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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF713 Gene

protein-coding   GIFtS: 44
GCID: GC07P055947

Zinc Finger Protein 713

  Search for ZNF713
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 7131 2

External Ids:    HGNC: 220431   Entrez Gene: 3490752   Ensembl: ENSG000001786657   UniProtKB: Q8N8593   

Export aliases for ZNF713 gene to outside databases

Previous GC identifers: GC07P055755 GC07P055794


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF713 Gene: 
ZNF713 (zinc finger protein 713) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZFP69.

UniProtKB/Swiss-Prot: ZN713_HUMAN, Q8N859
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_033968.6  NC_018918.2  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF713 gene promoter:
         Lmo2   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZNF713 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF713

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF713


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p11.2   Ensembl cytogenetic band:  7p11.2   HGNC cytogenetic band: 7p11.2

ZNF713 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF713 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P055947:  view genomic region     (about GC identifiers)

Start:
55,955,169 bp from pter      End:
56,009,918 bp from pter
Size:
54,750 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 55,984,578-56,012,680     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN713_HUMAN, Q8N859 (See protein sequence)
Recommended Name: Zinc finger protein 713  
Size: 430 amino acids; 50172 Da
Subcellular location: Nucleus (Potential)

Explore the universe of human proteins at neXtProt for ZNF713: NX_Q8N859

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N859

  • ZNF713 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_872439.1  
    ENSEMBL proteins: 
     ENSP00000416974   ENSP00000416662  
    Reactome Protein details: Q8N859
    Human Recombinant Protein Products for ZNF713: 
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF713 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8N859

    ProtoNet protein and cluster: Q8N859

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN713_HUMAN, Q8N859
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 5 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF713 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN713_HUMAN, Q8N859
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF713 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF713 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF713
        Generic Transcription Pathway
    Gene Expression



    ZNF713 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF713

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF713 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF713 (ZN713)

    Search CenterWatch for drugs/clinical trials and news about ZNF713 / ZN713

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF713 gene: 
    NM_182633.1  

    Unigene Cluster for ZNF713:

    Zinc finger protein 713
    Hs.660834  [show with all ESTs]
    Unigene Representative Sequence: BC094796
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000466630 ENST00000411863 ENST00000484120 ENST00000482436 ENST00000429591(uc003tra.2 uc003trc.1)

    miRNA
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    hsa-miR-3679-3p hsa-miR-561 hsa-miR-155* hsa-miR-3074-3p hsa-miR-944
    SwitchGear 3'UTR luciferase reporter plasmidZNF713 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF713

    Additional mRNA sequence: 

    AK097282.1 BC094796.1 

    4 DOTS entries:

    DT.92008238  DT.121041392  DT.100694850  DT.91752805 

    24/115 AceView cDNA sequences (see all 115):

    BQ433785 AA609325 AI189259 BM726653 NM_015969 AI637782 AA596076 AW024426 
    AI640295 BC037405 BE466705 BF001717 AA738409 N55773 BE744730 CR590495 
    CR605786 BG113607 AI141870 CF528777 AI309197 BX375551 BU184305 AB049950 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF713    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5
    SP1:                                          
    SP2:        -                                 


    ECgene alternative splicing isoforms for ZNF713

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF713 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGGTGGAG
    ZNF713 Expression
    About this image


    Genevestigator expression for ZNF713

    SOURCE GeneReport for Unigene cluster: Hs.660834
        SABiosciences Custom PCR Arrays for ZNF713
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF713

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF713 gene from 1/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF7131 zinc finger protein 713 88.81(n)
    84.43(a)
      606818  XM_843250.3  XP_848343.3 


    ENSEMBL Gene Tree for ZNF713 (if available)
    TreeFam Gene Tree for ZNF713 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF713 gene
    ZFP692  ENSG000001876072  ZNF286B2  ZNF5142  ZFP69B2  ZNF286A2  ZNF82  ZNF3912  
    18/443 SIMAP similar genes for ZNF713 using alignment to 2 protein entries:     ZN713_HUMAN (see all proteins) (see all similar genes):
    ZNF232    ZNF    DKFZp313M0722    ZNF167    ZNF323    HZF30
    ZNF391    ZNF204    ZNF22    ZNF664    ZNF702P    DKFZp666C237
    ZNF107    ZNF239    ZNF500    ZSCAN21    ZSCAN22    ZSCAN23

    ZNF713 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/608 SNPs in ZNF713 are shown (see all 608)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1487309771,2
    --55792062(+) TCATCA/GTGTTG 1 -- us2k10--------
    rs102386581,2
    C--55792120(+) gcctcC/Tcaaag 1 -- us2k10--------
    rs1133864351,2
    C,F--55792321(+) AACCCG/ATCTGC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1394227071,2
    --55792471(+) AATGGC/TTGCCT 1 -- us2k10--------
    rs1466313321,2
    --55792690(+) CTTTCA/TAAAGA 1 -- us2k10--------
    rs1391367931,2
    --55792833(+) ATTCTA/GAAAGT 1 -- us2k10--------
    rs2016103621,2
    --55792860(+) TGCCA-/CAA   
      AGGTGG
    CACCT
    1 -- cds10--------
    rs2016421231,2
    --55792866(+) ACCTT-/AAGG  
            
    ACTGT
    1 -- us2k10--------
    rs1439885871,2
    --55793022(+) GCCAGG/TATGCA 1 -- us2k10--------
    rs44271151,2
    C,H--55793149(+) AGATTC/GTGAGA 1 -- us2k14Minor allele frequency- G:0.00NS EA 408

    HapMap Linkage Disequilibrium report for ZNF713 (55955169 - 56009918 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for ZNF713:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2674331CNV Deletion23128226
    esv2734448CNV Deletion23290073
    dgv1201e199CNV Deletion23128226
    esv2734425CNV Deletion23290073
    esv2734447CNV Deletion23290073
    nsv824110CNV Loss20364138
    nsv365792CNV Loss16902084
    nsv888064CNV Gain21882294
    esv28230CNV Gain+Loss19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF713 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF713)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    4. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 349075 HGNC: 22043 AceView: MRPS17andFLJ39963 Ensembl:ENSG00000178665 euGenes: HUgn349075
    ECgene: ZNF713 H-InvDB: ZNF713

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF713 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF713 gene:
    Search GeneIP for patents involving ZNF713

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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