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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF714 Gene

protein-coding   GIFtS: 46
GCID: GC19P021264

Zinc Finger Protein 714

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 7141 2

External Ids:    HGNC: 271241   Entrez Gene: 1482062   Ensembl: ENSG000001603527   UniProtKB: Q96N383   

Export aliases for ZNF714 gene to outside databases

Previous GC identifers: GC19P021052 GC19P020755


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF714 Gene: 
ZNF714 (zinc finger protein 714) is a protein-coding gene. Diseases associated with ZNF714 include cleft lip, and gastric cancer, and among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF85.

UniProtKB/Swiss-Prot: ZN714_HUMAN, Q96N38
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011295.11  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF714 gene promoter:
         Ik-2   IRF-7A   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF714 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF714

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF714


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p12   Ensembl cytogenetic band:  19p12   HGNC cytogenetic band: 19p12

ZNF714 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF714 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P021264:  view genomic region     (about GC identifiers)

Start:
21,264,953 bp from pter      End:
21,308,073 bp from pter
Size:
43,121 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN714_HUMAN, Q96N38 (See protein sequence)
Recommended Name: Zinc finger protein 714  
Size: 554 amino acids; 63883 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=AAH50468.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAD39077.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q49AI1 Q86W65 Q8ND40
Alternative splicing: 3 isoforms:  Q96N38-1   Q96N38-2   Q96N38-3   

Explore the universe of human proteins at neXtProt for ZNF714: NX_Q96N38

Explore proteomics data for ZNF714 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96N38

  • ZNF714 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF714 Protein Expression
    REFSEQ proteins: NP_872321.2  
    ENSEMBL proteins: 
     ENSP00000472536   ENSP00000469616   ENSP00000470107   ENSP00000472368   ENSP00000471430  
     ENSP00000470378   ENSP00000472072   ENSP00000468862   ENSP00000291770  
    Reactome Protein details: Q96N38
    Human Recombinant Protein Products for ZNF714: 
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    Cloud-Clone Corp. Proteins for ZNF714 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF714 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96N38

    ProtoNet protein and cluster: Q96N38

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN714_HUMAN, Q96N38
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 14 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF714 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN714_HUMAN, Q96N38
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF714 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF714 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF714
        Generic Transcription Pathway
    Gene Expression



    ZNF714 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF714

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for ZNF714 (Q96N383 ENSP000002917704) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LZTR1Q8N6533, ENSP000002157394I2D: score=1 STRING: ENSP00000215739
    PCBD1P614573, ENSP000002992994I2D: score=1 STRING: ENSP00000299299
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF714 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF714 (ZN714)

    Search CenterWatch for drugs/clinical trials and news about ZNF714 / ZN714

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF714 gene: 
    NM_182515.3  

    Unigene Cluster for ZNF714:

    Zinc finger protein 714
    Hs.729186  [show with all ESTs]
    Unigene Representative Sequence: NM_182515
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000597424 ENST00000596053 ENST00000597086 ENST00000596143 ENST00000596367
    ENST00000601416 ENST00000600770 ENST00000600435 ENST00000291770(uc002npl.3 uc002npo.4 uc002npn.3 uc010ecp.2)
    ENST00000600535
    miRNA
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    Additional mRNA sequence: 

    AK056006.1 AK090987.1 AK125662.1 BC022527.1 BC064985.1 D70836.1 

    15 DOTS entries:

    DT.91752512  DT.75139333  DT.422722  DT.97836776  DT.100812017  DT.75107785  DT.40122199  DT.97796758 
    DT.100780718  DT.121638152  DT.95356385  DT.100839174  DT.100786363  DT.101970160  DT.92063411 

    24/66 AceView cDNA sequences (see all 66):

    AA907814 CB068631 AW190511 BX097519 AA993846 BG388618 AA837464 BE294154 
    AA814750 BX452046 AA768770 BU944550 CB069894 AA309607 AI364599 BG708988 
    BC037782 BQ024987 AI819525 BG178551 AA911503 AW044151 BE161336 AA452421 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF714 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g · 5h
    SP1:                                                                                                
    SP2:                                                                                                
    SP3:                                                  -                                             
    SP4:                                                  -                                             
    SP5:                                -                 -                                             


    ECgene alternative splicing isoforms for ZNF714

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF714 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAATCCCC
    ZNF714 Expression
    About this image


    See ZNF714 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.729186
        SABiosciences Custom PCR Arrays for ZNF714
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF714 gene from 1/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    25(a)
    1 → many
    GL343733.1(125230-159240)
            Species with no ortholog for ZNF714

    ENSEMBL Gene Tree for ZNF714 (if available)
    TreeFam Gene Tree for ZNF714 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF714 gene
    ZNF852  ZNF4862  ZNF1952  ZNF7272  ZNF922  ZNF1002  ZNF7322  ZNF6752  
    ZNF1382  ZNF5062  ZNF662  ZNF2732  ZNF6952  ZNF6262  ZNF6802  ZNF4792  
    ZNF2532  ZNF6822  ZNF4922  ZNF6762  ZNF6812  ZNF1412  ZNF7362  ZNF6792  
    ZNF2572  ZNF2672  ZNF2542  ZNF7372  ZNF982  ZNF7162  ZNF5192  ZNF4302  
    ZNF7302  ZNF7082  ZNF1172  ZNF4312  ZNF902  ZNF7262  ZNF7282  
    18/536 SIMAP similar genes for ZNF714 using alignment to 7 protein entries:     ZN714_HUMAN (see all proteins) (see all similar genes):
    ZFS-6    ZNF818P    ZNF431    DKFZp686M04222    DKFZp762K012    ZNF56
    ZNF78L1    ZFS-1    smap-7    ZNF492    A4GALT    DKFZp666C237
    ZNF232    ZNF702P    ZNF91    kr-znf3    ZNF283    HZF30

    ZNF714 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/994 SNPs in ZNF714 are shown (see all 994)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs586185651,2
    --21198152(+) TACACA/GTGTGT 1 -- us2k10--------
    rs730206251,2
    C--21263064(+) CACCAC/TTACAG 1 -- us2k13Minor allele frequency- T:0.08NA WA 240
    rs1912247831,2
    --21263331(+) TGGTAA/GAGACA 1 -- us2k10--------
    rs1449322101,2
    --21263451(+) ATTCTA/GTTTTA 1 -- us2k10--------
    rs1836349211,2
    --21263463(+) TCGTTG/TATCTT 1 -- us2k10--------
    rs81068011,2
    C,F,H--21263518(+) TAACAG/AAGAGT 1 -- us2k1 tfbs330Minor allele frequency- A:0.08NS EA NA WA CSA 2763
    rs1386470321,2
    C--21263569(+) TGAAGG/TGTACA 1 -- us2k10--------
    rs730206281,2
    C,F--21263645(+) TTACAC/ATCCTC 1 -- us2k13Minor allele frequency- A:0.08NA WA 240
    rs730206301,2
    C,F--21263668(+) ATACAA/GTAATA 1 -- us2k13Minor allele frequency- G:0.15NA 124
    rs1492873441,2
    --21263737(+) TTCTGC/TAAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF714 (21264953 - 21308073 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for ZNF714 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2718324CNV Deletion23290073
    dgv551e201CNV Deletion23290073
    esv5243CNV Deletion18987735
    esv2718325CNV Deletion23290073
    esv2665276CNV Deletion23128226
    esv2660807CNV Deletion23128226
    nsv911412CNV Loss21882294
    dgv72e19CNV Loss19470904
    nsv911413CNV Gain21882294
    nsv458377CNV Gain19166990

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for ZNF714:    About MalaCards
    cleft lip    gastric cancer

    1 disease from the University of Copenhagen DISEASES database for ZNF714:
    Cleft lip

    ZNF714 for disorders           About GeneDecksing


    Export disorders for ZNF714 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF714 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF714)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    4. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
    5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    8. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 148206 HGNC: 27124 AceView: LOC148206 Ensembl:ENSG00000160352 euGenes: HUgn148206
    ECgene: ZNF714 H-InvDB: ZNF714

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF714 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF714 gene:
    Search GeneIP for patents involving ZNF714

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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