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ZNF710 Gene

protein-coding   GIFtS: 44
GCID: GC15P090544

Zinc Finger Protein 710

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 7101 2

External Ids:    HGNC: 253521   Entrez Gene: 3746552   Ensembl: ENSG000001405487   UniProtKB: Q8N1W23   

Export aliases for ZNF710 gene to outside databases

Previous GC identifers: GC15P088346 GC15P066721


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF710 Gene:
ZNF710 (zinc finger protein 710) is a protein-coding gene. An important paralog of this gene is ZNF366.

UniProtKB/Swiss-Prot: ZN710_HUMAN, Q8N1W2
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF710 gene promoter:
         HFH-3   AML1a   Tal-1   ATF-2   GATA-1   E47   FOXI1   HEN1   CRE-BP1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF710 promoter sequence
   Search Chromatin IP Primers for ZNF710

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF710


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.1   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q26.1

ZNF710 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF710 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P090544:  view genomic region     (about GC identifiers)

Start:
90,544,624 bp from pter      End:
90,625,438 bp from pter
Size:
80,815 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN710_HUMAN, Q8N1W2 (See protein sequence)
Recommended Name: Zinc finger protein 710  
Size: 664 amino acids; 74461 Da
Secondary accessions: A0AVS3 Q6ZMK9 Q8NDU0

Explore the universe of human proteins at neXtProt for ZNF710: NX_Q8N1W2

Explore proteomics data for ZNF710 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF710 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_940928.2  
    ENSEMBL proteins: 
     ENSP00000268154   ENSP00000452993   ENSP00000453404   ENSP00000453147  
    Reactome Protein details: Q8N1W2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8N1W2

    ProtoNet protein and cluster: Q8N1W2

    UniProtKB/Swiss-Prot: ZN710_HUMAN, Q8N1W2
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 11 C2H2-type zinc fingers


    Find genes that share domains with ZNF710           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN710_HUMAN, Q8N1W2
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF710           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF710
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    miRNA
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    miRTarBase miRNAs that target ZNF710:
    hsa-mir-17-3p (MIRT050777), hsa-mir-320a (MIRT044509)

    Block miRNA regulation of human, mouse, rat ZNF710 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZNF710 (see all 70):
    hsa-miR-579 hsa-miR-140-5p hsa-miR-1321 hsa-miR-199a-3p hsa-miR-374a hsa-miR-3622b-3p hsa-miR-637 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidZNF710 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZNF710

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN710_HUMAN, Q8N1W2: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF710           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF710 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF710           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF710
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF710
    Interactions:

        Search GeneGlobe Interaction Network for ZNF710

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF710           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF710 (ZN710)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF710 gene: 
    NM_198526.2  

    Unigene Cluster for ZNF710:

    Zinc finger protein 710
    Hs.459311  [show with all ESTs]
    Unigene Representative Sequence: NM_198526
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000268154(uc002bov.2) ENST00000559419 ENST00000558883 ENST00000559360
    ENST00000560908
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZNF710 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZNF710 (see all 70):
    hsa-miR-579 hsa-miR-140-5p hsa-miR-1321 hsa-miR-199a-3p hsa-miR-374a hsa-miR-3622b-3p hsa-miR-637 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidZNF710 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ZNF710
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF710
    Clone
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    GenScript: all cDNA clones in your preferred vector: ZNF710 (NM_198526)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF710
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF710
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF710
      QuantiFast Probe-based Assays in human, mouse, rat ZNF710

    Additional mRNA sequence: 

    AK094712.1 AK160373.1 AL831826.1 BC020301.1 BC126476.1 BC130541.1 

    5 DOTS entries:

    DT.121027175  DT.100027620  DT.97802552  DT.439227  DT.91766554 

    Selected AceView cDNA sequences (see all 184):

    AW137795 AL831826 BM803864 T33651 BQ941527 BE249848 AA905524 AI569675 
    AI378912 T31225 AI962492 AI796844 AW015547 AA976277 BE856772 BG059753 
    AI468156 BQ614288 F01734 AI417408 BF514761 AA907113 AK094712 AK160373 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF710 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCAGGGCA
    ZNF710 Expression
    About this image

    ZNF710 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF710 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.459311
        Custom PCR Arrays for ZNF710
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF710

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ZNF710 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp7101 , 5 zinc finger protein 7101, 5 88.91(n)1
    94.58(a)1
      7 (45.36 cM)5
    2092251  NM_001145999.11  NP_001139471.11 
     800248145 
    chicken
    (Gallus gallus)
    Aves ZNF7101 zinc finger protein 710 80.3(n)
    78.43(a)
      100858113  XM_003641833.2  XP_003641881.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF7106
    zinc finger protein 710
    67(a)
    1 ↔ 1
    AAWZ02035329(26054-29508)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia znf7101 zinc finger protein 710 68.54(n)
    72.15(a)
      100488876  XM_004912644.1  XP_004912701.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi04b072 wufi04b07 80.24(n)   327348  BC054704.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PZF1(YPR186C)4 Transcription factor IIIA (TFIIIA); essential DNA binding more   --   16(911022-909733) 856316  NP_015512.1 


    ENSEMBL Gene Tree for ZNF710 (if available)
    TreeFam Gene Tree for ZNF710 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF710 gene
    ZNF3662  
    Selected SIMAP similar genes for ZNF710 using alignment to 4 protein entries:     ZN710_HUMAN (see all proteins) (see all similar genes):
    ZNF366    ZNF55    GFI1    ZFP112    ZNF596    kr-znf3
    A-328A3.4    ZBTB44    ZFP41    ZNF226    ZNF72    HKR1
    ZFS-1    ZSCAN21    ZSCAN22    ZNF    ZNF112    HZF16

    Find genes that share paralogs with ZNF710           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF710 (see all 1684)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs355220871,2
    C--70288237(+) TCCCC-/G/GC  
            
    CCCCG
    1 -- int11NA 2
    rs727565971,2
    --90542882(+) GCACCA/GGGAGC 1 -- us2k10--------
    rs1917680431,2
    --90543093(+) AGTGTA/GGGAGG 1 -- us2k10--------
    rs1839345281,2
    --90543140(+) AGCCGA/GGAGGA 1 -- us2k10--------
    rs1456122511,2
    --90543297(+) TGGCTA/GCAGCC 1 -- us2k10--------
    rs1382202501,2
    --90543323(+) GGCATC/TCAGCA 1 -- us2k10--------
    rs727565981,2
    --90543337(+) GCTCAA/GTACTT 1 -- us2k10--------
    rs1426536011,2
    --90543511(+) GGCTCC/TGGACC 1 -- us2k10--------
    rs285491751,2
    C,F--90543529(+) CGTTGC/GAGTCG 1 -- us2k14Minor allele frequency- G:0.47WA CSA 123
    rs1147414501,2
    F--90543906(+) CCAGGC/TCCATC 1 -- us2k11Minor allele frequency- T:0.02WA 118

    HapMap Linkage Disequilibrium report for ZNF710 (90544624 - 90625438 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ZNF710:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv997696CNV Deletion20482838
    nsv94745CNV Loss16902084
    nsv827430CNV Loss20364138
    dgv112e55CNV Gain17911159
    nsv904486CNV Gain21882294
    dgv776e1CNV Complex17122850
    dgv777e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF710 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF710)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 374655 HGNC: 25352 AceView: DKFZp547K1113 Ensembl:ENSG00000140548 euGenes: HUgn374655
    ECgene: ZNF710 H-InvDB: ZNF710

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF710 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF710 gene:
    Search GeneIP for patents involving ZNF710

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