & Compoundsfor ZNF716 gene

Transcriptsfor ZNF716 gene

Expression for ZNF716 gene

Orthologsfor ZNF716 gene

Paralogsfor ZNF716 gene

Genomic Variantsfor ZNF716 gene

Disorders / Diseasesfor ZNF716 gene

Publicationsfor ZNF716 gene

External Searches for ZNF716 gene

Genome Databases showing ZNF716 gene

Other Databases showing ZNF716 gene

Specialized Databases showing ZNF716 gene

Intellectual Propertyfor ZNF716 gene

Productsfor ZNF716 gene

View Random Gene

Aliases
for ZNF716 gene

Summaries
for ZNF716 gene

Genomic Views
for ZNF716 gene

Proteins
for ZNF716 gene

Protein Domains /
Families
for ZNF716 gene

Function
for ZNF716 gene

Pathways & Interactions
for ZNF716 gene

Drugs & Compounds
for ZNF716 gene

Transcripts
for ZNF716 gene

Expression
for ZNF716 gene

Orthologs
for ZNF716 gene

Paralogs
for ZNF716 gene

Genomic Variants
for ZNF716 gene

Disorders / Diseases
for ZNF716 gene

Publications
for ZNF716 gene

Intellectual Property
for ZNF716 gene

Products
for ZNF716 gene