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ZNF713 Gene

protein-coding   GIFtS: 44
GCID: GC07P055947

Zinc Finger Protein 713

  Search for ZNF713
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 7131 2

External Ids:    HGNC: 220431   Entrez Gene: 3490752   Ensembl: ENSG000001786657   UniProtKB: Q8N8593   

Export aliases for ZNF713 gene to outside databases

Previous GC identifers: GC07P055755 GC07P055794


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF713 Gene:
ZNF713 (zinc finger protein 713) is a protein-coding gene. An important paralog of this gene is ZFP69B.

UniProtKB/Swiss-Prot: ZN713_HUMAN, Q8N859
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF713 gene promoter:
         Lmo2   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZNF713 promoter sequence
   Search Chromatin IP Primers for ZNF713

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF713


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p11.2   Ensembl cytogenetic band:  7p11.2   HGNC cytogenetic band: 7p11.2

ZNF713 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF713 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P055947:  view genomic region     (about GC identifiers)

Start:
55,955,169 bp from pter      End:
56,009,918 bp from pter
Size:
54,750 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 55,984,578-56,012,680     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN713_HUMAN, Q8N859 (See protein sequence)
Recommended Name: Zinc finger protein 713  
Size: 430 amino acids; 50172 Da

Explore the universe of human proteins at neXtProt for ZNF713: NX_Q8N859

Explore proteomics data for ZNF713 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF713 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_872439.1  
    ENSEMBL proteins: 
     ENSP00000416974   ENSP00000416662  
    Reactome Protein details: Q8N859

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8N859

    ProtoNet protein and cluster: Q8N859

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN713_HUMAN, Q8N859
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 5 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF713 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN713_HUMAN, Q8N859
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    ZNF713 for ontologies           About GeneDecksing


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    SwitchGear 3'UTR luciferase reporter plasmidZNF713 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN713_HUMAN, Q8N859: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus3
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF713 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF713 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF713
        Generic Transcription Pathway



    ZNF713 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF713
    Interactions:

        Search GeneGlobe Interaction Network for ZNF713

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    ZNF713 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF713 (ZN713)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF713 gene: 
    NM_182633.1  

    Unigene Cluster for ZNF713:

    Zinc finger protein 713
    Hs.660834  [show with all ESTs]
    Unigene Representative Sequence: BC094796
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000466630 ENST00000411863 ENST00000484120 ENST00000482436 ENST00000429591(uc003tra.2 uc003trc.1)

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidZNF713 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK097282.1 BC094796.1 

    4 DOTS entries:

    DT.92008238  DT.121041392  DT.100694850  DT.91752805 

    Selected AceView cDNA sequences (see all 115):

    NM_015969 BQ433785 AI189259 BF001717 BE744730 BM726653 AA609325 N55773 
    AA596076 AA738409 AI637782 CR590495 CR605786 BE466705 BC037405 AI640295 
    AW024426 BX488717 AA461063 BC048108 BM272912 BE279197 AK026553 N32042 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF713    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5
    SP1:                                          
    SP2:        -                                 


    ECgene alternative splicing isoforms for ZNF713

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF713 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGGTGGAG
    ZNF713 Expression
    About this image

    ZNF713 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF713 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.660834
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF713 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF7131 zinc finger protein 713 88.45(n)
    84.07(a)
      606818  XM_005620907.1  XP_005620964.1 


    ENSEMBL Gene Tree for ZNF713 (if available)
    TreeFam Gene Tree for ZNF713 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF713 gene
    ZFP69B2  ZFP692  ZIM22  ZNF5142  
    Selected SIMAP similar genes for ZNF713 using alignment to 2 protein entries:     ZN713_HUMAN (see all proteins) (see all similar genes):
    ZNF232    ZNF    DKFZp313M0722    ZNF167    ZNF323    HZF30
    ZNF391    ZNF204    ZNF22    ZNF664    ZNF702P    DKFZp666C237
    ZNF107    ZNF239    ZNF500    ZSCAN21    ZSCAN22    ZSCAN23

    ZNF713 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF713 (see all 608)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1487309771,2
    --55792062(+) TCATCA/GTGTTG 1 -- us2k10--------
    rs102386581,2
    C--55792120(+) gcctcC/Tcaaag 1 -- us2k10--------
    rs1133864351,2
    C,F--55792321(+) AACCCG/ATCTGC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1394227071,2
    --55792471(+) AATGGC/TTGCCT 1 -- us2k10--------
    rs1466313321,2
    --55792690(+) CTTTCA/TAAAGA 1 -- us2k10--------
    rs1391367931,2
    --55792833(+) ATTCTA/GAAAGT 1 -- us2k10--------
    rs2016103621,2
    --55792860(+) TGCCA-/CAA   
      AGGTGG
    CACCT
    1 -- cds10--------
    rs2016421231,2
    --55792866(+) ACCTT-/AAGG  
            
    ACTGT
    1 -- us2k10--------
    rs1439885871,2
    --55793022(+) GCCAGG/TATGCA 1 -- us2k10--------
    rs44271151,2
    C,H--55793149(+) AGATTC/GTGAGA 1 -- us2k14Minor allele frequency- G:0.00NS EA 408

    HapMap Linkage Disequilibrium report for ZNF713 (55955169 - 56009918 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for ZNF713:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2674331CNV Deletion23128226
    esv2734448CNV Deletion23290073
    dgv1201e199CNV Deletion23128226
    esv2734425CNV Deletion23290073
    esv2734447CNV Deletion23290073
    nsv824110CNV Loss20364138
    nsv365792CNV Loss16902084
    nsv888064CNV Gain21882294
    esv28230CNV Gain+Loss19812545

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF713 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF713)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (Science 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 349075 HGNC: 22043 AceView: MRPS17andFLJ39963 Ensembl:ENSG00000178665 euGenes: HUgn349075
    ECgene: ZNF713 H-InvDB: ZNF713

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF713 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF713 gene:
    Search GeneIP for patents involving ZNF713

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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