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Aliases for ZNF711 Gene

Aliases for ZNF711 Gene

  • Zinc Finger Protein 711 2 3 5
  • Zinc Finger Protein 6 (CMPX1) 2 3
  • Zinc Finger Protein 6 2 4
  • CMPX1 3 4
  • ZNF6 3 4
  • DJ75N13.1 (Znf6-Like) 3
  • DJ75N13.1 3
  • Zfp711 3
  • MRX97 3
  • ZNF4 3
  • ZNF5 3

External Ids for ZNF711 Gene

Previous HGNC Symbols for ZNF711 Gene

  • ZNF6

Previous GeneCards Identifiers for ZNF711 Gene

  • GC0XP084385
  • GC0XP084498
  • GC0XP078072

Summaries for ZNF711 Gene

Entrez Gene Summary for ZNF711 Gene

  • This gene encodes a zinc finger protein of unknown function. It bears similarity to a zinc finger protein which acts as a transcriptional activator. This gene lies in a region of the X chromosome which has been associated with cognitive disability. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF711 Gene

ZNF711 (Zinc Finger Protein 711) is a Protein Coding gene. Diseases associated with ZNF711 include Mental Retardation, X-Linked 97 and X-Linked Non-Specific Intellectual Disability. Among its related pathways are Gene Expression. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is ZFX.

UniProtKB/Swiss-Prot for ZNF711 Gene

  • Transcription regulator required for brain development. Probably acts as a transcription factor that binds to the promoter of target genes and recruits PHF8 histone demethylase, leading to activate expression of genes involved in neuron development, such as KDM5C.

Additional gene information for ZNF711 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF711 Gene

Genomics for ZNF711 Gene

Regulatory Elements for ZNF711 Gene

Enhancers for ZNF711 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH085243 0.8 ENCODE 5.5 +0.6 594 2 PKNOX1 ATF1 GLIS2 ZNF366 ATF7 CREM EGR2 CEBPB OVOL3 ZNF341 ZNF711 POF1B
GH0XH085188 0.3 FANTOM5 1.8 -55.3 -55253 0 SATL1 ZNF711 ENSG00000276391 ENSG00000283446
GH0XH085357 0.6 ENCODE 0.1 +115.4 115365 3 ZNF217 SMARCE1 CTBP1 GATA3 RFX1 DPF2 POF1B ZNF711
GH0XH085373 0.6 ENCODE 0.1 +133.4 133421 7 POLR2A ELF1 ATF7 MLLT1 KLF4 ATF2 POF1B ZNF711
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF711 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF711 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000247445 781 2399 PKNOX1 ATF1 GLIS2 ZNF366 ATF7 CREM EGR2 CEBPB OVOL3 NFIL3

Genomic Location for ZNF711 Gene

Chromosome:
X
Start:
85,243,820 bp from pter
End:
85,273,362 bp from pter
Size:
29,543 bases
Orientation:
Plus strand

Genomic View for ZNF711 Gene

Genes around ZNF711 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF711 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF711 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF711 Gene

Proteins for ZNF711 Gene

  • Protein details for ZNF711 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y462-ZN711_HUMAN
    Recommended name:
    Zinc finger protein 711
    Protein Accession:
    Q9Y462
    Secondary Accessions:
    • B4DSV4
    • Q6NX42
    • Q9Y4J6

    Protein attributes for ZNF711 Gene

    Size:
    761 amino acids
    Molecular mass:
    86245 Da
    Quaternary structure:
    • Interacts with PHF8.
    SequenceCaution:
    • Sequence=BAG61766.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA39837.2; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=CAA39837.2; Type=Miscellaneous discrepancy; Note=Chimera.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF711 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF711 Gene

Post-translational modifications for ZNF711 Gene

  • Ubiquitination at Lys224 and Lys289
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF711 Gene

Domains & Families for ZNF711 Gene

Gene Families for ZNF711 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF711 Gene

Suggested Antigen Peptide Sequences for ZNF711 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y462

UniProtKB/Swiss-Prot:

ZN711_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF711: view

Function for ZNF711 Gene

Molecular function for ZNF711 Gene

UniProtKB/Swiss-Prot Function:
Transcription regulator required for brain development. Probably acts as a transcription factor that binds to the promoter of target genes and recruits PHF8 histone demethylase, leading to activate expression of genes involved in neuron development, such as KDM5C.

Gene Ontology (GO) - Molecular Function for ZNF711 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 20346720
GO:0043565 sequence-specific DNA binding IDA 20346720
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF711: view
genes like me logo Genes that share phenotypes with ZNF711: view

Human Phenotype Ontology for ZNF711 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for ZNF711 Gene

miRTarBase miRNAs that target ZNF711
Targeted motifs for ZNF711 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF711
  • Consensus sequence: AGGCCTAG Submotif: canonical Cell Type: SHSY5Y GEO ID: GSE20673

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Animal Models and Transcription Factor Targets for ZNF711 Gene

Localization for ZNF711 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF711 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF711 gene
Compartment Confidence
extracellular 5
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF711 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20346720
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with ZNF711: view

Pathways & Interactions for ZNF711 Gene

SuperPathways for ZNF711 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF711: view

Pathways by source for ZNF711 Gene

2 Reactome pathways for ZNF711 Gene

Gene Ontology (GO) - Biological Process for ZNF711 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045893 positive regulation of transcription, DNA-templated IMP 20346720
genes like me logo Genes that share ontologies with ZNF711: view

No data available for SIGNOR curated interactions for ZNF711 Gene

Drugs & Compounds for ZNF711 Gene

No Compound Related Data Available

Transcripts for ZNF711 Gene

Unigene Clusters for ZNF711 Gene

Zinc finger protein 711:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF711 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13
SP1: -
SP2:
SP3:
SP4: -
SP5: - - -
SP6:
SP7: - - - -
SP8:
SP9:

Relevant External Links for ZNF711 Gene

GeneLoc Exon Structure for
ZNF711
ECgene alternative splicing isoforms for
ZNF711

Expression for ZNF711 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF711 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF711 Gene

This gene is overexpressed in Testis (x5.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF711 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF711 Gene:

ZNF711

SOURCE GeneReport for Unigene cluster for ZNF711 Gene:

Hs.326801

mRNA Expression by UniProt/SwissProt for ZNF711 Gene:

Q9Y462-ZN711_HUMAN
Tissue specificity: Expressed in neural tissues.

Evidence on tissue expression from TISSUES for ZNF711 Gene

  • Nervous system(4.6)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF711 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Organs:
Head and neck:
  • brain
  • cerebellum
  • cheek
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • nose
  • outer ear
  • salivary gland
  • skull
  • tooth
Thorax:
  • lung
  • rib
  • rib cage
Pelvis:
  • pelvis
  • testicle
  • urinary bladder
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with ZNF711: view

Primer Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for ZNF711 Gene

Orthologs for ZNF711 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF711 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF711 33 34
  • 99.73 (n)
dog
(Canis familiaris)
Mammalia ZNF711 33 34
  • 95.53 (n)
cow
(Bos Taurus)
Mammalia ZNF711 33 34
  • 95.23 (n)
rat
(Rattus norvegicus)
Mammalia Zfp711 33
  • 92.86 (n)
mouse
(Mus musculus)
Mammalia Zfp711 33 16 34
  • 92.29 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF711 34
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF711 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF6 34
  • 82 (a)
OneToOne
ZNF711 33
  • 81.37 (n)
lizard
(Anolis carolinensis)
Reptilia ZNF711 34
  • 81 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii znf711 33 34
  • 67.94 (n)
Species where no ortholog for ZNF711 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF711 Gene

ENSEMBL:
Gene Tree for ZNF711 (if available)
TreeFam:
Gene Tree for ZNF711 (if available)

Paralogs for ZNF711 Gene

Paralogs for ZNF711 Gene

genes like me logo Genes that share paralogs with ZNF711: view

Variants for ZNF711 Gene

Sequence variations from dbSNP and Humsavar for ZNF711 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs367654949 Mental retardation, X-linked 97 (MRX97) [MIM:300803] 85,255,595(+) TAATG(A/G)ACACT reference, missense
rs760346140 Mental retardation, X-linked 97 (MRX97) [MIM:300803] 85,271,344(+) CACCA(A/G)TTCAA reference, missense
rs777239465 Mental retardation, X-linked 97 (MRX97) [MIM:300803] 85,265,160(+) TGGAC(A/G)TTCAG reference, missense
VAR_062995 Mental retardation, X-linked 97 (MRX97) [MIM:300803]
VAR_078572 Mental retardation, X-linked 97 (MRX97) [MIM:300803]

Structural Variations from Database of Genomic Variants (DGV) for ZNF711 Gene

Variant ID Type Subtype PubMed ID
esv2466752 CNV deletion 19546169
esv2740275 CNV deletion 23290073
esv3559049 CNV deletion 23714750

Variation tolerance for ZNF711 Gene

Residual Variation Intolerance Score: 18.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF711 Gene

Human Gene Mutation Database (HGMD)
ZNF711
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF711

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF711 Gene

Disorders for ZNF711 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ZNF711 Gene - From: HGMD, OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
mental retardation, x-linked 97
  • x-linked mental retardation 97
x-linked non-specific intellectual disability
  • x-linked non-syndromic intellectual disability
allan-herndon-dudley syndrome
  • allan-herndon syndrome
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ZN711_HUMAN
  • Mental retardation, X-linked 97 (MRX97) [MIM:300803]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269 PubMed:19377476, ECO:0000269 PubMed:27993705}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ZNF711

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF711
genes like me logo Genes that share disorders with ZNF711: view

No data available for Genatlas for ZNF711 Gene

Publications for ZNF711 Gene

  1. A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. (PMID: 19377476) Tarpey PS … Stratton MR (Nature genetics 2009) 2 3 4 60
  2. Mutations in two large pedigrees highlight the role of ZNF711 in X-linked intellectual disability. (PMID: 27993705) van der Werf IM … Frank Kooy R (Gene 2016) 3 4 60
  3. A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation. (PMID: 20346720) Kleine-Kohlbrecher D … Helin K (Molecular cell 2010) 3 4 60
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for ZNF711 Gene

Sources for ZNF711 Gene

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