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Aliases for ZNF711 Gene

Aliases for ZNF711 Gene

  • Zinc Finger Protein 711 2 3 5
  • Zinc Finger Protein 6 (CMPX1) 2 3
  • Zinc Finger Protein 6 2 4
  • CMPX1 3 4
  • ZNF6 3 4
  • DJ75N13.1 (Znf6-Like) 3
  • DJ75N13.1 3
  • Zfp711 3
  • MRX97 3
  • ZNF4 3
  • ZNF5 3

External Ids for ZNF711 Gene

Previous HGNC Symbols for ZNF711 Gene

  • ZNF6

Previous GeneCards Identifiers for ZNF711 Gene

  • GC0XP084385
  • GC0XP084498
  • GC0XP078072

Summaries for ZNF711 Gene

Entrez Gene Summary for ZNF711 Gene

  • This gene encodes a zinc finger protein of unknown function. It bears similarity to a zinc finger protein which acts as a transcriptional activator. This gene lies in a region of the X chromosome which has been associated with mental retardation. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF711 Gene

ZNF711 (Zinc Finger Protein 711) is a Protein Coding gene. Diseases associated with ZNF711 include mental retardation, x-linked 97 and znf711-related x-linked mental retardation. Among its related pathways are Gene Expression. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is ZNF639.

UniProtKB/Swiss-Prot for ZNF711 Gene

  • Transcription regulator required for brain development. Probably acts as a transcription factor that binds to the promoter of target genes and recruits PHF8 histone demethylase, leading to activate expression of genes involved in neuron development, such as KDM5C.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF711 Gene

Genomics for ZNF711 Gene

Regulatory Elements for ZNF711 Gene

Promoters for ZNF711 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF711 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF711 Gene

Chromosome:
X
Start:
85,243,820 bp from pter
End:
85,273,362 bp from pter
Size:
29,543 bases
Orientation:
Plus strand

Genomic View for ZNF711 Gene

Genes around ZNF711 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF711 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF711 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF711 Gene

Proteins for ZNF711 Gene

  • Protein details for ZNF711 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y462-ZN711_HUMAN
    Recommended name:
    Zinc finger protein 711
    Protein Accession:
    Q9Y462
    Secondary Accessions:
    • B4DSV4
    • Q6NX42
    • Q9Y4J6

    Protein attributes for ZNF711 Gene

    Size:
    761 amino acids
    Molecular mass:
    86245 Da
    Quaternary structure:
    • Interacts with PHF8.
    SequenceCaution:
    • Sequence=BAG61766.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA39837.2; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=CAA39837.2; Type=Miscellaneous discrepancy; Note=Chimera.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF711 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF711 Gene

Proteomics data for ZNF711 Gene at MOPED

Post-translational modifications for ZNF711 Gene

  • Ubiquitination at Lys 224 and Lys 289
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF711 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF711 Gene

Domains & Families for ZNF711 Gene

Suggested Antigen Peptide Sequences for ZNF711 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y462

UniProtKB/Swiss-Prot:

ZN711_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF711: view

Function for ZNF711 Gene

Molecular function for ZNF711 Gene

UniProtKB/Swiss-Prot Function:
Transcription regulator required for brain development. Probably acts as a transcription factor that binds to the promoter of target genes and recruits PHF8 histone demethylase, leading to activate expression of genes involved in neuron development, such as KDM5C.

Gene Ontology (GO) - Molecular Function for ZNF711 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0005515 protein binding IPI 20346720
genes like me logo Genes that share ontologies with ZNF711: view
genes like me logo Genes that share phenotypes with ZNF711: view

Human Phenotype Ontology for ZNF711 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for ZNF711 Gene

miRTarBase miRNAs that target ZNF711
Targeted motifs for ZNF711 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF711
  • Consensus sequence: AGGCCTAG Submotif: canonical Cell Type: SHSY5Y GEO ID: GSE20673

No data available for Enzyme Numbers (IUBMB) , Animal Models and Transcription Factor Targets for ZNF711 Gene

Localization for ZNF711 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF711 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF711 Gene COMPARTMENTS Subcellular localization image for ZNF711 gene
Compartment Confidence
extracellular 5
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZNF711 Gene

Pathways & Interactions for ZNF711 Gene

SuperPathways for ZNF711 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF711: view

Pathways by source for ZNF711 Gene

2 Reactome pathways for ZNF711 Gene

Gene Ontology (GO) - Biological Process for ZNF711 Gene

None

No data available for SIGNOR curated interactions for ZNF711 Gene

Drugs & Compounds for ZNF711 Gene

No Compound Related Data Available

Transcripts for ZNF711 Gene

Unigene Clusters for ZNF711 Gene

Zinc finger protein 711:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF711 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13
SP1: -
SP2:
SP3:
SP4: -
SP5: - - -
SP6:
SP7: - - - -
SP8:
SP9:

Relevant External Links for ZNF711 Gene

GeneLoc Exon Structure for
ZNF711
ECgene alternative splicing isoforms for
ZNF711

Expression for ZNF711 Gene

mRNA expression in normal human tissues for ZNF711 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF711 Gene

This gene is overexpressed in Testis (x5.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF711 Gene



SOURCE GeneReport for Unigene cluster for ZNF711 Gene Hs.326801

mRNA Expression by UniProt/SwissProt for ZNF711 Gene

Q9Y462-ZN711_HUMAN
Tissue specificity: Expressed in neural tissues.
genes like me logo Genes that share expression patterns with ZNF711: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for ZNF711 Gene

Orthologs for ZNF711 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF711 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF711 35
  • 99.73 (n)
  • 99.86 (a)
ZNF711 36
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF711 36
  • 98 (a)
OneToOne
ZNF711 35
  • 95.23 (n)
  • 97.63 (a)
dog
(Canis familiaris)
Mammalia ZNF711 35
  • 95.53 (n)
  • 98.16 (a)
ZNF711 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp711 16
Zfp711 36
  • 90 (a)
OneToOne
Zfp711 35
  • 92.29 (n)
  • 96.32 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNF711 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF711 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp711 35
  • 92.86 (n)
  • 97.24 (a)
chicken
(Gallus gallus)
Aves ZNF711 35
  • 81.37 (n)
  • 87.19 (a)
ZNF6 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF711 36
  • 81 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii znf711 36
  • 69 (a)
OneToOne
znf711 35
  • 67.94 (n)
  • 73.53 (a)
Species with no ortholog for ZNF711:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF711 Gene

ENSEMBL:
Gene Tree for ZNF711 (if available)
TreeFam:
Gene Tree for ZNF711 (if available)

Paralogs for ZNF711 Gene

Paralogs for ZNF711 Gene

genes like me logo Genes that share paralogs with ZNF711: view

Variants for ZNF711 Gene

Sequence variations from dbSNP and Humsavar for ZNF711 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_062990 -
VAR_062991 -
VAR_062992 -
VAR_062993 -
VAR_062994 -

Structural Variations from Database of Genomic Variants (DGV) for ZNF711 Gene

Variant ID Type Subtype PubMed ID
esv2466752 CNV Deletion 19546169
esv2740275 CNV Deletion 23290073

Variation tolerance for ZNF711 Gene

Residual Variation Intolerance Score: 18.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF711 Gene

HapMap Linkage Disequilibrium report
ZNF711
Human Gene Mutation Database (HGMD)
ZNF711

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF711 Gene

Disorders for ZNF711 Gene

MalaCards: The human disease database

(6) MalaCards diseases for ZNF711 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, and DISEASES

Disorder Aliases PubMed IDs
mental retardation, x-linked 97
  • mental retardation, x-linked, znf711-related
znf711-related x-linked mental retardation
  • mental retardation, x-linked, znf711-related
non-syndromic x-linked intellectual disability
  • mrx
mental retardation, autosomal recessive 48
  • mrt48
allan-herndon-dudley syndrome
  • allan-herndon syndrome
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ZN711_HUMAN
  • Mental retardation, X-linked, ZNF711-related (MRXZ) [MIM:300803]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269 PubMed:19377476}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ZNF711

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF711
genes like me logo Genes that share disorders with ZNF711: view

No data available for Genatlas for ZNF711 Gene

Publications for ZNF711 Gene

  1. A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. (PMID: 19377476) Tarpey P.S. … Stratton M.R. (Nat. Genet. 2009) 2 3 4 67
  2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  3. Fine mapping of Xq11.1-q21.33 and mutation screening of RPS6KA6, ZNF711, ACSL4, DLG3, and IL1RAPL2 for autism spectrum disorders (ASD). (PMID: 21384559) KantojAorvi K. … JAorvelAo I. (Autism Res 2011) 3
  4. A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation. (PMID: 20346720) Kleine-Kohlbrecher D. … Helin K. (Mol. Cell 2010) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for ZNF711 Gene

Sources for ZNF711 Gene

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