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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF710 Gene

protein-coding   GIFtS: 43
GCID: GC15P090544

Zinc Finger Protein 710

  Search for ZNF710
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 7101 2

External Ids:    HGNC: 253521   Entrez Gene: 3746552   Ensembl: ENSG000001405487   UniProtKB: Q8N1W23   

Export aliases for ZNF710 gene to outside databases

Previous GC identifers: GC15P088346 GC15P066721


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF710 Gene: 
ZNF710 (zinc finger protein 710) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF366.

UniProtKB/Swiss-Prot: ZN710_HUMAN, Q8N1W2
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010274.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF710 gene promoter:
         HFH-3   AML1a   Tal-1   ATF-2   GATA-1   E47   FOXI1   HEN1   CRE-BP1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF710 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF710

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF710


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.1   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q26.1

ZNF710 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF710 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P090544:  view genomic region     (about GC identifiers)

Start:
90,544,624 bp from pter      End:
90,625,438 bp from pter
Size:
80,815 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN710_HUMAN, Q8N1W2 (See protein sequence)
Recommended Name: Zinc finger protein 710  
Size: 664 amino acids; 74461 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: A0AVS3 Q6ZMK9 Q8NDU0

Explore the universe of human proteins at neXtProt for ZNF710: NX_Q8N1W2

Explore proteomics data for ZNF710 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N1W2

  • ZNF710 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF710 Protein Expression
    REFSEQ proteins: NP_940928.2  
    ENSEMBL proteins: 
     ENSP00000268154   ENSP00000452993   ENSP00000453404   ENSP00000453147  
    Reactome Protein details: Q8N1W2
    Human Recombinant Protein Products for ZNF710: 
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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZNF710 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8N1W2

    ProtoNet protein and cluster: Q8N1W2

    UniProtKB/Swiss-Prot: ZN710_HUMAN, Q8N1W2
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 11 C2H2-type zinc fingers


    ZNF710 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN710_HUMAN, Q8N1W2
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF710 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF710 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF710
        Generic Transcription Pathway
    Gene Expression



    ZNF710 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF710

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF710 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF710 (ZN710)

    Search CenterWatch for drugs/clinical trials and news about ZNF710 / ZN710

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF710 gene: 
    NM_198526.2  

    Unigene Cluster for ZNF710:

    Zinc finger protein 710
    Hs.459311  [show with all ESTs]
    Unigene Representative Sequence: NM_198526
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000268154(uc002bov.2) ENST00000559419 ENST00000558883 ENST00000559360
    ENST00000560908
    miRNA
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    hsa-miR-579 hsa-miR-140-5p hsa-miR-1321 hsa-miR-199a-3p hsa-miR-374a hsa-miR-3622b-3p hsa-miR-637 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidZNF710 3' UTR sequence
    Inhib. RNA
    Products:
         
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF710

    Additional mRNA sequence: 

    AK094712.1 AK160373.1 AL831826.1 BC020301.1 BC126476.1 BC130541.1 

    5 DOTS entries:

    DT.121027175  DT.100027620  DT.97802552  DT.439227  DT.91766554 

    24/184 AceView cDNA sequences (see all 184):

    Z39988 BC020301 NM_198526 AI092856 BQ614288 T33651 AA905524 BM675961 
    AK160373 AK094712 BE249848 BQ941527 AI962492 AW015547 AI422098 T31225 
    AW151866 AA976277 AW137795 AI796844 F01734 AI378912 BG059753 AA417562 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF710 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCAGGGCA
    ZNF710 Expression
    About this image


    See ZNF710 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF710

    SOURCE GeneReport for Unigene cluster: Hs.459311
        SABiosciences Custom PCR Arrays for ZNF710
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF710

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF710 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp7101 , 5 zinc finger protein 7101, 5 89.11(n)1
    95.03(a)1
      7 (45.36 cM)5
    2092251  NM_001145999.11  NP_001139471.11 
     800248145 
    chicken
    (Gallus gallus)
    Aves ZNF7101 zinc finger protein 710 80.87(n)
    80.06(a)
      100858113  XM_003641833.1  XP_003641881.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF7106
    Uncharacterized protein
    69(a)
    1 ↔ 1
    AAWZ02035329(26054-29508)
    zebrafish
    (Danio rerio)
    Actinopterygii wufi04b072 wufi04b07 80.24(n)   327348  BC054704.1 


    ENSEMBL Gene Tree for ZNF710 (if available)
    TreeFam Gene Tree for ZNF710 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF710 gene
    ZNF3662  
    18/304 SIMAP similar genes for ZNF710 using alignment to 4 protein entries:     ZN710_HUMAN (see all proteins) (see all similar genes):
    ZNF366    ZNF55    GFI1    ZFP112    ZNF596    kr-znf3
    A-328A3.4    ZBTB44    ZFP41    ZNF226    ZNF72    HKR1
    ZFS-1    ZSCAN21    ZSCAN22    ZNF    ZNF112    HZF16

    ZNF710 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1684 SNPs in ZNF710 are shown (see all 1684)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs355220871,2
    C--70288237(+) TCCCC-/G/GC  
            
    CCCCG
    1 -- int11NA 2
    rs727565971,2
    --90542882(+) GCACCA/GGGAGC 1 -- us2k10--------
    rs1917680431,2
    --90543093(+) AGTGTA/GGGAGG 1 -- us2k10--------
    rs1839345281,2
    --90543140(+) AGCCGA/GGAGGA 1 -- us2k10--------
    rs1456122511,2
    --90543297(+) TGGCTA/GCAGCC 1 -- us2k10--------
    rs1382202501,2
    --90543323(+) GGCATC/TCAGCA 1 -- us2k10--------
    rs727565981,2
    --90543337(+) GCTCAA/GTACTT 1 -- us2k10--------
    rs1426536011,2
    --90543511(+) GGCTCC/TGGACC 1 -- us2k10--------
    rs285491751,2
    C,F--90543529(+) CGTTGC/GAGTCG 1 -- us2k14Minor allele frequency- G:0.47WA CSA 123
    rs1147414501,2
    F--90543906(+) CCAGGC/TCCATC 1 -- us2k11Minor allele frequency- T:0.02WA 118

    HapMap Linkage Disequilibrium report for ZNF710 (90544624 - 90625438 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ZNF710:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv997696CNV Deletion20482838
    nsv94745CNV Loss16902084
    nsv827430CNV Loss20364138
    dgv112e55CNV Gain17911159
    nsv904486CNV Gain21882294
    dgv776e1CNV Complex17122850
    dgv777e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF710 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF710)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    5. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 374655 HGNC: 25352 AceView: DKFZp547K1113 Ensembl:ENSG00000140548 euGenes: HUgn374655
    ECgene: ZNF710 H-InvDB: ZNF710

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF710 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF710 gene:
    Search GeneIP for patents involving ZNF710

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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