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Aliases for ZNF716 Gene

Aliases for ZNF716 Gene

  • Zinc Finger Protein 716 2 3

External Ids for ZNF716 Gene

Previous GeneCards Identifiers for ZNF716 Gene

  • GC07P057321
  • GC07P057501
  • GC07P057110
  • GC07P057513

Summaries for ZNF716 Gene

GeneCards Summary for ZNF716 Gene

ZNF716 (Zinc Finger Protein 716) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF253.

UniProtKB/Swiss-Prot for ZNF716 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF716 Gene

Genomics for ZNF716 Gene

Regulatory Elements for ZNF716 Gene

Genomic Location for ZNF716 Gene

57,450,177 bp from pter
57,473,559 bp from pter
23,383 bases
Plus strand

Genomic View for ZNF716 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF716 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF716 Gene

Proteins for ZNF716 Gene

  • Protein details for ZNF716 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 716
    Protein Accession:
    Secondary Accessions:

    Protein attributes for ZNF716 Gene

    495 amino acids
    Molecular mass:
    57006 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF716 Gene

Proteomics data for ZNF716 Gene at MOPED

Post-translational modifications for ZNF716 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF716 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF716 Gene

Domains for ZNF716 Gene

Gene Families for ZNF716 Gene

  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF716 Gene

Suggested Antigen Peptide Sequences for ZNF716 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • A6NP11
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF716: view

Function for ZNF716 Gene

Molecular function for ZNF716 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF716 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF716: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF716 Gene

Localization for ZNF716 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF716 Gene

Subcellular locations from

Jensen Localization Image for ZNF716 Gene COMPARTMENTS Subcellular localization image for ZNF716 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF716 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF716: view

Pathways for ZNF716 Gene

SuperPathways for ZNF716 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF716: view

Pathways by source for ZNF716 Gene

2 Reactome pathways for ZNF716 Gene

Interacting Proteins for ZNF716 Gene

Gene Ontology (GO) - Biological Process for ZNF716 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF716: view

Transcripts for ZNF716 Gene

mRNA/cDNA for ZNF716 Gene

(1) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF716 Gene

Zinc finger protein 716:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF716

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF716 Gene

No ASD Table

Relevant External Links for ZNF716 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF716 Gene

mRNA expression in normal human tissues for ZNF716 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF716 Gene

This gene is overexpressed in Testis (47.4).

SOURCE GeneReport for Unigene cluster for ZNF716 Gene Hs.533121

genes like me logo Genes that share expressions with ZNF716: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for ZNF716 Gene

Orthologs for ZNF716 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF716 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF716 35
  • 99.06 (n)
  • 98.38 (a)
ZNF716 36
  • 98 (a)
(Bos Taurus)
Mammalia -- 36
  • 47 (a)
(Canis familiaris)
Mammalia -- 36
  • 35 (a)
(Mus musculus)
Mammalia Zfp493 36
  • 55 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 34 (a)
-- 36
  • 47 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
-- 36
  • 30 (a)
-- 36
  • 36 (a)
-- 36
  • 35 (a)
-- 36
  • 28 (a)
-- 36
  • 29 (a)
-- 36
  • 28 (a)
-- 36
  • 26 (a)
Species with no ortholog for ZNF716:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF716 Gene

Gene Tree for ZNF716 (if available)
Gene Tree for ZNF716 (if available)

Paralogs for ZNF716 Gene

Selected SIMAP similar genes for ZNF716 Gene using alignment to 1 proteins: Pseudogenes for ZNF716 Gene

genes like me logo Genes that share paralogs with ZNF716: view

Variants for ZNF716 Gene

Sequence variations from dbSNP and Humsavar for ZNF716 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1851773 -- 57,459,845(+) TTGTT(C/G)TTCTC intron-variant
rs1851774 -- 57,460,035(+) TTCAG(C/G)GAAAG intron-variant
rs2103101 -- 57,459,289(+) TCCTG(A/G)GCACA intron-variant
rs2396950 -- 57,457,438(+) ctccc(A/G)ggttc intron-variant
rs2894770 -- 57,457,834(+) ctcag(A/T)gtctg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF716 Gene

Variant ID Type Subtype PubMed ID
nsv464484 CNV Gain 19166990
nsv520659 CNV Gain 19592680
esv2752161 CNV Gain 17911159
esv2752162 CNV Gain 17911159
dgv816n27 CNV Gain 19166990
dgv2083e1 CNV Complex 17122850
esv2752163 CNV Gain 17911159
nsv464486 CNV Gain 19166990

Relevant External Links for ZNF716 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF716 Gene

Disorders for ZNF716 Gene

Relevant External Links for ZNF716

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with ZNF716: view

No data available for UniProtKB/Swiss-Prot for ZNF716 Gene

Publications for ZNF716 Gene

  1. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3
  4. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3
  5. Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9. (PMID: 24376456) Simino J. … Rao D.C. (Front Genet 2013) 3

Products for ZNF716 Gene

Sources for ZNF716 Gene

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